{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:43:46Z","timestamp":1786992226892,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005672","name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006417","name":"Universidade Estadual de Mato Grosso do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006417","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centro Universit\u00e1rio da Grande Dourados"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jep.2019.112418","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T17:49:46Z","timestamp":1574531386000},"page":"112418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Anti-inflammatory and anti-arthritic activity in extract from the leaves of Eriobotrya japonica"],"prefix":"10.1016","volume":"249","author":[{"given":"\u00c2ngela Midori","family":"Kuraoka-Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce Alencar Santos","family":"Radai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maicon Matos","family":"Leit\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Andrea","family":"Lima Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo Euclides","family":"Silva-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e2ndida Aparecida","family":"Leite Kassuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jep.2019.112418_bib1","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/eji.200939578","article-title":"Animal models of rheumatoid arthritis","volume":"39","author":"Asquith","year":"2009","journal-title":"Eur. J. Immunol."},{"issue":"10","key":"10.1016\/j.jep.2019.112418_bib2","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1248\/bpb.28.1995","article-title":"Anti-inflammatory and antitumor-promoting effects of the triterpene acids from the leaves of Eriobotrya japonica","volume":"28","author":"Banno","year":"2005","journal-title":"Biol. Pharm. Bull."},{"issue":"4","key":"10.1016\/j.jep.2019.112418_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6704a1","article-title":"Geographic variations in arthritis prevalence, health-related characteristics, and management - United States, 2015","volume":"67","author":"Barbour","year":"2018","journal-title":"MMWR SurveillSumm"},{"key":"10.1016\/j.jep.2019.112418_bib4","series-title":"RENISUS","year":"2017"},{"issue":"6","key":"10.1016\/j.jep.2019.112418_bib5","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.2353\/ajpath.2009.080597","article-title":"Alternative proteolytic processing of hepatocyte growth factor during wound repair","volume":"174","author":"Buchstein","year":"2009","journal-title":"Am. J. Pathol."},{"issue":"Feb 10","key":"10.1016\/j.jep.2019.112418_bib6","first-page":"280","article-title":"Correlation between chronic venous ulcer exudate proteins and clinical profile: a cross sectional study","volume":"192","author":"Cavassan","year":"2018","journal-title":"J. Proteom."},{"issue":"2","key":"10.1016\/j.jep.2019.112418_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jep.2010.12.017","article-title":"Anti-inflammatory and antinociceptive properties of the leaves of Eriobotrya japonica","volume":"134","author":"Cha","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2019.112418_bib8","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.foodchem.2011.01.114","article-title":"Anti-inflammatory activities of tormentic acid from suspension cells of Eriobotrya Japonica ex vivo and in vivo","volume":"127","author":"Chang","year":"2011","journal-title":"Food Chem."},{"issue":"4","key":"10.1016\/j.jep.2019.112418_bib9","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1084\/jem.20052371","article-title":"Neutrophil-derived leukotriene B 4 is required for inflammatory arthritis","volume":"203","author":"Chen","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jep.2019.112418_bib10","volume":"vol. 1","author":"Chinese Pharmacopoeia Committee","year":"2010"},{"issue":"3","key":"10.1016\/j.jep.2019.112418_bib11","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0304-3959(94)90023-X","article-title":"Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain","volume":"59","author":"Choi","year":"1994","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.jep.2019.112418_bib12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2249.2006.03261.x","article-title":"Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1\u03b2 generation","volume":"147","author":"Ferrero-Miliani","year":"2007","journal-title":"Clin. Exp. Immunol."},{"issue":"4","key":"10.1016\/j.jep.2019.112418_bib13","first-page":"1147","article-title":"Anti-inflammatory and antipyretic activity of Eriobotrya japonica leaves","volume":"4","author":"Ghaiye","year":"2011","journal-title":"J. Pharm. Res."},{"issue":"10","key":"10.1016\/j.jep.2019.112418_bib14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4252\/wjsc.v4.i10.101","article-title":"Human umbilical cord mesenchymal stem cells as treatment of adjuvant rheumatoid arthritis in a rat model","volume":"4","author":"Greish","year":"2012","journal-title":"World J. Stem Cells"},{"issue":"15","key":"10.1016\/j.jep.2019.112418_bib15","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.3390\/ijms20153633","article-title":"Herb-induced liver injury: phylogenetic relationship, structure-toxicity relationship, and herb-ingredient network analysis","volume":"25","author":"He","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2019.112418_bib16","first-page":"243","article-title":"Mouse paw edema. A new model for inflammation?","volume":"20","author":"Henriques","year":"1987","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"2","key":"10.1016\/j.jep.2019.112418_bib17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00011-006-5185-0","article-title":"Effect of triterpene acids of Eriobotrya japonica (Thunb.)Lindl.leaf on inflammatory cytokine and mediator induction from alveolar macrophages of chronic bronchitic rats","volume":"56","author":"Huang","year":"2007","journal-title":"Inflamm. Res."