{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:47:58Z","timestamp":1793386078319,"version":"4.5.0"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.jep.2020.112564","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T20:24:32Z","timestamp":1578601472000},"page":"112564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Ginsenoside metabolite 20(S)-protopanaxatriol from Panax ginseng attenuates inflammation-mediated NLRP3 inflammasome activation"],"prefix":"10.1016","volume":"251","author":[{"given":"Jun","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahbuba","family":"Akther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Lan","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Hu","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushruta","family":"Koppula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hyuk","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spandana Rajendra","family":"Kopalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Bong","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.112564_bib1","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0006-2952(99)00212-9","article-title":"Ginseng pharmacology: multiple constituents and multiple actions","volume":"58","author":"Attele","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2020.112564_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5142\/jgr.2013.37.1","article-title":"The world ginseng market and the ginseng (Korea)","volume":"37","author":"Baeg","year":"2013","journal-title":"J. Ginseng. Res."},{"key":"10.1016\/j.jep.2020.112564_bib3","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1038\/sj.cdd.4402194","article-title":"The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation","volume":"14","author":"Fernandes-Alnemri","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2020.112564_bib4","first-page":"23","article-title":"The review and all the problem to solve on the Naeuiwonjabon\u2013a preceding study on the Dongeuibogam","volume":"17","author":"Ha","year":"2008","journal-title":"Uisahak"},{"key":"10.1016\/j.jep.2020.112564_bib5","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1248\/bpb.25.861","article-title":"Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acid-conjugate of protopanaxatriol","volume":"25","author":"Hasegawa","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2020.112564_bib6","series-title":"Donguibogam (\u201cPrinciples and Practice of Eastern Medicine\u201d)","author":"Heo","year":"1613"},{"key":"10.1016\/j.jep.2020.112564_bib7","first-page":"1","article-title":"The influence of Donguibogam during the middle Joseon era based on clinical records on low back pain in Seungjeongwon ilgi","volume":"20","author":"Jung","year":"2011","journal-title":"Uisahak"},{"key":"10.1016\/j.jep.2020.112564_bib8","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s11926-013-0400-9","article-title":"The crystallization of monosodium urate","volume":"16","author":"Martillo","year":"2014","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.jep.2020.112564_bib9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jep.2020.112564_bib10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.canlet.2003.09.037","article-title":"20(S)-protopanaxatriol, one of ginsenoside metabolites, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expressions through inactivation of nuclear factor-kappaB in RAW 264.7 macrophages stimulated with lipopolysaccharide","volume":"205","author":"Oh","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jep.2020.112564_bib11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1248\/bpb.b14-00669","article-title":"Anti-stress effects of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol in immobilized mice","volume":"38","author":"Oh","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2020.112564_bib12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jep.2017.03.043","article-title":"Protective effects of Cinnamomum cassia (Lamaceae) against gout and septic responses via attenuation of inflammasome activation in experimental models","volume":"205","author":"Shin","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112564_bib13","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jep.2013.09.056","article-title":"Lysimachia clethroides duby extract attenuates inflammatory response in raw 264.7 macrophages stimulated with lipopolysaccharide and in acute lung injury mouse model","volume":"150","author":"Shim","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112564_bib14","doi-asserted-by":"crossref","first-page":"15020","DOI":"10.1038\/s41598-017-15314-8","article-title":"BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination","volume":"7","author":"Shim","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2020.112564_bib15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/nyas.12458","article-title":"Mechanism of NLRP3 inflammasome activation","volume":"1319","author":"Sutterwala","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jep.2020.112564_bib16","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ni.2228","article-title":"A role for the NLRP3 inflammasome in metabolic diseases--did warburg miss inflammation?","volume":"13","author":"Wen","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jep.2020.112564_bib17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411933404X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411933404X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:30:37Z","timestamp":1759941037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887411933404X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":17,"alternative-id":["S037887411933404X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.112564","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ginsenoside metabolite 20(S)-protopanaxatriol from Panax ginseng attenuates inflammation-mediated NLRP3 inflammasome activation","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.112564","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112564"}}