{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:05:57Z","timestamp":1790859957494,"version":"4.1.0"},"reference-count":188,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jep.2019.111934","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T12:03:24Z","timestamp":1558613004000},"page":"111934","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Traditional uses, secondary metabolites, and pharmacology of Celastrus species - a review:"],"prefix":"10.1016","volume":"241","author":[{"given":"Yue","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-lian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin-xiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-zhong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2019.111934_bib2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.phytochem.2012.07.025","article-title":"Studies of naturally occurring friedelane triterpenoids as insulin sensitizers in the treatment type 2 diabetes mellitus","volume":"84","author":"Ardiles","year":"2012","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib3","first-page":"290","article-title":"Celastrus paniculatus, an endangered Indian medicinal plant with miraculous cognitive and other therapeutic properties: an overview","volume":"3","author":"Arora","year":"2012","journal-title":"Int. J. Pharma Bio Sci."},{"key":"10.1016\/j.jep.2019.111934_bib4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.indcrop.2014.07.025","article-title":"GC\u2013MS analysis of the essential oil of Celastrus paniculatus Willd. seeds and antioxidant, anti-inflammatory study of its various solvent extracts","volume":"61","author":"Arora","year":"2014","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.jep.2019.111934_bib5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.clim.2015.01.011","article-title":"Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ","volume":"157","author":"Astry","year":"2015","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jep.2019.111934_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/460136","article-title":"Ethyl acetate extract from Celastrus aculeatus Merr. Suppresses synovial inflammation in adjuvant arthritis rats through apoptosis induction of CD4+CD25+FOXP3+ T cells","volume":"2014","author":"Bai","year":"2014","journal-title":"Evid. Based Complement Altern. Med."},{"key":"10.1016\/j.jep.2019.111934_bib7","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3109\/13880200903127391","article-title":"Nootropic activity of Celastrus paniculatus seed","volume":"48","author":"Bhanumathy","year":"2010","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2019.111934_bib8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.4103\/0253-7613.194853","article-title":"Neuroprotective effect of Celastrus paniculatus on chronic stress-induced cognitive impairment","volume":"48","author":"Bhagya","year":"2016","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.jep.2019.111934_bib9","first-page":"201","article-title":"Progress on active compositions and pharmacological effects on Celastrus orbiculatus","volume":"33","author":"Bian","year":"2015","journal-title":"J. Pharm. Pract."},{"key":"10.1016\/j.jep.2019.111934_bib10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0378-8741(90)90080-D","article-title":"Antispermatogenic action of Celastrus paniculatus, seed extract in the rat with reversible changes in the liver","volume":"28","author":"Bidwai","year":"1990","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.111934_bib11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cell.2004.12.018","article-title":"PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells","volume":"120","author":"Boire","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jep.2019.111934_bib12","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1055\/s-2007-981543","article-title":"Identification of a new sesquiterpene polyol ester from Celastrus paniculatus","volume":"73","author":"Borbone","year":"2007","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2019.111934_bib13","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1055\/s-2004-827190","article-title":"New sesquiterpenes with intestinal relaxant effect from Celastrus paniculatus","volume":"70","author":"Borrelli","year":"2004","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2019.111934_bib14","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jep.2009.02.003","article-title":"Potent relaxant effect of Celastrus paniculatus extract in the rat and human ileum","volume":"122","author":"Borrelli","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.111934_bib15","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1124\/mol.109.056259","article-title":"Reactive oxygen species-dependent activation of Bax and poly (ADPribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells","volume":"76","author":"Byun","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jep.2019.111934_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.phytochem.2017.06.013","article-title":"Distinct sesquiterpene pyridine alkaloids from in salvadoran and peruvian celastraceae species","volume":"142","author":"Callies","year":"2017","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib17","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1021\/np500903a","article-title":"Restoration of chemosensitivity in p-glycoprotein-dependent multidrug-resistant cells by dihydro-\u03b2-agarofuran sesquiterpenes from Celastrus vulcanicola","volume":"78","author":"Callies","year":"2015","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.phytol.2009.05.002","article-title":"Cytotoxic agarofurans from the seeds of the australian rainforest vine Celastrus subspicata","volume":"2","author":"Carroll","year":"2009","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.jep.2019.111934_bib19","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s12272-013-0145-z","article-title":"Chemical constituents of the stems of Celastrus rugosus","volume":"36","author":"Chang","year":"2013","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2019.111934_bib20","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1016\/0031-9422(92)83628-C","article-title":"Angulatueoids a-d, four sesquiterpenes from the seeds of Celastrus angulatus","volume":"31","author":"Cheng","year":"1992","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/jisesa\/iew051","article-title":"Effects of celangulin IV and V from Celastrus angulatus Maxim on Na+\/K+-ATPase activities of the oriental armyworm (Lepidoptera: noctuidae)","volume":"16","author":"Cheng","year":"2016","journal-title":"J. Insect Sci."