{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:33:11Z","timestamp":1774657991421,"version":"3.50.1"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jep.2020.112883","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T19:08:45Z","timestamp":1587236925000},"page":"112883","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Contribution of salidroside to the relieve of symptom and sign in the early acute stage of osteoarthritis in rat model"],"prefix":"10.1016","volume":"259","author":[{"given":"Lina","family":"Sa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daigang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruhuan","family":"Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.112883_bib1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/s13075-016-1154-3","article-title":"Protein oxidation, nitration and glycation biomarkers for early-stage diagnosis of osteoarthritis of the knee and typing and progression of arthritic disease","volume":"18","author":"Ahmed","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2020.112883_bib2","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1136\/ard.2004.025270","article-title":"Synovial tissue inflammation in early and late osteoarthritis","volume":"64","author":"Benito","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2020.112883_bib3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrrheum.2010.213","article-title":"The role of mitochondria in osteoarthritis","volume":"7","author":"Blanco","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2020.112883_bib4","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S1063-4584(03)00163-8","article-title":"Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis","volume":"11","author":"Bove","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jep.2020.112883_bib5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/art.38279","article-title":"In vivo luminescent imaging of NF-\u03baB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis","volume":"66","author":"Bowles","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2020.112883_bib6","first-page":"575","volume":"vol. 71","author":"Cai","year":"2019"},{"key":"10.1016\/j.jep.2020.112883_bib7","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.ijcard.2016.04.108","article-title":"Cardioprotective effects of salidroside on myocardial ischemia-reperfusion injury in coronary artery occlusion-induced rats and Langendorff-perfused rat hearts","volume":"215","author":"Chang","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jep.2020.112883_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jep.2020.112883_bib9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1142\/S0192415X16500373","article-title":"Traditional Chinese medications for knee osteoarthritis pain: a meta-analysis of randomized controlled trials","volume":"44","author":"Chen","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2020.112883_bib11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jfda.2015.04.007","article-title":"Rhodiola plants: chemistry and biological activity","volume":"23","author":"Chiang","year":"2015","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.jep.2020.112883_bib12","series-title":"Pharmacopoeia of the People's Republic of China","year":"2015"},{"issue":"9","key":"10.1016\/j.jep.2020.112883_bib13","first-page":"3312","article-title":"Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals","volume":"9","author":"Chow","year":"2003","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.jep.2020.112883_bib14","series-title":"Jing Zhu Ben Cao","author":"Dge-b\u015bes","year":"1986"},{"key":"10.1016\/j.jep.2020.112883_bib15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/BOR.0b013e32835a0fe1","article-title":"Use of imaging techniques to predict progression in osteoarthritis","volume":"25","author":"Ding","year":"2013","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jep.2020.112883_bib16","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.joca.2003.11.008","article-title":"Site specific changes in gene expression and cartilage metabolism during early experimental osteoarthritis","volume":"12","author":"Dumond","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jep.2020.112883_bib17","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1111\/j.1476-5381.2010.00640.x","article-title":"Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan-induced knee joint synovitis in the rat","volume":"159","author":"Ekundi-Valentim","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2020.112883_bib18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0304-4165(86)90306-5","article-title":"Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue","volume":"883","author":"Farndale","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2020.112883_bib19","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jpain.2008.05.012","article-title":"Assessment of movement-evoked pain in osteoarthritis by the knee-bend and CatWalk tests: a clinically relevant study","volume":"9","author":"Ferreira-Gomes","year":"2008","journal-title":"J. Pain"},{"key":"10.1016\/j.jep.2020.112883_bib20","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2020.112883_bib21","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/BOR.0b013e328349c2b1","article-title":"Inflammation in osteoarthritis","volume":"23","author":"Goldring","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jep.2020.112883_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0076-6879(96)68026-4","article-title":"Quantitation of nitrate and nitrite in extracellular fluids","volume":"268","author":"Grisham","year":"1996","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jep.2020.112883_bib23","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3109\/08923973.2011.567988","article-title":"Adjuvant effects of salidroside from Rhodiola rosea L. on the immune responses to ovalbumin in