},{"issue":"5","key":"10.1016\/j.jep.2019.112418_bib18","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1248\/cpb.48.687","article-title":"Polyphenols from Eriobotrya japonica and their cytotoxicity against human oral tumor cell lines","volume":"48","author":"Ito","year":"2000","journal-title":"Chem. Pharm. Bull."},{"issue":"6","key":"10.1016\/j.jep.2019.112418_bib19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.plefa.2008.08.001","article-title":"COX-2 expression and function in the hyperalgesic response to paw inflammation in mice","volume":"79","author":"Jain","year":"2008","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"issue":"4","key":"10.1016\/j.jep.2019.112418_bib20","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.fct.2010.11.043","article-title":"Neuroprotective effects of Eriobotrya japonica against \u03b2-amyloid-induced oxidative stress and memory impairment","volume":"49","author":"Kim","year":"2011","journal-title":"Food Chem. Toxicol."},{"issue":"7","key":"10.1016\/j.jep.2019.112418_bib21","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.tiv.2009.07.036","article-title":"Anti-inflammatory effect of leaves of Eriobotrya japonica correlating with attenuation of p38 MAPK, ERK, and NF-\u03baB activation in mast cells","volume":"23","author":"Kim","year":"2009","journal-title":"Toxicol. In Vitro"},{"issue":"1","key":"10.1016\/j.jep.2019.112418_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0091-3057(86)90043-2","article-title":"Pain threshold changes in adjuvant-induced inflammation: a possible model of chronic pain in the mouse","volume":"24","author":"Larson","year":"1986","journal-title":"Pharmacol., Biochem. Behav."},{"key":"10.1016\/j.jep.2019.112418_bib23","first-page":"9","article-title":"Acute and subacute oral toxicity evaluation of Eriobotrya japonica leaf triterpene acids in ICR mice","volume":"2017","author":"Li","year":"2017","journal-title":"Evid. Based Complement Altern. Med."},{"issue":"13","key":"10.1016\/j.jep.2019.112418_bib24","article-title":"Herb induced liver injury after using herbal medicine: a systemic review and case-control study","volume":"98","author":"Lin","year":"2019","journal-title":"Medicine (Baltim.)"},{"issue":"12","key":"10.1016\/j.jep.2019.112418_bib25","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.3390\/ijms17121983","article-title":"Biological activities of extracts from loquat (Eriobotrya japonica Lindl.): a review","volume":"17","author":"Liu","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jep.2019.112418_bib26","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/03602532.2017.1335750","article-title":"Liver toxicity mechanisms of herbs commonly used in Latin America","volume":"49","author":"L\u00f3pez-Gil","year":"2017","journal-title":"Drug Metab. Rev."},{"issue":"2","key":"10.1016\/j.jep.2019.112418_bib27","first-page":"320","article-title":"A hippocratic screen for pure or crude drug materiais","volume":"25","author":"Malone","year":"1962","journal-title":"J. Nat. Prod. (Lloydia)"},{"issue":"3","key":"10.1016\/j.jep.2019.112418_bib28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cyto.2007.10.003","article-title":"The differential effect of Eriobotrya japonica hydrophilic leaf extract on cytokines production and modulation","volume":"40","author":"Matalka","year":"2007","journal-title":"Cytokine"},{"issue":"6","key":"10.1016\/j.jep.2019.112418_bib29","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2010.03.006","article-title":"Inflammation 2010: new adventures of an old flame","volume":"140","author":"Medzhitov","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jep.2019.112418_bib30","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.jep.2016.11.003","article-title":"Acute and subacute toxicity of the aqueous extract of Alibertia edulis (Rich.) A. Rich. ex DC. in rats","volume":"24","author":"Menegati","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"1\u20132","key":"10.1016\/j.jep.2019.112418_bib31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0165-0270(98)00083-1","article-title":"Assessing mechanical allodynia in the rat paw with a new electronic algometer","volume":"84","author":"M\u00f6ller","year":"1998","journal-title":"J. Neurosci. Methods"},{"issue":"11","key":"10.1016\/j.jep.2019.112418_bib32","first-page":"106","article-title":"Vascular permeability and evans blue dye: a physiological and pharmacological approach","volume":"4","author":"Nidavani","year":"2014","journal-title":"J. Appl. Pharm. Sci."},{"key":"10.1016\/j.jep.2019.112418_bib33","article-title":"Organisation for economic Co-operation and development","volume":"27","author":"OECD","year":"2008"},{"issue":"1","key":"10.1016\/j.jep.2019.112418_bib34","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3181\/00379727-91-22179","article-title":"Development of arthritis, periarthritis and periostitis in rats given adjuvants","volume":"91","author":"Pearson","year":"1956","journal-title":"PSEBM (Proc. Soc. Exp. Biol. Med.)"},{"issue":"4","key":"10.1016\/j.jep.2019.112418_bib35","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.toxrep.2017.10.005","article-title":"Acute oral toxicity evaluation of aqueous ethanolic extract of Saccharum munja Roxb. roots in albino mice as per OECD 425 TG","volume":"31","author":"Saleem","year":"2017","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.jep.2019.112418_bib36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-1-4615-5325-0_24","article-title":"Distribution of COX-1 and COX-2 in normal and inflamed tissues","volume":"400A","author":"Seibert","year":"1997","journal-title":"Adv. Exp. Med. Biol."