},{"key":"10.1016\/j.jep.2019.111934_bib22","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0031-9422(99)00079-5","article-title":"Triterpene caffeoyl esters and diterpenes from Celastrus stephanotifolius","volume":"51","author":"Chen","year":"1999","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib23","first-page":"35","article-title":"Studies on the root barks of Celastrus Angulatus","volume":"4","author":"Chen","year":"2002","journal-title":"StraitPharm J"},{"key":"10.1016\/j.jep.2019.111934_bib24","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1021\/jf903833a","article-title":"Terpenoids induce cell cycle arrest and apoptosis from the stems of Celastrus kusanoi associated with reactive oxygen species","volume":"58","author":"Chen","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2019.111934_bib25","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1021\/np50081a010","article-title":"Anti-AIDS agents, salaspermic acid, an anti-HIV principle from tripterycium wilfordii, and the structure-activity correlation with its related secondary metabolites","volume":"55","author":"Chen","year":"1992","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib26","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3184\/030823410X12658949561706","article-title":"3-Oxo-11\u03b2-hydroxyfriedelane from the roots of Celastrus monospermus","volume":"34","author":"Chen","year":"2010","journal-title":"J. Chem. Res."},{"key":"10.1016\/j.jep.2019.111934_bib27","first-page":"651","article-title":"Chemical constituents of Celastrus monospermus","volume":"4","author":"Chen","year":"2011","journal-title":"Chin. Tradit. Pat. Med."},{"key":"10.1016\/j.jep.2019.111934_bib28","series-title":"Study of Identify Classification and Celastrol Determination from Plants of Genus Celastrus","first-page":"1","author":"Chen","year":"2012"},{"key":"10.1016\/j.jep.2019.111934_bib29","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bse.2012.06.023","article-title":"Olean-type triterpenes of Celastrus orbiculatus","volume":"44","author":"Chen","year":"2012","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.jep.2019.111934_bib30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jep.2017.02.029","article-title":"COE inhibits vasculogenic mimicry in hepatocellular carcinoma via suppressing Notch1 signaling","volume":"208","author":"Chen","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.111934_bib31","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.tiv.2008.01.003","article-title":"Antiproliferative activity of pristimerin isolated from Maytenus ilicifolia (Celastraceae) in human HL-60 cells. Toxicol","volume":"22","author":"Costa","year":"2008","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.jep.2019.111934_bib32","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.intimp.2015.11.001","article-title":"Pristimerin inhibits angiogenesis in adjuvant-induced arthritic rats by suppressing VEGFR2 signaling pathways","volume":"29","author":"Deng","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2019.111934_bib33","first-page":"18","article-title":"Celastrus paniculatus: traditional uses and ethnobotanical study","volume":"2","author":"Deodhar","year":"2015","journal-title":"Indian. J. Adv. Plant. Res."},{"key":"10.1016\/j.jep.2019.111934_bib34","first-page":"5526","article-title":"Celastrus paniculatus; medicinal and pharmacological properties: a review","volume":"5","author":"Deodhar","year":"2015","journal-title":"Int. J. Res. Dev."},{"key":"10.1016\/j.jep.2019.111934_bib35","first-page":"672","article-title":"Chemical constituents of genus Celastrus","volume":"16","author":"Feng","year":"2007","journal-title":"Chin. J. N. Drugs"},{"key":"10.1016\/j.jep.2019.111934_bib36","series-title":"Flora of China","author":"Flora of China Editorial Committee","year":"2001"},{"key":"10.1016\/j.jep.2019.111934_bib37","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1016\/0031-9422(90)80182-G","article-title":"Quinone-methide, phenolic and related triterpenoids of plants of Celastraceae: further evidence for the structure of celastranhydride","volume":"29","author":"Gamlath","year":"1990","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib38","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0091-3057(96)00391-7","article-title":"Reversal of scopolamine-induced deficits in navigational memory performance by the seed oil of Celastrus paniculatus","volume":"57","author":"Gattu","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jep.2019.111934_bib39","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/IGC.0b013e31822b62be","article-title":"Oleanen induces apoptosis of cervical cancer cells by up-regulation of bim","volume":"22","author":"Gan","year":"2012","journal-title":"Int. J. Gynecol."},{"key":"10.1016\/j.jep.2019.111934_bib40","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1021\/acs.jnatprod.6b00648","article-title":"\u03b2-dihydroagarofuran-type sesquiterpenes from the seeds of Celastrus monospermus and their lifespan-extending effects on the nematode caenorhabditis elegans","volume":"79","author":"Gao","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib41","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1039\/b601473a","article-title":"The dihydro-\u03b2-agarofuran sesquiterpenoids","volume":"24","author":"Gao","year":"2007","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.jep.2019.111934_bib42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.phymed.2003.11.011","article-title":"Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells","volume":"13","author":"Godkar","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2019.111934_bib43","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jep.2004.03.051","article-title":"Celastrus paniculatus seed water soluble extracts protect against glutamate toxicity in neuronal cultures from rat forebrain","volume":"93","author":"Godkar","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.111934_bib44","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/s12906-016-1232-8","article-title":"Celastrus orbiculatus extract inhibits the migration and invasion of human glioblastoma cells in vitro","volume":"16","author":"Gu","year":"2016","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.jep.2019.111934_bib45","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.fitote.2004.12.008","article-title":"A new alkaloid from the fruits of Celastrus orbiculatus","volume":"76","author":"Guo","year":"2005","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2019.111934_bib46","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1080\/10286020412331286498","article-title":"A new sesquiterpene ester inhibiting no production from the fruits of Celastrus orbiculatus","volume":"8","author":"Guo","year":"2006","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2019.111934_bib47","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1021\/np500317t","article-title":"\u03b2-Agarofurans and sesquiterpene pyridine alkaloids from Maytenus spinosa","volume":"77","author":"Gutierrez-Nicolas","year":"2014","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib48","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s10600-015-1225-8","article-title":"Chemical constituents of Celastrus angulatus","volume":"51","author":"Hu","year":"2015","journal-title":"Chem. Nat. Comp."