{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:24:56Z","timestamp":1777353896271,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.jep.2019.111929","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T01:39:39Z","timestamp":1556674779000},"page":"111929","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Improvement of chemotherapy through reducing of cachexia by using Citrus unshiu peel extract"],"prefix":"10.1016","volume":"242","author":[{"given":"S.","family":"Tahaghoghi-Hajghorbani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Ebrahimzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rafiei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Golpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Hosseini-Khah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Akhtari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jep.2019.111929_bib1","doi-asserted-by":"crossref","first-page":"e102436","DOI":"10.1371\/journal.pone.0102436","article-title":"Tocilizumab, a proposed therapy for the cachexia of Interleukin6-expressing lung cancer","volume":"9","author":"Ando","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jep.2019.111929_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4251\/wjgo.v7.i4.17","article-title":"Cancer cachexia, mechanism and treatment","volume":"7","author":"Aoyagi","year":"2015","journal-title":"World J. Gastrointest. Oncol."},{"issue":"3","key":"10.1016\/j.jep.2019.111929_bib3","doi-asserted-by":"crossref","first-page":"737","DOI":"10.20546\/ijcmas.2018.703.086","article-title":"Antimicrobial properties of orange (citrus reticulata var. Kinnow) peel extracts gainst pathogenic bacteria","volume":"7","author":"Arvind","year":"2018","journal-title":"Int. J. Curr. Microbiol. App. Sci."},{"issue":"7","key":"10.1016\/j.jep.2019.111929_bib4","first-page":"186","article-title":"Serum resistin level in patients with colorectal cancer","volume":"5","author":"Baker","year":"2016","journal-title":"Int. J. Enhanc. Res. Sci."},{"issue":"1","key":"10.1016\/j.jep.2019.111929_bib5","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s13277-015-3774-7","article-title":"Hesperidin from Citrus seed induces human hepatocellular carcinoma HepG2 cewll apoptosis via both mitochondrial and death receptor pathways","volume":"37","author":"Banjerdpongchai","year":"2016","journal-title":"Tumour Biol.: J.Int. Soc. Oncodevelopmental Biol. Med."},{"key":"10.1016\/j.jep.2019.111929_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8296451","article-title":"Protective effect of boswellic acids against doxorubicin-induced hepatotoxicity: impact on Nrf2\/HO-1 defense pathway","author":"Barakat","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.jep.2019.111929_bib7","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3389\/fphys.2016.00472","article-title":"Cancer and chemotherapy contribute to muscle loss by activating common signaling pathways","volume":"7","author":"Barreto","year":"2016","journal-title":"Front. Physiol."},{"issue":"3","key":"10.1016\/j.jep.2019.111929_bib8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.6004\/jnccn.2017.0037","article-title":"An expanding role for immunotherapy in colorectal cancer","volume":"15","author":"Bever","year":"2017","journal-title":"J. Natl. Compr. Cancer Netw. : J. Natl. Compr. Cancer Netw."},{"issue":"10","key":"10.1016\/j.jep.2019.111929_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013262","article-title":"Tumor necrosis factor-alpha regulates distinct molecular pathways and gene networks in cultured skeletal muscle cells","volume":"5","author":"Bhatnagar","year":"2010","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.jep.2019.111929_bib10","first-page":"4","article-title":"Advances in immunotherapy in the treatment of colorectal cancer AJHO","volume":"13","author":"Birendra","year":"2017"},{"key":"10.1016\/j.jep.2019.111929_bib11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1242\/dmm.010389","article-title":"Cellular and molecular mechanisms of muscle atrophy","volume":"6","author":"Bonaldo PS","year":"2013","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.jep.2019.111929_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5958429","article-title":"Proinflammatory cytokines IL-6 and TNF-alpha increased telomerase activity through NF-kappaB\/STAT1\/STAT3 activation, and withaferin a inhibited the signaling in colorectal cancer cells","author":"Chung","year":"2017","journal-title":"Mediat. Inflamm."},{"issue":"2","key":"10.1016\/j.jep.2019.111929_bib13","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3109\/13880209.2014.914233","article-title":"Effect of citral on the cytotoxicity of doxorubicin in human B-lymphoma cells","volume":"53","author":"Dangkong","year":"2015","journal-title":"Pharmaceut. Biol."