{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:56:49Z","timestamp":1768449409129,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006143","name":"Department of Science and Technology, Government of Kerala","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.jep.2019.112280","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T10:28:56Z","timestamp":1570444136000},"page":"112280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Anti-depressant activity of Erythrina variegata bark extract and regulation of monoamine oxidase activities in mice"],"prefix":"10.1016","volume":"248","author":[{"given":"Jeanette","family":"Martins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Brijesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2019.112280_bib1","first-page":"345","article-title":"Evaluation of antidepressant activity of granisetron in albino mice","volume":"27","author":"Aithal","year":"2014","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"10.1016\/j.jep.2019.112280_bib2","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1021\/jm300484d","article-title":"Novel acylethanolamide derivatives that modulate body weight through enhancement of hypothalamic pro-opiomelanocortin (POMC) and\/or decreased neuropeptide Y (NPY)","volume":"56","author":"Avraham","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.jep.2019.112280_bib3","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1515\/revneuro-2015-0009","article-title":"Phytochemical constituents as future antidepressants: a comprehensive review","volume":"26","author":"Bahramsoltani","year":"2015","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.jep.2019.112280_bib4","first-page":"235","article-title":"Pharmacological studies of the alkaloids of Erythrina variegata (mandar)","volume":"6","author":"Bhattacharya","year":"1971","journal-title":"J.\u00a0Res. Indian Med."},{"key":"10.1016\/j.jep.2019.112280_bib5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1542\/peds.87.2.215","article-title":"Sucrose as an analgesic in newborn humans","volume":"87","author":"Blass","year":"1991","journal-title":"Pediatrics"},{"key":"10.1016\/j.jep.2019.112280_bib6","series-title":"Toxicity and Drug Testing","first-page":"143","article-title":"Drug synergy \u2013 mechanisms and methods of analysis","author":"Breitinger","year":"2012"},{"key":"10.1016\/j.jep.2019.112280_bib7","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0278-5846(02)00209-9","article-title":"Dependence potential of antidepressants compared to benzodiazepines","volume":"26","author":"Broekhoven","year":"2002","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jep.2019.112280_bib8","first-page":"3769","article-title":"The tail suspension test","volume":"59","author":"Can","year":"2012","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.jep.2019.112280_bib9","series-title":"Guide to Research Techniques in Neuroscience. Animal Behavior","first-page":"39","author":"Carter","year":"2015"},{"key":"10.1016\/j.jep.2019.112280_bib10","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1472-8206.2012.01040.x","article-title":"Antidepressant-like activity of gallic acid in mice subjected to unpredictable chronic mild stress","volume":"27","author":"Chhillar","year":"2013","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2019.112280_bib11","series-title":"The Oxford Handbook of Impulse Control Disorders","first-page":"385","article-title":"Impulsive\/compulsive sexual behavior: assessment and treatment","author":"Coleman","year":"2011"},{"key":"10.1016\/j.jep.2019.112280_bib12","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1001\/archgenpsychiatry.2011.73","article-title":"Antidepressant use during pregnancy and childhood autism spectrum disorders","volume":"68","author":"Croen","year":"2011","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.jep.2019.112280_bib13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jep.2019.112280_bib14","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.euroneuro.2016.08.007","article-title":"Anandamide reverses depressive-like behavior, neurochemical abnormalities and oxidative-stress parameters in streptozotocin-diabetic rats: role of CB1 receptors","volume":"26","author":"DeMorais","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jep.2019.112280_bib15","first-page":"133","article-title":"Pharmacological evaluation for antidepressant-like activity of Asparagus racemosus willd. In mice","volume":"3","author":"Dhingra","year":"2007","journal-title":"Pharmacologyonline"},{"key":"10.1016\/j.jep.2019.112280_bib16","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/humrep\/des383","article-title":"The risks of selective serotonin reuptake inhibitor use in infertile women: a review of the impact on fertility, pregnancy, neonatal health and beyond","volume":"28","author":"Domar","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jep.2019.112280_bib17","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/jps.2600610821","article-title":"Erythrina- chemical and pharmacological evaluation II: alkaloids of Erythrina variegata L","volume":"61","author":"Ghosal","year":"1972","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.jep.2019.112280_bib18","series-title":"Erythrina in the New Old Worlds","first-page":"77","article-title":"Cultivation and uses of Erythrina variegata in western India","author":"Hegde","year":"1993"},{"key":"10.1016\/j.jep.2019.112280_bib19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00404-015-3849-0","article-title":"Low-dose isoflavone aglycone alleviates psychological symptoms of menopause in Japanese women: a randomized, double-blind, placebo-controlled study","volume":"293","author":"Hirose","year":"2016","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.jep.2019.112280_bib20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1081\/CLT-120037428","article-title":"Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose","volume":"42","author":"Isbister","year":"2004","journal-title":"J.\u00a0Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.jep.2019.112280_bib21","series-title":"Stress: Myth, Theory and Research","author":"Jones","year":"2001"},{"key":"10.1016\/j.jep.2019.112280_bib22","first-page":"6","article-title":"MPH history of the use of antidepressants in primary care","volume":"5","author":"Joseph","year":"2003","journal-title":"J.