},{"key":"10.1016\/j.jep.2019.111934_bib49","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.phytol.2013.11.015","article-title":"A new macrocyclic lactone and a new quinoflavan from Celastrus hindsii","volume":"7","author":"Hu","year":"2014","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.jep.2019.111934_bib50","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s12272-013-0296-y","article-title":"Three new diphenylpropanes from Celastrus hindsii","volume":"37","author":"Hu","year":"2014","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2019.111934_bib51","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1248\/cpb.48.1079","article-title":"A novel agarofuran sesquiterpene, celahin D from Celastrus hindsii BENTH","volume":"48","author":"Huang","year":"2000","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.jep.2019.111934_bib52","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1021\/np000251l","article-title":"Antioxidant benzoylated flavan-3-ol glycoside from Celastrus orbiculatus","volume":"64","author":"Hwang","year":"2001","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib53","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1572-5995(00)80048-4","article-title":"Anti-tumor secondary metabolites isolated from higher plants","volume":"24","author":"Itokawa","year":"2000","journal-title":"Stud. Nat. Prod. Chem."},{"key":"10.1016\/j.jep.2019.111934_bib54","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.ento.51.110104.151146","article-title":"Botanical insectides, deterrents, and repellents in modern agriculture and an increasingly regulated world","volume":"51","author":"Isman","year":"2006","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.jep.2019.111934_bib55","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1021\/np010428r","article-title":"Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-\u03baB activation and NO production","volume":"65","author":"Jin","year":"2002","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib56","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/14786410701192967","article-title":"Four novel insecticidal sesquiterpene esters from Celastrus angulatus","volume":"21","author":"Ji","year":"2007","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2019.111934_bib57","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1080\/14786410802086217","article-title":"Three new insecticidal sesquiterpene pyridine alkaloids from Celastrus angulatus","volume":"23","author":"Ji","year":"2009","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2019.111934_bib58","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.indcrop.2014.01.043","article-title":"Phytochemical analysis and exercise enhancing effects of hydroalcoholic extract of Celastrus paniculatus Willd","volume":"55","author":"Kandikattu","year":"2014","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.jep.2019.111934_bib59","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1021\/jm010970c","article-title":"Chemosensitization of a multidrug-resistant leishmania tropica line by new sesquiterpenes from Maytenus magellanica and Maytenus chubutensis","volume":"44","author":"Kennedy","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jep.2019.111934_bib60","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1365-2362.2009.02186.x","article-title":"Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated from Celastrus regelii","volume":"39","author":"Kim","year":"2009","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.jep.2019.111934_bib61","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1021\/np9804379","article-title":"Sesquiterpene esters from Celastrus orbiculatus and their structure\u2212activity relationship on the modulation of multidrug resistance","volume":"62","author":"Kim","year":"1999","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib62","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1021\/np9702392","article-title":"A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer cells","volume":"61","author":"Kim","year":"1998","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib63","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s10456-007-9081-1","article-title":"Angiogenesis as a therapeutic target in arthritis: learning the lessons of the colorectal cancer experience","volume":"10","author":"Khong","year":"2007","journal-title":"Angiogenesis"},{"key":"10.1016\/j.jep.2019.111934_bib64","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s10616-014-9733-0","article-title":"Celastrus paniculatus Willd. mitigates t-BHP induced oxidative and apoptotic damage in C2C12 murine muscle cells","volume":"67","author":"Kumar","year":"2015","journal-title":"Cytotechnology"},{"key":"10.1016\/j.jep.2019.111934_bib65","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1078\/0944-7113-00136","article-title":"Antioxidant property of Celastrus paniculatus Willd.: a possible mechanism in enhancing cognition","volume":"9","author":"Kumar","year":"2002","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2019.111934_bib66","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1021\/np50104a011","article-title":"Two new macrolide sesquiterpene pyridine alkaloids from maytenus emarginata: emarginatine G and the cytotoxic emarginatine F","volume":"57","author":"Kuo","year":"1994","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib67","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1021\/np50125a015","article-title":"Celahinine A, a new sesquiterpene pyridine alkaloid from Celastrus hindsii","volume":"58","author":"Kuo","year":"1995","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib68","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0031-9422(95)00588-9","article-title":"Sesquiterpene ester from Celastrus hindsii","volume":"41","author":"Kuo","year":"1996","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib69","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0031-9422(96)00719-4","article-title":"Antitumour and anti-AIDS triterpenes from Celastrus hindsii","volume":"44","author":"Kuo","year":"1997","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib70","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3159\/07-RA-028.1","article-title":"Distinguishing native (Celastrus scandens L.) and invasive (C. orbiculatus Thunb.) bittersweet species using morphological characteristics","volume":"134","author":"Leicht-Young","year":"2007","journal-title":"J. Torrey Bot. Soc."