{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:27:06Z","timestamp":1790965626203,"version":"4.1.0"},"reference-count":120,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["KLEM-ZZ201904"],"award-info":[{"award-number":["KLEM-ZZ201904"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["KLEM-ZZ201906"],"award-info":[{"award-number":["KLEM-ZZ201906"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003512","name":"State Administration of Foreign Experts Affairs","doi-asserted-by":"publisher","award":["B08044"],"award-info":[{"award-number":["B08044"]}],"id":[{"id":"10.13039\/501100003512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003512","name":"State Administration of Foreign Experts Affairs","doi-asserted-by":"publisher","award":["BBZZKY-2019082"],"award-info":[{"award-number":["BBZZKY-2019082"]}],"id":[{"id":"10.13039\/501100003512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013801","name":"Minzu University of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014760","name":"Ministry of Ecology and Environment, The People\u2019s Republic of China","doi-asserted-by":"publisher","award":["2019HB2096001006"],"award-info":[{"award-number":["2019HB2096001006"]}],"id":[{"id":"10.13039\/501100014760","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020746","name":"Jiansheng Fresh Herb Medicine R and D Foundation","doi-asserted-by":"publisher","award":["JSYY-20190101-043"],"award-info":[{"award-number":["JSYY-20190101-043"]}],"id":[{"id":"10.13039\/501100020746","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020746","name":"Jiansheng Fresh Herb Medicine R and D Foundation","doi-asserted-by":"publisher","award":["YLDXXK201819"],"award-info":[{"award-number":["YLDXXK201819"]}],"id":[{"id":"10.13039\/501100020746","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31761143001"],"award-info":[{"award-number":["31761143001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870316"],"award-info":[{"award-number":["31870316"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007263","name":"Virginia Polytechnic Institute and State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.jep.2020.112686","type":"journal-article","created":{"date-parts":[[2020,2,23]],"date-time":"2020-02-23T09:09:01Z","timestamp":1582448941000},"page":"112686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":118,"special_numbering":"C","title":["Ethnopharmacology of Hypericum species in China: A comprehensive review on ethnobotany, phytochemistry and pharmacology"],"prefix":"10.1016","volume":"254","author":[{"given":"Ruifei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Kennelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.112686_bib1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.26650\/eor.2018.505","article-title":"The effect of Hypericum perforatum on wound healing of oral mucosa in diabetic rats","volume":"52","author":"Altan","year":"2018","journal-title":"Euro. Oral Res."},{"key":"10.1016\/j.jep.2020.112686_bib2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/10942910903189256","article-title":"In vitro antimicrobial and antioxidant activity of ethanol extract of three Hypericum and three Achillea species from Turkey","volume":"14","author":"Baris","year":"2011","journal-title":"Int. J. Food Prop."},{"key":"10.1016\/j.jep.2020.112686_bib3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.phytochem.2018.08.002","article-title":"Structural diversity and biological activities of phloroglucinol derivatives from Hypericum species","volume":"155","author":"Bridi","year":"2018","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2020.112686_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1055\/s-2002-19871","article-title":"Antiplatelet and anti-inflammatory constituents and new oxygenated xanthones from Hypericum geminiflorum","volume":"68","author":"Chung","year":"2002","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2020.112686_bib5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/0972060X.2014.895150","article-title":"Regulatory effect of Iranian Hypericum scabrum essential oils on hepatic metabolizing enzymes in rats treated by acetaminophen","volume":"18","author":"Dadkhah","year":"2015","journal-title":"J. Essent. Oil Bear. Pl."