{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:52:15Z","timestamp":1792191135052,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860773"],"award-info":[{"award-number":["81860773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873185"],"award-info":[{"award-number":["81873185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760645"],"award-info":[{"award-number":["81760645"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1703108"],"award-info":[{"award-number":["U1703108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.jep.2019.03.045","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T18:36:33Z","timestamp":1553020593000},"page":"182-191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Effect of water extract from Berberis heteropoda Schrenk roots on diarrhea-predominant irritable bowel syndrome by adjusting intestinal flora"],"prefix":"10.1016","volume":"237","author":[{"given":"Hui-min","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-ya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2019.03.045_bib1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4291\/wjgp.v1.i3.97","article-title":"Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome","volume":"3","author":"Akiho","year":"2010","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"10.1016\/j.jep.2019.03.045_bib2","first-page":"207","article-title":"Advances in research on pathogenesis of irritable bowel syndrome","volume":"03","author":"Bingbing","year":"2004","journal-title":"Beijing Med."},{"key":"10.1016\/j.jep.2019.03.045_bib3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/BJ20082222","article-title":"The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection","volume":"2","author":"Burger-van","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.jep.2019.03.045_bib4","doi-asserted-by":"crossref","first-page":"G775","DOI":"10.1152\/ajpgi.00155.2012","article-title":"Irritable Bowel Syndrome: methods, Mechanisms, and Pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome","volume":"7","author":"Camilleri","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver"},{"key":"10.1016\/j.jep.2019.03.045_bib5","first-page":"71","article-title":"The epidemiology of irritable bowel syndrome","author":"Canavan","year":"2014","journal-title":"Clin. Epidemiol."},{"key":"10.1016\/j.jep.2019.03.045_bib6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1440-1746.2006.04672.x","article-title":"Irritable bowel syndrome in the 21st century: perspectives from Asia or South-east Asia","volume":"1","author":"Chang","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2019.03.045_bib7","doi-asserted-by":"crossref","first-page":"e54183","DOI":"10.1371\/journal.pone.0054183","article-title":"A school-based study with rome III criteria on the prevalence of functional gastrointestinal disorders in Chinese college and university students","volume":"1","author":"Dong","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2019.03.045_bib8","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature09646","article-title":"Bifidobacteria can protect from enteropathogenic infection through production of acetate","volume":"7331","author":"Fukuda","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jep.2019.03.045_bib9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000333083","article-title":"Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis","volume":"1","author":"Gecse","year":"2012","journal-title":"Digestion"},{"key":"10.1016\/j.jep.2019.03.045_bib10","first-page":"135","article-title":"Intestinal mucosal barrier, intestinal flora and intestinal homeostasis","volume":"03","author":"Huan","year":"2014","journal-title":"J. Clin. Dig. Dis."},{"key":"10.1016\/j.jep.2019.03.045_bib11","first-page":"492","article-title":"Comparative study on in vitro antibacterial activity of root extract and root xylem extract of Xinjiang blackberry","volume":"04","author":"Huimin","year":"2018","journal-title":"Northwest. Pharm. J."},{"key":"10.1016\/j.jep.2019.03.045_bib12","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/j.1365-2036.2005.02463.x","article-title":"Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact","volume":"11","author":"Hungin","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jep.2019.03.045_bib13","first-page":"20","article-title":"Berberis heteropoda Schrenk has great development potential","volume":"05","author":"Jiang","year":"2002","journal-title":"Plant J."},{"key":"10.1016\/j.jep.2019.03.045_bib14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0149-7634(81)90005-1","article-title":"Acute and chronic stress effects on open field activity in the rat: implications for a model of depression","volume":"2","author":"Katz","year":"1981","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jep.2019.03.045_bib15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ejpain.2010.08.005","article-title":"Spinal cord plasticity and acid-sensing ion channels involvement in a rodent model of irritable bowel syndrome","volume":"4","author":"Matricon","year":"2011","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.jep.2019.03.045_bib16","first-page":"394","article-title":"Advances in research on relationship between irritable bowel syndrome and intestinal microecology","volume":"03","author":"Mengting","year":"2014","journal-title":"West. Med."