{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:40:32Z","timestamp":1768282832254,"version":"3.49.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002994","name":"Ministry of Knowledge Economy","doi-asserted-by":"publisher","award":["B0012328"],"award-info":[{"award-number":["B0012328"]}],"id":[{"id":"10.13039\/501100002994","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002994","name":"Ministry of Knowledge Economy","doi-asserted-by":"publisher","award":["00000-63206-A000900032"],"award-info":[{"award-number":["00000-63206-A000900032"]}],"id":[{"id":"10.13039\/501100002994","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002648","name":"Catholic University of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.jep.2019.111874","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T20:52:59Z","timestamp":1555102379000},"page":"111874","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Preclinical study of safety of Dendropanax morbifera Leveille leaf extract: General and genetic toxicology"],"prefix":"10.1016","volume":"238","author":[{"given":"Jun-Won","family":"Yun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Soon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jin","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Ran","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Young","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Hee","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Euna","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoung-Chin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja-June","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Sung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Hwan","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong-Cheol","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2019.111874_bib1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1248\/bpb.b15-00823","article-title":"Potent anti-inflammatory and analgesic actions of the chloroform extract of Dendropanax morbifera mediated by the Nrf2\/HO-1 pathway","volume":"39","author":"Akram","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2019.111874_bib2","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/tox.21968","article-title":"Detection of genotoxicity and mutagenicity of chlorthiophos using micronucleus, chromosome aberration, sister chromatid exchange, and Ames tests","volume":"30","author":"Aky\u0131l","year":"2015","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jep.2019.111874_bib3","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s10068-015-0193-x","article-title":"Hepatoprotective effects of aqueous extracts from leaves of Dendropanax morbifera Leveille against alcohol-induced hepatotoxicity in rats and in vitro anti-oxidant effects","volume":"24","author":"Bae","year":"2015","journal-title":"Food Sci. Biotechnol."},{"key":"10.1016\/j.jep.2019.111874_bib4","series-title":"The Medicinal Plants of Korea","author":"Bae","year":"2000"},{"key":"10.1016\/j.jep.2019.111874_bib5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.yrtph.2014.09.003","article-title":"Toxicologic assessment of Paecilomyces tenuipes in rats: renal toxicity and mutagenic potential","volume":"70","author":"Che","year":"2014","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2019.111874_bib6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.yrtph.2015.01.012","article-title":"Genotoxicity and subchronic toxicity of Sophorae radix in rats: hepatotoxic and genotoxic potential","volume":"71","author":"Che","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2019.111874_bib7","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.taap.2013.01.032","article-title":"Assessment of cisplatin-induced kidney injury using an integrated rodent platform","volume":"268","author":"Chen","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2019.111874_bib8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jbiosc.2014.12.012","article-title":"Anti-thrombotic effect of rutin isolated from Dendropanax morbifera Leveille","volume":"120","author":"Choi","year":"2015","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.jep.2019.111874_bib9","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/ptr.2838","article-title":"In vitro evaluation of the antiplasmodial activity of Dendropanax morbifera against chloroquine-sensitive strains of Plasmodium falciparum","volume":"23","author":"Chung","year":"2009","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2019.111874_bib10","first-page":"547","article-title":"Antiatherogenic activity of Dendropanax morbifera essential oil in rats","volume":"64","author":"Chung","year":"2009","journal-title":"Pharmazie"},{"key":"10.1016\/j.jep.2019.111874_bib11","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.bse.2009.06.004","article-title":"Chemical composition and larvicidal effects of essential oil of Dendropanax morbifera against Aedes aegypti L","volume":"37","author":"Chung","year":"2009","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.jep.2019.111874_bib12","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/ptr.3336","article-title":"Anticomplement activity of polyacetylenes from leaves of Dendropanax morbifera Leveille","volume":"25","author":"Chung","year":"2011","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2019.111874_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0165-1161(85)90015-9","article-title":"Measurement of micronuclei in human lymphocytes","volume":"148","author":"Fenech","year":"1985","journal-title":"Mutat. Res."},{"key":"10.1016\/j.jep.2019.111874_bib14","first-page":"173","article-title":"Phylogenetic relationships of the Dendropanax morbifera and D-trifidus based on PCR-RAPD","volume":"20","author":"Han","year":"1998","journal-title":"Kor. J. Genet."},{"key":"10.1016\/j.jep.2019.111874_bib15","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s00216-011-4797-6","article-title":"Multienzyme-modified biosensing surface for the electrochemical analysis of aspartate transaminase and alanine transaminase in human plasma","volume":"400","author":"Han","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jep.2019.111874_bib16","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1902\/jop.2009.090002","article-title":"1-Tetradecanol complex: therapeutic actions in experimental periodontitis","volume":"80","author":"Hasturk","year":"2009","journal-title":"J. Periodontol."