{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:47:53Z","timestamp":1789015673608,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.jep.2020.112668","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T11:32:19Z","timestamp":1581679939000},"page":"112668","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Different proteomic profiles of cinnabar upon therapeutic and toxic exposure reveal distinctive biological manifestations"],"prefix":"10.1016","volume":"253","author":[{"given":"Mimi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jep.2020.112668_bib1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1042\/CS20160211","article-title":"RNA splicing in human disease and in the clinic","volume":"131","author":"Baralle","year":"2017","journal-title":"Clin. Sci."},{"issue":"4","key":"10.1016\/j.jep.2020.112668_bib2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1242\/jeb.02014","article-title":"The V-type H+ ATPase: molecular structure and function, physiological roles and regulation","volume":"209","author":"Beyenbach","year":"2006","journal-title":"J. Exp. Biol."},{"issue":"8","key":"10.1016\/j.jep.2020.112668_bib3","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","article-title":"ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks","volume":"25","author":"Bindea","year":"2009","journal-title":"Bioinformatics"},{"issue":"22","key":"10.1016\/j.jep.2020.112668_bib4","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1093\/bioinformatics\/btp536","article-title":"QuickGO: a web-based tool for Gene Ontology searching","volume":"25","author":"Binns","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2020.112668_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/5653291","article-title":"Oxidative biochemistry disbalance and changes on proteomic profile in salivary glands of rats induced by chronic exposure to methylmercury","volume":"2017","author":"Bittencourt","year":"2017","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"10.1016\/j.jep.2020.112668_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0300-483X(01)00348-1","article-title":"Abnormal auditory brainstem responses for mice treated with mercurial compounds: involvement of excessive nitric oxide","volume":"162","author":"Chuu","year":"2001","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.jep.2020.112668_bib7","first-page":"128","article-title":"Effects of methyl mercury, mercuric sulfide and cinnabar on active avoidance responses, Na+\/K+-ATPase activities and tissue mercury contents in rats","volume":"25","author":"Chuu","year":"2001","journal-title":"Proc. Natl. Sci. Counc. Repub. China B"},{"issue":"3","key":"10.1016\/j.jep.2020.112668_bib8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s002100000279","article-title":"Neurotoxicity of mercury sulfide in the vestibular ocular reflex system of Guinea pigs","volume":"364","author":"Chuu","year":"2001","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2020.112668_bib9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.toxlet.2006.12.006","article-title":"Differential neurotoxic effects of methylmercury and mercuric sulfide in rats","volume":"169","author":"Chuu","year":"2007","journal-title":"Toxicol. Lett."},{"issue":"6","key":"10.1016\/j.jep.2020.112668_bib10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00204-007-0255-9","article-title":"Attenuation by methyl mercury and mercuric sulfide of pentobarbital induced hypnotic tolerance in mice through inhibition of ATPase activities and nitric oxide production in cerebral cortex","volume":"82","author":"Chuu","year":"2008","journal-title":"Arch. Toxicol."},{"issue":"12","key":"10.1016\/j.jep.2020.112668_bib11","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"10.1016\/j.jep.2020.112668_bib12","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: database for annotation, visualization, and integrated Discovery","volume":"4","author":"Dennis","year":"2003","journal-title":"Genome Biol."},{"issue":"8","key":"10.1016\/j.jep.2020.112668_bib13","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1084\/jem.20182238","article-title":"The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer's amyloid pathology","volume":"216","author":"Fan","year":"2019","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.jep.2020.112668_bib14","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.bbamcr.2013.02.014","article-title":"Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the resistance conferred by Bcl-2","volume":"1833","author":"Gallerne","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.jep.2020.112668_bib15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2017.107","article-title":"Sphingolipids and their metabolism in physiology and disease","volume":"19","author":"Hannun","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.jep.2020.112668_bib16","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.neuro.2008.01.005","article-title":"Ototoxicity induced by cinnabar (a naturally occurring HgS) in mice through oxidative stress and down-regulated Na(+)\/K(+)-ATPase activities","volume":"29","author":"Huang","year":"2008","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jep.2020.112668_bib17","series-title":"Neuroproteomics: Methods and Protocols","author":"Kobeissy","year":"2017"},{"issue":"1","key":"10.1016\/j.jep.2020.112668_bib18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-biochem-060614-034316","article-title":"Mechanisms and regulation of alternative pre-mRNA splicing","volume":"84","author":"Lee","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jep.2020.112668_bib19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.envpol.2018.03.019","article-title":"Methylmercury exposure alters RNA splicing in human neuroblastoma SK-N-SH cells: implications from proteomic and post-transcriptional responses","volume":"238","author":"Li","year":"2018","journal-title":"Environ. Pollut."