{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:40:29Z","timestamp":1778506829963,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.jep.2019.112537","type":"journal-article","created":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T07:32:24Z","timestamp":1577863944000},"page":"112537","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Exploration the active compounds of Astragali Radix in treatment of adriamycin nephropathy by network pharmacology combined with transcriptomic approach"],"prefix":"10.1016","volume":"258","author":[{"given":"Ai-Ping","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Sheng","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang-Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Mei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2019.112537_bib1","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1053\/j.ajkd.2007.07.032","article-title":"Treatment of idiopathic membranous nephropathy with the herb Astragalus membranaceus","volume":"50","author":"Ahmed","year":"2007","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.jep.2019.112537_bib2","doi-asserted-by":"crossref","first-page":"D154","DOI":"10.1093\/nar\/gki070","article-title":"The universal protein resource (UniProt)","volume":"33","author":"Bairoch","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2019.112537_bib3","first-page":"16","article-title":"Adriamycin-induced nephrotic syndrome in rats: sequence of pathologic events","volume":"46","author":"Bertani","year":"1982","journal-title":"Lab. Investig."},{"key":"10.1016\/j.jep.2019.112537_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2202\/1544-6115.1075","article-title":"PLS dimension reduction for classification with microarray data","volume":"3","author":"Boulesteix","year":"2004","journal-title":"Stat. Appl. Genet. Mol."},{"key":"10.1016\/j.jep.2019.112537_bib5","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.jep.2011.11.035","article-title":"The healing and anti-scar effects of astragaloside IV on the wound repair in vitro and in vivo","volume":"139","author":"Chen","year":"2012","journal-title":"J. Ethnophmacol."},{"key":"10.1016\/j.jep.2019.112537_bib6","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1055\/s-0030-1250628","article-title":"Inhibitory effects of two major isoflavonoids in Radix Astragali on high glucose-induced mesangial cells proliferation and AGEs-induced endothelial cells apoptosis","volume":"77","author":"Dan","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2019.112537_bib7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10495-013-0801-2","article-title":"Astragaloside IV prevents acute kidney injury in two rodent models by inhibiting oxidative stress and apoptosis pathways","volume":"18","author":"Gui","year":"2013","journal-title":"Apoptosis"},{"key":"10.1016\/j.jep.2019.112537_bib8","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jep.2019.112537_bib9","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.fitote.2012.08.019","article-title":"The effect of Astragaloside IV on immune function of regulatory T cell mediated by high mobility group box 1 protein in vitro","volume":"83","author":"Huang","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2019.112537_bib10","first-page":"89","article-title":"Intermediate filament protein expression pattern and inflammatory response changes in kidneys of rats receiving doxorubicin chemotherapy and quercetin","volume":"288","author":"Khalil","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.jep.2019.112537_bib11","doi-asserted-by":"crossref","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","article-title":"PubChem substance and compound databases","volume":"44","author":"Kim","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2019.112537_bib12","doi-asserted-by":"crossref","first-page":"111921","DOI":"10.1016\/j.jep.2019.111921","article-title":"Astragalus membranaceus (Huang Qi) as adjunctive therapy for diabetic kidney disease: an updated systematic review and meta-analysis","volume":"239","author":"La","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.112537_bib13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1440-1797.2010.01383.x","article-title":"Adriamycin nephropathy: a model of focal segmental glomerulosclerosis","volume":"16","author":"Lee","year":"2011","journal-title":"Nephrology"},{"key":"10.1016\/j.jep.2019.112537_bib14","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.2147\/DDDT.S166525","article-title":"Astragaloside IV\/lncRNA-TUG1\/TRAF5 signaling pathway participates in podocyte apoptosis of diabetic nephropathy rats","volume":"12","author":"Lei","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2019.112537_bib15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.17305\/bjbms.2016.887","article-title":"Huaiqihuang may protect from proteinuria by resisting MPC5 podocyte damage via targeting p-ERK\/CHOP pathway","volume":"16","author":"Li","year":"2016","journal-title":"Bosn. J. Basic Med."},{"key":"10.1016\/j.jep.2019.112537_bib16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jpba.2017.05.009","article-title":"Systematic screening and characterization of prototype constituents and metabolites of total astragalosides using HPLC-ESI-IT-TOF-MS(n) after oral administration to rats","volume":"142","author":"Li","year":"2017","journal-title":"J. Pharm. Biomed."},{"key":"10.1016\/j.jep.2019.112537_bib17","doi-asserted-by":"crossref","first-page":"19809","DOI":"10.1038\/srep19809","article-title":"Systems-pharmacology dissection of traditional Chinese medicine compound saffron formula reveals multi-scale treatment strategy for cardiovascular diseases","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2019.112537_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2018.05.015","article-title":"Material basis research for Huangqi Jianzhong Tang against chronic atrophic gastritis rats through integration of urinary metabonomics and SystemsDock","volume":"223","author":"Liu","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2019.112537_bib19","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1093\/bioinformatics\/btq430","article-title":"Cytoscape Web: an interactive web-based network browser","volume":"26","author":"Lopes","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2019.112537_bib20","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3389\/fphar.2018.00739","article-title":"Formononetin treatment in type 2 diabetic rats reduces insulin resistance and hyperglycemia","volume":"9","author":"Oza","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2019.112537_bib21","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/mnfr.201200178","article-title":"Selected nutraceutic screening by therapeutic effects on doxorubicin-induced chronic kidney disease","volume":"56","author":"Peng","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jep.2019.112537_bib22","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0254-6272(13)60189-2","article-title":"Pharmacological effects of Astragaloside IV: a literature review","volume":"33","author":"Ren","year":"2013","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2019.112537_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminf."