{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:44:40Z","timestamp":1789062280465,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007292","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.jep.2020.112606","type":"journal-article","created":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T02:23:40Z","timestamp":1579919020000},"page":"112606","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Investigation of the mechanism of action of Porana sinensis Hemsl. against gout arthritis using network pharmacology and experimental validation"],"prefix":"10.1016","volume":"252","author":[{"given":"Xia","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lintao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.112606_bib1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3389\/fphar.2018.00187","article-title":"Exploring the mechanism of Dangguiliuhuang decoction against hepatic fibrosis by network pharmacology and experimental validation","volume":"9","author":"Cao","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.jep.2020.112606_bib2","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1172\/JCI28075","article-title":"MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals","volume":"116","author":"Chen","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.jep.2020.112606_bib3","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jep.2013.08.059","article-title":"Comparison of active constituents, acute toxicity, anti-nociceptive and anti-inflammatory activities of Porana sinensis Hemsl., Erycibe obtusifolia Benth. and Erycibe schmidtii Craib","volume":"150","author":"Chen","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2020.112606_bib4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/pca.2814","article-title":"Qualitative and quantitative analysis of Porana sinensis Hemsl by UHPLC-Q-Exactive MS, TLC autographic method and DART-MS","volume":"30","author":"Chen","year":"2019","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jep.2020.112606_bib5","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3389\/fphar.2017.00230","article-title":"Wu-Tou decoction in rheumatoid arthritis: integrating network pharmacology and in vivo pharmacological evaluation","volume":"8","author":"Guo","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2020.112606_bib6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.phytol.2015.12.008","article-title":"Caffeoylquinic acid derivatives from the roots of Arctium lappa L.(burdock) and their structure-activity relationships (SARs) of free radical scavenging activities","volume":"15","author":"Jiang","year":"2016","journal-title":"Phytochem. Lett."},{"issue":"1","key":"10.1016\/j.jep.2020.112606_bib7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12906-017-1834-9","article-title":"Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model","volume":"17","author":"Jiang","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2020.112606_bib8","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/nar\/gkr1088","article-title":"The IntAct molecular interaction database in 2012","volume":"40","author":"Kerrien","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.jep.2020.112606_bib9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2105-11-91","article-title":"BisoGenet: a new tool for gene network building, visualization and analysis","volume":"11","author":"Martin","year":"2010","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.jep.2020.112606_bib10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.jep.2020.112606_bib11","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1002\/prot.25085","article-title":"Crystal structure of the N-terminal domain of human SIRT7 reveals a three-helical domain architecture","volume":"84","author":"Priyanka","year":"2016","journal-title":"Proteins Struct. Funct. Bioinf."},{"issue":"4","key":"10.1016\/j.jep.2020.112606_bib12","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/iub.1491","article-title":"5-HT(1A) receptor antagonist improves behavior performance of delirium rats through inhibiting PI3K\/Akt\/mTOR activation-induced NLRP3 activity","volume":"68","author":"Qiu","year":"2016","journal-title":"IUBMB Life"},{"key":"10.1016\/j.jep.2020.112606_bib13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jff.2018.06.025","article-title":"The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NF\u03baB and macrophage release of IL-1\u03b2","volume":"48","author":"Ruiz-Miyazawa","year":"2018","journal-title":"J. Funct. Foods"},{"issue":"11","key":"10.1016\/j.jep.2020.112606_bib14","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.jep.2020.112606_bib15","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jep.2016.06.008","article-title":"Traditional Chinese Medicine Formula \u201cXiaofeng granules\u201d suppressed gouty arthritis animal models and inhibited the proteoglycan degradation on chondrocytes induced by monosodium urate","volume":"191","author":"Shi","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112606_bib16","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/nar\/gkj109","article-title":"BioGRID: a general repository for interaction datasets","volume":"34","author":"Stark","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2020.112606_bib17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biosystems.2014.11.005","article-title":"CytoNCA: a cytoscape plugin for centrality analysis and evaluation of protein interaction networks","volume":"127","author":"Tang","year":"2015","journal-title":"Biosystems"},{"issue":"1","key":"10.1016\/j.jep.2020.112606_bib18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/nrg1266","article-title":"Human protein reference database","volume":"5","author":"Wilson","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jep.2020.112606_bib19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jep.2018.04.025","article-title":"Achyranthis bidentatae radix enhanced articular distribution and anti-inflammatory effect of berberine in Sanmiao Wan using an acute gouty arthritis rat model","volume":"221","author":"Wu","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2020.112606_bib20","first-page":"669","article-title":"Prediction about the targets and pathways of Jiangsuanchubi recipe on gout based on network pharmacology","volume":"35","author":"Xiao","year":"2018","journal-title":"J. Shenyang Pharm. Univ."},{"issue":"1","key":"10.1016\/j.jep.2020.112606_bib21","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/nar\/30.1.303","article-title":"DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions","volume":"30","author":"Xenarios","year":"2002","journal-title":"Nucleic Acids Res."},{"issue":"81","key":"10.1016\/j.jep.2020.112606_bib22","doi-asserted-by":"crossref","first-page":"51151","DOI":"10.1039\/C7RA10767F","article-title":"Comparative evaluations on phenolic antioxidants of nine adulterants and anti-inflammation of four alternatives with their original herb Erycibe schmidtii","volume":"7","author":"Xue","year":"2017","journal-title":"RSC Adv."},{"issue":"4","key":"10.1016\/j.jep.2020.112606_bib23","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.intimp.2012.07.024","article-title":"Inhibition of monosodium urate crystal-induced inflammation by scopoletin and underlying mechanisms","volume":"14","author":"Yao","year":"2012","journal-title":"Int. Immunopharm."},{"issue":"1","key":"10.1016\/j.jep.2020.112606_bib24","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s12906-018-2356-9","article-title":"Network pharmacology-based strategy to investigate pharmacological mechanisms of Zuojinwan for treatment of gastritis","volume":"18","author":"Yu","year":"2018","journal-title":"BMC Compl. Alternative Med."},{"issue":"1","key":"10.1016\/j.jep.2020.112606_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0014-5793(01)03293-8","article-title":"MINT: a Molecular INTeraction database","volume":"513","author":"Zanzoni","year":"2002","journal-title":"FEBS Lett."},{"issue":"4","key":"10.1016\/j.jep.2020.112606_bib26","first-page":"1","article-title":"Pharmacological basis for use of Selaginella moellendorffii in gouty arthritis: antihyperuricemic, anti-inflammatory, and xanthine oxidase inhibition","volume":"2017","author":"Zhao","year":"2017","journal-title":"Evid. base Compl. Alternative Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119344393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119344393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:29:42Z","timestamp":1759940982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874119344393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":26,"alternative-id":["S0378874119344393"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.112606","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of the mechanism of action of Porana sinensis Hemsl. against gout arthritis using network pharmacology and experimental validation","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.112606","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112606"}}