{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:11:21Z","timestamp":1784297481974,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jep.2019.112375","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T02:12:46Z","timestamp":1572833566000},"page":"112375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Historical chemical annotations of Cinchona bark collections are comparable to results from current day high-pressure liquid chromatography technologies"],"prefix":"10.1016","volume":"249","author":[{"given":"Nataly Allasi","family":"Canales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias Nikolaj","family":"Gress Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Cornett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Driver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Antonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Nesbitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"R\u00f8nsted","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2019.112375_bib1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1475-2875-10-144","article-title":"Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria","volume":"10","author":"Achan","year":"2011","journal-title":"Malar. J."},{"key":"10.1016\/j.jep.2019.112375_bib2","series-title":"The Andean Wonder Drug: Cinchona Bark and Imperial Science in the Spanish Atlantic, 1630-1800","author":"Crawford","year":"2016"},{"key":"10.1016\/j.jep.2019.112375_bib3","series-title":"Malarial Subjects: Empire, Medicine and Nonhumans in British India, 1820\u20131909","author":"Deb Roy","year":"2017"},{"key":"10.1016\/j.jep.2019.112375_bib4","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1021\/ed028p454","article-title":"Joseph Pelletier and Joseph Caventou","volume":"28","author":"Delepine","year":"1951","journal-title":"J. Chem. Educ."},{"key":"10.1016\/j.jep.2019.112375_bib5","doi-asserted-by":"crossref","first-page":"E491","DOI":"10.3390\/toxins10120491","article-title":"The Fever Tree: from malaria to neurological diseases","volume":"23","author":"Eyal","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.jep.2019.112375_bib6","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.3389\/fpls.2018.01877","article-title":"Hundred fifty years of herbarium collections provide a reliable resource of volatile terpenoid profiles showing strong species effect in four medicinal species of Salvia across the Mediterranean","volume":"9","author":"Foutami","year":"2018","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.jep.2019.112375_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/jse.12315","article-title":"Collections-based science in the 21st century","volume":"56","author":"Funk","year":"2018","journal-title":"J. Syst. Evol."},{"key":"10.1016\/j.jep.2019.112375_bib8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3797\/scipharm.1410-14","article-title":"An efficient, robust, and inexpensive grinding device for herbal samples like Cinchona bark","volume":"83","author":"Hansen","year":"2015","journal-title":"Sci. Pharm."},{"key":"10.1016\/j.jep.2019.112375_bib9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1098\/rspl.1857.0003","article-title":"Researches on the Cinchona alkaloids","volume":"9","author":"Herapath","year":"1859","journal-title":"Proc. R. Soc. Lond."},{"key":"10.1016\/j.jep.2019.112375_bib10","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/pca.2684","article-title":"An optimised method for routine separation and quantification of major alkaloids in Cortex Cinchona by HPLC coupled with UV and fluorescence detection: HPLC analysis of major Cinchona alkaloids","volume":"28","author":"Holmfred","year":"2017","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jep.2019.112375_bib11","series-title":"The Fever Trail. The Hunt for the Cure for Malaria","author":"Honigsbaum","year":"2001"},{"key":"10.1016\/j.jep.2019.112375_bib12","first-page":"99","article-title":"\u00dcber den Geschlechtsunterschied und dessen Einflu\u00df auf die organische Natur","volume":"1","author":"Humboldt","year":"1795","journal-title":"Die Horen"},{"key":"10.1016\/j.jep.2019.112375_bib13","series-title":"Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes","first-page":"605","article-title":"Chemistry and biology of Cinchona alkaloids","author":"Kacprzak","year":"2013"},{"key":"10.1016\/j.jep.2019.112375_bib14","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/anie.200400663","article-title":"The quest for quinine: those who won the battles and those who won the war","volume":"44","author":"Kaufman","year":"2005","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jep.2019.112375_bib15","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s00706-017-1940-x","article-title":"Historical injection solutions of quinine analyzed by HPLC\/MS","volume":"148","author":"Kudl\u00e1\u010dek","year":"2017","journal-title":"Monatshefte Chem."},{"key":"10.1016\/j.jep.2019.112375_bib16","first-page":"8","article-title":"Part 1: Cinchona or the Peruvian bark","volume":"32","author":"Lee","year":"2002","journal-title":"J. R. Coll. Phys. Edinb."},{"key":"10.1016\/j.jep.2019.112375_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2017.00391","article-title":"Phylogeny predicts the quantity of antimalarial alkaloids within the iconic yellow Cinchona bark (Rubiaceae: Cinchona calisaya)","volume":"8","author":"Maldonado","year":"2017","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.jep.2019.112375_bib18","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/geb.12326","article-title":"Estimating species diversity and distribution in the era of Big Data: to what extent can we trust public databases?: species diversity and distribution in the era of Big Data","volume":"24","author":"Maldonado","year":"2015","journal-title":"Glob. Ecol. Biogeogr."