{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:06:17Z","timestamp":1791295577836,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Hebei Science and Technology Department","award":["17275505D"],"award-info":[{"award-number":["17275505D"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.jep.2019.02.045","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T18:13:25Z","timestamp":1551982405000},"page":"124-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Antiviral activity of sophoridine against enterovirus 71 in vitro"],"prefix":"10.1016","volume":"236","author":[{"given":"Gang","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guotao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haipeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengjun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jep.2019.02.045_bib1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/jmv.23741","article-title":"Recombination and evolutionary dynamics of human echovirus 6","volume":"86","author":"Cabrerizo","year":"2014","journal-title":"J. Med. Virol."},{"issue":"10","key":"10.1016\/j.jep.2019.02.045_bib2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/iub.1434","article-title":"Enterovirus 71 infection caused neuronal cell death and cytokine expression in cultured rat neural cells","volume":"67","author":"Chang","year":"2015","journal-title":"IUBMB Life"},{"issue":"11","key":"10.1016\/j.jep.2019.02.045_bib3","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1111\/j.1462-5822.2007.00988.x","article-title":"Enterovirus 71 triggering of neuronal apoptosis through activation of Abl-Cdk5 signalling","volume":"9","author":"Chen","year":"2007","journal-title":"Cell Microbiol."},{"issue":"2","key":"10.1016\/j.jep.2019.02.045_bib4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1142\/S0192415X17500197","article-title":"Flos farfarae inhibits enterovirus 71-induced cell injury by preventing viral replication and structural protein expression","volume":"45","author":"Chiang","year":"2017","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2019.02.045_bib5","series-title":"Traditional Chinese Medicine Useful for Treating Pediatric Hand-Foot-And-Mouth Disease, Contains Cyclea Barbata, Subprostrate sophora, Golden Cypress, Yam, Tuckahoe, Viola Philippica, Stellaria Saxatilis and Veronica Serpyllifolia","first-page":"4","author":"Guo","year":"2013"},{"key":"10.1016\/j.jep.2019.02.045_bib6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jep.2015.06.010","article-title":"Sophora flavescens Ait.: traditional usage, phytochemistry and pharmacology of an important traditional Chinese medicine","volume":"172","author":"He","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.02.045_bib7","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jep.2016.03.034","article-title":"Gan-Lu-Siao-Du-yin, a prescription of traditional Chinese medicine, inhibited enterovirus 71 replication, translation, and virus-induced cell apoptosis","volume":"185","author":"Hsieh","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.02.045_bib8","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.virol.2014.09.017","article-title":"Enterovirus 71 infects brain-derived neural progenitor cells","volume":"468\u2013470","author":"Huang","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.jep.2019.02.045_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1743-422X-7-47","article-title":"The cross-reactivity of the enterovirus 71 to human brain tissue and identification of the cross-reactivity related fragments","volume":"7","author":"Jia","year":"2010","journal-title":"Virol. J."},{"issue":"11","key":"10.1016\/j.jep.2019.02.045_bib10","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1002\/jmv.23391","article-title":"Diagnosis of hand, foot, and mouth disease caused by EV71 and other enteroviruses by a one-step, single tube, duplex RT-PCR","volume":"84","author":"Jiang","year":"2012","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jep.2019.02.045_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2015.10.011","article-title":"Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses","volume":"124","author":"Kang","year":"2015","journal-title":"Antivir. Res."},{"issue":"2","key":"10.1016\/j.jep.2019.02.045_bib12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1586\/erv.09.152","article-title":"Development of enterovirus 71 vaccines","volume":"9","author":"Lee","year":"2010","journal-title":"Expert Rev. Vaccines"},{"issue":"6","key":"10.1016\/j.jep.2019.02.045_bib13","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1086\/527326","article-title":"Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication","volume":"197","author":"Li","year":"2008","journal-title":"J. Infect. Dis."},{"issue":"4","key":"10.1016\/j.jep.2019.02.045_bib14","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/jmv.20216","article-title":"Human endothelial cell activation and apoptosis induced by enterovirus 71 infection","volume":"74","author":"Liang","year":"2004","journal-title":"J. Med. Virol."},{"issue":"25\u201326","key":"10.1016\/j.jep.2019.02.045_bib15","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.lfs.2012.09.021","article-title":"Sophoridine exerts an anti-colorectal carcinoma effect through apoptosis induction in vitro and in vivo","volume":"91","author":"Liang","year":"2012","journal-title":"Life Sci."