{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:03:09Z","timestamp":1787508189490,"version":"build-2736575974"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.jep.2020.112689","type":"journal-article","created":{"date-parts":[[2020,2,23]],"date-time":"2020-02-23T01:18:11Z","timestamp":1582420691000},"page":"112689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["A network pharmacology approach to investigating the mechanism of Tanshinone IIA for the treatment of liver fibrosis"],"prefix":"10.1016","volume":"253","author":[{"given":"Miao-Juan","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Li","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben-Sheng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Na","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Bing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.112689_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7629724","article-title":"Clinical advancements in the targeted therapies against liver fibrosis","author":"Bansal","year":"2016","journal-title":"Mediat. Inflamm."},{"issue":"2","key":"10.1016\/j.jep.2020.112689_bib2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.jep.2020.112689_bib3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bbadis.2017.11.001","article-title":"PGE2 induces apoptosis of hepatic stellate cells and attenuates liver fibrosis in mice by downregulating miR-23a-5p and miR-28a-5p","volume":"1864","author":"Brea","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.jep.2020.112689_bib4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1742-7843.2009.00465.x","article-title":"Tanshinone II A induces apoptosis and S phase cell cycle arrest in activated rat hepatic stellate cells","volume":"106","author":"Che","year":"2010","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.jep.2020.112689_bib5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1177\/1756283X11413002","article-title":"Current status of novel antifibrotic therapies in patients with chronic liver disease","volume":"4","author":"Cohen-Naftaly","year":"2011","journal-title":"Therap. Adv. Gastroenterol."},{"issue":"4","key":"10.1016\/j.jep.2020.112689_bib6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11655-013-1433-7","article-title":"Treatment of posthepatitic cirrhosis by Fuzheng Huayu Tablet for reinforcing qi and resolvingstasis","volume":"19","author":"Deng","year":"2013","journal-title":"Chin. J. Integr. Med."},{"issue":"5","key":"10.1016\/j.jep.2020.112689_bib7","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: database for annotation, visualization, and integrated discovery","volume":"4","author":"Dennis G","year":"2003","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.jep.2020.112689_bib8","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.apjtm.2017.05.012","article-title":"Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepaticstellate cell activation\/proliferation and induction of apoptosis","volume":"10","author":"El-Lakkany","year":"2017","journal-title":"Asian. Pac. J. Trop. Med."},{"issue":"Database issue","key":"10.1016\/j.jep.2020.112689_bib9","doi-asserted-by":"crossref","first-page":"D514","DOI":"10.1093\/nar\/gki033","article-title":"Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders","volume":"33","author":"Hamosh","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2020.112689_bib10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ","volume":"117","author":"Iredale","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2020.112689_bib11","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ejphar.2015.07.047","article-title":"Inhibition of cytochrome P450 2J2 by tanshinone IIA induces apoptotic celldeath in hepatocellular carcinoma HepG2 cells","volume":"764","author":"Jeon","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2020.112689_bib12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s12975-017-0526-6","article-title":"Sodium tanshinone IIA sulfonate enhances effectiveness rt-PA treatment in acute ischemic stroke patients associated with ameliorating blood-brain barrier damage","volume":"8","author":"Ji","year":"2017","journal-title":"Transl. Stroke. Res."},{"issue":"6","key":"10.1016\/j.jep.2020.112689_bib13","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0168-8278(99)80260-8","article-title":"Expression of cyclins D1, D2 and E correlates with proliferation of rat stellatecells in culture","volume":"30","author":"Kawada","year":"1999","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.jep.2020.112689_bib14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/emm.2005.43","article-title":"Cell cycle protein profile of the hepatic stellate cells (HSCs) in dimethylnitrosamine-induced rat hepatic fibrosis","volume":"37","author":"Kim","year":"2005","journal-title":"Exp. Mol. Med."},{"issue":"2\u20133","key":"10.1016\/j.jep.2020.112689_bib15","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ejphar.2007.07.042","article-title":"Tanshinone congeners improve memory impairments induced by scopolamine on passiveavoidance tasks in mice","volume":"574","author":"Kim","year":"2007","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2020.112689_bib16","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1248\/bpb.32.220","article-title":"Protective effect of Tanshinone IIA on the early stage of experimental diabetic nephropathy","volume":"32","author":"Kim","year":"2009","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.jep.2020.112689_bib17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"Database issue","key":"10.1016\/j.jep.2020.112689_bib18","first-page":"D684","article-title":"STITCH: interaction networks of chemicals and proteins","volume":"36","author":"Kuhn","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.jep.2020.112689_bib19","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.celrep.2018.06.057","article-title":"Differences in cell cycle status underlie transcriptional heterogeneity in the HSC compartment","volume":"24","author":"Lauridsen","year":"2018","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.jep.2020.112689_bib20","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/gutjnl-2014-306842","article-title":"Pathobiology of liver fibrosis: a translational success story","volume":"64","author":"Lee","year":"2015","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.jep.2020.112689_bib21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1049\/iet-syb:20060032","article-title":"Understanding ZHENG in traditional Chinese medicine in the context of neuro-endocrine-immune network","volume":"1","author":"Li","year":"2007","journal-title":"IET Syst. Biol."