{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:18:40Z","timestamp":1790252320962,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004809","name":"FINEP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007396","name":"MCT","doi-asserted-by":"publisher","award":["01.05.0812.00"],"award-info":[{"award-number":["01.05.0812.00"]}],"id":[{"id":"10.13039\/501100007396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002248","name":"MS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002248","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DECIT"},{"DOI":"10.13039\/100004811","name":"CT","doi-asserted-by":"publisher","award":["551023\/2007-4"],"award-info":[{"award-number":["551023\/2007-4"]}],"id":[{"id":"10.13039\/100004811","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010689","name":"BIOTEC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010689","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.jep.2019.02.014","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T11:50:58Z","timestamp":1549972258000},"page":"248-254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Aleurites moluccanus and its main active constituent, the flavonoid 2\u2033-O-rhamnosylswertisin, in experimental model of rheumatoid arthritis"],"prefix":"10.1016","volume":"235","author":[{"given":"Nara Lins Meira","family":"Quint\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ver\u00f4nica D\u00e1vila","family":"Pastor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla de-Souza","family":"Antonialli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislaine Francieli","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian W\u00fcnsch","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talita Elisa","family":"Bert\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Maria","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Meyre-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth Meri","family":"Lucinda-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania Mari Belle","family":"Bresolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir","family":"Cechinel Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jep.2019.02.014_bib1","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1002\/art.30303","article-title":"Imaging studies in Freund's complete adjuvant model of regional polyarthritis, a model suitable for the study of pain mechanisms, in the rat","volume":"63","author":"Almarestani","year":"2011","journal-title":"Arthritis Rheumatol."},{"issue":"2","key":"10.1016\/j.jep.2019.02.014_bib2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.jep.2019.02.014_bib3","doi-asserted-by":"crossref","first-page":"R140","DOI":"10.1186\/ar3079","article-title":"Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis","volume":"12","author":"Boettger","year":"2010","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"10.1016\/j.jep.2019.02.014_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/1715163514521377","article-title":"Practice guidelines for pharmacists: the pharmacological management of rheumatoid arthritis with traditional and biologic disease-modifying antirheumatic drugs","volume":"147","author":"Bornstein","year":"2014","journal-title":"Can. Pharm. J. (Ott.)."},{"key":"10.1016\/j.jep.2019.02.014_bib5","first-page":"271","article-title":"Prevalence of arthritis according to age, sex and socioeconomic status in six low and middle income countries: analysis of data from the World Health Organization study on global AGEing and adult health (SAGE) Wave 1","volume":"18","author":"Brennan-Olsen","year":"2017"},{"issue":"1","key":"10.1016\/j.jep.2019.02.014_bib6","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jep.2012.06.051","article-title":"Antinociceptive, anti-inflammatory and wound healing features in animal models treated with a semisolid herbal medicine based on Aleurites moluccana L. Willd. Euforbiaceae standardized leaf extract: semisolid herbal","volume":"143","author":"Cesca","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.02.014_bib7","series-title":"Dicion\u00e1rio das plantas \u00fateis do Brasil e das ex\u00f3ticas cultivadas","first-page":"294","volume":"5","author":"Corr\u00eaa","year":"1984"},{"issue":"3","key":"10.1016\/j.jep.2019.02.014_bib8","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1124\/jpet.109.155762","article-title":"In vivo up-regulation of kinin B1 receptors after treatment with Porphyromonas gingivalis lipopolysaccharide in rat paw","volume":"330","author":"Dornelles","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jep.2019.02.014_bib9","series-title":"Handbook of Medicinal Herbs","author":"Duke","year":"1929"},{"issue":"12","key":"10.1016\/j.jep.2019.02.014_bib10","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1002\/art.34675","article-title":"The role of interleukin-1\u03b2 in arthritic pain: main involvement in thermal, but not mechanical, hyperalgesia in rat antigen-induced arthritis","volume":"64","author":"Ebbinghaus","year":"2012","journal-title":"Arthritis Rheumatol."