{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:02:34Z","timestamp":1759971754538,"version":"build-2065373602"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.jep.2019.112321","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T01:57:20Z","timestamp":1571795840000},"page":"112321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Influence of Echeveria gibbiflora DC aqueous crude extract on mouse sperm energy metabolism and calcium-dependent channels"],"prefix":"10.1016","volume":"248","author":[{"given":"Joaqu\u00edn","family":"Cordero-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Flores-Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charmina","family":"Aguirre-Alvarado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma","family":"Oviedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Alc\u00e1ntara-Farf\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Armando","family":"Garc\u00eda-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla Fernanda","family":"Berm\u00fadez-Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guadalupe Elizabeth","family":"Jim\u00e9nez-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Rodr\u00edguez-P\u00e1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2019.112321_bib1","first-page":"229","article-title":"Immobilization and agglutination effects of Echeveria gibbifora (Crassulaceae) aqueous crude extract on human spermatozoa","volume":"11","author":"Huacuja","year":"1985","journal-title":"Adv. Contracept. Deliv. Syst. Monograph"},{"issue":"6","key":"10.1016\/j.jep.2019.112321_bib2","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.cell.2019.03.047","article-title":"Dual sensing of physiologic pH and calcium by EFCAB9 regulates sperm motility","volume":"177","author":"Hwang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jep.2019.112321_bib3","article-title":"Purification and characterization of a malic enzyme from the ruminal bacterium Streptococcus bovis ATCC 15352 and cloning and sequencing of its gene","volume":"62","author":"Kawai","year":"1995","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jep.2019.112321_bib4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/prot.22570","article-title":"Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: four approaches that performed well in CASP8","volume":"77","author":"Krieger","year":"2009","journal-title":"Proteins"},{"issue":"4","key":"10.1016\/j.jep.2019.112321_bib5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1177\/1087057109359807","article-title":"Cell-based potassium ion channel screening using the FluxOR assay","volume":"15","author":"Beacham","year":"2010","journal-title":"J.\u00a0Biomol. Screen"},{"key":"10.1016\/j.jep.2019.112321_bib6","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/biolre\/ioy020","article-title":"Isoform-specific requirement for GSK3\u03b1 in sperm for male fertility","volume":"99","author":"Bhattacharjee","year":"2018","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jep.2019.112321_bib7","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/rda.12973","article-title":"Participation of phosphofructokinase, malate dehydrogenase and isocitrate dehydrogenase in capacitation and acrosome reaction of boar spermatozoa","volume":"52","author":"Breininger","year":"2017","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.jep.2019.112321_bib8","article-title":"Assessing reproductive status\/stages in mice","volume":"4","author":"Caligioni","year":"2009","journal-title":"Curr. Protoc. Neurosci. Appendix"},{"key":"10.1016\/j.jep.2019.112321_bib9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/19396368.2016.1203044","article-title":"Effects of aqueous crude extract of Echeveria gibbiflora on mouse sperm function","volume":"62","author":"Cordero-Mart\u00ednez","year":"2016","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.jep.2019.112321_bib10","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1002\/jcb.26789","article-title":"TMEM16A inhibition impedes capacitation and acquisition of hyperactivated motility in Guinea pig sperm","volume":"119","author":"Cordero-Mart\u00ednez","year":"2018","journal-title":"J.\u00a0Cell. Biochem."},{"issue":"4","key":"10.1016\/j.jep.2019.112321_bib11","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s12013-018-0856-3","article-title":"Calcium induces mitochondrial oxidative stress because of its binding to adenine nucleotide translocase","volume":"76","author":"Correa","year":"2018","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.jep.2019.112321_bib12","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jcma.2015.03.008","article-title":"Antifertility activity of medicinal plants","volume":"78","author":"Daniyal","year":"2015","journal-title":"J.\u00a0Chin. Med. Assoc."},{"key":"10.1016\/j.jep.2019.112321_bib13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/(SICI)1099-1573(199902)13:1<46::AID-PTR373>3.0.CO;2-S","article-title":"Effects of a purified fraction from Echeveria gibbiflora aqueous crude extract on Guinea-pig spermatozoa","volume":"13","author":"Delgado","year":"1999","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2019.112321_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/cge.12896","article-title":"Genetics of mitochondrial dysfunction and infertility","volume":"91","author":"Demain","year":"2017","journal-title":"Clin. Genet."