{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:23:55Z","timestamp":1783383835174,"version":"3.54.6"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.jep.2020.112887","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T19:08:42Z","timestamp":1587236922000},"page":"112887","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Total flavonoids from Anchusa italica Retz. Improve cardiac function and attenuate cardiac remodeling post myocardial infarction in mice"],"prefix":"10.1016","volume":"257","author":[{"given":"Shoubao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junke","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianhua","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhua","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2020.112887_bib1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3892\/etm.2016.3328","article-title":"Attenuation effect of Abnormal Savda Munziq on liver and heart toxicity caused by chemotherapy in mice","volume":"12","author":"Aikemu","year":"2016","journal-title":"Exp Ther Med"},{"issue":"5","key":"10.1016\/j.jep.2020.112887_bib2","first-page":"7","article-title":"The pharmacology of Anchusa italica and Anchusa strigosa. A review","volume":"6","author":"Al-snafi","year":"2014","journal-title":"Int. J. Pharm. Pharmaceut. Sci."},{"issue":"12","key":"10.1016\/j.jep.2020.112887_bib3","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.jacc.2013.11.053","article-title":"The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries","volume":"63","author":"Ambrosy","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"issue":"18","key":"10.1016\/j.jep.2020.112887_bib4","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.2174\/138161211796390976","article-title":"Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure","volume":"17","author":"Aoyagi","year":"2011","journal-title":"Curr. Pharmaceut. Des."},{"issue":"7","key":"10.1016\/j.jep.2020.112887_bib5","first-page":"1091","article-title":"Poly[3-(3,4-dihydroxyphenyl)glyceric acid] from Anchusa italica roots","volume":"5","author":"Barbakadze","year":"2010","journal-title":"Nat Prod Commun"},{"issue":"8","key":"10.1016\/j.jep.2020.112887_bib6","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1080\/14786419.2016.1258557","article-title":"A new oleanolic-type triterpene glycoside from Anchusa italica","volume":"31","author":"Chen","year":"2017","journal-title":"Nat. Prod. Res."},{"issue":"3","key":"10.1016\/j.jep.2020.112887_bib7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1172\/JCI24178","article-title":"Protein kinase cascades in the regulation of cardiac hypertrophy","volume":"115","author":"Dorn","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.jep.2020.112887_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s12906-018-2273-y","article-title":"Perceptions of traditional Chinese medicine for chronic disease care and prevention: a cross-sectional study of Chinese hospital-based health care professionals","volume":"18","author":"Fan","year":"2018","journal-title":"BMC Compl. Alternative Med."},{"issue":"12","key":"10.1016\/j.jep.2020.112887_bib9","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1161\/CIRCRESAHA.110.223925","article-title":"A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse","volume":"107","author":"Gao","year":"2010","journal-title":"Circ. Res."},{"issue":"11","key":"10.1016\/j.jep.2020.112887_bib10","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/bph.13708","article-title":"Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response?","volume":"174","author":"Goszcz","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2020.112887_bib11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ejphar.2015.05.056","article-title":"Kaempferol protects cardiomyocytes against anoxia\/reoxygenation injury via mitochondrial pathway mediated by SIRT1","volume":"761","author":"Guo","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2020.112887_bib12","first-page":"87","article-title":"Review: dietary phenolic compounds, health benefits and bioaccessibility","volume":"66","author":"GutiErrez-Grijalva","year":"2016","journal-title":"Arch. Latinoam. Nutr."},{"issue":"2","key":"10.1016\/j.jep.2020.112887_bib13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ejhf.696","article-title":"Myocardial fibrosis: biomedical research from bench to bedside","volume":"19","author":"Gyongyosi","year":"2017","journal-title":"Eur. J. Heart Fail."},{"issue":"11","key":"10.1016\/j.jep.2020.112887_bib14","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1056\/NEJMsa050467","article-title":"Major causes of death among men and women in China","volume":"353","author":"He","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.jep.2020.112887_bib15","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00395-013-0356-y","article-title":"How can we cure a heart \"in flame\"? A translational view on inflammation in heart failure","volume":"108","author":"Hofmann","year":"2013","journal-title":"Basic Res. Cardiol."