},{"key":"10.1016\/j.jep.2020.112686_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jep.2019.02.020","article-title":"Anti-quorum sensing and anti-biofilm activities of Hypericum perforatum L. extracts against Pseudomonas aeruginosa","volume":"235","author":"Do\u011fan","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112686_bib7","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1254\/jphs.FP0061088","article-title":"Antitumor activity of the methanol extract of Hypericum hookerianum stem against Ehrlich ascites carcinoma in Swiss albino mice","volume":"103","author":"Dongre","year":"2007","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.jep.2020.112686_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/ptr.2248","article-title":"Antitumor activity of Hypericum hookerianum against DLA induced tumor in mice and its possible mechanism of action","volume":"22","author":"Dongre","year":"2008","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2020.112686_bib9","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1016\/j.tetlet.2018.09.071","article-title":"Spirocyclic polycyclic polyprenylated acylphloroglucinols from the ethyl acetate fraction of Hypericum henryi","volume":"59","author":"Duan","year":"2018","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jep.2020.112686_bib10","doi-asserted-by":"crossref","first-page":"8234","DOI":"10.1039\/C9OB01500K","article-title":"Przewalcyrones A\u2013F, epoxychromene-containing polycyclic polyprenylated acylphloroglucinols with immunosuppressive activity from Hypericum przewalskii Maxim","volume":"17","author":"Duan","year":"2019","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.jep.2020.112686_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3389\/fphar.2013.00177","article-title":"The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety","volume":"4","author":"Ekor","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2020.112686_bib12","first-page":"2780","article-title":"Research progress on chemical constituents of Hypericum attenuatum and their pharmacological activities","volume":"48","author":"Feng","year":"2017","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.jep.2020.112686_bib13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/jphp.12775","article-title":"St John's wort for depression: scoping review about perceptions and use by general practitioners in clinical practice","volume":"71","author":"Forsdike","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2020.112686_bib14","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jep.2017.02.016","article-title":"Hypericum perforatum (St John's wort) beyond depression: a therapeutic perspective for pain conditions","volume":"200","author":"Galeotti","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112686_bib16","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s11011-017-0022-4","article-title":"Effects of Hypericum scabrum extract on learning and memory and oxidant\/antioxidant status in rats fed a long-term high-fat diet","volume":"32","author":"Ganji","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jep.2020.112686_bib17","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.fitote.2016.10.003","article-title":"Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum","volume":"115","author":"Gao","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2020.112686_bib15","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s11011-016-9940-9","article-title":"Effects of Hypericum scabrum extract on anxiety and oxidative stress biomarkers in rats fed a long-term high-fat diet","volume":"32","author":"Ganji","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jep.2020.112686_bib18","first-page":"3083","article-title":"Effect of compatibility of Hypericum attenuatum and Salvia miltiorrhiza extracts on myocardial ischemia in mice","volume":"27","author":"Gao","year":"2012","journal-title":"Chin. J. Trad. Chin. Med. Pharm."},{"key":"10.1016\/j.jep.2020.112686_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3109\/13880209.2013.821663","article-title":"Chemical composition and bioactivity of essential oils of Hypericum helianthemoides, Hypericum perforatum and Hypericum scabrum","volume":"52","author":"Ghasemi","year":"2014","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2020.112686_bib20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11101-012-9223-y","article-title":"Hypericum sp.: essential oil composition and biological activities","volume":"11","author":"Guedes","year":"2012","journal-title":"Phytochemistry Rev."},{"key":"10.1016\/j.jep.2020.112686_bib21","article-title":"Cytotoxic activity and apoptosis induction of Hypericum scabrum L. Iran","volume":"17","author":"Hamzeloo-Moghadam","year":"2015","journal-title":"Red. Crescent Med. J."