},{"key":"10.1016\/j.jep.2019.111934_bib71","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3724\/SP.J.1009.2012.00279","article-title":"Chemical constituents from the stems of Celastrus orbiculatus","volume":"10","author":"Li","year":"2012","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2019.111934_bib72","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1472-6882-14-62","article-title":"Anti-invasive effects of Celastrus orbiculatus extract on interleukin-1 beta and tumour necrosis factor-alpha combination-stimulated fibroblast-like synoviocytes","volume":"14","author":"Li","year":"2014","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.jep.2019.111934_bib73","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1007\/s10600-014-0816-0","article-title":"Kaurane diterpenoids from Celastrus orbiculatus","volume":"49","author":"Li","year":"2014","journal-title":"Chem. Nat. Comp."},{"key":"10.1016\/j.jep.2019.111934_bib74","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1055\/s-0035-1568597","article-title":"Elucidation of the intestinal absorption mechanism of Celastrol using the Caco-2 cell transwell model","volume":"82","author":"Li","year":"2016","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2019.111934_bib75","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1021\/acs.jnatprod.6b00314","article-title":"Caffeyl triterpenoid esters as potential anti-ischemic stroke agents from Celastrus orbiculatus","volume":"79","author":"Li","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib76","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.pestbp.2015.09.010","article-title":"Modulation of the Ca (2+) signaling pathway by celangulin I in the central neurons of spodoptera exigua","volume":"127","author":"Li","year":"2016","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.jep.2019.111934_bib77","series-title":"Studies on Pharmacognosy and Fingerprint of Celastrus Orbiculatus Thunb","first-page":"1","author":"Liang","year":"2008"},{"key":"10.1016\/j.jep.2019.111934_bib78","first-page":"294","article-title":"Erteng Tongbi Mixture for the treatment of rheumatoid arthritis: an clinical observation of 162 cases","volume":"4","author":"Liu","year":"2005","journal-title":"Tradit. Chin. Drug Res. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2019.111934_bib79","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1055\/s-2006-960175","article-title":"Two new sesquiterpene esters from Celastrus glaucophyllus","volume":"57","author":"Liu","year":"1991","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2019.111934_bib80","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1016\/0031-9422(91)83224-9","article-title":"Two sesquiterpene alkaloids from Celastrus angulatus","volume":"30","author":"Liu","year":"1991","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib81","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0031-9422(95)00350-G","article-title":"Four sesquiterpenes from the insecticidal plant Celastrus angulatus","volume":"40","author":"Liu","year":"1995","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib82","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0031-9422(00)95026-X","article-title":"A sesquiterpene evoninoate alkaloid from the root bark of Celastrus angulatus","volume":"32","author":"Liu","year":"1993","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib83","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/0031-9422(90)85175-F","article-title":"Insect antifeeding agents: sesquiterpene alkaloids from Celastrus angulatus","volume":"29","author":"Liu","year":"1990","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib84","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3987\/COM-12-12420","article-title":"New dihydroagarofuranoid sesquiterpenes from Celastrus angulatus","volume":"85","author":"Liu","year":"2012","journal-title":"Heterocycles"},{"key":"10.1016\/j.jep.2019.111934_bib85","first-page":"11","article-title":"The scavenging effect of phenolic secondary metabolites from C. angulatus Max. on hydroxyl free radicals","volume":"5","author":"Liu","year":"1999","journal-title":"Nat. Prod. Res. Dev."},{"key":"10.1016\/j.jep.2019.111934_bib86","first-page":"1293","article-title":"Clinical study on ErtengTongbi mixture plus Zhengqing Fengtongning sustained released tablet in the treatment of rheumatoid arthritis: a report of 30 cases","volume":"52","author":"Lin","year":"2011","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2019.111934_bib87","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/toxins8030079","article-title":"Validation of the target protein of insecticidal dihydroagarofuran sesquiterpene polyesters","volume":"8","author":"Lu","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.jep.2019.111934_bib88","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ps.953","article-title":"Antifungal properties of pristimerin and celastrol isolated from Celastrus hypoleucus","volume":"61","author":"Luo","year":"2005","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.jep.2019.111934_bib89","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1021\/np500280x","article-title":"Nitrogen-containing dihydro-\u03b2-agarofuran derivatives from Tripterygium wilfordii","volume":"77","author":"Luo","year":"2014","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib90","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1021\/jf052743f","article-title":"Isolation and characterization of rosmarinic acid oligomers in Celastrus hindsii benth leaves and their antioxidative activity","volume":"54","author":"Ly","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2019.111934_bib91","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1080\/13880209.2017.1285945","article-title":"Ameliorating effect of Celastrus paniculatus standardized extract and its fractions on 3-nitropropionic acid induced neuronal damage in rats: possible antioxidant mechanism","volume":"55","author":"Malik","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2019.111934_bib92","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.phytochem.2009.04.018","article-title":"Sterically hindered carotenoids with 3Z, 5Z, configuration from the seeds of oriental bitter sweet, Celastrus orbiculatus","volume":"70","author":"Maoka","year":"2009","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib93","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.phytochem.2013.06.022","article-title":"Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis","volume":"96","author":"Mba'ning","year":"2013","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib94","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1055\/s-2006-960813","article-title":"(-)-Epiafzelechin: cyclooxygenase-1 inhibitor and anti-inflammatory agent from aerial parts of Celastrus orbiculatus","volume":"65","author":"Min","year":"1999","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2019.111934_bib95","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.3390\/molecules17066854","article-title":"Pristimerin, a triterpenoid, inhibits tumor angiogenesis by targeting VEGFR2 