},{"key":"10.1016\/j.jep.2020.112689_bib22","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.intimp.2015.06.032","article-title":"Tanshinone IIA represses inflammatory response and reduces radiculopathic pain by inhibitingIRAK-1 and NF-\u03baB\/p38\/JNK signaling","volume":"28","author":"Li","year":"2015","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2020.112689_bib23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.biopha.2018.12.019","article-title":"Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation","volume":"111","author":"Li","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2020.112689_bib24","article-title":"An NQO1-initiated and p53-independent apoptotic pathway determines the anti-tumor effect of tanshinone IIA against non-small cell lung cancer","volume":"7","author":"Liu","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.jep.2020.112689_bib25","doi-asserted-by":"crossref","first-page":"21146","DOI":"10.1038\/srep21146","article-title":"BATMAN-TCM: a bioinformatics analysis tool for molecular mechANism of traditional Chinese medicine","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jep.2020.112689_bib26","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.jep.2014.07.010","article-title":"Tanshinone IIA, a major component of Salvia milthorriza Bunge, inhibits platelet activation via Erk-2 signaling pathway","volume":"155","author":"Maione","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2020.112689_bib27","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1053\/j.gastro.2008.03.001","article-title":"Diagnosis and quantitation of fibrosis","volume":"134","author":"Manning","year":"2008","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.jep.2020.112689_bib28","doi-asserted-by":"crossref","first-page":"650","DOI":"10.4161\/auto.7.6.15248","article-title":"Targeting phospshatidylinositol 3-kinase signaling with novelphosphatidylinositol 3,4,5-triphosphate antagonists","volume":"7","author":"Miao","year":"2011","journal-title":"Autophagy"},{"issue":"11","key":"10.1016\/j.jep.2020.112689_bib29","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1016\/j.celrep.2015.11.030","article-title":"Stem cell-specific mechanisms ensure genomic fidelity within HSCs and upon aging of HSCs","volume":"13","author":"Moehrle","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2020.112689_bib30","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1016\/j.febslet.2007.05.050","article-title":"Wnt signaling enhances the activation and survival of human hepatic stellate cells","volume":"581","author":"Myung","year":"2007","journal-title":"FEBS Lett."},{"issue":"10","key":"10.1016\/j.jep.2020.112689_bib31","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.bbadis.2013.06.001","article-title":"Overexpression of c-myc in hepatocytes promotes activation of hepatic stellatecells and facilitates the onset of liver fibrosis","volume":"1832","author":"Nevzorova","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.jep.2020.112689_bib32","first-page":"137","article-title":"Clinical efficiency of tanshinone IIA-sulfonate in treatment of liver fibrosis of advanced schistosomiasis","volume":"25","author":"Niu","year":"2013","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"issue":"1","key":"10.1016\/j.jep.2020.112689_bib33","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1053\/j.gastro.2004.10.003","article-title":"Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis","volume":"128","author":"Oakley","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2020.112689_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/734987","article-title":"Explore the molecular mechanism of apoptosis induced by tanshinone IIA on activated rat hepatic stellate cells","author":"Pan","year":"2012","journal-title":"Evid. Based. Complement. Alternat. Med."},{"issue":"3","key":"10.1016\/j.jep.2020.112689_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092216","article-title":"The complex regulation of tanshinone IIA in rats with hypertension-induced left ventricular hypertrophy","volume":"9","author":"Pang","year":"2014","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.jep.2020.112689_bib36","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s12272-014-0425-2","article-title":"Anti-fibrotic effect of PF2401-SF, a standardized fraction of Salvia miltiorrhiza, in thioacetamide-induced experimental rats liver fibrosis","volume":"38","author":"Parajuli","year":"2015","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2020.112689_bib37","doi-asserted-by":"crossref","first-page":"762","DOI":"10.3389\/fphar.2018.00762","article-title":"Salvia miltiorrhiza ameliorates liver fibrosis by activating hepatic natural killer cells in vivo and in vitro","volume":"9","author":"Peng","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.jep.2020.112689_bib38","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1074\/jbc.M212927200","article-title":"The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression","volume":"278","author":"Reif","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2020.112689_bib39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejphar.2016.11.046","article-title":"Tanshinone IIA induced cell death via miR30b-p53-PTPN11\/SHP2 signaling pathway in human hepatocellular carcinoma cells","volume":"796","author":"Ren","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2020.112689_bib40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminf."},{"key":"10.1016\/j.jep.2020.112689_bib41","series-title":"GeneCards Version 3: the Human Gene Integrator","author":"Safran","year":"2010"},{"issue":"9","key":"10.1016\/j.jep.2020.112689_bib42","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1038\/s41418-018-0239-8","article-title":"The transcription factor c-Jun\/AP-1 promotes liver fibrosis during non-alcoholic steatohepatitis by regulating Osteopontin expression","volume":"26","author":"Schulien","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2020.112689_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/756519","article-title":"The effect of sodium tanshinone IIA sulfate and simvastatin on elevated serum levels of inflammatory markers in patients with coronary heart disease: a study protocol for a randomized controlled trial","volume":"2013","author":"Shang","year":"2013","journal-title":"Evid. Based. Complement. Alternat. Med."