},{"issue":"6","key":"10.1016\/j.jep.2019.112418_bib37","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.semarthrit.2005.01.011","article-title":"Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects","volume":"34","author":"Setty","year":"2005","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.jep.2019.112418_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/784689","article-title":"Effect of estragole on leukocyte behavior and phagocytic activity of macrophages","volume":"2014","author":"Silva-Comar","year":"2014","journal-title":"Evid. Based Complement Altern. Med."},{"key":"10.1016\/j.jep.2019.112418_bib39","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.biopha.2016.10.084","article-title":"Effect of patchouli (Pogostemon cablin) essential oil on in vitro and in vivo leukocytes behavior in acute inflammatory response","volume":"84","author":"Silva-Filho","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2019.112418_bib40","series-title":"Nutritional Composition of Fruit Cultivars","first-page":"796","author":"Simmonds","year":"2016"},{"key":"10.1016\/j.jep.2019.112418_bib41","first-page":"1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"2","key":"10.1016\/j.jep.2019.112418_bib42","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1021\/np1003017","article-title":"Quercetin reduces neutrophil recruitment induced by CXCL8, LTB4, and fMLP: inhibition of actin polymerization","volume":"74","author":"Souto","year":"2011","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2019.112418_bib43","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.fct.2014.10.026","article-title":"Acute and subacute (28 days) oral toxicity assessment of the oil extracted from Acrocomia aculeata pulp in rats","volume":"74","author":"Traesel","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"19","key":"10.1016\/j.jep.2019.112418_bib44","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1182\/blood-2016-05-718999","article-title":"Aged neutrophils contribute to the first line of defense in the acute inflammatory response","volume":"128","author":"Uhl","year":"2016","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.jep.2019.112418_bib45","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1142\/S0192415X10008408","article-title":"Eriobotryae folium extract suppresses LPS-induced iNOS and COX-2 expression by inhibition of NF-kappaB and MAPK activation in murine macrophages","volume":"38","author":"Uto","year":"2010","journal-title":"Am. J. Chin. Med."},{"issue":"3","key":"10.1016\/j.jep.2019.112418_bib46","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3181\/00379727-143-37397","article-title":"Some quantitative temporal characteristic of carrageenin-induced pleurisy in the rat","volume":"143","author":"Vinegar","year":"1973","journal-title":"PSEBM (Proc. Soc. Exp. Biol. Med.)"},{"issue":"4","key":"10.1016\/j.jep.2019.112418_bib47","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1142\/S0192415X13500614","article-title":"Anti-inflammatory activity of ocimum americanum L. Essential oil in experimental model of zymosan-induced arthritis","volume":"41","author":"Yamada","year":"2013","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2019.112418_bib48","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jff.2013.11.019","article-title":"Anti-inflammatory effects and molecular mechanisms of loquat (Eriobotrya japonica) tea","volume":"6","author":"Zar","year":"2014","journal-title":"J. Funct. Foods"},{"issue":"2","key":"10.1016\/j.jep.2019.112418_bib49","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.3390\/ijms16022913","article-title":"Systems pharmacology dissection of the anti-inflammatory mechanism for the medicinal herb folium eriobotryae","volume":"16","author":"Zhang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jep.2019.112418_bib50","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.phymed.2014.02.003","article-title":"Therapeutic effects of standardized Vitexnegundo seeds extract on complete Freund\u2019s adjuvant induced arthritis in rats","volume":"21","author":"Zheng","year":"2014","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jep.2019.112418_bib52","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/medicines6020055","article-title":"Evidence for anti-inflammatory activity of isoliquiritigenin, 18\u03b2 glycyrrhetinic acid, ursolic acid, and the traditional Chinese medicine plants Glycyrrhiza glabra and Eriobotrya japonica, at the molecular level","volume":"6","author":"Zhou","year":"2019","journal-title":"Medicines"},{"issue":"19","key":"10.1016\/j.jep.2019.112418_bib51","doi-asserted-by":"crossref","first-page":"7822","DOI":"10.1021\/jf071273h","article-title":"Carotenoids in white- and red-fleshed loquat fruits","volume":"55","author":"Zhou","year":"2007","journal-title":"J. Agric. Food Chem."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119329289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119329289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:30:53Z","timestamp":1759941053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874119329289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":52,"alternative-id":["S0378874119329289"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.112418","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory and anti-arthritic activity in extract from the leaves of Eriobotrya japonica","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.112418","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112418"}}