activation","volume":"17","author":"Mu","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2019.111934_bib96","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1074\/jbc.M112.356816","article-title":"Celastrus and its bioactive celastrol protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk","volume":"287","author":"Nanjundaiah","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2019.111934_bib97","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1021\/acs.jnatprod.5b00234","article-title":"Natural \u03b2-dihydroagarofuran-type sesquiterpenoids as cognition-enhancing and neuroprotective agents from medicinal plants of the genus Celastrus","volume":"78","author":"Ning","year":"2015","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib98","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1039\/c39820001048","article-title":"Structure and stereochemistry of maytenfolic acid and maytenfoliol, two new antileukemic triterpenes from Maytenus diversifolia: X-ray crystal structures","volume":"0","author":"Nozaki","year":"1982","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"10.1016\/j.jep.2019.111934_bib99","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.phytol.2012.01.004","article-title":"Unusual D: B-friedobaccharane and oxygenated friedelane-type triterpenoids from salvadorean Celastraceae species","volume":"5","author":"N\u00fa\u00f1ez","year":"2012","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.jep.2019.111934_bib100","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.phytol.2012.12.003","article-title":"Triterpenoids from Cassine xylocarpa and Celastrus vulcanicola (celastraceae)","volume":"6","author":"N\u00fa\u00f1ez","year":"2013","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.jep.2019.111934_bib101","series-title":"Celastrus Paniculatus (PROSEA)","author":"Ong","year":"2016"},{"key":"10.1016\/j.jep.2019.111934_bib102","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.jep.2011.07.052","article-title":"Antinociceptive and hypnotic properties of Celastrus orbiculatus","volume":"137","author":"Park","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.111934_bib103","series-title":"Healing Plants of Peninsular India. Wallingford, UK","author":"Parrotta","year":"2001"},{"key":"10.1016\/j.jep.2019.111934_bib104","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1021\/jm991066b","article-title":"New natural sesquiterpenes as modulators of daunomycin resistance in a multidrug-resistant leishmania tropica Line","volume":"42","author":"Perez-Victoria","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jep.2019.111934_bib105","doi-asserted-by":"crossref","first-page":"7582","DOI":"10.1002\/chem.201600294","article-title":"Montecrinanes\u2005a\u2013c: triterpenes with an unprecedented rearranged tetracyclic skeleton from Celastrus vulcanicola. insights into triterpenoid biosynthesis based on dft calculations","volume":"22","author":"Purino","year":"2016","journal-title":"Chemistry"},{"key":"10.1016\/j.jep.2019.111934_bib106","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1007\/s11655-011-0819-7","article-title":"Celastrus orbiculatus extract inhibits tumor angiogenesis by targeting vascular endothelial growth factor signaling pathway and shows potent antitumor activity in hepatocarcinomas in vitro, and in vivo","volume":"18","author":"Qian","year":"2012","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2019.111934_bib107","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ecoenv.2010.10.004","article-title":"Ultrastructural effects of celangulin V on midgut cells of the oriental armyworm, mythimna separata walker (lepidoptera: noctuidae)","volume":"74","author":"Qi","year":"2011","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jep.2019.111934_bib108","series-title":"Chih-Wu Ming-Shih T'u Kao","first-page":"446","author":"Qi","year":"1957"},{"key":"10.1016\/j.jep.2019.111934_bib109","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.scienta.2009.07.008","article-title":"Fatty acids, bioactive lipids and radical scavenging activity of Celastrus paniculatus Willd","volume":"123","author":"Ramadan","year":"2009","journal-title":"Sci. Hortic."},{"key":"10.1016\/j.jep.2019.111934_bib110","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1021\/jm070290v","article-title":"Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-\u03b2-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance","volume":"50","author":"Reyes","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jep.2019.111934_bib111","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1572-5995(00)80024-1","article-title":"Natural triterpenoids as anti-inflammatory agents","volume":"22","author":"Rios","year":"2000","journal-title":"Stud. Nat. Prod. Chem."},{"key":"10.1016\/j.jep.2019.111934_bib112","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1584\/jpestics.R08-01","article-title":"Biorational insecticides in pest management","volume":"33","author":"Rosell","year":"2008","journal-title":"J. Pestic. Sci."},{"key":"10.1016\/j.jep.2019.111934_bib113","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/0031-9422(91)84206-8","article-title":"Dihydroagarofuran sesquiterpenoids from Celastrus paniculatus","volume":"30","author":"Sang","year":"1991","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib114","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1002\/hlca.201400021","article-title":"Tirucallane-type triterpenoids from Celastrus stylosus wall","volume":"97","author":"Shan","year":"2005","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.jep.2019.111934_bib115","first-page":"22","article-title":"Plants used in the treatment of joint diseases (rheumatism, arthritis, gout, lumbago) in Mayurbhunj district of Odisha, India","volume":"2","author":"Singh","year":"2010","journal-title":"Rep. Opin."},{"key":"10.1016\/j.jep.2019.111934_bib191","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1021\/jo00882a012","article-title":"Celorbicol, isocelorbicol, and their esters: new sesquiterpenoids from Celastrus orbiculatus","volume":"41","author":"Smith","year":"1976","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.jep.2019.111934_bib116","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/cbdv.200700403","article-title":"Chemical and pharmacological studies of the plants from genus Celastrus","volume":"6","author":"Su","year":"2009","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jep.2019.111934_bib117","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1021\/np50096a003","article-title":"Structures of sesquiterpene polyol esters from Celastrus stephanotiifolius with potential tumor-promotion inhibitory activity","volume":"56","author":"Takaishi","year":"1993","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib118","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bse.2014.01.001","article-title":"Chemical constituents from