},{"issue":"1\u20132","key":"10.1016\/j.jep.2019.112321_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mce.2014.08.005","article-title":"Sperm glucose transport and metabolism in diabetic individuals","volume":"396","author":"Dias","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jep.2019.112321_bib16","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1159\/000076824","article-title":"Inhibition of lactate dehydrogenase C4 (LDH-C4) blocks capacitation of mouse sperm in vitro","volume":"103","author":"Duan","year":"2003","journal-title":"Cytogenet. Genome Res."},{"key":"10.1016\/j.jep.2019.112321_bib17","first-page":"397","article-title":"Protective effect of silymarin on viability, motility and mitochondrial membrane potential of ram sperm treated with sodium arsenite","volume":"6","author":"Eskandari","year":"2016","journal-title":"Int. J. Reprod. Biomed."},{"key":"10.1016\/j.jep.2019.112321_bib18","first-page":"2","article-title":"Signaling mechanisms in mammalian sperm motility","volume":"96","author":"Freitas","year":"2017","journal-title":"Biol. Reprod."},{"issue":"7\u20139","key":"10.1016\/j.jep.2019.112321_bib19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1387\/ijdb.150202et","article-title":"Ion currents involved in gamete physiology","volume":"59","author":"Gallo","year":"2015","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.jep.2019.112321_bib20","first-page":"155","article-title":"Antifertility effects of methanolic pod extract of Albizzia lebbeck (L.) Benth in male rats","volume":"6","author":"Gupta","year":"2004","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.jep.2019.112321_bib21","first-page":"13","article-title":"Hypotonic-like effect of a purified fraction from Echeveria gibbiflora on bovine gametes","volume":"72","author":"Hern\u00e1ndez","year":"2001","journal-title":"Advances in Reproduction"},{"key":"10.1016\/j.jep.2019.112321_bib22","doi-asserted-by":"crossref","first-page":"24397","DOI":"10.1074\/jbc.M701603200","article-title":"Involvement of cystic fibrosis transmembrane conductance regulator in mouse sperm capacitation","volume":"282","author":"Hern\u00e1ndez-Gonz\u00e1lez","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jep.2019.112321_bib23","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/cm.21338","article-title":"Functional anatomy of the mammalian sperm flagellum","volume":"73","author":"Lindemann","year":"2016","journal-title":"Cytoskeleton"},{"key":"10.1016\/j.jep.2019.112321_bib24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-physiol-020911-153258","article-title":"The control of male fertility by spermatozoan ion channels","volume":"74","author":"Lishko","year":"2012","journal-title":"Annu. Rev. Physiol."},{"issue":"4","key":"10.1016\/j.jep.2019.112321_bib25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1017\/S0967199418000242","article-title":"Spermatic mitochondria: role in oxidative homeostasis, sperm function and possible tools for their assessment","volume":"26","author":"Losano","year":"2018","journal-title":"Zygote"},{"key":"10.1016\/j.jep.2019.112321_bib26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.mce.2016.07.008","article-title":"Ghrelin acts as energy status sensor of male reproduction by modulating Sertoli cells glycolytic metabolism and mitochondrial bioenergetics","volume":"434","author":"Martins","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.jep.2019.112321_bib27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ceca.2014.10.009","article-title":"Flagellar ion channels of sperm: similarities and differences between species","volume":"58","author":"Miller","year":"2015","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jep.2019.112321_bib28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.anireprosci.2018.03.024","article-title":"The sperm mitochondrion: organelle of many functions","volume":"194","author":"Moraes","year":"2018","journal-title":"Anim. Reprod. Sci."},{"issue":"16","key":"10.1016\/j.jep.2019.112321_bib29","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock 4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J.\u00a0Comput. Chem."},{"issue":"5\u20136","key":"10.1016\/j.jep.2019.112321_bib30","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1387\/ijdb.072554bn","article-title":"Ion channels that control fertility in mammalian spermatozoa","volume":"52","author":"Navarro","year":"2008","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.jep.2019.112321_bib31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/mrd.21276","article-title":"Can curcumin provide an ideal contraceptive?","volume":"78","author":"Naz","year":"2011","journal-title":"Mol. Reprod. Dev."},{"issue":"2","key":"10.1016\/j.jep.2019.112321_bib32","first-page":"62","article-title":"The effect of curcumin on intracellular pH (pHi), membrane hyperpolarization and sperm motility","volume":"15","author":"Naz","year":"2014","journal-title":"J.\u00a0Reproduction Infertil."},{"issue":"2","key":"10.1016\/j.jep.2019.112321_bib33","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s10695-016-0291-6","article-title":"NAD-preferring malic enzyme: localization, regulation and its potential role in herring (Clupea harengus) sperm cells","volume":"43","author":"Nied\u017awiecka","year":"2017","journal-title":"Fish Physiol. Biochem."