},{"issue":"21","key":"10.1016\/j.jep.2020.112887_bib16","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1080\/14786419.2017.1320789","article-title":"Anti-complementary constituents of Anchusa italica","volume":"31","author":"Hou","year":"2017","journal-title":"Nat. Prod. Res."},{"issue":"3","key":"10.1016\/j.jep.2020.112887_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.5530\/amdhs.2019.3.10","article-title":"A comprehensive review on pharmacognostical and pharmacological characters of Anchusa azurea","volume":"2","author":"Hussain","year":"2019","journal-title":"Adv Med Dental Health Sci"},{"key":"10.1016\/j.jep.2020.112887_bib18","doi-asserted-by":"crossref","first-page":"15881","DOI":"10.1038\/srep15881","article-title":"The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload","volume":"5","author":"Ikeda","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2020.112887_bib19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/bs.afnr.2017.12.001","article-title":"Polyphenols and their interactions with other dietary compounds: implications for human health","volume":"84","author":"Kardum","year":"2018","journal-title":"Adv. Food Nutr. Res."},{"issue":"1","key":"10.1016\/j.jep.2020.112887_bib20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.15420\/cfr.2018:1:1","article-title":"A review of plant-based diets to prevent and treat heart failure","volume":"4","author":"Kerley","year":"2018","journal-title":"Card. Fail. Rev."},{"issue":"7\u20138","key":"10.1016\/j.jep.2020.112887_bib21","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1515\/znc-2012-7-802","article-title":"Investigation on anti-inflammatory and antiulcer activities of Anchusa azurea extracts and their major constituent rosmarinic acid","volume":"67","author":"Kuruuzum-Uz","year":"2012","journal-title":"Z Naturforsch C J Biosci"},{"issue":"11","key":"10.1016\/j.jep.2020.112887_bib22","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1139\/cjpp-2012-0432","article-title":"Quercetin provides greater cardioprotective effect than its glycoside derivative rutin on isoproterenol-induced cardiac fibrosis in the rat","volume":"91","author":"Li","year":"2013","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2020.112887_bib23","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1159\/000447884","article-title":"Short-term hesperidin pretreatment attenuates rat myocardial ischemia\/reperfusion injury by inhibiting high mobility group box 1 protein expression via the PI3K\/Akt pathway","volume":"39","author":"Li","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"issue":"7","key":"10.1016\/j.jep.2020.112887_bib24","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1161\/CIRCRESAHA.116.302317","article-title":"Innate immunity and the failing heart: the cytokine hypothesis revisited","volume":"116","author":"Mann","year":"2015","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.jep.2020.112887_bib25","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3945\/ajcn.111.016634","article-title":"Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults","volume":"95","author":"McCullough","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jep.2020.112887_bib26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fcvm.2019.00032","article-title":"Three in a box: understanding cardiomyocyte, fibroblast, and innate immune cell interactions to orchestrate cardiac repair processes","volume":"6","author":"Psarras","year":"2019","journal-title":"Front Cardiovasc Med"},{"issue":"4","key":"10.1016\/j.jep.2020.112887_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/nu9040415","article-title":"Association of polyphenol biomarkers with cardiovascular disease and mortality risk: a systematic review and meta-analysis of observational studies","volume":"9","author":"Rienks","year":"2017","journal-title":"Nutrients"},{"issue":"1\u20132","key":"10.1016\/j.jep.2020.112887_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11010-016-2767-1","article-title":"Cardioprotective effects of rutin via alteration in TNF-alpha, CRP, and BNP levels coupled with antioxidant effect in STZ-induced diabetic rats","volume":"420","author":"Saklani","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.jep.2020.112887_bib29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"6","key":"10.1016\/j.jep.2020.112887_bib30","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1152\/japplphysiol.00033.2007","article-title":"Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches","volume":"102","author":"Takagawa","year":"2007","journal-title":"J. Appl. Physiol."},{"issue":"3","key":"10.1016\/j.jep.2020.112887_bib31","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00441-016-2431-9","article-title":"Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration","volume":"365","author":"Talman","year":"2016","journal-title":"Cell Tissue Res."