{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:57:14Z","timestamp":1792270634381,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002641","name":"Konkuk University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002641","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jep.2019.111917","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T20:49:51Z","timestamp":1556138991000},"page":"111917","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Chrysanthemum indicum extract inhibits NLRP3 and AIM2 inflammasome activation via regulating ASC phosphorylation"],"prefix":"10.1016","volume":"239","author":[{"given":"Sang-Hyeun","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myong-Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahbuba","family":"Akther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hyuk","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Bong","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2019.111917_bib1","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1002\/art.1780291209","article-title":"Monosodium urate crystals in the knee joints of patients with asymptomatic nontophaceous gout","volume":"29","author":"Bomalaski","year":"1986","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2019.111917_bib2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2019.111917_bib3","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1128\/IAI.01382-08","article-title":"Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila","volume":"77","author":"Case","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jep.2019.111917_bib4","first-page":"5070","article-title":"Chrysanthemum indicum L. ethanol extract reduces high-fat diet-induced obesity in mice","volume":"15","author":"Cha","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2019.111917_bib5","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1172\/JCI28075","article-title":"MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals","volume":"116","author":"Chen","year":"2006","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jep.2019.111917_bib6","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jep.2005.04.035","article-title":"Anti-inflammatory and immunomodulatory activities of the extracts from the inflorescence of Chrysanthemum indicum Linne","volume":"101","author":"Cheng","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.111917_bib7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/jocd.12211","article-title":"Dermatologic evaluation of cosmetic formulations containing Chrysanthemum indicum extract","volume":"15","author":"Choi","year":"2016","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.jep.2019.111917_bib8","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev-immunol-031210-101405","article-title":"The inflammasome NLRs in immunity, inflammation, and associated diseases","volume":"29","author":"Davis","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jep.2019.111917_bib9","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3285394","article-title":"The impacts of Chrysanthemum indicum extract on oxidative stress and inflammatory responses in adjuvant-induced arthritic rats","author":"Dong","year":"2017","journal-title":"Evid. Based Compl. Alternat. Med."},{"key":"10.1016\/j.jep.2019.111917_bib10","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jep.2019.111917_bib11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/imr.12607","article-title":"The NLRC 4 inflammasome","volume":"281","author":"Duncan","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jep.2019.111917_bib12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nature07710","article-title":"AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA","volume":"458","author":"Fernandes-Alnemri","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jep.2019.111917_bib13","doi-asserted-by":"crossref","first-page":"8102","DOI":"10.3390\/ijms16048102","article-title":"Anti-inflammatory effect of emodin via attenuation of NLRP3 inflammasome activation","volume":"16","author":"Han","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2019.111917_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jep.2016.05.059","article-title":"Juniperus rigida Sieb. extract inhibits inflammatory responses via attenuation of TRIF-dependent signaling and inflammasome activation","volume":"190","author":"Han","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.111917_bib15","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/ni.2749","article-title":"Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity","volume":"14","author":"Hara","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jep.2019.111917_bib16","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jep.2019.111917_bib17","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.4049\/jimmunol.1600406","article-title":"Ethanol and other short-chain alcohols inhibit NLRP3 inflammasome activation through protein tyrosine phosphatase stimulation","volume":"197","author":"Hoyt","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2019.111917_bib18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0165-0270(87)90041-0","article-title":"Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay","volume":"20","author":"Koh","year":"1987","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jep.2019.111917_bib19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0378-8741(00)00305-6","article-title":"Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout","volume":"73","author":"Kong","year":"2000","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.111917_bib20","series-title":"Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation. Mediators. Inflamm.","author":"Kwak","year":"2018"},{"key":"10.1016\/j.jep.2019.111917_bib21","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/eji.201545839","article-title":"AIM2 inflammasome in infection, cancer, and autoimmunity: role in DNA sensing, inflammation, and innate immunity","volume":"46","author":"Man","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jep.2019.111917_bib22","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf","volume":"430","author":"Mariathasan","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jep.2019.111917_bib23","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-\u03b2","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell."