{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:17:54Z","timestamp":1773267474520,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jep.2019.112484","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T03:17:52Z","timestamp":1576207072000},"page":"112484","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Prunus serrulata var. spontanea inhibits mast cell activation and mast cell-mediated anaphylaxis"],"prefix":"10.1016","volume":"250","author":[{"given":"Min-Jong","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Ae","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Kyeong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon-Yong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Nam","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gil-Saeng","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Yong","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Hyun","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jep.2019.112484_bib1","doi-asserted-by":"crossref","first-page":"S379","DOI":"10.1016\/S0091-6749(98)70225-8","article-title":"Side effects of rhinitis medications","volume":"101","author":"Aaronson","year":"1998","journal-title":"J. Allergy Clin. Immunol."},{"issue":"12","key":"10.1016\/j.jep.2019.112484_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167366","article-title":"Silver nanoparticle-directed mast cell degranulation is mediated through calcium and PI3K signaling independent of the high affinity IgE receptor","volume":"11","author":"Alsaleh","year":"2016","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.jep.2019.112484_bib3","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.4049\/jimmunol.147.7.2253","article-title":"Tumor necrosis factor-\u03b1 dependent cytotoxicity of human skin mast cells is enhanced by anti-IgE antibodies","volume":"147","author":"Benyon","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2019.112484_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fimmu.2014.00071","article-title":"Regulation of the NF-\u03baB-mediated transcription of inflammatory genes","volume":"5","author":"Bhatt","year":"2014","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.jep.2019.112484_bib5","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/all.12407","article-title":"miRNA-155 controls mast cell activation by regulating the PI3K\u03b3 pathway and anaphylaxis in a mouse model","volume":"69","author":"Biethahn","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jep.2019.112484_bib6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/164_2017_18","article-title":"Histamine release from mast cells and basophils","volume":"241","author":"Borriello","year":"2017","journal-title":"Handb. Exp. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2019.112484_bib7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/WOX.0b013e3182093e19","article-title":"Antihistaminic, anti-inflammatory, and antiallergic properties of the nonsedating second-generation antihistamine desloratadine: a review of the evidence","volume":"4","author":"Canonica","year":"2011","journal-title":"World Allergy Organ. J."},{"issue":"6","key":"10.1016\/j.jep.2019.112484_bib8","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1002\/eji.200535464","article-title":"Histamine modulates mast cell degranulation through an indirect mechanism in a model IgE-mediated reaction","volume":"36","author":"Carlos","year":"2006","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.jep.2019.112484_bib9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0002-9440(10)61708-7","article-title":"New insights into the role of nuclear factor-\u03baB in cell growth regulation","volume":"159","author":"Chen","year":"2001","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.jep.2019.112484_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2015.11.005","article-title":"Oleanolic acid acetate inhibits rheumatoid arthritis by modulating T cell immune responses and matrix-degrading enzymes","volume":"290","author":"Choi","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2019.112484_bib11","doi-asserted-by":"crossref","first-page":"6884","DOI":"10.1038\/s41598-019-43412-2","article-title":"Avenanthramide C from germinated oats exhibits anti-allergic inflammatory effects in mast cells","volume":"9","author":"Dhakal","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.jep.2019.112484_bib12","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1177\/039463201302600303","article-title":"Impact of capsaicin on mast cell inflammation","volume":"26","author":"Frydas","year":"2013","journal-title":"Int. J. Immunopathol. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2019.112484_bib13","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.4049\/jimmunol.1302520","article-title":"Does \u03b2-hexosaminidase function only as a degranulation indicator in mast cells? The primary role of \u03b2-hexosaminidase in mast cell granules","volume":"193","author":"Fukuishi","year":"2014","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.jep.2019.112484_bib14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nm.2755","article-title":"IgE and mast cells in allergic disease","volume":"18","author":"Galli","year":"2012","journal-title":"Nat. Med."},{"issue":"7203","key":"10.1016\/j.jep.2019.112484_bib15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature07204","article-title":"The development of allergic inflammation","volume":"454","author":"Galli","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jep.2019.112484_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/569853","article-title":"Prokinetic activity of Prunus persica (L.) Batsch flowers extract and its possible mechanism of action in rats","volume":"2015","author":"Han","year":"2015","journal-title":"BioMed Res. Int."},{"issue":"18","key":"10.1016\/j.jep.2019.112484_bib17","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1101\/gad.1228704","article-title":"Signaling to NF-\u03baB","volume":"18","author":"Hayden","year":"2004","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/j.jep.2019.112484_bib18","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00281-012-0320-1","article-title":"Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity","volume":"34","author":"Hogan","year":"2012","journal-title":"Semin. Immunopathol."