},{"issue":"3","key":"10.1016\/j.jep.2019.02.014_bib11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejphar.2007.04.059","article-title":"Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea","volume":"569","author":"Fernandes","year":"2007","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.jep.2019.02.014_bib12","first-page":"935","article-title":"Toxicity of candlenut seed (Aleurites moluccanus), a purported herbal weight loss supplement","volume":"55","author":"Gonz\u00e1lez-Stuart","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.jep.2019.02.014_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"issue":"8","key":"10.1016\/j.jep.2019.02.014_bib14","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1271\/bbb.70792","article-title":"Effects of a casein hydrolysate prepared from Aspergillus oryzae protease on adjuvant arthritis in rats","volume":"72","author":"Hatori","year":"2008","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"4","key":"10.1016\/j.jep.2019.02.014_bib15","doi-asserted-by":"crossref","first-page":"R807","DOI":"10.1186\/ar1743","article-title":"The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation","volume":"7","author":"Inglis","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2019.02.014_bib16","first-page":"239","article-title":"Laau Lapa\u2019au: herbal healing among contemporary Hawaiian healers","volume":"5","author":"Judd","year":"1998","journal-title":"Pac. Health Dialog"},{"issue":"10","key":"10.1016\/j.jep.2019.02.014_bib17","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1002\/art.21297","article-title":"Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation","volume":"52","author":"Keeble","year":"2005","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"10.1016\/j.jep.2019.02.014_bib18","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/ar3222","article-title":"Molecular targets of natural health products in arthritis","volume":"13","author":"Khalif\u00e9","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2019.02.014_bib19","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fnut.2017.00052","article-title":"Managing Rheumatoid Arthritis with Dietary Interventions","volume":"4","author":"Khanna","year":"2017","journal-title":"Front Nutr."},{"issue":"2","key":"10.1016\/j.jep.2019.02.014_bib20","first-page":"E95","article-title":"The effects of pressure on arthritic knees in a rat model of CFA-induced arthritis","volume":"16","author":"Koo","year":"2013","journal-title":"Pain Physician"},{"issue":"1","key":"10.1016\/j.jep.2019.02.014_bib21","doi-asserted-by":"crossref","first-page":"R6","DOI":"10.1186\/ar2354","article-title":"Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis","volume":"10","author":"Koufany","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2019.02.014_bib22","first-page":"3","article-title":"Ecology, silviculture and productivity Aleurites moluccana (L.)Willd","author":"Krisnawati","year":"2011","journal-title":"Cent. Int. For. Res."},{"issue":"3","key":"10.1016\/j.jep.2019.02.014_bib23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000026429","article-title":"Local application of capsaicin into the draining lymph nodes attenuates expression of adjuvant-induced arthritis","volume":"7","author":"Lorton","year":"2000","journal-title":"Neuroimmunomodulation"},{"issue":"2","key":"10.1016\/j.jep.2019.02.014_bib24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0944-7113(98)80006-8","article-title":"Preliminary phytochemical and pharmacological studies of Aleurites moluccana leaves (L.) Willd","volume":"5","author":"Meyre-Silva","year":"1998","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2019.02.014_bib25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1055\/s-2006-960785","article-title":"Isolation of C-glycoside flavonoid with antinociceptive action from Aleurites moluccana leaves","volume":"65","author":"Meyre-Silva","year":"1999","journal-title":"Planta Med."},{"issue":"6","key":"10.1016\/j.jep.2019.02.014_bib26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2094","article-title":"Cytokines in the pathogenesis of rheumatoid arthritis","volume":"7","author":"McInnes","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2019.02.014_bib27","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1254\/jphs.FP0070534","article-title":"Tranilast suppresses the disease development of the adjuvant- and streptococcal cell wall-induced arthritis in rats","volume":"105","author":"Nagate","year":"2007","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.jep.2019.02.014_bib28","series-title":"National Clinical Guideline Centre (UK)","author":"NICE Clinical Guidelines, NG. 100","year":"2018"},{"issue":"8","key":"10.1016\/j.jep.2019.02.014_bib29","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1080\/13543776.2018.1502748","article-title":"New strategies for patenting biological medicines used in rheumatoid arthritis treatment","volume":"28","author":"Oliveira","year":"2018","journal-title":"Expert. Opin. Ther. Pat."