},{"issue":"1","key":"10.1016\/j.jep.2020.112887_bib32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12967-017-1191-y","article-title":"Apoptosis in ischemic heart disease","volume":"15","author":"Teringova","year":"2017","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.jep.2020.112887_bib33","doi-asserted-by":"crossref","DOI":"10.1590\/s2175-97902018000117251","article-title":"Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion","volume":"54","author":"Torki","year":"2018","journal-title":"Braz J Pharm Sci"},{"issue":"4","key":"10.1016\/j.jep.2020.112887_bib34","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2515\/therapie:2004083","article-title":"Uighur traditional medicine syndrome of Abnormal Savda in men is associated with oxidative stress, which can be improved by Munziq and Mushil of Abnormal Savda","volume":"59","author":"Upur","year":"2004","journal-title":"Therapie"},{"issue":"1","key":"10.1016\/j.jep.2020.112887_bib35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cardiores.2005.04.012","article-title":"Myocyte apoptosis in heart failure","volume":"67","author":"van Empel","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jep.2020.112887_bib36","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5278218","article-title":"Kaempferide protects against myocardial ischemia\/reperfusion injury through activation of the PI3K\/Akt\/GSK-3beta pathway","volume":"2017","author":"Wang","year":"2017","journal-title":"Mediat. Inflamm."},{"issue":"1","key":"10.1016\/j.jep.2020.112887_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S000711451300278X","article-title":"Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studies","volume":"111","author":"Wang","year":"2014","journal-title":"Br. J. Nutr."},{"issue":"5","key":"10.1016\/j.jep.2020.112887_bib38","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2131\/jts.43.329","article-title":"Protective effects of rutin on lipopolysaccharide-induced heart injury in mice","volume":"43","author":"Xianchu","year":"2018","journal-title":"J. Toxicol. Sci."},{"issue":"6","key":"10.1016\/j.jep.2020.112887_bib39","first-page":"875","article-title":"[Effect and mechanism of total flavonoids of bugloss on rats with myocardial ischemia and reperfusion injury]","volume":"49","author":"Xu","year":"2014","journal-title":"Yao Xue Xue Bao"},{"key":"10.1016\/j.jep.2020.112887_bib40","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cbi.2018.10.016","article-title":"Rutin alleviates hypoxia\/reoxygenation-induced injury in myocardial cells by up-regulating SIRT1 expression","volume":"297","author":"Yang","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2020.112887_bib41","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7670854","article-title":"Naringenin attenuates myocardial ischemia-reperfusion injury via cGMP-PKGIalpha signaling and in vivo and in vitro studies","volume":"2019","author":"Yu","year":"2019","journal-title":"Oxid Med Cell Longev"},{"issue":"12","key":"10.1016\/j.jep.2020.112887_bib42","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.cardfail.2017.09.014","article-title":"Contemporary epidemiology, management, and outcomes of patients hospitalized for heart failure in China: results from the China heart failure (China-HF) registry","volume":"23","author":"Zhang","year":"2017","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.jep.2020.112887_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/481405","article-title":"Protective effects of kaempferol against myocardial ischemia\/reperfusion injury in isolated rat heart via antioxidant activity and inhibition of glycogen synthase kinase-3beta","author":"Zhou","year":"2015","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"10.1016\/j.jep.2020.112887_bib44","doi-asserted-by":"crossref","first-page":"H435","DOI":"10.1152\/ajpheart.00597.2018","article-title":"Innate immune response in the pathogenesis of heart failure in survivors of myocardial infarction","volume":"316","author":"Zimmer","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119347087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874119347087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:34:19Z","timestamp":1759941259000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874119347087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":44,"alternative-id":["S0378874119347087"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.112887","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Total flavonoids from Anchusa italica Retz. Improve cardiac function and attenuate cardiac remodeling post myocardial infarction in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.112887","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112887"}}