},{"issue":"1","key":"10.1016\/j.jep.2019.112484_bib19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1051\/parasite\/2011181049","article-title":"Histamine and TNF-\u03b1 release by rat peritoneal mast cells stimulated with Trichomonas vaginalis","volume":"18","author":"Im","year":"2011","journal-title":"Parasite"},{"issue":"4","key":"10.1016\/j.jep.2019.112484_bib20","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bbrc.2010.10.098","article-title":"IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen","volume":"402","author":"Ishikawa","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.jep.2019.112484_bib21","first-page":"20","article-title":"Isolation and characterization of new flavonoid glycoside from the seeds of Prunus cerasoides","volume":"3","author":"Jangwan","year":"2015","journal-title":"J. Med. Plants Stud."},{"issue":"6","key":"10.1016\/j.jep.2019.112484_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129829","article-title":"Tyrosol suppresses allergic inflammation by inhibiting the activation of phosphoinositide 3-Kinase in mast cells","volume":"10","author":"Je","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jep.2019.112484_bib23","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1177\/1535370214555663","article-title":"SG-HQ2 inhibits mast cell-mediated allergic inflammation through suppression of histamine release and pro-inflammatory cytokines","volume":"240","author":"Je","year":"2015","journal-title":"Exp. Biol. Med."},{"issue":"1","key":"10.1016\/j.jep.2019.112484_bib24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1248\/cpb.52.157","article-title":"A new pentacyclic triterpenoid glucoside from Prunus serrulata var","volume":"52","author":"Jung","year":"2004","journal-title":"spontanea. Chem. Pharm. Bull. (Tokyo)"},{"issue":"11","key":"10.1016\/j.jep.2019.112484_bib25","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/ni.f.216","article-title":"New developments in mast cell biology","volume":"9","author":"Kalesnikoff","year":"2008","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.jep.2019.112484_bib26","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0091-6749(81)90134-2","article-title":"Effects of infused histamine: analysis of the effects of H-1 and H-2 histamine receptor antagonists on cardiovascular and pulmonary responses","volume":"68","author":"Kaliner","year":"1981","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2019.112484_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/937904","article-title":"The anti-inflammatory effect of Prunus yedoensis bark extract on adipose tissue in diet-induced obese mice","volume":"2015","author":"Kang","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"6","key":"10.1016\/j.jep.2019.112484_bib28","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.3892\/ijmm.2014.1956","article-title":"Genistein inhibits proinflammatory cytokines in human mast cell activation through the inhibition of the ERK pathway","volume":"34","author":"Kim","year":"2014","journal-title":"Int. J. Mol. Med."},{"issue":"3","key":"10.1016\/j.jep.2019.112484_bib29","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3892\/ijmm.2013.1430","article-title":"Vigna angularis inhibits mast cell-mediated allergic inflammation","volume":"32","author":"Kim","year":"2013","journal-title":"Int. J. Mol. Med."},{"issue":"3","key":"10.1016\/j.jep.2019.112484_bib30","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.taap.2013.12.006","article-title":"Inhibitory effect of putranjivain A on allergic inflammation through suppression of mast cell activation","volume":"274","author":"Kim","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2019.112484_bib31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12906-015-0607-6","article-title":"Rhamnus davurica leaf extract inhibits Fyn activation by antigen in mast cells for anti-allergic activity","volume":"15","author":"Kim","year":"2015","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.jep.2019.112484_bib32","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3389\/fphar.2018.00591","article-title":"Elaeocarpusin inhibits mast cell-mediated allergic inflammation","volume":"9","author":"Kim","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2019.112484_bib33","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1016\/j.bmcl.2010.03.053","article-title":"Inhibition of antigen-induced degranulation by aryl compounds isolated from the bark of Betula platyphylla in RBL-2H3 cells","volume":"20","author":"Kim","year":"2010","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"3","key":"10.1016\/j.jep.2019.112484_bib34","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.3892\/mmr.2015.3824","article-title":"Beneficial effects of the traditional medicine Igongsan and its constituent ergosterol on dextran sulfate sodium-induced colitis in mice","volume":"12","author":"Kim","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.jep.2019.112484_bib35","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/aps.2016.112","article-title":"2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the Fc\u03b5RI signaling pathway","volume":"38","author":"Kim","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"issue":"6","key":"10.1016\/j.jep.2019.112484_bib36","doi-asserted-by":"crossref","first-page":"397","DOI":"10.5114\/pdia.2016.63942","article-title":"The role and choice criteria of antihistamines in allergy management - expert opinion","volume":"33","author":"Kuna","year":"2016","journal-title":"Postepy Dermatol. Allergol."},{"key":"10.1016\/j.jep.2019.112484_bib37","article-title":"Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-\u03baB and p38 MAPK activation","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2019.112484_bib38","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"issue":"6","key":"10.1016\/j.jep.2019.112484_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158104","article-title":"Isolation of mature (Peritoneum-derived) mast cells and immature (Bone marrow-derived) mast cell precursors from mice","volume":"11","author":"Meurer","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2019.112484_bib40","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.3389\/fimmu.2017.01665","article-title":"Differentiation and functionality of bone marrow-derived mast cells depend on varying physiologic oxygen conditions","volume":"8","author":"Mollerherm","year":"2017","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.jep.2019.112484_bib41","doi-asserted-by":"crossref","first-page":"S798","DOI":"10.1016\/S0091-6749(97)70128-3","article-title":"Appraisal of the validity of histamine-induced wheal and flare to predict the clinical efficacy of antihistamines","volume":"99","author":"Monroe","year":"1997","journal-title":"J. Allergy Clin. Immunol."