{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:51:28Z","timestamp":1791564688538,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["395502"],"award-info":[{"award-number":["395502"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jep.2020.112965","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T21:36:58Z","timestamp":1589319418000},"page":"112965","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["derived 5,6,8-trihydroxy-7,4\u2032 dimethoxy flavone inhibits ergosterol synthesis and the production of hyphae and biofilm in"],"prefix":"10.1016","volume":"259","author":[{"given":"Mrudula","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vartika","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijaz","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.112965_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10096-010-1050-8","article-title":"Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candida","volume":"30","author":"Ahmad","year":"2011","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.jep.2020.112965_bib2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.micpath.2009.10.001","article-title":"Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida","volume":"48","author":"Ahmad","year":"2010","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.jep.2020.112965_bib3","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.2174\/1381612822666160607072748","article-title":"Challenges in the development of antifungal agents against Candida: scope of phytochemical research","volume":"22","author":"Ahmad","year":"2016","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.jep.2020.112965_bib4","first-page":"45","volume":"9","author":"Al Aboody","year":"2020"},{"key":"10.1016\/j.jep.2020.112965_bib5","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1091\/mbc.e06-10-0931","article-title":"Identification of an N-acetylglucosamine transporter that mediates hyphal induction in Candida albicans","volume":"18","author":"Alvarez","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jep.2020.112965_bib6","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3934\/bioeng.2018.3.192","article-title":"Inhibition of Candida albicans biofilm by lipopeptide AC7 coated medical-grade silicone in combination with farnesol","volume":"5","author":"Ceresa","year":"2018","journal-title":"AIMS Bioeng."},{"key":"10.1016\/j.jep.2020.112965_bib7","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1038\/nprot.2008.192","article-title":"In vitro growth and analysis of Candida biofilms","volume":"3","author":"Chandra","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jep.2020.112965_bib8","series-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. Approved Standard M27-A3","author":"Clinical and Laboratory Standards Institute","year":"2008"},{"key":"10.1016\/j.jep.2020.112965_bib9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s12275-016-5621-y","article-title":"Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans","volume":"54","author":"Douglas","year":"2016","journal-title":"J. Microbiol."},{"key":"10.1016\/j.jep.2020.112965_bib10","first-page":"148","article-title":"The antimicrobial activity of 27 southern African members of the Combretaceae","volume":"95","author":"Eloff","year":"1999","journal-title":"South Afr. J. Sci."},{"key":"10.1016\/j.jep.2020.112965_bib11","doi-asserted-by":"crossref","first-page":"e576","DOI":"10.4317\/jced.51798","article-title":"Current treatment of oral candidiasis: a literature review","volume":"6","author":"Garcia-Cuesta","year":"2014","journal-title":"J. Clin. Exp. Dent."},{"key":"10.1016\/j.jep.2020.112965_bib12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0254-6299(16)30456-2","article-title":"Extraction of antibacterial compounds from Combretum microphyllum (Combretaceae) S","volume":"68","author":"Kotz\u00e9","year":"2002","journal-title":"Afr. J. Bot."},{"key":"10.1016\/j.jep.2020.112965_bib13","doi-asserted-by":"crossref","first-page":"e02396","DOI":"10.1128\/AAC.02396-16","article-title":"The emerging pathogen Candida auris: growth phenotype, virulence factors, activity of antifungals, and effect of SCY-078, a novel glucan synthesis inhibitor, on growth morphology and biofilm formation","volume":"61","author":"Larkin","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"issue":"Pt 11","key":"10.1016\/j.jep.2020.112965_bib14","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1099\/mic.0.051086-0","article-title":"Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formation","volume":"157","author":"Lattif","year":"2011","journal-title":"Microbiology"},{"issue":"1","key":"10.1016\/j.jep.2020.112965_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/femsyr\/foy003","article-title":"Apigenin induces cell shrinkage in Candida albicans by membrane perturbation","volume":"18","author":"Lee","year":"2018","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.jep.2020.112965_bib16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1186\/s12906-015-0934-7","article-title":"Isolation and characterization of an antifungal compound 5-hydroxy-7,4'-dimethoxyflavone from Combretum zeyheri","volume":"15","author":"Mangoyi","year":"2015","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2020.112965_bib17","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1128\/EC.3.3.675-684.2004","article-title":"Lipid raft polarization contributes to hyphal growth in Candida albicans","volume":"3","author":"Martin","year":"2004","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.jep.2020.112965_bib18","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1534\/g3.116.033969","article-title":"Proper sterol distribution is required for Candida albicans hyphal formation and virulence","volume":"6","author":"McCourt","year":"2016","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.jep.2020.112965_bib19","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1128\/aem.63.7.2897-2905.1997","article-title":"Development of the FUN-1 family of fluorescent probes for vacuole labelling and viability testing of yeasts","volume":"63","author":"Millard","year":"1997","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jep.2020.112965_bib20","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.micinf.2011.06.009","article-title":"Candida albicans interactions with epithelial cells and mucosal immunity","volume":"13","author":"Naglik","year":"2011","journal-title":"Microb. Infect."