},{"issue":"9","key":"10.1016\/j.jep.2019.111929_bib14","article-title":"The concentration of thiobarbituric acid reactive substances (TBARS) and paraoxonase activity in blood of patients with osteoarthrosis after endoprosthesis implantation","volume":"17","author":"Dorota","year":"2011","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.jep.2019.111929_bib15","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.phrs.2015.05.010","article-title":"Skeletal muscle atrophy: potential therapeutic agents and their mechanisms of action","volume":"99","author":"Dutt","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2019.111929_bib16","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.fct.2014.06.014","article-title":"Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium)","volume":"71","author":"Ho","year":"2014","journal-title":"Food Chem. Toxicol.: Int. J. Pub. Br. Ind. Biol. Res. Assoc."},{"issue":"5","key":"10.1016\/j.jep.2019.111929_bib17","doi-asserted-by":"crossref","first-page":"565","DOI":"10.5582\/bst.2017.01218","article-title":"Induction of apoptosis by ethanol extract of Citrus unshiu Markovich peel in human bladder cancer T24 cells through ROS-mediated inactivation of the PI3K\/Akt pathway","volume":"11","author":"Im Ahn","year":"2017","journal-title":"Biosci. Trend."},{"issue":"5","key":"10.1016\/j.jep.2019.111929_bib18","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.3892\/or.2013.2711","article-title":"Flavonoids from Citrus unshiu Marc. inhibit cancer cell adhesion to endothelial cells by selective inhibition of VCAM-1","volume":"30","author":"Jin","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jep.2019.111929_bib19","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/acm.2000.6.557","article-title":"The effect of a traditional Chinese prescription for a case of lung carcinoma","volume":"6","author":"Kamei","year":"2000","journal-title":"J. Altern. Complement. Med."},{"issue":"3","key":"10.1016\/j.jep.2019.111929_bib20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5487\/TR.2011.27.3.173","article-title":"The inhibitory effect of premature Citrus unshiu extract on atopic dermatitis in vitro and in vivo","volume":"27","author":"Kang","year":"2011","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.jep.2019.111929_bib21","doi-asserted-by":"crossref","first-page":"24214","DOI":"10.1038\/srep24214","article-title":"Citrus unshiu peel extract alleviates cancer-induced weight loss in mice bearing CT-26 adenocarcinoma","volume":"6","author":"Kim","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jep.2019.111929_bib22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4162\/nrp.2018.12.2.129","article-title":"Reactive oxygen species-dependent apoptosis induction by water extract of Citrus unshiu peel in MDA-MB-231 human breast carcinoma cells","volume":"12","author":"Kim","year":"2018","journal-title":"Nutr. Res. Pract."},{"issue":"5","key":"10.1016\/j.jep.2019.111929_bib24","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1248\/bpb.b17-00898","article-title":"Induction of apoptosis by citrus unshiu peel in human breast cancer MCF-7 cells: involvement of ROS-dependent activation of AMPK","volume":"41","author":"Kim","year":"2018","journal-title":"Biol. Pharm. Bull."},{"issue":"3","key":"10.1016\/j.jep.2019.111929_bib25","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jep.2010.07.018","article-title":"Extracts from Citrus unshiu promote immune-mediated inhibition of tumor growth in a murine renal cell carcinoma model","volume":"133","author":"Lee","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2019.111929_bib26","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.3390\/molecules20069656","article-title":"A herbal formula HT048, Citrus unshiu and Crataegus pinnatifida, prevents obesity by inhibiting adipogenesis and lipogenesis in 3T3-L1 preadipocytes and HFD-induced obese rats","volume":"20","author":"Lee","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2019.111929_bib27","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1089\/jmf.2015.3584","article-title":"Aqueous extraction of Citrus unshiu peel induces proangiogenic effects through the FAK and ERK1\/2 signaling pathway in human umbilical vein endothelial cells","volume":"19","author":"Lee","year":"2016","journal-title":"J. Med. Food"},{"issue":"1","key":"10.1016\/j.jep.2019.111929_bib28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1089\/jmf.2017.3984","article-title":"Fermented extraction