{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:19:00Z","timestamp":1790093940587,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.jep.2019.112209","type":"journal-article","created":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T01:51:51Z","timestamp":1567216311000},"page":"112209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Synergistic nourishing \u2018Yin\u2019 effect of iridoid and phenylpropanoid glycosides from Radix Scrophulariae in vivo and in vitro"],"prefix":"10.1016","volume":"246","author":[{"given":"Pu-yang","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-wei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-zhi","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2019.112209_bib1","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1210\/endo-121-6-2112","article-title":"Lipid peroxidation and free radical scavengers in thyroid dysfunction in the rat: a possible mechanism of injury to heart and skeletal muscle in hyperthyroidism","volume":"121","author":"Asayama","year":"1987","journal-title":"Endocrinology"},{"key":"10.1016\/j.jep.2019.112209_bib2","first-page":"308","article-title":"Differential expression of plasma protein profile in patients with kidney-yin deficiency syndrome","volume":"34","author":"Bi","year":"2017","journal-title":"J. Guangzhou Universtiy Tradit. Chinese Med."},{"key":"10.1016\/j.jep.2019.112209_bib3","first-page":"47","article-title":"Structural characterization and identification of major consti- tuents in Radix Scrophulariae by HPLC coupled with electro- spray ionization quadrupole time-of-flight tandem mass spec- trometry","volume":"12","author":"Chen","year":"2014","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2019.112209_bib4","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1016\/j.lfs.2003.10.008","article-title":"Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity","volume":"74","author":"D\u00edaz","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2019.112209_bib5","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1210\/endo-117-2-496","article-title":"Superoxide radical generation, NADPH oxidase activity, and cytochrome P-450 content of rat liver microsomal fractions in an experimental hyperthyroid state: relation to lipid peroxidation","volume":"117","author":"Fern\u00e1ndez","year":"1985","journal-title":"Endocrinology"},{"key":"10.1016\/j.jep.2019.112209_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/10715768809066914","article-title":"Chemiluminescent and respiratory responses related to thyroid hormone-induced liver oxidative stress","volume":"5","author":"Fernandez","year":"1988","journal-title":"Free Radic. Res. Commun."},{"key":"10.1016\/j.jep.2019.112209_bib7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/ptr.2650080407","article-title":"Antihepatotoxic and immunostimulant properties of iridoid glycosides of Scrophularia koelzii","volume":"8","author":"Garg","year":"1994","journal-title":"Phyther. Res."},{"key":"10.1016\/j.jep.2019.112209_bib8","first-page":"1","article-title":"CorrelatiVe study between the exterior signs of mice model induced by thyroxine and HyperactiVity of Fire due to yin deficiency symdrome","volume":"30","author":"He","year":"2013","journal-title":"Lab. Anim. Sci."},{"key":"10.1016\/j.jep.2019.112209_bib9","first-page":"87","article-title":"The study of Scrophulariaceae ethanol extract on the exterior signs of mice model induced by thyroxine","volume":"29","author":"He","year":"2013","journal-title":"Pharmacol. Clin. Chinese Mater. Medica"},{"key":"10.1016\/j.jep.2019.112209_bib10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.phymed.2011.09.079","article-title":"Effects of ethanolic extract from Radix Scrophulariae on ventricular remodeling in rats","volume":"19","author":"Huang","year":"2012","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2019.112209_bib11","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejphar.2008.04.015","article-title":"Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice","volume":"588","author":"Jeong","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2019.112209_bib12","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/aps.2014.169","article-title":"An integrated metabonomic and proteomic study on Kidney-Yin Deficiency Syndrome patients with diabetes mellitus in China","volume":"36","author":"Jiang","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2019.112209_bib13","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.jpba.2011.07.032","article-title":"Journal of Pharmaceutical and Biomedical Analysis Development of an in-line HPLC fingerprint ion-trap mass spectrometric method for identification and quality control of Radix Scrophulariae","volume":"56","author":"Jing","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2019.112209_bib14","first-page":"798131","article-title":"WNT10B polymorphism in Korean stroke patients with Yin Deficiency pattern. Evidence-based Complement","author":"Ko","year":"2012","journal-title":"Altern. Med."},{"key":"10.1016\/j.jep.2019.112209_bib15","first-page":"1440","article-title":"Experimental study on the rat's yin de fi ciency situation induced by pungent and hot Chinese Herbs","volume":"24","author":"Lai","year":"2009","journal-title":"China J. Tradit. Chinese Med. Pharm."},{"key":"10.1016\/j.jep.2019.112209_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1142\/S0192415X07004576","article-title":"Development and validation of yin-deficiency questionnaire","volume":"35","author":"Lee","year":"2007","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2019.112209_bib17","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1080\/14786410802696247","article-title":"Study of chemical composition and antimicrobial activity of leaves and roots of Scrophularia ningpoensis","volume":"23","author":"Li","year":"2009","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2019.112209_bib18","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/S2213-8587(16)30378-3","article-title":"Prevention of type 2 diabetes with the Chinese herbal medicine Tianqi capsule: a systematic review and meta-analysis","volume":"4","author":"Lian","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jep.2019.112209_bib19","first-page":"61","article-title":"Inhibitory effect of harmine derivative B-9-3 combined with five traditional anti-tumor drugs on cancer cells in vitro","volume":"41","author":"Ma","year":"2018","journal-title":"Drug Eval. Res."