},{"key":"10.1016\/j.jep.2019.112537_bib24","first-page":"D1089","article-title":"TCMID: traditional Chinese Medicine integrative database for herb molecular mechanism analysis","volume":"41","author":"Ruichao","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2019.112537_bib25","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.jep.2019.112537_bib26","doi-asserted-by":"crossref","first-page":"D433","DOI":"10.1093\/nar\/gki005","article-title":"STRING: known and predicted protein-protein associations, integrated and transferred across organisms","volume":"33","author":"von Mering","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2019.112537_bib27","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s12272-014-0336-2","article-title":"Astragaloside IV possesses antiarthritic effect by preventing interleukin 1\u03b2-induced joint inflammation and cartilage damage","volume":"37","author":"Wang","year":"2014","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2019.112537_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jchromb.2015.01.021","volume":"985","author":"Wang","year":"2015","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jep.2019.112537_bib29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12882-015-0031-7","article-title":"Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress","volume":"16","author":"Wang","year":"2015","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.jep.2019.112537_bib30","first-page":"270","article-title":"Protective effects of astragaloside in rats with adriamycin nephropathy and underlying mechanism","volume":"14","author":"Wang","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2019.112537_bib31","doi-asserted-by":"crossref","first-page":"W356","DOI":"10.1093\/nar\/gkx374","article-title":"PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2019.112537_bib32","first-page":"1","article-title":"Traditional Chinese medicine for refractory nephrotic syndrome: strategies and promising treatments","volume":"2018","author":"Wang","year":"2018","journal-title":"Evid. Based Compl. Altern."},{"key":"10.1016\/j.jep.2019.112537_bib33","first-page":"1465","article-title":"Astragalus (a traditional Chinese medicine) for treating chronic kidney disease","volume":"10","author":"Wei","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jep.2019.112537_bib34","first-page":"1","article-title":"A network pharmacology analysis to explore the effect of Astragali radix-radix Angelica sinensis on traumatic brain injury","volume":"5","author":"Xie","year":"2018","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2019.112537_bib35","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3389\/fphar.2018.00525","article-title":"The active components of Fuzheng Huayu formula and their potential mechanism of action in inhibiting the hepatic stellate cells viability \u2013 a network pharmacology and transcriptomics approach","volume":"9","author":"Xing","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2019.112537_bib36","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1124\/dmd.105.008300","article-title":"Absorption and metabolism of Astragali radix decoction: in silico, in vitro, and a case study in vivo","volume":"34","author":"Xu","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jep.2019.112537_bib37","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.3390\/ijms13066964","article-title":"A novel chemometric method for the prediction of human oral bioavailability","volume":"13","author":"Xu","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2019.112537_bib38","doi-asserted-by":"crossref","first-page":"486","DOI":"10.4149\/BLL_2015_092","article-title":"Effects of quercetin on kidney injury induced by doxorubicin","volume":"116","author":"Yagmurca","year":"2015","journal-title":"Bratisl Med. J."},{"key":"10.1016\/j.jep.2019.112537_bib39","doi-asserted-by":"crossref","first-page":"i246","DOI":"10.1093\/bioinformatics\/btq176","article-title":"Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework","volume":"26","author":"Yamanishi","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2019.112537_bib40","first-page":"1671","article-title":"Calycosin ameliorates diabetes-induced renal inflammation via the NF-\u03baB pathway in vitro and in vivo","volume":"25","author":"Ying-Ying","year":"2019","journal-title":"J. Exp. Clin. Res."},{"key":"10.1016\/j.jep.2019.112537_bib41","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3389\/fphar.2017.00694","article-title":"System pharmacology-based dissection of the synergistic mechanism of huangqi and huanglian for diabetes mellitus","volume":"8","author":"Yue","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2019.112537_bib42","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jpba.2018.05.045","article-title":"Metabolomics coupled with system pharmacology reveal the protective effect of total flavonoids of Astragali Radix against adriamycin-induced rat nephropathy model","volume":"158","author":"Zhang","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2019.112537_bib43","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jep.2018.10.004","article-title":"Effects and mechanisms of Danshen-Shanzha herb-pair for atherosclerosis treatment using network pharmacology and experimental pharmacology","volume":"229","author":"Zhang","year":"2019","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119337845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119337845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:36:15Z","timestamp":1759941375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874119337845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":43,"alternative-id":["S0378874119337845"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2019.112537","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploration the active compounds of Astragali Radix in treatment of adriamycin nephropathy by network pharmacology combined with transcriptomic approach","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2019.112537","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112537"}}