},{"key":"10.1016\/j.jep.2019.03.045_bib17","series-title":"Handbook of Chinese Herbal Medicines in Xinjiang","author":"Ministry Of Health","year":"1970"},{"key":"10.1016\/j.jep.2019.03.045_bib18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/00365528708991878","article-title":"Short-chain fatty acids and the irritable bowel syndrome: the effect of wheat bran","volume":"2","author":"Mortensen","year":"1987","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.jep.2019.03.045_bib19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.biopsych.2008.06.026","article-title":"Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses","volume":"3","author":"O'Mahony","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jep.2019.03.045_bib20","series-title":"Interpretation of the National Standards for Food Safety, Food Microbiological Testing for Mold and Yeast Count","author":"Qun-fei","year":"2018"},{"key":"10.1016\/j.jep.2019.03.045_bib21","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/ajg.2015.220","article-title":"Altered colonic bacterial fermentation as a potential pathophysiological factor in irritable bowel syndrome","volume":"9","author":"Ringel-Kulka","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jep.2019.03.045_bib22","series-title":"Discussion on the New Mechanism of Tongxie Yaofang in the Treatment of IBS Model Rats Based on \"Cerebral Enteric axis\"","author":"Rong","year":"2016"},{"key":"10.1016\/j.jep.2019.03.045_bib23","volume":"vol. 53","author":"Shenggang","year":"2017"},{"key":"10.1016\/j.jep.2019.03.045_bib24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/B978-0-12-800100-4.00003-9","article-title":"The role of short-chain fatty acids in health and disease","author":"Tan","year":"2014","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.jep.2019.03.045_bib25","first-page":"280","article-title":"Fecal short-chain fatty acids in patients with diarrhea-predominant irritable bowel syndrome: in vitro studies of carbohydrate fermentation","volume":"3","author":"Treem","year":"1996","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.jep.2019.03.045_bib26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2147\/CEG.S11349","article-title":"Intestinal fermentation in patients with self-reported food hypersensitivity: painful, but protective?","author":"Valeur","year":"2010","journal-title":"Clin. Exp. Gastroenterol."},{"key":"10.1016\/j.jep.2019.03.045_bib27","first-page":"5815","article-title":"Advances in short-chain fatty acid-mediated microbial-host interaction and irritable bowel syndrome","volume":"36","author":"Wanli","year":"2015","journal-title":"World Chin. J. Dig."},{"key":"10.1016\/j.jep.2019.03.045_bib28","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0016-5085(88)90231-4","article-title":"Stress-induced changes in intestinal transit in the rat: a model for irritable bowel syndrome","volume":"94","author":"Williams","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2019.03.045_bib29","first-page":"24","article-title":"Quality of life in managed care patients with irritable bowel syndrome","volume":"2","author":"Wilson","year":"2004","journal-title":"Manag. Care Interface"},{"key":"10.1016\/j.jep.2019.03.045_bib30","series-title":"The Xinjiang Uygur Autonomous Region Uygur Medicine Standard","author":"Xinjiang","year":"1993"},{"key":"10.1016\/j.jep.2019.03.045_bib31","first-page":"52","article-title":"Drug therapy for irritable bowel syndrome","volume":"01","author":"Xu","year":"2015","journal-title":"J. Clin. Dig. Dis."},{"key":"10.1016\/j.jep.2019.03.045_bib32","first-page":"231","article-title":"Study on identification method of thin layer of Berberis heteropoda Schrenk in Xinjiang","volume":"03","author":"Yingping","year":"2013","journal-title":"Northwest. Pharm. J."},{"key":"10.1016\/j.jep.2019.03.045_bib33","series-title":"Molecular Mechanism of Berberine in the Treatment of Diarrhea","author":"Yongguo","year":"2009"},{"key":"10.1016\/j.jep.2019.03.045_bib34","series-title":"Health Food Inspection and Evaluation Technical Specification Implementation Manual","author":"Yusan","year":"2003"},{"key":"10.1016\/j.jep.2019.03.045_bib35","first-page":"505","article-title":"Effect of changjiang recipe on JAK2\/STAT3 signaling pathway in D-IBS rats","volume":"08","author":"Yusheng","year":"2017","journal-title":"Pharm. Today"},{"key":"10.1016\/j.jep.2019.03.045_bib36","first-page":"350","article-title":"Butyric acid in irritable bowel syndrome","volume":"6","author":"Zaleski","year":"2013","journal-title":"Przeglad Gastroenterol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118340960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118340960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:21:56Z","timestamp":1759940516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874118340960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":36,"alternative-id":["S0378874118340960"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.03.045","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of water extract from Berberis heteropoda Schrenk roots on diarrhea-predominant irritable bowel syndrome by adjusting intestinal flora","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.03.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}