Celastrus aculeatus Merr","volume":"54","author":"Tang","year":"2014","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.jep.2019.111934_bib119","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10456-011-9208-2","article-title":"Angiogenesis as a therapeutic target in arthritis in 2011: learning the lessons of the colorectal cancer experience","volume":"14","author":"Thairu","year":"2011","journal-title":"Angiogenesis"},{"key":"10.1016\/j.jep.2019.111934_bib120","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1182\/blood-2008-09-179796","article-title":"Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-\u03baB with antimyeloma activity in vitro and in vivo","volume":"113","author":"Tiedemann","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jep.2019.111934_bib121","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/j.bmc.2011.02.034","article-title":"Dihydro-\u03b2-agarofuran sesquiterpenes isolated from Celastrus vulcanicola as potential anti-Mycobacterium tuberculosis multidrug-resistant agents","volume":"19","author":"Torres-Romero","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jep.2019.111934_bib122","doi-asserted-by":"crossref","first-page":"10847","DOI":"10.1021\/jf1022115","article-title":"Friedelane triterpenes from Celastrus vulcanicola as photosynthetic inhibitors","volume":"58","author":"Torres-Romero","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2019.111934_bib123","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0031-9422(00)95226-9","article-title":"Sesquiterpene polyol esters from Celastrus rosthornianus","volume":"30","author":"Tu","year":"1991","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib124","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1016\/0031-9422(91)83492-4","article-title":"Sesquiterpene polyol esters from Celastrus rosthornianus","volume":"30","author":"Tu","year":"1991","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib125","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1021\/np50077a022","article-title":"Sesquiterpene polyol esters from Celastrus paniculatus","volume":"54","author":"Tu","year":"1991","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib126","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1039\/p19910000425","article-title":"Structure of two new sesquiterpenoid insect antifeedants from Celastrus rosthornianus","volume":"22","author":"Tu","year":"1991","journal-title":"J. Chem. Soc. Perkin. Trans."},{"key":"10.1016\/j.jep.2019.111934_bib127","first-page":"219","article-title":"A new alkaloid from Celastrus Angulatus","volume":"4","author":"Tu","year":"1993","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jep.2019.111934_bib128","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/0031-9422(92)80387-T","article-title":"A sesquiterpene polyol ester from Celastrus rosthornianus","volume":"31","author":"Tu","year":"1992","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib129","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1016\/0031-9422(92)83743-I","article-title":"Sesquiterpene polyol esters from Celastrus angulatus","volume":"31","author":"Tu","year":"1992","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib130","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1021\/np50087a024","article-title":"Alkaloids from Celastrus angulatus","volume":"55","author":"Tu","year":"1992","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib131","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1016\/0031-9422(90)87106-5","article-title":"Sesquiterpene polyol esters from Celastrus gemmatus","volume":"29","author":"Tu","year":"1990","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib132","doi-asserted-by":"crossref","first-page":"5229","DOI":"10.1016\/j.bmc.2012.06.050","article-title":"Suppression of autoimmune arthritis by celastrus-derived celastrol through modulation of pro-inflammatory chemokines","volume":"20","author":"Venkatesha","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jep.2019.111934_bib133","doi-asserted-by":"crossref","first-page":"15138","DOI":"10.1074\/jbc.M111.226365","article-title":"Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses","volume":"286","author":"Venkatesha","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2019.111934_bib134","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1021\/np50057a014","article-title":"Celangulin: a nonalkaloidal insect antifeedant from Chinese Bittersweet, Celastrus angulatus","volume":"51","author":"Wakabaysshi","year":"1988","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib135","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.3892\/ol.2017.6470","article-title":"Celastrus orbiculatus extract suppresses the epithelial-mesenchymal transition by mediating cytoskeleton rearrangement via inhibition of the Cofilin 1 signaling pathway in human gastric cancer","volume":"14","author":"Wang","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jep.2019.111934_bib136","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jep.2017.04.030","article-title":"Anticancer efficacy of the ethyl acetate extract from the traditional Chinese medicine herb Celastrus orbiculatus against human gastric cancer","volume":"205","author":"Wang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.111934_bib137","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/hlca.200900426","article-title":"A new nortriterpene from the root of Celastrus hypoleucus","volume":"93","author":"Wang","year":"2010","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.jep.2019.111934_bib138","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/01480545.2010.494664","article-title":"Toxic effects of celastrol on embryonic development of zebrafish (danio rerio)","volume":"34","author":"Wang","year":"2010","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.jep.2019.111934_bib139","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1007\/s10600-016-1769-2","article-title":"Lupene-type triterpenoids from Celastrus oblanceifolius","volume":"52","author":"Wang","year":"2016","journal-title":"Chem. Nat. Comp."