{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:02:40Z","timestamp":1759971760739,"version":"build-2065373602"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Herbarium of Bolivia and the Fundaci\u00f3n de la Universidad Aut\u00f3noma de Madrid"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.jep.2019.112036","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T18:56:28Z","timestamp":1561229788000},"page":"112036","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Flavonoids of Tripodanthus acutifolius inhibit TNF\u2013\u03b1 production in LPS\u2013activated THP\u20131 and B16\u2013F10\u202fcells"],"prefix":"10.1016","volume":"242","author":[{"given":"L.","family":"Apaza T","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea Madalina","family":"Serban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.H.","family":"Cabanillas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Villacampa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Rumbero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jep.2019.112036_bib1","first-page":"66","article-title":"Medicinal plants marketed by chifleras of La Paz and El Alto cities (Bolivia)","volume":"50","author":"Justo\u2013Chipana","year":"2015","journal-title":"Ecolog\u00eda en Bolivia"},{"issue":"1\u20133","key":"10.1016\/j.jep.2019.112036_bib2","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ejphar.2006.03.070","article-title":"Cardamonin, inhibits pro\u2013inflammatory mediators in activated RAW 264.7 cells and whole blood","volume":"538","author":"Ahmad","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2019.112036_bib3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0378-8741(91)90069-P","article-title":"Screening of plants used in south Brazilian folk medicine","volume":"35","author":"Alice","year":"1991","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2019.112036_bib4","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1021\/cc100076k","article-title":"Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors","volume":"12","author":"Alvim","year":"2010","journal-title":"J. Comb. Chem."},{"key":"10.1016\/j.jep.2019.112036_bib5","first-page":"61","article-title":"A molecular phylogeny of the mistletoe genus Tripodanthus (Loranthaceae)","volume":"45","author":"Amico","year":"2007","journal-title":"Drawiniana"},{"key":"10.1016\/j.jep.2019.112036_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jep.2019.02.015","article-title":"Alkamides from Tropaeolum tuberosum inhibit inflammatory response induced by TNF\u2013\u03b1 and NF\u2013\u03baB","volume":"235","author":"Apaza","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.112036_bib7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.phytochem.2007.08.003","article-title":"Flavones from Struthiola argentea with anthelmintic activity in vitro","volume":"69","author":"Ayers","year":"2008","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.112036_bib8","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1016\/j.phytochem.2011.07.002","article-title":"Hybrid flavan\u2013chalcones, aromatase and lipoxygenase inhibitors from Desmos cochinchinensis","volume":"72","author":"Bajgai","year":"2011","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.112036_bib9","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0031-9422(00)81116-4","article-title":"An HPLC study of flavones from some Spanish Sideritis species","volume":"24","author":"Barberan","year":"1985","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.112036_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-62703-290-2_7","article-title":"Detection of necrosis by release of lactate dehydrogenase (LDH) activity","volume":"979","author":"Chan","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jep.2019.112036_bib11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0031-9422(95)00217-U","article-title":"Free flavonoid aglycones from Thymus herba barona and its monoterpenoid chemotypes","volume":"40","author":"Corticchiato","year":"1995","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.112036_bib12","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jep.2006.05.002","article-title":"Anti\u2013inflammatory, anti\u2013nociceptive and antipyretic effects of extracts of Phrygilanthus acutifolius flowers","volume":"108","author":"Daud","year":"2006","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2019.112036_bib13","first-page":"183","article-title":"Topical anti\u2013inflammatory activity of Tripodanthus acutifolius flowers gel formulation","volume":"4","author":"Daud","year":"2012","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.jep.2019.112036_bib14","first-page":"49","article-title":"Recursos herbolarios de San Luis (Argentina). Primera parte: plantas nativas","volume":"6","author":"Del Vitto","year":"1997","journal-title":"Multequina"},{"key":"10.1016\/j.jep.2019.112036_bib15","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.bbagrm.2013.04.007","article-title":"Transcriptional control by NF\u2013\u03baB: elongation in focus","volume":"1829","author":"Diamant","year":"2013","journal-title":"Biochim. Biophys."