{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T17:26:26Z","timestamp":1774027586212,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Show Chwan Memorial Hospital","award":["RD105025"],"award-info":[{"award-number":["RD105025"]}]},{"DOI":"10.13039\/100008903","name":"Taiwan Ministry of Health and Welfare Clinical Trial Center","doi-asserted-by":"publisher","award":["MOHW106-TDU-B-212-113004"],"award-info":[{"award-number":["MOHW106-TDU-B-212-113004"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Technology","award":["107-2320-B-039-029-MY3"],"award-info":[{"award-number":["107-2320-B-039-029-MY3"]}]},{"name":"Ministry of Science and Technology","award":["108-2320-B-039-032-MY3"],"award-info":[{"award-number":["108-2320-B-039-032-MY3"]}]},{"name":"RSC program of Ministry of Education"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jep.2019.112431","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T11:29:40Z","timestamp":1574767780000},"page":"112431","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Regulation effect and mechanism of Sheng-Hua-Tang on female reproductive system: From experimental transcriptomic analysis to clinical applications"],"prefix":"10.1016","volume":"249","author":[{"given":"Jung-Miao","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Chih","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Chi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Yi","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Yun","family":"Hsiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tin-Yun","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2019.112431_bib1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.biopsycho.2009.12.010","article-title":"Influence of functional tryptophan hydroxylase 2 gene variation and sex on the startle response in children, young adults, and older adults","volume":"83","author":"Armbruster","year":"2010","journal-title":"Biol. Psychol."},{"issue":"3","key":"10.1016\/j.jep.2019.112431_bib2","first-page":"3123","article-title":"The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis","volume":"18","author":"Balkowiec","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.jep.2019.112431_bib3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-0757.2011.00409.x","article-title":"Physiology of the female reproductive axis","volume":"61","author":"Bates","year":"2013","journal-title":"Periodontol"},{"issue":"4","key":"10.1016\/j.jep.2019.112431_bib4","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1210\/er.2011-1040","article-title":"Molecular mechanisms of prolactin and its receptor","volume":"33","author":"Brooks","year":"2012","journal-title":"Endocr. Rev."},{"issue":"6","key":"10.1016\/j.jep.2019.112431_bib5","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.ijnurstu.2008.12.015","article-title":"Chinese herbal medicine use in Taiwan during pregnancy and the postpartum period: a population-based cohort study","volume":"46","author":"Chuang","year":"2009","journal-title":"Int. J. Nurs. Stud."},{"key":"10.1016\/j.jep.2019.112431_bib6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/1472-6963-9-207","article-title":"Age, chronic non-communicable disease and choice of traditional Chinese and western medicine outpatient services in a Chinese population","volume":"9","author":"Chung","year":"2009","journal-title":"BMC Health Serv. Res."},{"issue":"5","key":"10.1016\/j.jep.2019.112431_bib7","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.theriogenology.2013.11.019","article-title":"The administration of Sheng Hua Tang immediately after delivery to reduce the incidence of retained placenta in Holstein dairy cows","volume":"81","author":"Cui","year":"2014","journal-title":"Theriogenology"},{"issue":"10","key":"10.1016\/j.jep.2019.112431_bib8","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1080\/07399332.2011.603872","article-title":"The health of women and girls determines the health and well-being of our modern world: a white paper from the International Council on Women's Health Issues","volume":"32","author":"Davidson","year":"2011","journal-title":"Health Care Women Int."},{"key":"10.1016\/j.jep.2019.112431_bib9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000331697","article-title":"Menstrual disorders","volume":"22","author":"Deligeoroglou","year":"2012","journal-title":"Endocr. Dev."},{"issue":"1","key":"10.1016\/j.jep.2019.112431_bib10","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbapap.2011.09.003","article-title":"Regulation of matrix metalloproteinases activity studied in human endometrium as a paradigm of cyclic tissue breakdown and regeneration","volume":"1824","author":"Gaide Chevronnay","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2019.112431_bib11","first-page":"318961","article-title":"Rapid identification of the multiple absorbed bioactive components and metabolites in rat serum after oral administration of Wu-jia sheng-hua capsule by UPLC-ESI-MS","author":"Geng","year":"2013","journal-title":"J. Anal. Methods Chem."},{"key":"10.1016\/j.jep.2019.112431_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev.physiol.64.081501.131049","article-title":"Prolactin: the new biology of an old hormone","volume":"64","author":"Goffin","year":"2002","journal-title":"Annu. Rev. Physiol."},{"issue":"1","key":"10.1016\/j.jep.2019.112431_bib13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.fertnstert.2012.08.038","article-title":"Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis","volume":"99","author":"Guo","year":"2013","journal-title":"Fertil. Steril."},{"issue":"8","key":"10.1016\/j.jep.2019.112431_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044285","article-title":"Stromal-to-epithelial transition during postpartum endometrial regeneration","volume":"7","author":"Huang","year":"2012","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.jep.2019.112431_bib15","article-title":"Chinese herbal products for female infertility in Taiwan: a population-based cohort study","volume":"95","author":"Hung","year":"2016","journal-title":"Medicine (Baltim.)"