},{"key":"10.1016\/j.jep.2019.112209_bib20","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1248\/bpb.21.1394","article-title":"Induction of cytokines by a phenylpropanoid glycoside acteoside","volume":"21","author":"Makoto","year":"1998","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.jep.2019.112209_bib21","first-page":"036","article-title":"Antioxidant activity of phenolic and flavonoid fractions of Cleome gynandra and Maerua angolensis of Burkina Faso","volume":"3","author":"Meda","year":"2013","journal-title":"J. Appl. Pharm. Sci."},{"key":"10.1016\/j.jep.2019.112209_bib22","first-page":"767","article-title":"Pharmacological activities and mechanisms of natural phenylpropanoid glycosides","author":"Pan","year":"2003","journal-title":"Die Pharmazie"},{"key":"10.1016\/j.jep.2019.112209_bib23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/13510002.1996.11747042","article-title":"Antioxidant action of acteoside and its analogs on lipid peroxidation","volume":"2","author":"Pan","year":"1996","journal-title":"Redox Rep."},{"key":"10.1016\/j.jep.2019.112209_bib24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1089\/acm.2011.0677","article-title":"Development and validation of the Yin deficiency scale","volume":"19","author":"Park","year":"2013","journal-title":"J. Altern. Complement. Med."},{"key":"10.1016\/j.jep.2019.112209_bib25","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.jep.2016.10.045","article-title":"Anti-inflammatory effect of volatile oil from Schizonepeta tenuifolia on carrageenin-induced pleurisy in rats and its application to study of appropriate harvesting time coupled with multi-attribute comprehensive index method","volume":"194","author":"Shan","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.112209_bib26","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s12906-015-0842-x","article-title":"Radix Scrophulariae extracts (harpagoside) suppresses hypoxia-induced microglial activation and neurotoxicity","volume":"15","author":"Sheu","year":"2015","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.jep.2019.112209_bib27","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1007\/BF02980238","article-title":"A phenylpropanoid glycoside with antioxidant activity from picria tel-ferae","volume":"30","author":"Thuan","year":"2007","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2019.112209_bib28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jep.2012.08.020","article-title":"Curculigo orchioides (Xian Mao) modifies the activity and protein expression of CYP3A in normal and Kidney-Yang Deficiency model rats","volume":"144","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.112209_bib29","first-page":"1257","article-title":"Identification of chemical constituents in Scrophulariae Radix by HPLC-IT-TOF-MS","volume":"41","author":"Wang","year":"2016","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2019.112209_bib30","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jpba.2010.04.032","article-title":"Thyroxine and reserpine-induced changes in metabolic profiles of rat urine and the therapeutic effect of Liu Wei Di Huang Wan detected by UPLC-HDMS","volume":"53","author":"Wang","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2019.112209_bib31","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3390\/molecules21070850","article-title":"Quality evaluation of Scrophulariae Radix processed by different \u201csweating\u201d methods based on simultaneous determination of multiple bioactive constituents combined with grey relational analysis","volume":"21","author":"Wang","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2019.112209_bib32","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1016\/j.lfs.2003.03.005","article-title":"Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts","volume":"74","author":"Wang","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2019.112209_bib33","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/10020070612331343205","article-title":"Antiviral compounds and one new iridoid glycoside from Cornus officinalis","volume":"16","author":"Wang","year":"2006","journal-title":"Prog. Nat. Sci. Mater. Int."},{"key":"10.1016\/j.jep.2019.112209_bib34","author":"Wu"},{"key":"10.1016\/j.jep.2019.112209_bib35","first-page":"521","article-title":"LC-LTQ-Orbitrap analysis on chemical constituents in Scrophulariae Radix extract and their metabolites in rat plasma","volume":"41","author":"Xu","year":"2016","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2019.112209_bib36","first-page":"63","article-title":"Progress in related pharmacodynamics research on cooling blood and nourishing yin of Radix Scrophulariae","volume":"13","author":"Yu","year":"2007","journal-title":"Chinese J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2019.112209_bib37","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pharmthera.2016.02.004","article-title":"Effect of Liuwei Dihuang decoction, a traditional Chinese medicinal prescription, on the neuroendocrine immunomodulation network","volume":"162","author":"Zhou","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jep.2019.112209_bib38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0254-6272(12)60004-1","article-title":"Multi-central clinical research into treating 80 cases of chronic thrombocytopenia with qi-supplementing and yin-nourishing therapy and western medicine","volume":"31","author":"Zhou","year":"2011","journal-title":"J. Tradit. Chin. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411932478X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411932478X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:24:47Z","timestamp":1759940687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887411932478X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":38,"alternative-id":["S037887411932478X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.112209","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic nourishing \u2018Yin\u2019 effect of iridoid and phenylpropanoid glycosides from Radix Scrophulariae in vivo and in vitro","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.112209","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112209"}}