},{"key":"10.1016\/j.jep.2019.112036_bib16","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0031-9422(00)95197-5","article-title":"Flavonoid constituents of Stachys aegyptiaca","volume":"30","author":"El Ansari","year":"1991","journal-title":"Phytochemistry"},{"issue":"9","key":"10.1016\/j.jep.2019.112036_bib17","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1016\/j.ejmech.2009.03.018","article-title":"Discovering a new analogue of thalidomide which may be used as a potent modulator of TNF\u2013alpha production","volume":"44","author":"Fern\u00e1ndez","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jep.2019.112036_bib18","first-page":"185","article-title":"5,3',4'\u2013trihydroxy\u20136,7,8\u2013trimethoxyflavone from Sideritis leucantha","volume":"186","author":"Ferreres","year":"1979","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.112036_bib19","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nri2423","article-title":"New regulators of NF\u2013\u03baB in inflammation","volume":"8","author":"Ghosh","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.jep.2019.112036_bib20","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1039\/C8FO00279G","article-title":"Anti\u2013inflammatory effect of 5,4'\u2013Dihydroxy\u20136,7,8\u2013trimethoxyflavone, a major colonic metabolite of 5\u2013demethyltangeretin","volume":"9","author":"Guo","year":"2018","journal-title":"Food Funct"},{"issue":"23","key":"10.1016\/j.jep.2019.112036_bib21","doi-asserted-by":"crossref","first-page":"6408","DOI":"10.1039\/C6AN01596D","article-title":"Accurate quantification of apoptosis progression and toxicity using a dielectrophoretic approach","volume":"141","author":"Henslee","year":"2016","journal-title":"Analyst"},{"key":"10.1016\/j.jep.2019.112036_bib22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1089\/109662003772519930","article-title":"Inhibitory effect of some flavonoids on tumour necrosis factor\u2013alpha production in lipopolysaccharide\u2013stimulated mouse macrophage cell line J774.1","volume":"6","author":"Herath","year":"2003","journal-title":"J. Med. Food"},{"issue":"6","key":"10.1016\/j.jep.2019.112036_bib23","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.semarthrit.2004.11.006","article-title":"The benefit\/risk profile of TNF\u2013blocking agents: findings of a consensus panel","volume":"34","author":"Hochberg","year":"2005","journal-title":"Semin. Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.jep.2019.112036_bib24","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1111\/j.1365-2249.2008.03718.x","article-title":"Allergy and the skin","author":"Incorvaia","year":"2008","journal-title":"Clin. Exp. Immunol."},{"issue":"5","key":"10.1016\/j.jep.2019.112036_bib25","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.jaci.2005.08.014","article-title":"IL\u201317 suppresses TNF\u2013\u03b1\u2013induced CCL27 production through induction of COX\u20132 in human keratinocytes","volume":"116","author":"Kanda","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"issue":"17","key":"10.1016\/j.jep.2019.112036_bib26","first-page":"30901","article-title":"Biological therapies in inflammatory bowel disease: beyond anti\u2013TNF therapies","volume":"12","author":"Katsanos","year":"2018","journal-title":"Clin. Immunol."},{"issue":"2","key":"10.1016\/j.jep.2019.112036_bib27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.toxlet.2004.01.010","article-title":"Effect of retinoids on LPS\u2013induced COX\u20132 expression and COX\u20132 associated PGE(2) release from mouse peritoneal macrophages and TNF\u2013alpha release from rat peripheral blood mononuclear cells","volume":"150","author":"Kim","year":"2004","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.jep.2019.112036_bib28","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.leukres.2012.08.027","article-title":"Lack of association between TNF\u2013\u03b1 promoter polymorphisms and multiple myeloma: a meta\u2013analysis","volume":"37","author":"Li","year":"2013","journal-title":"Leuk. Res."},{"key":"10.1016\/j.jep.2019.112036_bib29","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.phytochem.2015.02.021","article-title":"Sterols from Hericium erinaceum and their inhibition of TNF\u2013\u03b1 and NO production in lipopolysaccharide\u2013induced RAW 264.7 cells","volume":"115","author":"Li","year":"2015","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.112036_bib30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.phytochem.2019.03.021","article-title":"Anti\u2013inflammatory terpenes from Schefflera rubriflora C. J. Tseng & G. Hoo with their TNF\u2013\u03b1 and IL\u20136 inhibitory activities","volume":"163","author":"Li","year":"2019","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2019.112036_bib31","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jep.2011.09.038","article-title":"Detection of antifungal compounds in Polygonum ferrugineum Weed. extracts by bioassay\u2013guided fractionation. Some evidences of their mode of action","volume":"138","author":"L\u00f3pez","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.112036_bib32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jep.2004.11.022","article-title":"An ethnobotanical survey of medicinal plants commercialized in the markets of La Paz and El Alto, Bolivia","volume":"97","author":"Macia","year":"2005","journal-title":"J. Ethnopharmacol."},{"issue":"18","key":"10.1016\/j.jep.2019.112036_bib33","article-title":"TNF\u2013\u03b1 inhibitor\u2013induced psoriasis: a decade of experience at the cleveland clinic","volume":"18","author":"Mazloom","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"issue":"9","key":"10.1016\/j.jep.2019.112036_bib34","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.bcp.2010.07.026","article-title":"Inhibition of cell growth and potentiation of tumour necrosis factor\u2013\u03b1 (TNF\u2013\u03b1)\u2013induced apoptosis by a phenanthroindolizidine alkaloid antofine in human colon cancer cells","volume":"80","author":"Min","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2019.112036_bib35","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cyto.2016.08.014","article-title":"Molecular mechanisms of action of anti\u2013TNF\u2013\u03b1 agents \u2013 comparison among therapeutic TNF\u2013\u03b1 antagonists","volume":"101","author":"Mitoma","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.jep.2019.112036_bib36","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1248\/cpb.56.956","article-title":"Medicinal