},{"key":"10.1016\/j.jep.2019.111874_bib17","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1902\/jop.2007.060293","article-title":"1-Tetradecanol complex reduces progression of Porphyromonas gingivalis-induced experimental periodontitis in rabbits","volume":"78","author":"Hasturk","year":"2007","journal-title":"J. Periodontol."},{"key":"10.1016\/j.jep.2019.111874_bib18","series-title":"The Bone Marrow Micronucleus Test in Handbook of Mutagenicity Test Procedures","first-page":"441","author":"Heddle","year":"1984"},{"key":"10.1016\/j.jep.2019.111874_bib19","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.foodchem.2013.05.021","article-title":"Evaluation of anti-oxidant and anti-cancer properties of Dendropanax morbifera L\u00e9veille","volume":"141","author":"Hyun","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2019.111874_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.indcrop.2015.05.002","article-title":"Anti-inflammatory activity and phenolic composition of Dendropanax morbifera leaf extracts","volume":"74","author":"Hyun","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.jep.2019.111874_bib21","series-title":"Studies on the Technical Improvement to Use \u201cHwangchil-Traditional Korean Golden Varnish\u201d and the Diversified Uses of Dendropanax Morbiera Lev","author":"Im","year":"1996"},{"key":"10.1016\/j.jep.2019.111874_bib22","first-page":"427","article-title":"The in vitro chromosomal aberration test using Chinese hamster lung (CHL) fibroblast cells in culture","volume":"5","author":"Ishidate","year":"1985","journal-title":"Prog. Mutat. Res."},{"key":"10.1016\/j.jep.2019.111874_bib23","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.yrtph.2013.12.011","article-title":"Toxicological assessment of enzyme-treated asparagus extract in rat acute and subchronic oral toxicity studies and genotoxicity tests","volume":"68","author":"Ito","year":"2014","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2019.111874_bib24","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.tips.2005.09.006","article-title":"Therapeutic wisdom in traditional Chinese medicine: a perspective from modern science","volume":"26","author":"Jiang","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jep.2019.111874_bib25","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1016\/S0040-4039(01)96337-3","article-title":"Two new antifungal compounds from Dendropanax trifidus","volume":"33","author":"Kawazu","year":"1973","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jep.2019.111874_bib26","series-title":"Good Laboratory Practice Regulation for Non-clinical Laboratory Studies (Notification No. 2012-61). KFDA, Korea","author":"KFDA","year":"2014"},{"key":"10.1016\/j.jep.2019.111874_bib27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1515\/sg-2006-0002","article-title":"Genetic variation and population structure of Dendropanax morbifera L\u00e9v. (Araliaceae) in Korea","volume":"55","author":"Kim","year":"2006","journal-title":"Silvae Genet."},{"key":"10.1016\/j.jep.2019.111874_bib28","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s12906-015-0786-1","article-title":"Antioxidant effects of Dendropanax morbifera L\u00e9veille extract in the hippocampus of mercury-exposed rats","volume":"15","author":"Kim","year":"2015","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.jep.2019.111874_bib29","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1186\/1472-6882-14-428","article-title":"Dendropanax morbifera L\u00e9veille extract facilitates cadmium excretion and prevents oxidative damage in the hippocampus by increasing antioxidant levels in cadmium-exposed rats","volume":"14","author":"Kim","year":"2014","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.jep.2019.111874_bib30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/BF03216754","article-title":"Screening and isolation of antibiotic resistance inhibitors from herb materials-resistance inhibition of volatile components of Korean aromatic herbs","volume":"21","author":"Lee","year":"1998","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2019.111874_bib31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.5625\/lar.2012.28.2.115","article-title":"Historical control data from 13-week repeated toxicity studies in Crj:CD (SD) rats","volume":"28","author":"Lee","year":"2012","journal-title":"Lab. Anim. Res."},{"key":"10.1016\/j.jep.2019.111874_bib32","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.yrtph.2015.02.014","article-title":"Acute and subchronic (28 days) oral toxicity studies of Codonopsis lanceolate extract in SpragueeDawley rats","volume":"71","author":"Lee","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2019.111874_bib33","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3892\/or.2013.2542","article-title":"Induction of human leukemia U937 cell apoptosis by an ethanol extract of Dendropanax morbifera Lev. through the caspase-dependent pathway","volume":"30","author":"Lee","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jep.2019.111874_bib34","first-page":"73","article-title":"Effects of 1-tetradecanol and \u03b2-sitosterol Isolated from Dendropanax morbifera Lev. on skin whitening, moisturizing and preventing hair loss","volume":"41","author":"Lee","year":"2015","journal-title":"J. Soc. Cosmet. Sci. Korea"},{"key":"10.1016\/j.jep.2019.111874_bib35","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1002\/jssc.200800134","article-title":"Traditional Chinese medicine and separation science","volume":"31","author":"Liu","year":"2008","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jep.2019.111874_bib36","doi-asserted-by":"crossref","first-page":"394","DOI":"10.14218\/JCTH.2017.00027","article-title":"Elevated liver enzymes in asymptomatic patients - what should I do?","volume":"5","author":"Malakouti","year":"2017","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.jep.2019.111874_bib37","first-page":"39","article-title":"Safety issues in using complementary and alternative medicine","volume":"20","author":"Markman","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jep.2019.111874_bib38","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1177\/0960327110382131","article-title":"Antidiabetic effects of dendropanoxide from leaves of Dendropanax morbifera Leveille in normal and streptozotocin-induced diabetic rats","volume":"30","author":"Moon","year":"2011","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.jep.2019.111874_bib39","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/ptr.1498","article-title":"Hepatoprotective