mice","volume":"33","author":"Guan","year":"2011","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.jep.2020.112883_bib24","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/art.1780400917","article-title":"Mono-iodoacetate-induced experimental osteoarthritis: a dose-response study of loss of mobility, morphology, and biochemistry","volume":"40","author":"Guingamp","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2020.112883_bib25","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.3390\/molecules17044733","article-title":"Simultaneous determination of salidroside and its aglycone metabolite p-tyrosol in rat plasma by liquid chromatography-tandem mass spectrometry","volume":"17","author":"Guo","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2020.112883_bib26","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/01926230390241800","article-title":"Mono-iodoacetate-induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis","volume":"31","author":"Guzman","year":"2003","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.jep.2020.112883_bib27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbrc.2010.06.033","article-title":"Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells","volume":"398","author":"Hu","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2020.112883_bib28","first-page":"291","article-title":"Protective effect of synthetic salidroside on acute lung injury in rats","volume":"69","author":"Huang","year":"2017","journal-title":"Sheng Li Xue Bao"},{"key":"10.1016\/j.jep.2020.112883_bib29","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2020.112883_bib30","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/annrheumdis-2013-203413","article-title":"Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain","volume":"74","author":"Kelly","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2020.112883_bib31","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/art.38053","article-title":"A lipidomic study of phospholipid classes and species in human synovial fluid","volume":"65","author":"Kosinska","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2020.112883_bib32","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1089\/jmf.2017.4034","article-title":"The combination of probiotic complex, rosavin, and zinc improves pain and cartilage destruction in an osteoarthritis rat model","volume":"21","author":"Kwon","year":"2018","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2020.112883_bib33","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ijcard.2014.04.132","article-title":"Protective effect of salidroside on cardiac apoptosis in mice with chronic intermittent hypoxia","volume":"174","author":"Lai","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jep.2020.112883_bib34","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2018.09.025","article-title":"Redox and NF-\u03baB signaling in osteoarthritis","volume":"132","author":"Lepetsos","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2020.112883_bib35","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1182\/blood-2011-10-387332","article-title":"Salidroside stimulates DNA repair enzyme Parp-1 activity in mouse HSC maintenance","volume":"119","author":"Li","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jep.2020.112883_bib36","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jpba.2014.11.036","article-title":"An UPLC-MS-based metabolomics investigation on the anti-fatigue effect of salidroside in mice","volume":"105","author":"Ma","year":"2015","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2020.112883_bib37","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrrheum.2013.138","article-title":"Towards a mechanism-based approach to pain management in osteoarthritis","volume":"9","author":"Malfait","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2020.112883_bib38","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.joca.2013.06.003","article-title":"A commentary on modelling osteoarthritis pain in small animals","volume":"21","author":"Malfait","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jep.2020.112883_bib39","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2106\/00004623-197153030-00009","article-title":"Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data","volume":"53","author":"Mankin","year":"1971","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jep.2020.112883_bib40","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nrrheum.2012.80","article-title":"Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis","volume":"8","author":"Mapp","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2020.112883_bib41","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/joor.12679","article-title":"The efficacy of curcumin in managing acute inflammation pain on the post-surgical removal of impacted third molars patients: a randomised controlled trial","volume":"45","author":"Maulina","year":"2018","journal-title":"J. Oral Rehabil."},{"key":"10.1016\/j.jep.2020.112883_bib42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03baB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.jep.2020.112883_bib43","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-biophys-083012-130338","article-title":"Molecular basis of NF-\u03baB signaling","volume":"42","author":"Napetschnig","year":"2013","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.jep.2020.112883_bib44","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12031-017-0951-8","article-title":"Salidroside ameliorates diabetic neuropathic pain in rats by inhibiting neuroinflammation","volume":"63","author":"Ni","year":"2017","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.jep.2020.112883_bib45","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1359\/JBMR.040322","article-title":"Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor)","volume":"19","author":"Nishida","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jep.2020.112883_bib46","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.phymed.2010.02.002","article-title":"Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy","volume":"17","author":"Panossian","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2020.112883_bib47","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1097\/j.pain.0000000000001052","article-title":"Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis","volume":"158","author":"Philpott","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.jep.2020.112883_bib48","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jep.2016.09.021","article-title":"Efficacy