foodstaffs XXXIV. Structures and new prenylchalcones and prenylflavanones with TNF\u2013\u03b1 and aminopeptidase N inhibitory activities from Boesenbergia rotunda","volume":"56","author":"Morikawa","year":"2008","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.jep.2019.112036_bib37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0378-8741(99)00191-9","article-title":"A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part III. Evaluation of the antimalarial activity of plants used by Alte\u00f1os Indians","volume":"71","author":"Mu\u00f1oz","year":"2000","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2019.112036_bib38","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.crohns.2011.10.004","article-title":"Anti\u2013TNF\u2013\u03b1 antibodies improve intestinal barrier function in Crohn's disease","volume":"6","author":"Noth","year":"2012","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.jep.2019.112036_bib39","series-title":"Plantas medicinales de Bolivia","first-page":"260","author":"Oblitas","year":"1993"},{"key":"10.1016\/j.jep.2019.112036_bib40","first-page":"125","article-title":"The contribution of keratinocytes to the pathogenesis of atopic dermatitis","volume":"16","author":"Pastore","year":"2006","journal-title":"Eur. J. Dermatol."},{"issue":"15\u201316","key":"10.1016\/j.jep.2019.112036_bib41","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.drudis.2006.06.002","article-title":"Modulating TNF\u2013\u03b1 signalling with natural products","volume":"11","author":"Paul","year":"2006","journal-title":"Drug Discov. Today"},{"issue":"1","key":"10.1016\/j.jep.2019.112036_bib42","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.humimm.2015.10.008","article-title":"The relationship between body weight and inflammation: lesson from anti\u2013TNF\u2013\u03b1 antibody therapy","volume":"77","author":"Peluso","year":"2016","journal-title":"Hum. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2019.112036_bib43","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jaci.2018.02.043","article-title":"Blockade of TNF receptor superfamily 1 (TNFR1)\u2013dependent and TNFR1\u2013independent cell death is crucial for normal epidermal differentiation","volume":"143","author":"Piao","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2019.112036_bib44","series-title":"9th. Antognazzi & Cia, SRL: Rosario, Santa Fe\u2013Argentina","first-page":"65","article-title":"Yerbas Medicinales Argentinas: breves apuntes de las propiedades de las mismas e indicaciones para su uso","author":"Saggese","year":"1949"},{"issue":"1","key":"10.1016\/j.jep.2019.112036_bib45","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jep.2003.12.003","article-title":"Medicinal plants used by the criollos of northwestern Argentine chaco","volume":"91","author":"Scarpa","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.112036_bib46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3989\/rdtp.2004.v59.i2.126","article-title":"El s\u00edndrome c\u00e1lido\u2013fresco en la medicina popular criolla del Chaco argentino","volume":"59","author":"Scarpa","year":"2004","journal-title":"Rev. Dialectol. Tradic. Pop."},{"issue":"3","key":"10.1016\/j.jep.2019.112036_bib47","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.it.2019.01.001","article-title":"Immunoreceptor engineering and synthetic cytokine signalling for therapeutics","volume":"40","author":"Scheller","year":"2019","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jep.2019.112036_bib48","first-page":"88","article-title":"Study of anti\u2013inflammatory activity of metabolites isolated from Tripodanthus acutifolius","volume":"21","author":"Sober\u00f3n","year":"2010","journal-title":"Mol. Med. Chem."},{"issue":"9\u201310","key":"10.1016\/j.jep.2019.112036_bib49","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.lfs.2011.06.027","article-title":"(E)\u20132',4'\u2013Dihydroxy\u20136'\u2013methoxy\u2013chalcone suppresses nitric oxide production via blocking the IFN\u2013\u03b3\/STAT pathway in endotoxin\u2013challenged peritoneal macrophages of ICR mice","volume":"89","author":"Takahashi","year":"2011","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2019.112036_bib50","first-page":"853","article-title":"Studies on chemical constituents of Alpinia katsumadai","volume":"31","author":"Wang","year":"2008","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.jep.2019.112036_bib51","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/0031-9422(93)85293-Z","article-title":"Exudate flavonoids from two Australian Asteraceae, Bracteantha viscosa and Cassinia quinquefaria","volume":"33","author":"Wollenweber","year":"1993","journal-title":"Phytochemistry"},{"issue":"2","key":"10.1016\/j.jep.2019.112036_bib52","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.clim.2007.08.013","article-title":"TNFalpha blockade in human diseases: mechanisms and future directions","volume":"126","author":"Wong","year":"2008","journal-title":"Clin. Immunol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119306865?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119306865?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:21:53Z","timestamp":1759940513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874119306865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":52,"alternative-id":["S0378874119306865"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.112036","relation":{},"ISSN":["0378-8741"],"issn-type":[{"type":"print","value":"0378-8741"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flavonoids of Tripodanthus acutifolius inhibit TNF\u2013\u03b1 production in LPS\u2013activated THP\u20131 and B16\u2013F10\u202fcells","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.112036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112036"}}