},{"key":"10.1016\/j.jep.2020.112965_bib21","doi-asserted-by":"crossref","first-page":"261978","DOI":"10.1155\/2013\/261978","article-title":"Dodonaea viscosa var. angustifolia inhibits biofilm and germ tube formation by C. albicans","volume":"2013","author":"Naicker","year":"2013","journal-title":"Evid. Based Complement Alternat. Med."},{"key":"10.1016\/j.jep.2020.112965_bib22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.sajb.2017.05.024","article-title":"Identification of 5,6,8-Trihydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one with antimicrobial activity from Dodonaea viscosa var. angustifolia","author":"Ngabaza","year":"2017","journal-title":"S. Afr. J. Bot112"},{"key":"10.1016\/j.jep.2020.112965_bib23","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1128\/EC.00194-06","article-title":"Function of Candida albicans adhesin Hwp1 in biofilm formation","volume":"5","author":"Nobile","year":"2006","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.jep.2020.112965_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jep.2008.03.009","article-title":"Antifungal activity of the plant Dodonaea viscosa var. angustifolia on Candida albicans from HIV infected patients","volume":"118","author":"Patel","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112965_bib25","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jep.2009.05.002","article-title":"The effect of Dodonaea viscosa var. angustifolia on Candida albicans proteinase and phospholipase production and adherence to oral epithelial cells","volume":"124","author":"Patel","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112965_bib26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijantimicag.2011.02.016","article-title":"Candida bloodstream infections: comparison of species distribution and resistance to echinocandin and azole antifungal agents in Intensive Care Unit (ICU) and non-ICU settings in the SENTRY Antimicrobial Surveillance Program (2008-2009)","volume":"38","author":"Pfaller","year":"2011","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.jep.2020.112965_bib27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.phymed.2012.09.029","article-title":"\u03b2-Asarone, an active principle of Acorus calamus rhizome, inhibits morphogenesis, biofilm formation and ergosterol biosynthesis in Candida albicans","volume":"20","author":"Rajput","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2020.112965_bib28","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3389\/fmicb.2019.00677","article-title":"Confocal Laser Scanning Microscopy for analysis of Pseudomonas aeruginosa biofilm architecture and matrix localization","volume":"10","author":"Reichhardt","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2020.112965_bib29","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1080\/08927014.2019.1604948","article-title":"Antifungal effects of the flavonoids kaempferol and quercetin: a possible alternative for the control of fungal biofilms","volume":"35","author":"Rocha","year":"2019","journal-title":"Biofouling"},{"key":"10.1016\/j.jep.2020.112965_bib30","doi-asserted-by":"crossref","first-page":"104586","DOI":"10.1016\/j.archoralbio.2019.104586","article-title":"Anti-acidogenic, anti-biofilm and slow release properties of Dodonaea viscosa var. angustifolia flavone stabilized polymeric nanoparticles","volume":"109","author":"Sebelemetja","year":"2020","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.jep.2020.112965_bib31","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.archoralbio.2016.08.030","article-title":"Review of flavonoids: a diverse group of natural compounds with anti-Candida albicans activity in vitro","volume":"76","author":"Seleem","year":"2017","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.jep.2020.112965_bib32","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1099\/jmm.0.047852-0","article-title":"In vitro antifungal activity of the flavonoid baicalein against Candida species","volume":"61","author":"Serpa","year":"2012","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.jep.2020.112965_bib33","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jbiosc.2016.03.013","article-title":"Anti-biofilm activity of the metabolites of Streptomyces chrestomyceticus strain ADP4 against Candida albicans","volume":"122","author":"Srivastava","year":"2016","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.jep.2020.112965_bib34","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.micres.2016.12.008","article-title":"Antifungal activity of ionic liquids based on (\u2212)-menthol: a mechanism study","volume":"197","author":"Suchodolski","year":"2017","journal-title":"Microbiol. Res."},{"issue":"3","key":"10.1016\/j.jep.2020.112965_bib35","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3390\/12030593","article-title":"Characterization of flavonoid subgroups and hydroxy substitution by HPLC-MS\/MS","volume":"12","author":"Tsimogiannis","year":"2007","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2020.112965_bib36","series-title":"Medicinal Plants of South Africa","first-page":"108","author":"Van Wyk","year":"2002"},{"issue":"55","key":"10.1016\/j.jep.2020.112965_bib37","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1600-0757.2009.00338.x","article-title":"Candida biofilms and oral candidosis: treatment and prevention","volume":"2000","author":"Williams","year":"2011","journal-title":"Periodontol"},{"key":"10.1016\/j.jep.2020.112965_bib38","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.bbamem.2014.11.019","article-title":"Fungicidal effect of isoquercitrin via inducing membrane disturbance","volume":"1848","author":"Yun","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2020.112965_bib39","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12906-017-1773-5","article-title":"Membrane of Candida albicans as a target of berberine","volume":"17","author":"Zori\u0107","year":"2017","journal-title":"BMC Compl. Alternative Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412030951X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412030951X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:34:22Z","timestamp":1759941262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412030951X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":39,"alternative-id":["S037887412030951X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.112965","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dodonaea viscosa var angustifolia derived 5,6,8-trihydroxy-7,4\u2032 dimethoxy flavone inhibits ergosterol synthesis and the production of hyphae and biofilm in Candida albicans","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.112965","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112965"}}