},{"key":"10.1016\/j.jep.2020.112686_bib22","first-page":"65","article-title":"Study the botanical origin resource of Chinese drug Wang Pu Liu Shing","volume":"7","author":"Hsu","year":"1959","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.jep.2020.112686_bib23","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1021\/acs.orglett.6b00906","article-title":"Filicinic acid based meroterpenoids with anti-Epstein\u2013Barr virus activities from Hypericum japonicum","volume":"18","author":"Hu","year":"2016","journal-title":"Org. Lett."},{"key":"10.1016\/j.jep.2020.112686_bib24","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1016\/j.bmcl.2017.09.001","article-title":"Polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum scabrum","volume":"27","author":"Hu","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.jep.2020.112686_bib25","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1021\/acs.jnatprod.8b00176","article-title":"Methylated polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum ascyron","volume":"81","author":"Hu","year":"2018","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2020.112686_bib26","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1021\/acs.jnatprod.5b01119","article-title":"(\u00b1)-Japonicols A\u2013D, acylphloroglucinol-based meroterpenoid enantiomers with anti-KSHV activities from Hypericum japonicum","volume":"79","author":"Hu","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2020.112686_bib27","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3390\/molecules21040515","article-title":"Two new bioactive \u03b1-pyrones from Hypericum japonicum","volume":"21","author":"Hu","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2020.112686_bib28","doi-asserted-by":"crossref","first-page":"24101","DOI":"10.1039\/C8RA04073G","article-title":"Discovery of acylphloroglucinol-based meroterpenoid enantiomers as KSHV inhibitors from Hypericum japonicum","volume":"8","author":"Hu","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.jep.2020.112686_bib29","first-page":"50","article-title":"Study the botanical origin resource of lian qiao and han lian cao","volume":"4","author":"Huang","year":"1987","journal-title":"J. Chin. Med. Mater."},{"key":"10.1016\/j.jep.2020.112686_bib30","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3390\/molecules23051188","article-title":"Antioxidant activity and hepatoprotective potential of quercetin 7-rhamnoside in vitro and in vivo","volume":"23","author":"Huang","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2020.112686_bib31","volume":"vol. 2","author":"Huxley","year":"1992"},{"key":"10.1016\/j.jep.2020.112686_bib32","first-page":"132","article-title":"Ornamental Hypericum in China","volume":"145","author":"Ji","year":"2017","journal-title":"Bull. Nikitsky Bot. Gard."},{"issue":"18","key":"10.1016\/j.jep.2020.112686_bib33","first-page":"3701","article-title":"Chemical constituents of Hypericum stellatum and their antioxidant bioactivities","volume":"43","author":"Ji","year":"2018","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2020.112686_bib34","series-title":"Ethnobotanical and Phytochemical Studies on Hypericum Stellatum (Clusiaceae)","author":"Ji","year":"2018"},{"key":"10.1016\/j.jep.2020.112686_bib35","doi-asserted-by":"crossref","first-page":"11257","DOI":"10.3390\/molecules200611257","article-title":"Phytochemical profiling and evaluation of pharmacological activities of Hypericum scabrum L","volume":"20","author":"Jiang","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2020.112686_bib36","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jff.2018.11.031","article-title":"Hypoglycemic effect of Hypericum attenuatum Choisy extracts on type 2 diabetes by regulating glucolipid metabolism and modulating gut microbiota","volume":"52","author":"Jin","year":"2019","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.jep.2020.112686_bib37","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00044-010-9391-5","article-title":"\u03b1-Glucosidase inhibitory and antioxidant properties and antidiabetic activity of Hypericum ascyron L","volume":"20","author":"Kang","year":"2011","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.jep.2020.112686_bib38","first-page":"1","article-title":"Phytochemical compounds and antiradical, antimicrobial, and cytotoxic activities of the extracts from Hypericum scabrum L. flowers","volume":"2018","author":"Keser","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2020.112686_bib39","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/ptr.1460","article-title":"The antimicrobial activity of essential oils of Hypericum scabrum, Hypericum scabroides and Hypericum triquetrifolium","volume":"18","author":"K\u0131z\u0131l","year":"2004","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2020.112686_bib40","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/j.tetlet.2017.04.044","article-title":"seco-Polycyclic polyprenylated acylphloroglucinols with unusual carbon skeletons from Hypericum ascyron","volume":"58","author":"Kong","year":"2017","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jep.2020.112686_bib41","first-page":"171","article-title":"Plant resources of genus Hypericum L. in Yunnan","volume":"30","author":"Li","year":"2003","journal-title":"Acta Hortic. Sin."