{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T05:27:55Z","timestamp":1772515675504,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"publisher","award":["81673572"],"award-info":[{"award-number":["81673572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanxi Province","award":["201601D021164"],"award-info":[{"award-number":["201601D021164"]}]},{"name":"Innovation project of higher education institutions in Shanxi Province","award":["2016120"],"award-info":[{"award-number":["2016120"]}]},{"name":"Major research and development plan project of Shanxi Province","award":["201703D321023-3"],"award-info":[{"award-number":["201703D321023-3"]}]},{"name":"National S&T major projects for \u201cmajor new drugs innovation and development\u201d","award":["2017ZX09301047"],"award-info":[{"award-number":["2017ZX09301047"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.jep.2019.112533","type":"journal-article","created":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T21:31:17Z","timestamp":1578259877000},"page":"112533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Coniferyl ferulate exerts antidepressant effect via inhibiting the activation of NMDAR-CaMKII-MAPKs and mitochondrial apoptotic pathways"],"prefix":"10.1016","volume":"251","author":[{"given":"Wenxia","family":"Gong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2019.112533_bib1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.yjmcc.2015.10.014","article-title":"Oxidant stress promotes disease by activating CaMKII","volume":"89","author":"Anderson","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jep.2019.112533_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrn1846","article-title":"New approaches to antidepressant drug discovery: beyond monoamines","volume":"7","author":"Berton","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jep.2019.112533_bib3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.psyneuen.2014.09.025","article-title":"Is depression associated with increased oxidative stress? A systematic review and meta-analysis","volume":"51","author":"Black","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jep.2019.112533_bib4","first-page":"639083","article-title":"Coniferyl ferulate, a strong inhibitor of glutathione S-transferase isolated from Radix Angelicae sinensis, reverses multidrug resistance and downregulates p-glycoprotein","author":"Chen","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2019.112533_bib5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bcp.2015.03.011","article-title":"Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs","volume":"95","author":"Dale","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2019.112533_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.31887\/DCNS.2014.16.1\/rduman","article-title":"Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections","volume":"16","author":"Duman","year":"2014","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.jep.2019.112533_bib7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.12688\/f1000research.14344.1","article-title":"Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide","volume":"7","author":"Duman","year":"2018","journal-title":"F1000 Research"},{"key":"10.1016\/j.jep.2019.112533_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fphar.2014.00059","article-title":"Mechanisms of CaMKII activation in the heart","volume":"5","author":"Erickson","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2019.112533_bib9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pnpbp.2008.10.005","article-title":"Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression","volume":"33","author":"Feyissa","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jep.2019.112533_bib10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuropharm.2011.07.036","article-title":"Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders","volume":"62","author":"Gerard","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2019.112533_bib11","first-page":"491","article-title":"Pathophysiology of the glutamate and the glycine transporters: new therapeutic targets","volume":"67","author":"Gimenez","year":"2018","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.jep.2019.112533_bib12","first-page":"2856","article-title":"Identification of antidepression constituents from angelica sinensis Radix contrubuting to xiaoyaosan","volume":"46","author":"Gong","year":"2015","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.jep.2019.112533_bib13","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1159\/000480001","article-title":"Targeting the endocannabinoid\/CB1 receptor system for treating major depression through antidepressant activities of curcumin and dexanabinol-loaded solid lipid nanoparticles","volume":"42","author":"He","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2019.112533_bib14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ceca.2017.03.007","article-title":"Monitoring single-synapse glutamate release and presynaptic calcium concentration in organised brain tissue","volume":"64","author":"Jensen","year":"2017","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jep.2019.112533_bib15","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10571-014-0043-z","article-title":"Gastrodin inhibits glutamate-induced apoptosis of PC12 cells via inhibition of CaMKII\/ASK-1\/p38 MAPK\/p53 signaling cascade","volume":"34","author":"Jiang","year":"2014","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.jep.2019.112533_bib16","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fphar.2015.00166","article-title":"Ca2+ signaling in the myocardium by (redox) regulation of PKA\/CaMKII","volume":"6","author":"Johnston","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2019.112533_bib17","doi-asserted-by":"crossref","first-page":"26423","DOI":"10.1074\/jbc.M112.339085","article-title":"Key amino acid residues within the third membrane domains of NR1 and NR2 subunits contribute to the regulation of the surface delivery of N-methyl-D- aspartate receptors","volume":"287","author":"Kaniakova","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2019.112533_bib18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.pnpbp.2016.03.009","article-title":"Role of glutamate receptors and glial cells in the pathophysiology of treatment-resistant depression","volume":"70","author":"Kim","year":"2016","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jep.2019.112533_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fncel.2015.00091","article-title":"Researching glutamate-induced cytotoxicity in different cell lines: a comparative\/collective analysis\/study","volume":"9","author":"Kritis","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jep.2019.112533_bib20","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jep.2019.112533_bib21","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neuropharm.2017.08.035","article-title":"Inhibition of AMPA receptor and CaMKII activity in the lateral habenula reduces depressive-like behavior and alcohol intake in rats","volume":"126","author":"Li","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2019.112533_bib22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/BJ20121538","article-title":"Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38(MAPK) signalling involves CaMKII inhibition","volume":"456","author":"Lim","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.jep.2019.112533_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.pnpbp.2016.06.002","article-title":"N,N- dimethylglycine