},{"key":"10.1016\/j.jep.2019.111934_bib140","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1016\/j.bmcl.2006.01.021","article-title":"Novel skeleton terpenes from Celastrus hypoleucus with anti-tumor activities","volume":"37","author":"Wang","year":"2006","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.jep.2019.111934_bib141","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/hlca.200590094","article-title":"Two novel olean triterpenoids from Celastrus hypoleucus","volume":"88","author":"Wang","year":"2005","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.jep.2019.111934_bib142","first-page":"229","article-title":"Two new sequiterpenes frpm Celastrus obiculatus","volume":"3","author":"Wang","year":"1995","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jep.2019.111934_bib143","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1021\/np970042+","article-title":"Alternatamides A\u2212D:\u2009 new bromotryptamine peptide antibiotics from the atlantic marine bryozoan amathia alternata","volume":"60","author":"Wang","year":"1997","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib144","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1021\/np3008182","article-title":"(M)- and (P)-bicelaphanol A, dimeric trinorditerpenes with promising neuroprotective activity from Celastrus orbiculatus","volume":"76","author":"Wang","year":"2013","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib145","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.phymed.2013.04.017","article-title":"Promising effects on ameliorating mitochondrial function and enhancing Akt signaling in SH-SY5Y cells by (M)-bicelaphanol A, a novel dimeric podocarpane type trinorditerpene isolated from Celastrus orbiculatus","volume":"20","author":"Wang","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2019.111934_bib146","doi-asserted-by":"crossref","first-page":"10945","DOI":"10.1021\/jf503735t","article-title":"Isolation and characterization of sesquiterpenes from Celastrus orbiculatus and their antifungal activities against phytopathogenic fungi","volume":"62","author":"Wang","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2019.111934_bib147","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s10600-014-0892-1","article-title":"Chemical constituents from Celastrus monospermus","volume":"50","author":"Wang","year":"2014","journal-title":"Chem. Nat. Comp."},{"key":"10.1016\/j.jep.2019.111934_bib148","first-page":"51","article-title":"A new sesquiterpene from Celastrus angulatus","volume":"5","author":"Wang","year":"1994","journal-title":"Chem. Lett."},{"key":"10.1016\/j.jep.2019.111934_bib149","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1021\/np960486q","article-title":"Two new sesquiterpenes from Celastrus angulatus","volume":"60","author":"Wang","year":"1997","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib150","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1021\/np9705322","article-title":"Two new sesquiterpenoids from the Seeds of Celastrus angulatus","volume":"61","author":"Wang","year":"1998","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib151","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1007\/s10600-012-0101-z","article-title":"Antitumor sequiterpene polyol esters from Celastrus angulatus","volume":"47","author":"Wei","year":"2011","journal-title":"Chem. Nat. Comp."},{"key":"10.1016\/j.jep.2019.111934_bib152","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1002\/hlca.200900431","article-title":"New dihydroagarofuranoid sesquiterpenes from Celastrus paniculatus","volume":"93","author":"Weng","year":"2010","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.jep.2019.111934_bib153","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.phytochem.2013.05.022","article-title":"Cytotoxic constituents from Celastrus paniculatus induce apoptosis and autophagy in breast cancer cells","volume":"94","author":"Weng","year":"2013","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib154","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1021\/acs.jnatprod.7b00220","article-title":"Celastrofurans A-G: dihydro-\u03b2-agarofurans from the australian rainforest vine Celastrus subspicata and their inhibitory effect on leucine transport in prostate cancer cells","volume":"80","author":"Wibowo","year":"2017","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib155","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1158\/1535-7163.MCT-05-0027","article-title":"Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria","volume":"4","author":"Wu","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.jep.2019.111934_bib156","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1016\/0031-9422(92)80446-L","article-title":"Angulatueoid G and H, sesquiterpenes from the seeds of Celastrus angulatus","volume":"31","author":"Wu","year":"1992","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib157","doi-asserted-by":"crossref","DOI":"10.1021\/np50087a018","article-title":"Celangulins II, III, and IV: new insecticidal sesquiterpenoids from Celastrus angulatus","volume":"55","author":"Wu","year":"1992","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib158","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.phytochem.2011.11.023","article-title":"Terpenoids from root bark of Celastrus orbiculatus","volume":"75","author":"Wu","year":"2012","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib159","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0031-9422(01)00314-4","article-title":"Insecticidal sesquiterpene polyol esters from Celastrus angulatus","volume":"58","author":"Wu","year":"2001","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib160","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1021\/np0004193","article-title":"Five new insecticidal sesquiterpenoids from Celastrus angulatus","volume":"64","author":"Wu","year":"2001","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.111934_bib162","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3184\/174751912X13543807337784","article-title":"Three novel friedelane triterpenes with antimicrobial activity from the stems of Celastrus monospermus","volume":"37","author":"Xie","year":"2013","journal-title":"J. Chem. Res."},{"key":"10.1016\/j.jep.2019.111934_bib192","series-title":"Collection of Chinese Herbal Medicines","first-page":"649","author":"Xie","year":"1975"},{"key":"10.1016\/j.jep.2019.111934_bib163","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.fitote.2011.12.026","article-title":"Sesquiterpenes inhibiting NO production from Celastrus orbiculatus","volume":"83","author":"Xu","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2019.111934_bib164","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.phytol.2012.07.009","article-title":"Three new dihydroagarofuran sesquiterpenoids from Celastrus orbiculatus","volume":"5","author":"Xu","year":"2012","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.jep.2019.111934_bib165","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1515\/znc-2008-7-808","article-title":"Cytotoxic \u03b2-dihydroagarofuran sesquiterpenoids from the fruits of Celastrus orbiculatus","volume":"63","author":"Xu","year":"2008","journal-title":"Z. Naturforsch. C Biosci."},{"key":"10.1016\/j.jep.2019.111934_bib166","first-page":"87","article-title":"Preliminary study on the biological activity of Celastrus gemmatus lose hydrolysis","volume":"2","author":"Yang","year":"2005","journal-title":"Actaagriculturne Boreali-occidentalis Sin."