},{"key":"10.1016\/j.jep.2020.112686_bib42","article-title":"Chemical constituents from Hypericum erectum Thunb","volume":"1\u20138","author":"Li","year":"2019","journal-title":"Chin. J. Org. Chem."},{"key":"10.1016\/j.jep.2020.112686_bib43","series-title":"Clusiaceae (Guttiferae). Flora of China","author":"Li","year":"2009"},{"key":"10.1016\/j.jep.2020.112686_bib44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/bmc.3169","article-title":"Quality and antitumour activity evaluation of extract of Hypericum ascyron","volume":"29","author":"Li","year":"2015","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jep.2020.112686_bib45","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jep.2015.03.034","article-title":"The extract of Hypericum ascyron L. induces bacterial cell death through apoptosis pathway","volume":"166","author":"Li","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112686_bib46","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ejmech.2015.04.035","article-title":"Antibacterial active compounds from Hypericum ascyron L. induce bacterial cell death through apoptosis pathway","volume":"96","author":"Li","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jep.2020.112686_bib47","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.3892\/mmr.2015.4080","article-title":"Difference in protective effects of three structurally similar flavonoid glycosides from Hypericum ascyron against H2O2-induced injury in H9c2 cardiomyoblasts","volume":"12","author":"Li","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2020.112686_bib48","first-page":"3944","article-title":"Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L","volume":"15","author":"Li","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jep.2020.112686_bib49","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1021\/acs.jnatprod.8b00017","article-title":"Antibacterial dimeric acylphloroglucinols from Hypericum japonicum","volume":"81","author":"Li","year":"2018","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2020.112686_bib50","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.phytochem.2018.12.005","article-title":"Hyperbeanols F\u2013Q, diverse monoterpenoid polyprenylated acylphloroglucinols from the flowers of Hypericum beanii","volume":"159","author":"Li","year":"2019","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2020.112686_bib51","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1007\/s11426-016-0052-4","article-title":"Polyprenylated acylphloroglucinols from the fruits of Hypericum henryi","volume":"59","author":"Liao","year":"2016","journal-title":"Sci. China Chem."},{"key":"10.1016\/j.jep.2020.112686_bib52","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.phytochem.2017.06.011","article-title":"Polyprenylated acylphloroglucinols from Hypericum scabrum","volume":"142","author":"Liu","year":"2017","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2020.112686_bib53","doi-asserted-by":"crossref","first-page":"7953","DOI":"10.1021\/acs.orglett.8b03523","article-title":"Hypatulone A, a homoadamantane-type acylphloroglucinol with an intricately caged core from Hypericum patulum","volume":"20","author":"Liu","year":"2018","journal-title":"Org. Lett."},{"key":"10.1016\/j.jep.2020.112686_bib54","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.bioorg.2019.03.025","article-title":"Hyperpatulols A\u2013I, spirocyclic acylphloroglucinol derivatives with anti-migration activities from the flowers of Hypericum patulum","volume":"87","author":"Liu","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jep.2020.112686_bib55","first-page":"2119","article-title":"Influence of total flavonoids from Hypericum attenuatum Choisy. on L-type calcium channel currents of cardiomyocytes in arrhythmic model rats","volume":"31","author":"Ma","year":"2016","journal-title":"Chin. J. Trad. Chin. Med. Pharm."