},{"issue":"7","key":"10.1016\/j.jep.2020.112668_bib20","doi-asserted-by":"crossref","first-page":"810","DOI":"10.3181\/0712-MR-336","article-title":"Mercury in traditional medicines: is cinnabar toxicologically similar to common mercurials?","volume":"233","author":"Liu","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.jep.2020.112668_bib21","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jep.2017.08.037","article-title":"A review of cinnabar (HgS) and\/or realgar (As4S4)-containing traditional medicines","volume":"210","author":"Liu","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"Suppl. 5","key":"10.1016\/j.jep.2020.112668_bib22","first-page":"S22","article-title":"Vacuolar H(+)-ATPase in the kidney","volume":"15","author":"Nakhoul","year":"2002","journal-title":"J. Nephrol."},{"key":"10.1016\/j.jep.2020.112668_bib23","series-title":"Chinese Pharmacopeia Committee","year":"2015"},{"issue":"12","key":"10.1016\/j.jep.2020.112668_bib24","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1128\/MCB.00914-13","article-title":"Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain","volume":"34","author":"Piccoli","year":"2014","journal-title":"Mol. Cell Biol."},{"issue":"12","key":"10.1016\/j.jep.2020.112668_bib25","doi-asserted-by":"crossref","first-page":"28566","DOI":"10.3390\/ijms161226120","article-title":"Parallel reaction monitoring: a targeted experiment performed using high resolution and high mass accuracy mass spectrometry","volume":"16","author":"Rauniyar","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2020.112668_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tox.2016.03.001","article-title":"Proteome profiling reveals regional protein alteration in cerebrum of common marmoset (Callithrix jacchus) exposed to methylmercury","volume":"347\u2013349","author":"Shao","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.jep.2020.112668_bib27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.tiv.2019.02.013","article-title":"Proteome changes in methylmercury-exposed mouse primary cerebellar granule neurons and astrocytes","volume":"57","author":"Shao","year":"2019","journal-title":"Toxicol. Vitro"},{"issue":"12","key":"10.1016\/j.jep.2020.112668_bib28","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.130181","article-title":"Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage","volume":"3","author":"Sheridan","year":"2013","journal-title":"Open Biol"},{"issue":"5067","key":"10.1016\/j.jep.2020.112668_bib29","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1126\/science.1321493","article-title":"Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice","volume":"257","author":"Silva","year":"1992","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.jep.2020.112668_bib30","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1523\/JNEUROSCI.2068-16.2017","article-title":"A novel human CAMK2A mutation disrupts dendritic morphology and synaptic transmission, and causes ASD-related behaviors","volume":"37","author":"Stephenson","year":"2017","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.jep.2020.112668_bib31","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A next generation connectivity Map: L1000 platform and the first 1,000,000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.jep.2020.112668_bib32","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"issue":"1\u20133","key":"10.1016\/j.jep.2020.112668_bib33","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejphar.2007.03.018","article-title":"The anxiolytic effect of cinnabar involves changes of serotonin levels","volume":"565","author":"Wang","year":"2007","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2020.112668_bib34","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jep.2013.01.026","article-title":"A metabolic profiling analysis of the acute hepatotoxicity and nephrotoxicity of Zhusha Anshen Wan compared with cinnabar in rats using (1)H NMR spectroscopy","volume":"146","author":"Wang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112668_bib35","first-page":"1","article-title":"Cinnabar-induced subchronic renal injury is associated with increased apoptosis in rats","volume":"2015","author":"Wang","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2020.112668_bib36","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.jep.2020.112668_bib37","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1089\/omi.2015.0042","article-title":"(1)H NMR-based metabolomics and neurotoxicity study of cerebrum and cerebellum in rats treated with cinnabar, a traditional Chinese medicine","volume":"19","author":"Wei","year":"2015","journal-title":"OMICS"},{"key":"10.1016\/j.jep.2020.112668_bib38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-8695-8_1","article-title":"Filter-aided sample preparation for proteome analysis","volume":"1841","author":"Wisniewski","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.jep.2020.112668_bib39","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1186\/s12864-016-2864-2","article-title":"Quantitative analyses of the hepatic proteome of methylmercury-exposed Atlantic cod (Gadus morhua) suggest oxidative stress-mediated effects on cellular energy metabolism","volume":"17","author":"Yadetie","year":"2016","journal-title":"BMC Genom."},{"issue":"3","key":"10.1016\/j.jep.2020.112668_bib40","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1124\/jpet.110.172809","article-title":"Tipifarnib-induced apoptosis in acute myeloid leukemia and multiple myeloma cells depends on Ca2+ influx through plasma membrane Ca2+ channels","volume":"337","author":"Yanamandra","year":"2011","journal-title":"J. Pharmacol. Exp. Therapeut."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119346835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119346835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:32:38Z","timestamp":1759941158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874119346835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":40,"alternative-id":["S0378874119346835"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.112668","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Different proteomic profiles of cinnabar upon therapeutic and toxic exposure reveal distinctive biological manifestations","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.112668","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112668"}}