},{"key":"10.1016\/j.jep.2019.111934_bib167","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.3892\/ol.2016.5213","article-title":"Celastrus orbiculatus extract triggers apoptosis and autophagy via PI3K\/AKT\/mTOR inhibition in human colorectal cancer cells","volume":"12","author":"Yang","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jep.2019.111934_bib168","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/jcb.21399","article-title":"Pristimerin induces apoptosis by targeting the proteasome in prostate cancer cells","volume":"103","author":"Yang","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jep.2019.111934_bib169","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/cbdv.201400269","article-title":"Lupane- and friedelane-type triterpenoids from Celastrus stylosus","volume":"12","author":"Ying","year":"2015","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jep.2019.111934_bib170","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s10600-017-2060-x","article-title":"Chemical constituents of Celastrus rugosus","volume":"53","author":"Ying","year":"2017","journal-title":"Chem. Nat. Comp."},{"key":"10.1016\/j.jep.2019.111934_bib171","first-page":"487","article-title":"A novel sesquiterpene polyol ester from Celastrus angulatus and its antitumor activities","volume":"10","author":"Yin","year":"1999","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jep.2019.111934_bib172","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/S0031-9422(99)00216-2","article-title":"Two alkaloids from Chinese bittersweet Celastrus angulatus","volume":"52","author":"Yin","year":"1999","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib173","first-page":"67","article-title":"Anticancer activity of the 1, 3-Oxazacyclohexane alkaloid A, B from Celastrus angulatus","volume":"21","author":"Yin","year":"2000","journal-title":"J. Luoyang. Inst. Technol."},{"key":"10.1016\/j.jep.2019.111934_bib175","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/039463201202500215","article-title":"Celastrus treatment modulates antigen-induced gene expression in lymphoid cells of arthritic rats","volume":"25","author":"Yu","year":"2012","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.jep.2019.111934_bib177","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0254-6272(13)60081-3","article-title":"Celastrus orbiculatus extract induces mitochondrial-mediated apop-tosis in human hepatocellular carcinoma cells","volume":"32","author":"Zhang","year":"2012","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2019.111934_bib178","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.phytol.2013.10.002","article-title":"Four new sesquiterpene polyol esters from Celastrus angulatus","volume":"7","author":"Zhang","year":"2014","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.jep.2019.111934_bib179","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1080\/10286020.2011.555332","article-title":"Two new sesquiterpene polyol esters from the root barks of Celastrus angulatus","volume":"13","author":"Zhang","year":"2011","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2019.111934_bib180","doi-asserted-by":"crossref","first-page":"9596","DOI":"10.3390\/ijms12129596","article-title":"Synthesis and insecticidal activities of new ester-derivatives of Celangulin-V","volume":"12","author":"Zhang","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2019.111934_bib181","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0031-9422(97)00979-5","article-title":"Sesquiterpenes from Celastrus paniculatus subsp. Paniculatus","volume":"48","author":"Zhang","year":"1998","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.111934_bib182","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/hlca.200900424","article-title":"Glycosidic constituents of Celastrus orbiculatus","volume":"93","author":"Zhang","year":"2010","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.jep.2019.111934_bib183","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s11745-016-4145-x","article-title":"Celastrus orbiculatus Thunb. reduces lipid accumulation by promoting reverse cholesterol transport in hyperlipidemic mice","volume":"51","author":"Zhang","year":"2016","journal-title":"Lipids"},{"key":"10.1016\/j.jep.2019.111934_bib184","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s11745-013-3773-7","article-title":"Celastrus orbiculatus Thunb. decreases athero-susceptibility in lipoproteins and the aorta of Guinea pigs fed high fat diet","volume":"48","author":"Zhang","year":"2013","journal-title":"Lipids"},{"key":"10.1016\/j.jep.2019.111934_bib185","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.3390\/molecules22111811","article-title":"Design, synthesis and bioactivity evaluation of novel \u03b2-carboline 1,3,4-oxadiazole derivatives","volume":"22","author":"Zhang","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2019.111934_bib186","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/10286020.2011.641535","article-title":"Two new lignans from Celastrus flagellaris Rupr","volume":"14","author":"Zhao","year":"2012","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2019.111934_bib187","doi-asserted-by":"crossref","first-page":"948","DOI":"10.3390\/molecules22060948","article-title":"Two new \u03b2-dihydroagarofuran sesquiterpenes from Celastrus orbiculatus Thunb and their anti-proliferative activity","volume":"22","author":"Zhou","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2019.111934_bib188","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ejphar.2011.09.014","article-title":"Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-\u03baB activity","volume":"670","author":"Zhou","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2019.111934_bib189","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1177\/1534735415572880","article-title":"Antimetastatic effects of Celastrus orbiculatus on human gastric adenocarcinoma by inhibiting epithelial-mesenchymal transition and NF-\u03baB\/snail signaling pathway","volume":"14","author":"Zhu","year":"2015","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.jep.2019.111934_bib190","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1021\/np800052d","article-title":"Cytotoxic dihydroagarofuranoid sesquiterpenes from the seeds of Celastrus orbiculatus","volume":"71","author":"Zhu","year":"2008","journal-title":"J. Nat. Prod."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411833188X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411833188X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:20:58Z","timestamp":1759940458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887411833188X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":188,"alternative-id":["S037887411833188X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.111934","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Traditional uses, secondary metabolites, and pharmacology of Celastrus species - a review:","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.111934","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111934"}}