},{"key":"10.1016\/j.jep.2020.112686_bib56","first-page":"38","article-title":"Research of biologically active substances of Hypericum L. species","volume":"5","author":"Makovetska","year":"1998","journal-title":"Farm. Zh. (Kiev)"},{"key":"10.1016\/j.jep.2020.112686_bib57","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0009-9120(99)00075-2","article-title":"Antioxidant enzymes and human diseases","volume":"32","author":"Mat\u00e9s","year":"1999","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.jep.2020.112686_bib58","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0378-8741(99)00172-5","article-title":"Evaluation of in-vivo wound healing activity of Hypericum patulum (Family: hypericaceae) leaf extract on different wound model in rats","volume":"70","author":"Mukherjee","year":"2000","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112686_bib59","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/acm.2000.6.61","article-title":"The evaluation of wound-healing potential of Hypericum hookerianum leaf and stem extracts","volume":"6","author":"Mukherjee","year":"2000","journal-title":"J. Alternative Compl. Med."},{"key":"10.1016\/j.jep.2020.112686_bib60","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0367-326X(00)00331-2","article-title":"Antibacterial spectrum of Hypericum hookerianum","volume":"72","author":"Mukherjee","year":"2001","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2020.112686_bib61","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/ptr.1016","article-title":"Antimicrobial potential of two different Hypericum species available in India","volume":"16","author":"Mukherjee","year":"2002","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2020.112686_bib62","series-title":"St. John's Wort and its Active Principles in Depression and Anxiety","author":"M\u00fcller","year":"2005"},{"key":"10.1016\/j.jep.2020.112686_bib63","first-page":"779","article-title":"Nephroprotective effect of aqueous extract of aerial parts of Hypericum scabrum L. Toxicol","volume":"94","author":"Nabavi","year":"2012","journal-title":"Environ. Chem."},{"key":"10.1016\/j.jep.2020.112686_bib64","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1021\/np1000329","article-title":"Lessons learned from herbal medicinal products: the example of St. John's wort","volume":"73","author":"Nahrstedt","year":"2010","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2020.112686_bib65","first-page":"3","article-title":"Bioactive compounds from the aerial parts of Hypericum sampsonii","volume":"1","author":"Nguyen Viet","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2020.112686_bib66","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1021\/acs.jnatprod.9b00354","article-title":"Hypascyrins A\u2013E, prenylated acylphloroglucinols from Hypericum ascyron","volume":"82","author":"Niwa","year":"2019","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2020.112686_bib67","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3389\/fpls.2016.01004","article-title":"Neuroprotective activity of Hypericum perforatum and its major components","volume":"7","author":"Oliveira","year":"2016","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.jep.2020.112686_bib68","first-page":"10","article-title":"Clinical effect of external application of Hypericum attenuatum as a Chinese herbal medicine commonly used by Yao people in treatment of acute mastitis: an analysis of 60 cases","volume":"32","author":"Peng","year":"2016","journal-title":"Hunan J. Trad. Chin. Med."},{"key":"10.1016\/j.jep.2020.112686_bib69","first-page":"202","article-title":"Redefinition and analysis on \u201cYunnan Lianqiao\u201d in illustrated catalogue of plants","volume":"29","author":"Qi","year":"2014","journal-title":"Hebei J. Forest. Orch. Res."},{"key":"10.1016\/j.jep.2020.112686_bib70","first-page":"341","article-title":"\u201cSynonym\u201d and \u201chomonym\u201d of Hypericum","volume":"32","author":"Qi","year":"2017","journal-title":"Hebei J. Forest. Orchard Res."},{"key":"10.1016\/j.jep.2020.112686_bib71","doi-asserted-by":"crossref","first-page":"696","DOI":"10.17520\/biods.2017144","article-title":"Threatened species list of China's higher plants","volume":"25","author":"Qin","year":"2017","journal-title":"Biodivers. Sci."