and safety of Derris scandens (Roxb.) Benth. for musculoskeletal pain treatment: a systematic review and meta-analysis of randomized controlled trials","volume":"194","author":"Puttarak","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112883_bib49","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jep.2010.09.025","article-title":"Salidroside promotes erythropoiesis and protects erythroblasts against oxidative stress by up-regulating glutathione peroxidase and thioredoxin","volume":"133","author":"Qian","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112883_bib50","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nrrheum.2015.135","article-title":"Strategies for the prevention of knee osteoarthritis","volume":"12","author":"Roos","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2020.112883_bib51","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/BOR.0000000000000353","article-title":"Role of low-grade inflammation in osteoarthritis","volume":"29","author":"Scanzello","year":"2017","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jep.2020.112883_bib52","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jep.2014.04.010","article-title":"The genus Inula and their metabolites: from ethnopharmacological to medicinal uses","volume":"154","author":"Seca","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112883_bib53","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrrheum.2010.159","article-title":"The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis","volume":"6","author":"Sellam","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2020.112883_bib54","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1002\/art.21239","article-title":"The presence of molecular markers of in vivo lipid peroxidation in osteoarthritic cartilage: a pathogenic role in osteoarthritis","volume":"52","author":"Shah","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2020.112883_bib55","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/BOR.0000000000000351","article-title":"Recent developments in emerging therapeutic targets of osteoarthritis","volume":"29","author":"Sun","year":"2017","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jep.2020.112883_bib56","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1089\/ars.2000.2.4-681","article-title":"Serum 4-hydroxy-2-nonenal-modified albumin is elevated in patients with type 2 diabetes mellitus","volume":"2","author":"Toyokuni","year":"2000","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jep.2020.112883_bib57","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.ejpain.2008.09.008","article-title":"Differential analgesic effects of morphine and gabapentin on behavioural measures of pain and disability in a model of osteoarthritis pain in rats","volume":"13","author":"Vonsy","year":"2009","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.jep.2020.112883_bib58","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s12035-014-8755-0","article-title":"Protective effects of salidroside in the MPTP\/MPP(+)-induced model of Parkinson's disease through ROS-NO-related mitochondrion pathway","volume":"51","author":"Wang","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jep.2020.112883_bib59","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.pharmthera.2018.02.015","article-title":"Nutraceuticals and osteoarthritis pain","volume":"187","author":"Wang","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jep.2020.112883_bib60","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s10753-017-0573-x","article-title":"Salidroside inhibits inflammation through PI3K\/akt\/HIF signaling after focal cerebral ischemia in rats","volume":"40","author":"Wei","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2020.112883_bib61","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/humupd\/dmm015","article-title":"Evolution of medical treatment for endometriosis: back to the roots?","volume":"13","author":"Wieser","year":"2007","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jep.2020.112883_bib62","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/jcb.27076","article-title":"Salidroside attenuates interleukin-1\u03b2-induced inflammation in human osteoarthritis chondrocytes","volume":"120","author":"Zhang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jep.2020.112883_bib63","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/s41419-018-1024-9","article-title":"Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration","volume":"9","author":"Zhang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2020.112883_bib64","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3109\/01480540903373654","article-title":"Evaluation of salidroside in vitro and in vivo genotoxicity","volume":"33","author":"Zhu","year":"2010","journal-title":"Drug Chem. Toxicol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119345945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119345945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:32:35Z","timestamp":1759941155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874119345945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":63,"alternative-id":["S0378874119345945"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.112883","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Contribution of salidroside to the relieve of symptom and sign in the early acute stage of osteoarthritis in rat model","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.112883","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112883"}}