{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:34:23Z","timestamp":1790048063604,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Science & Technology Award for Young-aged Talents of China Association of Traditional Chinese Medicine","award":["CACM-2017-QNRC2-C12"],"award-info":[{"award-number":["CACM-2017-QNRC2-C12"]}]},{"name":"Guangdong Public Welfare Research and Capacity Building Projects","award":["2016A020217016"],"award-info":[{"award-number":["2016A020217016"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jep.2019.111975","type":"journal-article","created":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T13:33:55Z","timestamp":1558877635000},"page":"111975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Danhong Huayu Koufuye prevents venous thrombosis through antiinflammation via Sirtuin 1\/NF-\u03baB signaling pathway"],"prefix":"10.1016","volume":"241","author":[{"given":"Han","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenpei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoqin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jep.2019.111975_bib1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1365-2141.2008.07323.x","article-title":"Virchow and his triad: a question of attribution","volume":"143","author":"Bagot","year":"2010","journal-title":"Br. J. Haematol."},{"issue":"2","key":"10.1016\/j.jep.2019.111975_bib2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/cvr\/cvq339","article-title":"Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells","volume":"89","author":"Breitenstein","year":"2011","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.jep.2019.111975_bib3","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1538-7836.2011.04544.x","article-title":"Neutrophil extracellular traps promote deep vein thrombosis in mice","volume":"10","author":"Brill","year":"2012","journal-title":"J. Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.jep.2019.111975_bib4","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1084\/jem.20112322","article-title":"Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo","volume":"209","author":"Br\u00fchl","year":"2012","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.jep.2019.111975_bib5","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.it.2018.04.010","article-title":"Immune factors in deep vein thrombosis initiation","volume":"39","author":"Budnik","year":"2018","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.jep.2019.111975_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.abb.2005.06.005","article-title":"Tissue factor mediates inflammation","volume":"440","author":"Chu","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"issue":"8","key":"10.1016\/j.jep.2019.111975_bib7","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1089\/ars.2017.7178","article-title":"SIRT1 and SIRT6 signaling pathways in cardiovascular disease protection","volume":"28","author":"D'Onofrio","year":"2017","journal-title":"Antioxidants Redox Signal."},{"issue":"10063","key":"10.1016\/j.jep.2019.111975_bib8","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1016\/S0140-6736(16)30514-1","article-title":"Deep vein thrombosis and pulmonary embolism","volume":"388","author":"Di","year":"2016","journal-title":"Lancet"},{"issue":"18","key":"10.1016\/j.jep.2019.111975_bib9","first-page":"210","article-title":"Regulating effect of Danhong Huayu oral solution on cytokine network of retinal central venous obstruction","volume":"23","author":"Fu","year":"2017","journal-title":"Chin J Exp Tradit Med Form"},{"issue":"8","key":"10.1016\/j.jep.2019.111975_bib10","doi-asserted-by":"crossref","first-page":"L847","DOI":"10.1152\/ajplung.00274.2014","article-title":"Sirt1 restrains lung inflammasome activation in a murine model of sepsis","volume":"308","author":"Gao","year":"2015","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"6667","key":"10.1016\/j.jep.2019.111975_bib11","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/35393","article-title":"CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells","volume":"391","author":"Henn","year":"1998","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.jep.2019.111975_bib12","first-page":"104","article-title":"Antithrombotic effect of danhong Huayu Koufuye","volume":"21","author":"Hu","year":"2015","journal-title":"Chin J Exp Tradit Med Form"},{"issue":"5","key":"10.1016\/j.jep.2019.111975_bib13","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/cpr.12056","article-title":"In silico analysis and experimental validation of molecular mechanisms of salvianolic acid A-inhibited LPS-stimulated inflammation, in RAW264.7 macrophages","volume":"46","author":"Huang","year":"2013","journal-title":"Cell Prolif"},{"issue":"8","key":"10.1016\/j.jep.2019.111975_bib14","first-page":"1897","article-title":"The clinical research into central retinal vein occlusion treated with Danhong Huayu Koufuye in combination with laser","volume":"35","author":"Jia","year":"2015","journal-title":"Henan Trad Chin Med"},{"issue":"5","key":"10.1016\/j.jep.2019.111975_bib15","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.cjca.2015.11.022","article-title":"Sirtuins, cell senescence, and vascular aging","volume":"32","author":"Kida","year":"2016","journal-title":"Can. J. Cardiol."