},{"key":"10.1016\/j.jep.2020.112686_bib72","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1080\/14786410902885070","article-title":"Antioxidant activity of Hypericum hookerianum Wight and Arn","volume":"23","author":"Raghu Chandrashekhar","year":"2009","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2020.112686_bib73","doi-asserted-by":"crossref","first-page":"181","DOI":"10.11646\/phytotaxa.255.3.1","article-title":"And then came molecular phylogenetics-Reactions to a monographic study of Hypericum (Hypericaceae)","volume":"255","author":"Robson","year":"2016","journal-title":"Phytotaxa"},{"key":"10.1016\/j.jep.2020.112686_bib74","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s10600-017-2022-3","article-title":"Chemical constituents of Hypericum petiolulatum","volume":"53","author":"Rui","year":"2017","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.jep.2020.112686_bib75","first-page":"1739","article-title":"Antioxidant, antimicrobial activities and fatty acid components of flower, leaf, stem and seed of Hypericum scabrum","volume":"6","author":"Shafaghat","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.jep.2020.112686_bib76","first-page":"904","article-title":"Omega-3 content, antimicrobial and antioxidant activities of hexanic extract from seed and leaf of Hypericum scabrum from Northwestern Iran","volume":"6","author":"Shafaghat","year":"2012","journal-title":"Afr. J. Microbiol. Res."},{"key":"10.1016\/j.jep.2020.112686_bib121","first-page":"128","article-title":"Study on antidepressant activity of different extracts from Hypericum wightianum","volume":"27","author":"Shi","year":"2012","journal-title":"West Chin. J. Pharma. Sci."},{"key":"10.1016\/j.jep.2020.112686_bib77","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.phytochem.2008.12.016","article-title":"Dibenzofuran and pyranone metabolites from Hypericum revolutum ssp. revolutum and Hypericum choisianum","volume":"70","author":"Shiu","year":"2009","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2020.112686_bib78","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0378-8741(98)00189-5","article-title":"The in vitro antibacterial activity of Turkish medicinal plants","volume":"67","author":"Sokmen","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112686_bib79","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1080\/17425255.2017.1378342","article-title":"Clinical risks of St john's wort (Hypericum perforatum) co-administration","volume":"13","author":"Soleymani","year":"2017","journal-title":"Expert Opin. Drug Met."},{"key":"10.1016\/j.jep.2020.112686_bib80","volume":"vols. 7\u20139","author":"State Administration of TCM","year":"2004"},{"key":"10.1016\/j.jep.2020.112686_bib81","volume":"vol. 1","year":"2015"},{"key":"10.1016\/j.jep.2020.112686_bib82","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.2174\/0929867311320180001","article-title":"Do other Hypericum species have medical potential as St. John's wort (Hypericum perforatum)?","volume":"20","author":"Stojanovic","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jep.2020.112686_bib83","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1021\/acs.orglett.6b02725","article-title":"Hypatulins A and B, meroterpenes from Hypericum patulum","volume":"18","author":"Tanaka","year":"2016","journal-title":"Org. Lett."},{"key":"10.1016\/j.jep.2020.112686_bib120","first-page":"24","article-title":"Chemical constituents isolated from Hypericum erectum Thunb.","volume":"32","author":"Tao","year":"2018","journal-title":"Chin. Med. J. Res. Prac."},{"key":"10.1016\/j.jep.2020.112686_bib85","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/ptr.1271","article-title":"In vitro cytotoxicity and antitumour properties of Hypericum mysorense and Hypericum patulum","volume":"17","author":"Vijayan","year":"2003","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2020.112686_bib86","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.phymed.2009.07.015","article-title":"Chemical constituents and antidepressant activity of the new species Hypericum enshiense occurring in China","volume":"17","author":"Wang","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2020.112686_bib87","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.scr.2018.07.003","article-title":"Extractive from Hypericum ascyron L. promotes serotonergic neuronal differentiation in vitro","volume":"31","author":"Wang","year":"2018","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.jep.2020.112686_bib122","first-page":"612","article-title":"\u8fde\u7fd8\u4e0e\u8d2f\u53f6\u8fde\u7fd8\u7684\u672c\u8349\u8003\u8bc1 [Botanical identification of lian qiao and guan ye lian qiao in classic text]","volume":"27","author":"Wu","year":"2002","journal-title":"Chin. J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2020.112686_bib88","first-page":"129","article-title":"Progress on modern researches of Hypericum attenuatum","volume":"35","author":"Wu","year":"2018","journal-title":"Inf. Trad. Chin. Med."