},{"issue":"8","key":"10.1016\/j.jep.2019.02.045_bib16","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/jccs.201300584","article-title":"Electrochemical studies of anticancer herbal drug sophoridine and its interaction with DNA","volume":"61","author":"Liu","year":"2014","journal-title":"J. Chin. Chem. Soc."},{"issue":"3","key":"10.1016\/j.jep.2019.02.045_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1142\/S0192415X03001107","article-title":"Radix Sophorae flavescentis for chronic hepatitis B: a systematic review of randomized trials","volume":"31","author":"Liu","year":"2003","journal-title":"Am. J. Chin. Med."},{"issue":"10","key":"10.1016\/j.jep.2019.02.045_bib18","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/jmv.23372","article-title":"Identification and characterization of a monoclonal antibody recognizing the linear epitope RVADVI on VP1 protein of enterovirus 71","volume":"84","author":"Man-Li","year":"2012","journal-title":"J. Med. Virol."},{"issue":"5","key":"10.1016\/j.jep.2019.02.045_bib19","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1586\/14760584.2016.1138862","article-title":"EV71 vaccine, a new tool to control outbreaks of hand, foot and mouth disease (HFMD)","volume":"15","author":"Mao","year":"2016","journal-title":"Expert Rev. Vaccines"},{"issue":"1","key":"10.1016\/j.jep.2019.02.045_bib20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1574-6976.2002.tb00601.x","article-title":"An overview of the evolution of enterovirus 71 and its clinical and public health significance","volume":"26","author":"McMinn","year":"2002","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.jep.2019.02.045_bib21","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jep.2017.10.030","article-title":"A reactive oxygen species activation mechanism contributes to Sophoridine-induced apoptosis in rat liver BRL-3A cells","volume":"213","author":"Qiu","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2019.02.045_bib22","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/infdis\/129.3.304","article-title":"An apparently new enterovirus isolated from patients with disease of the central nervous system","volume":"129","author":"Schmidt","year":"1974","journal-title":"J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.jep.2019.02.045_bib23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3892\/ol.2013.1399","article-title":"Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF-kappa B signaling pathway","volume":"6","author":"Shao","year":"2013","journal-title":"Oncol. Lett."},{"issue":"5","key":"10.1016\/j.jep.2019.02.045_bib24","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.bmcl.2015.09.010","article-title":"Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines","volume":"26","author":"Tan","year":"2016","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.jep.2019.02.045_bib25","first-page":"503165","article-title":"Antiviral ability of Kalanchoe gracilis leaf extract against enterovirus 71 and coxsackievirus A16","volume":"2012","author":"Wang","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"4","key":"10.1016\/j.jep.2019.02.045_bib26","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1086\/376998","article-title":"Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema","volume":"188","author":"Wang","year":"2003","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.jep.2019.02.045_bib27","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1086\/520149","article-title":"Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications","volume":"29","author":"Wang","year":"1999","journal-title":"Clin. Infect. Dis."},{"issue":"2","key":"10.1016\/j.jep.2019.02.045_bib28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/jmv.2038","article-title":"Complete genome analysis of enterovirus 71 isolated from an outbreak in Taiwan and rapid identification of enterovirus 71 and coxsackievirus A16 by RT-PCR","volume":"65","author":"Yan","year":"2001","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jep.2019.02.045_bib29","series-title":"Traditional Chinese Medicine Preparation for Treating Hand, Foot and Mouth Disease Comprises Fructus Forsythia, Flos Lonicerae, Radix Arnebiae, and Radix Sophorae Flavescentis","first-page":"15","author":"Yang","year":"2013"},{"issue":"17","key":"10.1016\/j.jep.2019.02.045_bib30","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/j.lfs.2005.09.034","article-title":"Antiviral effects of sophoridine against coxsackievirus B3 and its pharmacokinetics in rats","volume":"78","author":"Zhang","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2019.02.045_bib31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jconrel.2016.10.019","article-title":"Transcutaneous immunization via rapidly dissolvable microneedles protects against hand-foot-and-mouth disease caused by enterovirus 71","volume":"243","author":"Zhu","year":"2016","journal-title":"J. Control. Release"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118348396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118348396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T13:18:47Z","timestamp":1558617527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874118348396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":31,"alternative-id":["S0378874118348396"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.02.045","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiviral activity of sophoridine against enterovirus 71 in vitro","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.02.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}