},{"key":"10.1016\/j.jep.2019.112375_bib19","series-title":"Travels in Peru and India while Superintending the Collection of Chinchona Plants and Seeds in South America, and Their Introduction into India","author":"Markham","year":"1862"},{"key":"10.1016\/j.jep.2019.112375_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9673(01)01557-6","article-title":"Analysis of the Cinchona alkaloids by high-performance liquid chromatography and other separation techniques","volume":"967","author":"McCalley","year":"2002","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jep.2019.112375_bib21","series-title":"Curating Biocultural Collections: A Handbook","first-page":"313","article-title":"Use of herbarium specimens in ethnobotany","author":"Nesbitt","year":"2014"},{"key":"10.1016\/j.jep.2019.112375_bib22","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1073\/pnas.1700125114","article-title":"Antimalarials inhibit hematin crystallization by unique drug\u2013surface site interactions","volume":"114","author":"Olafson","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jep.2019.112375_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF02864540","article-title":"Jesuits' bark (Cinchona [Rubiaceae]) and other medicines","volume":"55","author":"Prendergast","year":"2001","journal-title":"Econ. Bot."},{"key":"10.1016\/j.jep.2019.112375_bib24","volume":"vol. 7","author":"Rajamurugan","year":"2016"},{"key":"10.1016\/j.jep.2019.112375_bib25","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1475-2875-10-S1-S4","article-title":"Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions","volume":"10","author":"Rasoanaivo","year":"2011","journal-title":"Malar. J."},{"key":"10.1016\/j.jep.2019.112375_bib26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.shpsc.2014.05.019","article-title":"Science in the service of colonial agro-industrialism: the case of Cinchona cultivation in the Dutch and British East Indies, 1852-1900","volume":"47","author":"Roersch van der Hoogte","year":"2014","journal-title":"Stud. Hist. Philos. Biol. Biomed. Sci."},{"key":"10.1016\/j.jep.2019.112375_bib27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2307\/2480739","article-title":"The genus Cinchona in Bolivia","volume":"58","author":"Rusby","year":"1931","journal-title":"Bull. Torrey Bot. Club"},{"key":"10.1016\/j.jep.2019.112375_bib28","first-page":"192","article-title":"Bark stripping from forest tree species in Madjadjane, Southern Mozambique: medicinal uses and implications for conservation","volume":"05","author":"Senkoro","year":"2014","journal-title":"Nat. Resour."},{"key":"10.1016\/j.jep.2019.112375_bib29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0378-8741(90)90098-E","article-title":"Contemporary use of bark for medicine by two Salishan native elders of Southeast Vancouver Island, Canada","volume":"29","author":"Turner","year":"1990","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.112375_bib30","series-title":"Just the Tonic: a History of Tonic Water","author":"Walker","year":"2019"},{"key":"10.1016\/j.jep.2019.112375_bib31","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/jac\/30.5.571","article-title":"Antimalarial drug resistance: the pace quickens","volume":"30","author":"White","year":"1992","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.jep.2019.112375_bib32","series-title":"Advances in Parasitology","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0065-308X(08)60021-4","article-title":"The pathophysiology of malaria","author":"White","year":"1992"},{"key":"10.1016\/j.jep.2019.112375_bib33","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.jep.2019.112375_bib34","series-title":"Indigenous Forests and Woodlands in South Africa: Policy, People and Practice","first-page":"439","article-title":"Trade and socio-economic value of forest and woodland resources within the medicinal plant market in Johannesburg","author":"Williams","year":"2004"},{"key":"10.1016\/j.jep.2019.112375_bib35","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1039\/C6OB02110G","article-title":"Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum","volume":"15","author":"Woodland","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.jep.2019.112375_bib37","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1055\/s-0032-1315396","article-title":"Extraction of alkaloids for NMR-based profiling: exploratory analysis of an archaic Cinchona bark collection","volume":"78","author":"Yilmaz","year":"2012","journal-title":"Planta Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119312255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119312255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:29:21Z","timestamp":1759940961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874119312255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":36,"alternative-id":["S0378874119312255"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.112375","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Historical chemical annotations of Cinchona bark collections are comparable to results from current day high-pressure liquid chromatography technologies","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.112375","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112375"}}