},{"key":"10.1016\/j.jep.2020.112686_bib89","series-title":"New Platform for Chinese Material Medica","author":"Wu","year":"1988"},{"key":"10.1016\/j.jep.2020.112686_bib90","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/13880200701739405","article-title":"A naturally occurring inhibitory agent from Hypericum sampsonii with activity against multidrug-resistant staphylococcus aureus","volume":"46","author":"Xiao","year":"2008","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2020.112686_bib91","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.gene.2017.07.063","article-title":"Hyperoside protects against hypoxia\/reoxygenation induced injury in cardiomyocytes by suppressing the Bnip3 expression","volume":"629","author":"Xiao","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.jep.2020.112686_bib92","first-page":"322","article-title":"Chemical constituents of ethyl acetate fraction from Hypericum ascyron","volume":"39","author":"Xu","year":"2016","journal-title":"J. Chin. Med. Mater."},{"key":"10.1016\/j.jep.2020.112686_bib93","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1021\/acs.jnatprod.5b00066","article-title":"Hypermongones A\u2013J, rare methylated polycyclic polyprenylated acylphloroglucinols from the flowers of Hypericum monogynum","volume":"78","author":"Xu","year":"2015","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2020.112686_bib94","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1021\/acs.jnatprod.6b00251","article-title":"Polyprenylated tetraoxygenated xanthones from the roots of Hypericum monogynum and their neuroprotective activities","volume":"79","author":"Xu","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2020.112686_bib95","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1039\/C6QO00620E","article-title":"Furanmonogones A and B: two rearranged acylphloroglucinols with a 4, 5-seco-3(2H)-furanone core from the flowers of Hypericum monogynum","volume":"4","author":"Xu","year":"2017","journal-title":"Org. Chem. Front."},{"key":"10.1016\/j.jep.2020.112686_bib96","doi-asserted-by":"crossref","first-page":"8558","DOI":"10.1021\/acs.orglett.9b03098","article-title":"Hyperberins A and B, type B polycyclic polyprenylated acylphloroglucinols with bicyclo [5.3. 1] hendecane Core from Hypericum beanii","volume":"21","author":"Xu","year":"2019","journal-title":"Org. Lett."},{"key":"10.1016\/j.jep.2020.112686_bib97","doi-asserted-by":"crossref","first-page":"26646","DOI":"10.1039\/C8RA05322G","article-title":"Hyperelatosides A\u2013E, biphenyl ether glycosides from Hypericum elatoides, with neurotrophic activity","volume":"8","author":"Yan","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.jep.2020.112686_bib98","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.phytochem.2018.12.011","article-title":"Polycyclic polyprenylated acylphloroglucinol and phenolic metabolites from the aerial parts of Hypericum elatoides and their neuroprotective and anti-neuroinflammatory activities","volume":"159","author":"Yan","year":"2019","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2020.112686_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2019.112049","article-title":"Phenolic constituents with neuroprotective activities from Hypericum wightianum","volume":"165","author":"Yang","year":"2019","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2020.112686_bib100","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.tet.2016.12.042","article-title":"Homo-adamantane type polyprenylated acylphloroglucinols from Hypericum pseudohenryi","volume":"73","author":"Yang","year":"2017","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jep.2020.112686_bib101","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1021\/acs.chemrev.7b00551","article-title":"Research progress of polycyclic polyprenylated acylphloroglucinols","volume":"118","author":"Yang","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jep.2020.112686_bib102","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.fitote.2018.12.014","article-title":"homo-Adamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum hookerianum","volume":"133","author":"Ye","year":"2019","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2020.112686_bib103","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1093\/carcin\/bgl046","article-title":"Hypericum sampsonii induces apoptosis and nuclear export of retinoid X receptor-alpha","volume":"27","author":"Zeng","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jep.2020.112686_bib106","first-page":"9","article-title":"Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum","volume":"1","author":"Zeng","year":"2019","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2020.112686_bib108","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.phytol.2017.06.023","article-title":"Novel degraded polycyclic polyprenylated acylphloroglucinol and new polyprenylated benzophenone from Hypericum sampsonii","volume":"21","author":"Zhang","year":"2017","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.jep.2020.112686_bib110","doi-asserted-by":"crossref","first-page":"233","DOI":"10.17660\/ActaHortic.2015.1087.28","article-title":"Potential ornamental plants in Clusiaceae of China","volume":"1087","author":"Zhang","year":"2015","journal-title":"Acta Hortic."