of citrus unshiu peel inhibits viability and migration of human pancreatic cancers","volume":"21","author":"Lee","year":"2018","journal-title":"J. Med. Food"},{"issue":"3","key":"10.1016\/j.jep.2019.111929_bib29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tox.2010.03.012","article-title":"Dose- and time-dependent effects of doxorubicin on cytotoxicity, cell cycle and apoptotic cell death in human colon cancer cells","volume":"271","author":"Lupertz","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.jep.2019.111929_bib30","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s12272-013-0080-z","article-title":"Effects of dried Citrus unshiu peels on gastrointestinal motility in rodents","volume":"36","author":"Lyu","year":"2013","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"5","key":"10.1016\/j.jep.2019.111929_bib31","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jcsm.12225","article-title":"Establishment and characterization of a novel murine model of pancreatic cancer cachexia","volume":"8","author":"Michaelis","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.jep.2019.111929_bib32","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s41467-018-03473-9","article-title":"Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer","volume":"9","author":"Nam","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2019.111929_bib33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jep.2015.01.024","article-title":"Anti-inflammatory activity of a new cyclic peptide, citrusin XI, isolated from the fruits of Citrus unshiu","volume":"163","author":"Noh","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2019.111929_bib34","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1142\/S0192415X12500462","article-title":"Anti-inflammatory effect of Citrus unshiu peel in LPS-stimulated RAW 264.7 macrophage cells","volume":"40","author":"Oh","year":"2012","journal-title":"Am. J. Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2019.111929_bib35","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jnutbio.2011.12.009","article-title":"Citrus unshiu peel extract ameliorates hyperglycemia and hepatic steatosis by altering inflammation and hepatic glucose- and lipid-regulating enzymes in db\/db mice","volume":"24","author":"Park","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.jep.2019.111929_bib36","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jep.2017.12.029","article-title":"In vitro and in vivo evaluation of systemic and genetic toxicity of Citrus unshiu peel","volume":"215","author":"Park","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2019.111929_bib37","first-page":"19","article-title":"Burden of gastrointestinal cancer in Asia; an overview","volume":"8","author":"Pourhoseingholi","year":"2015","journal-title":"Gastroenterol. Hepatol. Bed to Bench"},{"issue":"5","key":"10.1016\/j.jep.2019.111929_bib38","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/s00535-013-0787-0","article-title":"Cancer cachexia--pathophysiology and management","volume":"48","author":"Suzuki","year":"2013","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.jep.2019.111929_bib39","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s10753-011-9295-7","article-title":"Hesperidin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model","volume":"35","author":"Wei","year":"2012","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2019.111929_bib40","series-title":"Evidence-based Complementary and Alternative Medicine","article-title":"Hochuekkito (TJ-41), a kampo formula, ameliorates cachexia induced by colon 26 adenocarcinoma in mice","author":"Yae","year":"2012"},{"issue":"1","key":"10.1016\/j.jep.2019.111929_bib41","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/14756360600988989","article-title":"Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts","volume":"22","author":"Zhang","year":"2007","journal-title":"J. Enzym. Inhib. Med. Chem."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118346488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118346488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:25:33Z","timestamp":1759940733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874118346488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":40,"alternative-id":["S0378874118346488"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.111929","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improvement of chemotherapy through reducing of cachexia by using Citrus unshiu peel extract","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.111929","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111929"}}