},{"issue":"6","key":"10.1016\/j.jep.2019.112321_bib34","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1530\/REP-17-0018","article-title":"Obesity, energy balance and spermatogenesis","volume":"153","author":"Oliveira","year":"2017","journal-title":"Reproduction"},{"issue":"11","key":"10.1016\/j.jep.2019.112321_bib35","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1113\/jphysiol.2011.224485","article-title":"Human spermatozoa possess a calcium-dependent chloride channel that may participate in the acrosomal reaction","volume":"590","author":"Orta","year":"2012","journal-title":"J.\u00a0Physiol."},{"issue":"3","key":"10.1016\/j.jep.2019.112321_bib36","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/andr.12607","article-title":"A\u00a0new system of sperm cryopreservation: evaluation of survival, motility, DNA oxidation, and mitochondrial activity","volume":"7","author":"Pab\u00f3n","year":"2019","journal-title":"Andrology"},{"key":"10.1016\/j.jep.2019.112321_bib37","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1046\/j.1365-2435.1998.00229.x","article-title":"Is Echeveria gibbiflora (Crassulaceae) fecundity limited by pollen availability? An experimental study","volume":"12","author":"Parra-Tabla","year":"1998","journal-title":"Funct. Ecol."},{"key":"10.1016\/j.jep.2019.112321_bib38","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/01485010290099327","article-title":"Male contraception IV: hypotoniclike effect from Echeveria gibbifora on human sperm","volume":"48","author":"Reyes","year":"2002","journal-title":"Arch. Androl."},{"issue":"6","key":"10.1016\/j.jep.2019.112321_bib39","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1080\/014850190944474","article-title":"Calcium (hydrogen-1-malate) hexahydrate on Echeveria gibbiflora leaves and its effect on sperm cells","volume":"51","author":"Reyes","year":"2005","journal-title":"Arch. Androl."},{"issue":"5","key":"10.1016\/j.jep.2019.112321_bib40","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10822-010-9352-6","article-title":"Ligand docking and binding site analysis with PyMOL and Autodock\/Vina","volume":"24","author":"Seeliger","year":"2010","journal-title":"J.\u00a0Comput. Aided Mol. Des."},{"key":"10.1016\/j.jep.2019.112321_bib41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.apjr.2016.04.004","article-title":"An overview of the current methodologies used for evaluation of anti-fertility agents","volume":"5","author":"Shah","year":"2016","journal-title":"Asian Pac J Reprod"},{"key":"10.1016\/j.jep.2019.112321_bib42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0378-8741(02)00335-5","article-title":"Spermicidal activity of the crude ethanol extract ofSedum praealtum in mice","volume":"85","author":"Silva-Torres","year":"2003","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.112321_bib43","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.contraception.2008.07.023","article-title":"Evaluation of antifertility potential of Brahmi in male mouse","volume":"79","author":"Singh","year":"2009","journal-title":"Contraception"},{"issue":"1","key":"10.1016\/j.jep.2019.112321_bib44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12958-017-0281-2","article-title":"The Catsper channel and its roles in male fertility: a systematic review","volume":"15","author":"Sun","year":"2017","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jep.2019.112321_bib45","first-page":"139","article-title":"Immobilizing\/agglutination effects of crude extract of crassulaceae plants on human sperm: screening study","volume":"8","author":"Taboada","year":"1992","journal-title":"Adv. Contracept. Deliv. Syst. (CDS)"},{"key":"10.1016\/j.jep.2019.112321_bib46","series-title":"Knobil and Neill's Physiology of Reproduction","first-page":"99","article-title":"The spermatozoon","author":"Toshimori","year":"2015"},{"issue":"5","key":"10.1016\/j.jep.2019.112321_bib47","doi-asserted-by":"crossref","first-page":"381","DOI":"10.4196\/kjpp.2019.23.5.381","article-title":"Onion peel extract and its constituent, quercetin inhibits human Slo3 in a pH and calcium dependent manner","volume":"23","author":"Wijerathne","year":"2019","journal-title":"KOREAN J. PHYSIOL. PHARMACOL."},{"key":"10.1016\/j.jep.2019.112321_bib48","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2105-9-40","article-title":"I-TASSER server for protein 3D structure prediction","volume":"9","author":"Zhang","year":"2008","journal-title":"BMC Bioinf."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119314345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119314345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:28:43Z","timestamp":1759940923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874119314345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":48,"alternative-id":["S0378874119314345"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.112321","relation":{},"ISSN":["0378-8741"],"issn-type":[{"type":"print","value":"0378-8741"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of Echeveria gibbiflora DC aqueous crude extract on mouse sperm energy metabolism and calcium-dependent channels","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.112321","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112321"}}