},{"key":"10.1016\/j.jep.2020.112686_bib104","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1039\/C8OB00650D","article-title":"Hypermonins A and B, two 6-norpolyprenylated acylphloroglucinols with unprecedented skeletons from Hypericum monogynum","volume":"16","author":"Zeng","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.jep.2020.112686_bib105","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.fitote.2017.12.013","article-title":"Chromanopyrones and a flavone from Hypericum monogynum","volume":"125","author":"Zeng","year":"2018","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2020.112686_bib111","series-title":"Ethnobotanical Study on Clusiaceae Plants","author":"Zhang","year":"2016"},{"key":"10.1016\/j.jep.2020.112686_bib112","article-title":"Polyphenolic chemical constituents from Hypericum ascyron","volume":"23","author":"Zhang","year":"2017","journal-title":"Chin. J. Appl. Environ. Biol."},{"key":"10.1016\/j.jep.2020.112686_bib109","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1186\/1471-2407-14-689","article-title":"Jacarelhyperol A induced apoptosis in leukaemia cancer cell through inhibition the activity of Bcl-2 proteins","volume":"14","author":"Zhang","year":"2014","journal-title":"BMC Canc."},{"key":"10.1016\/j.jep.2020.112686_bib113","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/cbdv.201300304","article-title":"Recent advances regarding constituents and bioactivities of plants from the genus Hypericum","volume":"12","author":"Zhao","year":"2015","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jep.2020.112686_bib114","first-page":"1755","article-title":"Ethyl acetate-soluble chemical constituents from branch of Hypericum petiolulatum","volume":"40","author":"Zhao","year":"2015","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2020.112686_bib115","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/10286020.2019.1581175","article-title":"Hyperascyrins L\u2212 N, rare methylated polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum ascyron","volume":"21","author":"Zhen","year":"2019","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2020.112686_bib116","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1021\/acs.jnatprod.5b00667","article-title":"Polycyclic polyprenylated derivatives from Hypericum uralum: neuroprotective effects and antidepressant-like activity of uralodin A","volume":"79","author":"Zhou","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2020.112686_bib117","doi-asserted-by":"crossref","first-page":"86710","DOI":"10.1039\/C6RA17885E","article-title":"Sampbenzophenones A\u2013G, prenylated benzoylphloroglucinol derivatives from Hypericum sampsonii","volume":"6","author":"Zhu","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.jep.2020.112686_bib118","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.3892\/mmr.2015.4086","article-title":"Ethyl acetate extract of Hypericum japonicum induces apoptosis via the mitochondria-dependent pathway in vivo and in vitro","volume":"12","author":"Zhuang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2020.112686_bib119","first-page":"151","article-title":"Study of the sources and identification of liu ji nu in hunan","volume":"22","author":"Zu","year":"2013","journal-title":"Chin. Pharm."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411933644X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411933644X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:31:23Z","timestamp":1759941083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887411933644X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":120,"alternative-id":["S037887411933644X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.112686","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ethnopharmacology of Hypericum species in China: A comprehensive review on ethnobotany, phytochemistry and pharmacology","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.112686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112686"}}