\u00a0Clin. Psychiatry"},{"key":"10.1016\/j.jep.2019.112280_bib23","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1021\/tx010073b","article-title":"Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors","volume":"14","author":"Kalgutkar","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jep.2019.112280_bib24","series-title":"Practical Pharmacognosy, Technique and Experiments","first-page":"149","author":"Khandelwal","year":"2014"},{"key":"10.1016\/j.jep.2019.112280_bib25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3109\/13880209.2010.529615","article-title":"Hypoglycemic activity of Erythrina variegata leaf in streptozotocin-induced diabetic rats","volume":"49","author":"Kumar","year":"2011","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2019.112280_bib26","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00008877-199711000-00010","article-title":"The forced swimming test as a model for core and component behavioral effects of antidepressant drugs","volume":"8","author":"Lucki","year":"1997","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.jep.2019.112280_bib27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neubiorev.2013.11.009","article-title":"Stress, serotonin and hippocampal neurogenesis in relation to depression and anti-depressant effects","volume":"38","author":"Mahar","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jep.2019.112280_bib28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s007020050062","article-title":"Repeated trimipramine induces dopamine D2\/D3 and alpha1-adrenergic up-regulation","volume":"105","author":"Maj","year":"1998","journal-title":"J.\u00a0Neural Transm."},{"key":"10.1016\/j.jep.2019.112280_bib29","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1097\/GME.0000000000000709","article-title":"Evaluation of the potential antidepressant effects of soybean isoflavones","volume":"23","author":"Messina","year":"2016","journal-title":"Menopause"},{"key":"10.1016\/j.jep.2019.112280_bib30","series-title":"Government of India. Ayurvedic Pharmacopoeia of India. Part I","first-page":"111","volume":"vol. 9","author":"Ministry of AYUSH","year":"2016"},{"key":"10.1016\/j.jep.2019.112280_bib31","series-title":"Quality Control Herbal Drugs: an Approach to Evaluation of Botanicals","author":"Mukherjee","year":"2008"},{"key":"10.1016\/j.jep.2019.112280_bib32","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.1038\/srep04199","article-title":"Oral administration of inosine produces antidepressant-like effects in mice","volume":"4","author":"Muto","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2019.112280_bib33","first-page":"508","volume":"vol. I","author":"Nadkarni","year":"1976"},{"key":"10.1016\/j.jep.2019.112280_bib34","doi-asserted-by":"crossref","first-page":"489","DOI":"10.4103\/0253-7613.99316","article-title":"Evaluation of anxiolytic effect of Erythrina mysorensis Gamb. In mice","volume":"44","author":"Nagaraja","year":"2012","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.jep.2019.112280_bib35","first-page":"934","article-title":"Pharmacological evaluation of alcoholic extract of stem bark of Erythrina variegata for anxiolytic and anticonvulsant activity in mice","volume":"3","author":"Pitchaiah","year":"2008","journal-title":"Pharmacologyonline"},{"key":"10.1016\/j.jep.2019.112280_bib36","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jep.2008.08.030","article-title":"Effects of South African traditional medicine in animal models for depression","volume":"119","author":"Pedersen","year":"2008","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.112280_bib37","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.jep.2019.112280_bib38","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1073\/pnas.93.10.4693","article-title":"Hippocampal acetylcholine release during memory testing in rats: augmentation by glucose","volume":"93","author":"Ragozzino","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jep.2019.112280_bib39","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1176\/jnp.8.2.168","article-title":"Sustained antidepressant effect of PEA replacement","volume":"8","author":"Sabelli","year":"1996","journal-title":"J.\u00a0Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.jep.2019.112280_bib40","first-page":"19","article-title":"Anticonvulsant effect of leaf and bark of Erythrina variegata Linn and Butea monosperma (LAM) taub. in different experimental convulsion model in rats","volume":"3","author":"Sangale","year":"2015","journal-title":"PharmaTutor"},{"key":"10.1016\/j.jep.2019.112280_bib41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0014-2999(96)00161-6","article-title":"Individual differences in sugar consumption predict amphetamine-induced dopamine overflow in nucleus accumbens","volume":"303","author":"Sills","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2019.112280_bib42","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1046\/j.1460-9568.1998.00201.x","article-title":"Mesolimbic dopaminergic mechanisms underlying individual differences in sugar consumption and amphetamine hyperlocomotion in Wistar rats","volume":"10","author":"Sills","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jep.2019.112280_bib43","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.bcp.2009.07.010","article-title":"The novel nicotinic receptor antagonist, N,N\u2032-Dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [3H] norepinephrine overflow from rat hippocampal slices","volume":"78","author":"Smith","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2019.112280_bib44","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00431-17","article-title":"The norepinephrine metabolite 3,4-dihydroxymandelic acid is produced by the commensal microbiota and promotes chemotaxis and virulence gene expression in enterohemorrhagic Escherichia coli","volume":"85","author":"Sule","year":"2017","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jep.2019.112280_bib45","series-title":"Depression Fact Sheet","author":"World Health Organisation","year":"2017"},{"key":"10.1016\/j.jep.2019.112280_bib46","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0378-8741(02)00211-8","article-title":"Antidepressant activity of aqueous extracts of Curcuma longa in mice","volume":"83","author":"Yu","year":"2002","journal-title":"J.\u00a0Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119302818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119302818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:30:10Z","timestamp":1759941010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874119302818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":46,"alternative-id":["S0378874119302818"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.112280","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-depressant activity of Erythrina variegata bark extract and regulation of monoamine oxidase activities in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.112280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112280"}}