},{"key":"10.1016\/j.jep.2019.111917_bib24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jep.2019.111917_bib25","doi-asserted-by":"crossref","first-page":"33835","DOI":"10.1074\/jbc.274.48.33835","article-title":"ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells","volume":"274","author":"Masumoto","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2019.111917_bib26","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1600-065X.2011.01044.x","article-title":"Caspase\u20101\u2010induced pyroptotic cell death","volume":"243","author":"Miao","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jep.2019.111917_bib27","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1183\/09031936.00158110","article-title":"Role of IL-1alpha and the Nlrp3\/caspase-1\/IL-1beta axis in cigarette smoke-induced pulmonary inflammation and COPD","volume":"38","author":"Pauwels","year":"2011","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jep.2019.111917_bib28","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.4049\/jimmunol.1000217","article-title":"Cutting edge: critical role for PYCARD\/ASC in the development of experimental autoimmune encephalomyelitis","volume":"184","author":"Shaw","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2019.111917_bib29","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.intimp.2017.11.007","article-title":"Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury","volume":"54","author":"Shi","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2019.111917_bib30","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1089\/jmf.2015.3556","article-title":"Cichorium intybus Linn. extract prevents type 2 diabetes through inhibition of NLRP3 inflammasome activation","volume":"19","author":"Shim","year":"2016","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2019.111917_bib31","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jep.2013.09.056","article-title":"Lysimachia clethroides Duby extract attenuates inflammatory response in Raw 264.7 macrophages stimulated with lipopolysaccharide and in acute lung injury mouse model","volume":"150","author":"Shim","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.111917_bib32","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.taap.2015.02.006","article-title":"A novel synthetic derivative of melatonin, 5-hydroxy-2\u2019-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation","volume":"284","author":"Shim","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2019.111917_bib33","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1183\/09031936.00105013","article-title":"Elevated expression of the NLRP3 inflammasome in neutrophilic asthma","volume":"43","author":"Simpson","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jep.2019.111917_bib34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0006-3002(63)90513-4","article-title":"Studies on succinate-tetrazolium reductase systems: III. Points of coupling of four different tetrazolium salts III. Points of coupling of four different tetrazolium salts","volume":"77","author":"Slater","year":"1963","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2019.111917_bib35","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jep.2019.111917_bib36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jep.2015.05.001","article-title":"Anti-inflammatory effect of Impatiens textori Miq. extract via inhibition of NLRP3 inflammasome activation in in vitro and in vivo experimental models","volume":"170","author":"Sun","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.111917_bib37","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.jep.2019.111917_bib38","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ni.2022","article-title":"Fatty acid\u2013induced NLRP3-ASC inflammasome activation interferes with insulin signaling","volume":"12","author":"Wen","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jep.2019.111917_bib39","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/413237","article-title":"Anti-inflammatory effect of supercritical-carbon dioxide fluid extract from flowers and buds of Chrysanthemum indicum linnen","author":"Wu","year":"2013","journal-title":"Evid. Based Compl. Alternat Med."},{"key":"10.1016\/j.jep.2019.111917_bib40","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1021\/acs.jnatprod.7b00867","article-title":"Highly oxidized guaianolide sesquiterpenoids with potential anti-inflammatory activity from chrysanthemum indicum","volume":"81","author":"Xue","year":"2018","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111917_bib41","first-page":"265","article-title":"Luteolin alleviates NLRP3 inflammasome activation and directs macrophage polarization in lipopolysaccharide-stimulated RAW264. 7 cells","volume":"10","author":"Zhang","year":"2018","journal-title":"Am. J Transl. Res."},{"key":"10.1016\/j.jep.2019.111917_bib42","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jep.2019.111917_bib43","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119303423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119303423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:21:38Z","timestamp":1759940498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874119303423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":43,"alternative-id":["S0378874119303423"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.111917","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chrysanthemum indicum extract inhibits NLRP3 and AIM2 inflammasome activation via regulating ASC phosphorylation","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.111917","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111917"}}