},{"issue":"11","key":"10.1016\/j.jep.2020.112689_bib44","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.jep.2020.112689_bib45","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jep.2019.01.027","article-title":"A network pharmacology approach to investigate the blood enriching mechanism of Dangguibuxue Decoction","volume":"235","author":"Shi","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"D1","key":"10.1016\/j.jep.2020.112689_bib46","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"9930","key":"10.1016\/j.jep.2020.112689_bib47","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","article-title":"Liver cirrhosis","volume":"383","author":"Tsochatzis","year":"2014","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jep.2020.112689_bib48","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jep.2012.10.044","article-title":"Hydrogen peroxide-mediated oxidative stress and collagen synthesis in cardiac fibroblasts: blockade by tanshinone IIA","volume":"145","author":"Wang","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"18","key":"10.1016\/j.jep.2020.112689_bib49","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1073\/pnas.1621375114","article-title":"Unifying mechanism for different fibrotic diseases","volume":"114","author":"Wernig","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jep.2020.112689_bib50","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/0-387-24180-9_5","article-title":"NF-kappaB, an evolutionarily conserved mediator of immune and inflammatory responses","volume":"560","author":"Xiao","year":"2005","journal-title":"Adv. Exp. Med. Biol."},{"issue":"7440","key":"10.1016\/j.jep.2020.112689_bib51","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nature10977","article-title":"Modernization: one step at a time","volume":"495","author":"Xu","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jep.2020.112689_bib52","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","article-title":"Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis","volume":"54","author":"Xu","year":"2005","journal-title":"Gut"},{"issue":"Database issue","key":"10.1016\/j.jep.2020.112689_bib53","first-page":"D1089","article-title":"TCMID: traditional Chinese Medicine integrative database for herb molecular mechanism analysis","volume":"41","author":"Xue","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2020.112689_bib54","first-page":"965","article-title":"Complete remission of acute promyelocytic leukemia resisting all-trans retinoic acid of one case treated by tanshinone II A","volume":"37","author":"Yang","year":"2006","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.jep.2020.112689_bib55","first-page":"1065","article-title":"A successful case of tanshinone II A treatment for relapsed acute promyelocytic leukemia after maintenance therapy of all-trans retinoic acid and arsenic trioxide","volume":"41","author":"Yang","year":"2010","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"issue":"8","key":"10.1016\/j.jep.2020.112689_bib56","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/s11655-016-2540-z","article-title":"Fuzheng Huayu Formula prevents rat renal interstitial fibrosis induced by HgCl2 via antioxidative stress and down-regulation of nuclear factor-kappa B activity","volume":"23","author":"Yuan","year":"2017","journal-title":"Chin. J. Integr. Med."},{"issue":"1","key":"10.1016\/j.jep.2020.112689_bib57","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jhep.2014.03.009","article-title":"Traditional Chinese Medicine (TCM) for fibrotic liver disease: hope and hype","volume":"61","author":"Zhang","year":"2014","journal-title":"J. Hepatol."},{"issue":"12","key":"10.1016\/j.jep.2020.112689_bib58","first-page":"1794","article-title":"Sodium tanshinone IIA silate as an add-on therapy in patients with unstable angina pectoris","volume":"6","author":"Zhang","year":"2014","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.jep.2020.112689_bib59","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jep.2015.01.047","article-title":"Tanshinone IIA exerts protective effects in a LCA-induced cholestatic liver model associated with participation of pregnane X receptor","volume":"164","author":"Zhang","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2020.112689_bib60","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.18632\/oncotarget.23262","article-title":"MiR-27a as a predictor for the activation of hepatic stellate cells and hepatitis B virus-induced liver cirrhosis","volume":"9","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.jep.2020.112689_bib61","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S2095-4964(14)60039-X","article-title":"Traditional Chinese medicine for treatment of liver diseases: progress, challenges and opportunities","volume":"12","author":"Zhao","year":"2014","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.jep.2020.112689_bib62","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.3389\/fphar.2018.01448","article-title":"Systems pharmacology dissection of multi-scale mechanisms of action of huo-Xiang-Zheng-QiFormula for the treatment of gastrointestinal diseases","volume":"9","author":"Zhao","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2020.112689_bib63","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.resp.2014.09.025","article-title":"Tanshinone IIA attenuates hypoxic pulmonary hypertension via modulating KV currents","volume":"205","author":"Zheng","year":"2015","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"6","key":"10.1016\/j.jep.2020.112689_bib64","first-page":"2694","article-title":"The Chinese medicine, Jianpi Huayu Decoction, inhibits the epithelial mesenchymal transition via the regulation of the Smad3\/Smad7 cascade","volume":"9","author":"Zhong","year":"2017","journal-title":"Am. J. Transl. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411934615X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411934615X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:32:16Z","timestamp":1759941136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887411934615X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":64,"alternative-id":["S037887411934615X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.112689","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A network pharmacology approach to investigating the mechanism of Tanshinone IIA for the treatment of liver fibrosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.112689","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112689"}}