},{"issue":"9","key":"10.1016\/j.jep.2019.112431_bib16","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.5713\/ajas.2013.13042","article-title":"Effects of sheng hua tang on uterine involution and ovarian activity in postpartum dairy cows","volume":"26","author":"Lee","year":"2013","journal-title":"Asian-Australas. J. Anim. Sci."},{"issue":"22","key":"10.1016\/j.jep.2019.112431_bib17","doi-asserted-by":"crossref","first-page":"5563","DOI":"10.1021\/acs.jafc.8b01582","article-title":"Vanillin-ameliorated development of azoxymethane\/dextran sodium sulfate-induced murine colorectal cancer: the involvement of proteasome\/nuclear factor-kappaB\/mitogen-activated protein kinase pathways","volume":"66","author":"Li","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.jep.2019.112431_bib18","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jep.2013.09.033","article-title":"Shenghua Decoction reduces uterine bleeding and regulates T-cell paradigm in human deciduas of RU486 medical abortion","volume":"150","author":"Li","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2019.112431_bib19","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3892\/etm.2015.2548","article-title":"Effect of Wujia Shenghua capsule on uterine bleeding following medically-induced incomplete abortion in rats during early pregnancy","volume":"10","author":"Liu","year":"2015","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"10.1016\/j.jep.2019.112431_bib20","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/gme.0b013e31820bf288","article-title":"Mechanisms of normal and abnormal endometrial bleeding","volume":"18","author":"Lockwood","year":"2011","journal-title":"Menopause"},{"issue":"7","key":"10.1016\/j.jep.2019.112431_bib21","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1016\/j.fertnstert.2010.03.015","article-title":"Possible roles of oxytocin receptor and vasopressin-1alpha receptor in the pathomechanism of dysperistalsis and dysmenorrhea in patients with adenomyosis uteri","volume":"94","author":"Mechsner","year":"2010","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.jep.2019.112431_bib22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1095\/biolreprod.115.138248","article-title":"Matrix metalloproteinase expression in the rat myometrium during pregnancy, term labor, and postpartum","volume":"95","author":"Nguyen","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jep.2019.112431_bib23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3389\/fphar.2018.00165","article-title":"Integrated metabolomics and network pharmacology approach to explain possible action mechanisms of xin-sheng-hua granule for treating anemia","volume":"9","author":"Pang","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2019.112431_bib24","article-title":"Current usage of traditional Chinese medicine for breast cancer-A narrative approach to the experiences of women with breast cancer in Australia-A pilot study","volume":"4","author":"Porter","year":"2017","journal-title":"Medicine"},{"issue":"3","key":"10.1016\/j.jep.2019.112431_bib25","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1172\/JCI117461","article-title":"Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones","volume":"94","author":"Rodgers","year":"1994","journal-title":"J. Clin. Investig."},{"issue":"502","key":"10.1016\/j.jep.2019.112431_bib26","first-page":"359","article-title":"An epidemiological survey of symptoms of menstrual loss in the community","volume":"54","author":"Shapley","year":"2004","journal-title":"Br. J. Gen. Pract."},{"issue":"1","key":"10.1016\/j.jep.2019.112431_bib27","first-page":"1","article-title":"Post-partum regeneration of the human endometrium","volume":"87","author":"Sharman","year":"1953","journal-title":"J. Anat."},{"issue":"4","key":"10.1016\/j.jep.2019.112431_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032540","article-title":"Gender differences in traditional Chinese medicine use among adults in Taiwan","volume":"7","author":"Shih","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.jep.2019.112431_bib29","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.socscimed.2008.06.011","article-title":"Insurance covered and non-covered complementary and alternative medicine utilisation among adults in Taiwan","volume":"67","author":"Shih","year":"2008","journal-title":"Soc. Sci. Med."},{"issue":"1","key":"10.1016\/j.jep.2019.112431_bib30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1053\/ybeog.2002.0342","article-title":"Menstrual disorders in adolescence","volume":"17","author":"Slap","year":"2003","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"issue":"6","key":"10.1016\/j.jep.2019.112431_bib31","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/j.bmc.2007.01.011","article-title":"Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs","volume":"15","author":"Verma","year":"2007","journal-title":"Bioorg. Med. Chem."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119335500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119335500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:31:03Z","timestamp":1759941063000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874119335500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":31,"alternative-id":["S0378874119335500"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.112431","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation effect and mechanism of Sheng-Hua-Tang on female reproductive system: From experimental transcriptomic analysis to clinical applications","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.112431","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112431"}}