},{"issue":"6","key":"10.1016\/j.jep.2019.111975_bib16","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.jid.2016.11.044","article-title":"SIRT1, a class III histone deacetylase, regulates LPS-induced inflammation in human keratinocytes and mediates the anti-inflammatory effects of hinokitiol","volume":"137","author":"Lee","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jep.2019.111975_bib17","series-title":"Compendium of Materia Medica (Bencao Gangmu)","author":"Li","year":"2006"},{"key":"10.1016\/j.jep.2019.111975_bib18","series-title":"Surgery of Chinese Medicine","author":"Li","year":"2012"},{"issue":"12","key":"10.1016\/j.jep.2019.111975_bib19","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2174\/1389201015666141111114442","article-title":"Naringin inhibits TNF-\u03b1 induced oxidative stress and inflammatory response in HUVECs via Nox4\/NF-\u03baB and PI3K\/Akt pathways","volume":"15","author":"Li","year":"2014","journal-title":"Curr. Pharmaceut. Biotechnol."},{"key":"10.1016\/j.jep.2019.111975_bib20","series-title":"Data for DHK Effect on Thrombus Weight, Blood Coagulation, Blood Cell Counts and Whole Blood Viscosity in Deep Vein Thrombosis Rats","author":"Liu","year":"2019"},{"issue":"12","key":"10.1016\/j.jep.2019.111975_bib21","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1161\/CIRCRESAHA.116.309301","article-title":"Innate effector-memory T cell activation regulates post-thrombotic vein wall inflammation and thrombus resolution","volume":"119","author":"Luther","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2019.111975_bib22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cytogfr.2017.11.001","article-title":"Nuclear sirtuins and inflammatory signaling pathways","volume":"38","author":"Mendes","year":"2017","journal-title":"Cytokine Growth Factor Rev."},{"issue":"20","key":"10.1016\/j.jep.2019.111975_bib23","doi-asserted-by":"crossref","DOI":"10.1101\/gad.435107","article-title":"SIRT1 controls endothelial angiogenic functions during vascular growth","volume":"21","author":"Potente","year":"2007","journal-title":"Genes Dev."},{"issue":"13","key":"10.1016\/j.jep.2019.111975_bib24","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1089\/ars.2017.7373","article-title":"SIRT1 controls acetaminophen hepatotoxicity by modulating inflammation and oxidative stress","volume":"28","author":"Rada","year":"2017","journal-title":"Antioxidants Redox Signal."},{"issue":"1","key":"10.1016\/j.jep.2019.111975_bib25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11357-011-9336-z","article-title":"Aging and vascular dysfunction: beneficial melatonin effects","volume":"35","author":"Rodella","year":"2013","journal-title":"Age"},{"issue":"20","key":"10.1016\/j.jep.2019.111975_bib26","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1182\/blood-2016-04-710632","article-title":"Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice","volume":"128","author":"Stark","year":"2016","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.jep.2019.111975_bib27","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1182\/blood-2016-05-718114","article-title":"The role of leukocytes in thrombosis","volume":"128","author":"Swystun","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jep.2019.111975_bib28","series-title":"Correction of Errors in Medical Works","author":"Wang","year":"1997"},{"issue":"3","key":"10.1016\/j.jep.2019.111975_bib29","first-page":"178","article-title":"Clinical observation on the treatment of retinal vein obstruction with Danhong Huayu Koufuye","volume":"8","author":"Wang","year":"2001","journal-title":"Chin. J. Integr. Tradit. West Med Intensive Crit. Care"},{"issue":"1","key":"10.1016\/j.jep.2019.111975_bib30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.thromres.2014.10.034","article-title":"Salvianolic acid B inhibits platelets-mediated inflammatory response in vascular endothelial cells","volume":"135","author":"Xu","year":"2014","journal-title":"Thromb. Res."},{"issue":"3","key":"10.1016\/j.jep.2019.111975_bib31","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1055\/s-0038-1676987","article-title":"Deep vein thrombosis is modulated by inflammation regulated via Sirtuin 1\/NF-\u03baB signaling pathway in a rat model","volume":"119","author":"Yao","year":"2019","journal-title":"Thromb. Haemostasis"},{"issue":"2","key":"10.1016\/j.jep.2019.111975_bib32","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/cvr\/cvn224","article-title":"Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice","volume":"80","author":"Zhang","year":"2008","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.jep.2019.111975_bib33","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jss.2015.11.008","article-title":"Danhong Huayu Koufuye prevents deep vein thrombosis through anti-inflammation in rats","volume":"201","author":"Zhang","year":"2016","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.jep.2019.111975_bib34","doi-asserted-by":"crossref","first-page":"23912","DOI":"10.1038\/srep23912","article-title":"Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"issue":"1\u20132","key":"10.1016\/j.jep.2019.111975_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2005.01.059","article-title":"Protocatechuic aldehyde suppresses TNF-alpha-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells","volume":"513","author":"Zhou","year":"2005","journal-title":"Eur. J. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118342958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118342958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T17:26:55Z","timestamp":1721323615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874118342958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":35,"alternative-id":["S0378874118342958"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.111975","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Danhong Huayu Koufuye prevents venous thrombosis through antiinflammation via Sirtuin 1\/NF-\u03baB signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.111975","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111975"}}