},{"issue":"29","key":"10.1016\/j.jep.2019.112484_bib42","doi-asserted-by":"crossref","first-page":"6653","DOI":"10.1016\/j.febslet.2005.09.104","article-title":"IL-4 modulates the histamine content of mast cells in a mast cell\/fibroblast co-culture through a STAT6 signaling pathway in fibroblasts","volume":"579","author":"Nabeshima","year":"2005","journal-title":"FEBS Lett."},{"issue":"4","key":"10.1016\/j.jep.2019.112484_bib43","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1248\/cpb.55.675","article-title":"Allergy-preventive flavonoids from Xanthorrhoea hastilis","volume":"55","author":"Ogawa","year":"2007","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"issue":"1\u20132","key":"10.1016\/j.jep.2019.112484_bib44","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.lfs.2012.05.018","article-title":"Betula platyphylla attenuated mast cell-mediated allergic inflammation in vivo and in vitro","volume":"91","author":"Oh","year":"2012","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.jep.2019.112484_bib45","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jaci.2017.06.003","article-title":"The pathophysiology of anaphylaxis","volume":"140","author":"Reber","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.jep.2019.112484_bib46","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4046\/trd.2013.75.5.205","article-title":"Effect of prunetin on TNF-\u03b1-induced MUC5AC mucin gene expression, production, degradation of I\u03baB and translocation of NF-\u03baB p65 in human airway epithelial cells","volume":"75","author":"Ryu","year":"2013","journal-title":"Tuberc. Respir. Dis."},{"issue":"10","key":"10.1016\/j.jep.2019.112484_bib47","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1016\/j.fct.2010.07.009","article-title":"Anti-allergic inflammatory activity of the fruit of Prunus persica: role of calcium and NF-\u03baB","volume":"48","author":"Shin","year":"2010","journal-title":"Food Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.jep.2019.112484_bib48","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.anai.2010.01.023","article-title":"World Allergy Organization survey on global availability of essentials for the assessment and management of anaphylaxis by allergy-immunology specialists in health care settings","volume":"104","author":"Simons","year":"2010","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"1","key":"10.1016\/j.jep.2019.112484_bib49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3831\/KPI.2016.19.002","article-title":"Historical medical value of Donguibogam","volume":"19","author":"Song","year":"2016","journal-title":"J. Pharmacopuncture"},{"issue":"1","key":"10.1016\/j.jep.2019.112484_bib50","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbadis.2010.12.014","article-title":"Mast cells and inflammation","volume":"1822","author":"Theoharides","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.jep.2019.112484_bib51","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/00005344-198307000-00004","article-title":"Cardiovascular effects of histamine infusion in man","volume":"5","author":"Vigorito","year":"1983","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"11","key":"10.1016\/j.jep.2019.112484_bib52","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1002\/mnfr.201400329","article-title":"The role of peptides derived from Spirulina maxima in downregulation of Fc\u03b5RI-mediated allergic responses","volume":"58","author":"Vo","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"issue":"1","key":"10.1016\/j.jep.2019.112484_bib53","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1182\/blood-2002-03-0921","article-title":"Early macrophage influx to sites of cutaneous granuloma formation is dependent on MIP-1\u03b1\/\u03b2 released from neutrophils recruited by mast cell-derived TNF-\u03b1","volume":"101","author":"von Stebut","year":"2003","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.jep.2019.112484_bib54","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1073\/pnas.88.10.4220","article-title":"Human dermal mast cells contain and release tumor necrosis factor-\u03b1, which induces endothelial leukocyte adhesion molecule 1","volume":"88","author":"Walsh","year":"1991","journal-title":"Proc. Nati. Acad. Sci. U S A"},{"issue":"3","key":"10.1016\/j.jep.2019.112484_bib55","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1021\/jf980936f","article-title":"Antioxidant polyphenols from tart cherries (Prunus cerasus)","volume":"47","author":"Wang","year":"1999","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.jep.2019.112484_bib56","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0091-6749(05)80223-4","article-title":"The role of histamine in allergic diseases","volume":"86","author":"White","year":"1990","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.jep.2019.112484_bib57","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1089\/jmf.2013.2825","article-title":"Prunus yedoensis bark inhibits lipopolysaccharide-induced inflammatory cytokine synthesis by I\u03baB\u03b1 degradation and MAPK activation in macrophages","volume":"17","author":"Yun","year":"2014","journal-title":"J. Med. Food"},{"issue":"5090","key":"10.1016\/j.jep.2019.112484_bib58","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1126\/science.1470922","article-title":"Neutrophil recruitment by tumor necrosis factor from mast cells in immune complex peritonitis","volume":"258","author":"Zhang","year":"1992","journal-title":"Science"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119333604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119333604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:27:20Z","timestamp":1759940840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874119333604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":58,"alternative-id":["S0378874119333604"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.112484","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prunus serrulata var. spontanea inhibits mast cell activation and mast cell-mediated anaphylaxis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.112484","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112484"}}