differentially modulates psychotomimetic and antidepressant-like effects of ketamine in mice","volume":"71","author":"Lin","year":"2016","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jep.2019.112533_bib24","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.psyneuen.2016.11.031","article-title":"Oxidative stress, inflammation and treatment response in major depression","volume":"76","author":"Lindqvist","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jep.2019.112533_bib25","article-title":"Longistyline C acts antidepressant in vivo and neuroprotection in vitro against glutamate-induced cytotoxicity by regulating NMDAR\/NR2B-ERK pathway in PC12 cells","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2019.112533_bib26","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s10571-010-9537-5","article-title":"Protective effects of Paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via antioxidant mechanisms and Ca2+ antagonism","volume":"30","author":"Mao","year":"2010","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.jep.2019.112533_bib27","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jamda.2016.12.071","article-title":"Clinical use of curcumin in depression: a meta-analysis","volume":"18","author":"Ng","year":"2017","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"10.1016\/j.jep.2019.112533_bib28","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pnpbp.2012.10.017","article-title":"Antioxidants as potential therapeutics for neuropsychiatric disorders","volume":"46","author":"Pandya","year":"2013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jep.2019.112533_bib29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.pnpbp.2016.07.007","article-title":"Adverse childhood experiences associate to reduced glutamate levels in the hippocampus of patients affected by mood disorders","volume":"71","author":"Poletti","year":"2016","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jep.2019.112533_bib30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/bs.apcsb.2015.10.003","article-title":"Glutamatergic NMDA receptor as therapeutic target for depression","volume":"103","author":"R\u00e9us","year":"2016","journal-title":"Adv Protein Chem Struct Biol"},{"key":"10.1016\/j.jep.2019.112533_bib31","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tins.2014.07.001","article-title":"Emerging role of CaMKII in neuropsychiatric disease","volume":"37","author":"Robison","year":"2014","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jep.2019.112533_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11011-017-0017-1","article-title":"Curcumin reverses the depressive-like behavior and insulin resistance induced by chronic mild stress","volume":"32","author":"Shen","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jep.2019.112533_bib33","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00204-013-1034-4","article-title":"Oxidative stress: the mitochondria- dependent and mitochondria-independent pathways of apoptosis","volume":"87","author":"Sinha","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jep.2019.112533_bib34","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tips.2009.09.002","article-title":"Glutamate-based antidepressants: 20 years on","volume":"30","author":"Skolnick","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jep.2019.112533_bib35","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1016\/S0006-3495(02)75331-9","article-title":"Staggering of subunits in NMDAR channels","volume":"83","author":"Sobolevsky","year":"2002","journal-title":"Biophys. J."},{"key":"10.1016\/j.jep.2019.112533_bib36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.etap.2014.05.017","article-title":"Neuroprotective effects of Arctium lappa L. roots against glutamate-induced oxidative stress by inhibiting phosphorylation of p38, JNK and ERK 1\/2 MAPKs in PC12 cells","volume":"38","author":"Tian","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2019.112533_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ntt.2018.07.002","article-title":"Metabolomics studies on corticosterone-induced PC12 cells: a strategy for evaluating an in vitro depression model and revealing the metabolic regulation mechanism","volume":"69","author":"Tian","year":"2018","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.jep.2019.112533_bib38","doi-asserted-by":"crossref","first-page":"E209","DOI":"10.1038\/70237","article-title":"Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?","volume":"1","author":"Vander Heiden","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jep.2019.112533_bib39","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s11011-013-9404-4","article-title":"Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses","volume":"28","author":"Xu","year":"2013","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jep.2019.112533_bib40","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuint.2014.03.003","article-title":"Neuroprotective effect of muscone on glutamate-induced apoptosis in PC12 cells via antioxidant and Ca2+ antagonism","volume":"70","author":"Yu","year":"2014","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jep.2019.112533_bib41","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12974-019-1610-5","article-title":"Potential link between the Raga-mTOR- p70S6K axis and depressive-behaviors during bacterial liposaccharide challenge","volume":"16","author":"Zhao","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2019.112533_bib42","doi-asserted-by":"crossref","first-page":"862","DOI":"10.3389\/fphar.2018.00862","article-title":"EphB2 deficiency induces depression-like behaviors and memory impairment: involvement of NMDA 2B receptor dependent signaling","volume":"9","author":"Zhen","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2019.112533_bib43","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jep.2012.02.018","article-title":"Identification and quantification of the major volatile constituents in antidepressant active fraction of xiaoyaosan by gas chromatography-mass spectrometry","volume":"141","author":"Zhou","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.112533_bib44","first-page":"7067984","article-title":"Oxidative stress-related biomarkers in postmenopausal osteoporosis: a systematic review and meta-analyses","author":"Zhou","year":"2016","journal-title":"Dis. Markers"},{"key":"10.1016\/j.jep.2019.112533_bib45","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1039\/C6FO01503D","article-title":"Protective effect of isoliquiritin against corticosterone- induced neurotoxicity in PC12 cells","volume":"8","author":"Zhou","year":"2017","journal-title":"Food Funct"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119336955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119336955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:28:21Z","timestamp":1759940901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874119336955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":45,"alternative-id":["S0378874119336955"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.112533","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coniferyl ferulate exerts antidepressant effect via inhibiting the activation of NMDAR-CaMKII-MAPKs and mitochondrial apoptotic pathways","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.112533","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112533"}}