},{"key":"10.1016\/j.jep.2019.02.014_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2017.04.020","article-title":"Anti-rheumatoid arthritis effects of traditional Chinese herb couple in adjuvant-induced arthritis in rats","volume":"205","author":"Pan","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2019.02.014_bib31","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.pbb.2012.05.005","article-title":"Aleurites moluccana and its main active ingredient, the flavonoid 2\u2033-O-rhamnosylswertisin, have promising antinociceptive effects in experimental models of hypersensitivity in mice","volume":"102","author":"Quint\u00e3o","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"4","key":"10.1016\/j.jep.2019.02.014_bib32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.phymed.2007.03.015","article-title":"Evaluation of the effects of the herbal product Catuama in inflammatory and neuropathic models of nociception in rats","volume":"15","author":"Quint\u00e3o","year":"2008","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2019.02.014_bib33","doi-asserted-by":"crossref","first-page":"179890","DOI":"10.1155\/2011\/179890","article-title":"Aleurites moluccana (L.) willd. Leaves: mechanical antinociceptive properties of a standardized dried extract and its chemical markers","volume":"2011","author":"Quint\u00e3o","year":"2011","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2019.02.014_bib34","doi-asserted-by":"crossref","first-page":"636839","DOI":"10.1155\/2014\/636839","article-title":"Contribution of \u03b1,\u03b2-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects of Aleurites moluccana (L.)Willd","volume":"2014","author":"Quint\u00e3o","year":"2014","journal-title":"BioMed. Res. Int."},{"issue":"3","key":"10.1016\/j.jep.2019.02.014_bib35","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/rheumatology\/kex308","article-title":"Divergent roles of immune cells and their mediators in pain","volume":"57","author":"Raoof","year":"2018","journal-title":"Rheumatol. (Oxf.)."},{"issue":"5","key":"10.1016\/j.jep.2019.02.014_bib36","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1080\/14397595.2016.1266071","article-title":"A review on interleukins: the key manipulators in rheumatoid arthritis","volume":"27","author":"Sharma","year":"2017","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.jep.2019.02.014_bib37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/molecules23050988","article-title":"Sulforaphane Modulates Joint Inflammation in a Murine Model of Complete Freund's Adjuvant-Induced Mono-Arthritis","volume":"23","author":"Silva Rodrigues","year":"2018","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.jep.2019.02.014_bib38","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/path.1400","article-title":"Extracellular matrix remodelling: the role of matrix metalloproteinases","volume":"200","author":"Stamenkovic","year":"2003","journal-title":"J. Pathol."},{"key":"10.1016\/j.jep.2019.02.014_bib39","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.biopha.2018.07.027","article-title":"Novel drug delivery systems for NSAIDs in management of rheumatoid arthritis: an overview","volume":"106","author":"Thakur","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.jep.2019.02.014_bib40","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.pbb.2007.05.010","article-title":"Evaluation of pain behavior and bone destruction in two arthritic models in guinea pig and rat","volume":"87","author":"Vermeirsch","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jep.2019.02.014_bib41","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.toxicon.2016.11.009","article-title":"Intra-articular injection of Botulinum toxin A reduces neurogenic inflammation in CFA-induced arthritic rat model","volume":"126","author":"Wang","year":"2017","journal-title":"Toxicon"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118335827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118335827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T15:38:04Z","timestamp":1565192284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874118335827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":41,"alternative-id":["S0378874118335827"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.02.014","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aleurites moluccanus and its main active constituent, the flavonoid 2\u2033-O-rhamnosylswertisin, in experimental model of rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}