activity of Centaurium erythraea on acetaminophen-induced hepatotoxicity in rats","volume":"18","author":"Mroueh","year":"2004","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2019.111874_bib40","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jep.2007.02.011","article-title":"Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents","volume":"112","author":"Mukinda","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.111874_bib41","series-title":"Guide for the Care and Use of Laboratory Animals","author":"NRC","year":"2010"},{"key":"10.1016\/j.jep.2019.111874_bib42","series-title":"OECD Guideline for Testing of Chemicals, Test No.473: in Vitro Mammalian Chromosome Aberration Test","author":"OECD","year":"1997"},{"key":"10.1016\/j.jep.2019.111874_bib43","series-title":"OECD Guideline for Testing of Chemicals, Test No.474","author":"OECD","year":"1997"},{"key":"10.1016\/j.jep.2019.111874_bib44","series-title":"OECD Guideline for Testing of Chemicals, Test No.408: Repeated Dose 90-day Oral Toxicity Study in Rodents","author":"OECD","year":"1998"},{"key":"10.1016\/j.jep.2019.111874_bib45","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1177\/0091270010361257","article-title":"Potential benefits of combined N-acetylcysteine and ciprofloxacin therapy in partial biliary obstruction","volume":"50","author":"Ozdil","year":"2010","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2019.111874_bib46","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jep.2003.11.002","article-title":"Isolation and anticomplement activity of compounds from Dendropanax morbifera","volume":"90","author":"Park","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.111874_bib47","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejphar.2017.02.002","article-title":"Tetradecanol reduces EL-4 T cell growth by the down regulation of NF-\u03baB mediated IL-2 secretion","volume":"799","author":"Park","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2019.111874_bib48","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s11064-014-1259-5","article-title":"Rutin from Dendropanax morbifera Leveille protects human dopaminergic cells against rotenone induced cell injury through inhibiting JNK and p38 MAPK signaling","volume":"39","author":"Park","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2019.111874_bib49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/258121a0","article-title":"Cytological detection of mutagencarcinogen exposure by sister-chromatid exchange","volume":"268","author":"Perry","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.jep.2019.111874_bib50","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.etp.2005.10.002","article-title":"Clinical chemistry and haematology historical data in control Sprague-Dawley rats from pre-clinical toxicity studies","volume":"57","author":"Petterino","year":"2006","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.jep.2019.111874_bib51","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.jep.2019.111874_bib52","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.fct.2013.01.043","article-title":"Single and 90-day repeated oral dose toxicity studies of fermented Rhus verniciflua stem bark extract in Sprague\u2013Dawley rats","volume":"55","author":"Shin","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2019.111874_bib53","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3892\/br.2014.309","article-title":"Triglyceride is strongly associated with nonalcoholic fatty liver disease among markers of hyperlipidemia and diabetes","volume":"2","author":"Tomizawa","year":"2014","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.jep.2019.111874_bib54","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0165-1110(93)90001-4","article-title":"Sister-chromatid exchange: second report of the gene-tox program","volume":"297","author":"Tucker","year":"1993","journal-title":"Mutat. Res."},{"key":"10.1016\/j.jep.2019.111874_bib55","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nbt.1623","article-title":"Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies","volume":"28","author":"Vaidya","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jep.2019.111874_bib56","doi-asserted-by":"crossref","first-page":"637512","DOI":"10.1155\/2012\/637512","article-title":"Oleifolioside A, a new active compound, attenuates LPS-stimulated iNOS and COX-2 expression through the downregulation of NF-\u03baB and MAPK activities in RAW 264.7 macrophages","volume":"2012","author":"Yu","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2019.111874_bib57","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1021\/jf3014475","article-title":"Oleifolioside A mediates caspase-independent human cervical carcinoma HeLa cell apoptosis involving nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG","volume":"60","author":"Yu","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2019.111874_bib58","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.yrtph.2015.05.025","article-title":"Safety evaluation of Angelica gigas: genotoxicity and 13-weeks oral subchronic toxicity in rats","volume":"72","author":"Yun","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2019.111874_bib59","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.yrtph.2015.04.008","article-title":"Evaluation of subchronic (13 week) toxicity and genotoxicity potential of vinegar-processed Genkwa Flos","volume":"72","author":"Yun","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2019.111874_bib60","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.yrtph.2015.07.006","article-title":"Pre-clinical in vitro and in vivo safety evaluation of Cimicifuga heracleifolia","volume":"73","author":"Yun","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118332872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118332872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:23:57Z","timestamp":1759940637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874118332872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":60,"alternative-id":["S0378874118332872"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.111874","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preclinical study of safety of Dendropanax morbifera Leveille leaf extract: General and genetic toxicology","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.111874","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111874"}}