{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:25:52Z","timestamp":1778599552687,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008783","name":"National Research Council of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008783","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.jep.2020.112999","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T02:32:25Z","timestamp":1590201145000},"page":"112999","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["An unbiased lipidomics approach identifies key lipid molecules as potential therapeutic targets of Dohongsamul-tang against non-alcoholic fatty liver diseases in a mouse model of obesity"],"prefix":"10.1016","volume":"260","author":[{"given":"Seong-hwan","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jueun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Seob","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geum-Sook","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeeyoun","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.112999_bib1","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.2337\/dc17-1318","article-title":"Specific hepatic sphingolipids relate to insulin resistance, oxidative stress, and inflammation in nonalcoholic steatohepatitis","volume":"41","author":"Apostolopoulou","year":"2018","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jep.2020.112999_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-1-4614-0650-1_6","article-title":"Sphingolipids and hepatic steatosis","volume":"721","author":"Bikman","year":"2011","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jep.2020.112999_bib3","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.jep.2020.112999_bib4","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-019-2596-3","article-title":"Evaluation of HuoXueHuaYu therapy for nonalcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trial","author":"Cai","year":"2019","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2020.112999_bib5","doi-asserted-by":"crossref","first-page":"10297","DOI":"10.1074\/jbc.M212307200","article-title":"A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids","volume":"278","author":"Chavez","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2020.112999_bib6","first-page":"257","article-title":"Study on TCM syndrome of nonalcoholic fatty liver disease","volume":"5","author":"Che","year":"2008","journal-title":"J. Integr. Tradit. West. Med. Liver Dis."},{"key":"10.1016\/j.jep.2020.112999_bib7","doi-asserted-by":"crossref","DOI":"10.3791\/55178","article-title":"Optimized analysis of in vivo and in vitro hepatic steatosis","author":"Cui","year":"2017","journal-title":"JoVE"},{"key":"10.1016\/j.jep.2020.112999_bib8","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1021\/bi00219a001","article-title":"Static and dynamic lipid asymmetry in cell membranes","volume":"30","author":"Devaux","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/j.jep.2020.112999_bib9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1136\/postgradmedj-2013-100404rep","article-title":"Republished: non-alcoholic fatty liver disease: a practical approach to treatment","volume":"91","author":"Dyson","year":"2015","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.jep.2020.112999_bib10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/978-3-319-48382-5_19","article-title":"Non-alcoholic fatty liver disease","volume":"960","author":"Engin","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jep.2020.112999_bib11","doi-asserted-by":"crossref","DOI":"10.1194\/jlr.R066514","article-title":"Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment","author":"Ertunc","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jep.2020.112999_bib12","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/pds.1804","article-title":"Case series of liver failure associated with rosiglitazone and pioglitazone","volume":"18","author":"Floyd","year":"2009","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.jep.2020.112999_bib13","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/hep.21687","article-title":"Effects of rosiglitazone on the liver histology and mitochondrial function in ob\/ob mice","volume":"46","author":"Garc\u00eda-Ruiz","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2020.112999_bib14","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1172\/JCI3135","article-title":"CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy","volume":"102","author":"Greenbaum","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2020.112999_bib15","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.1998.78.3.783","article-title":"Understanding adipocyte differentiation","author":"Gregoire","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jep.2020.112999_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/nrm2391","article-title":"Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes","author":"Guilherme","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jep.2020.112999_bib17","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3748\/wjg.v8.i6.1059","article-title":"Effect of bax, bcl-2 and bcl-xL on regulating apoptosis in tissues of normal liver and hepatocellular carcinoma","volume":"8","author":"Guo","year":"2002","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2020.112999_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/nrendo.2016.98","article-title":"Lipidomics for studying metabolism","author":"Han","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jep.2020.112999_bib19","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1046\/j.1463-1326.2003.00268.x","article-title":"Rapid reversal of hepatic steatosis, and reduction of muscle triglyceride, by rosiglitazone: MRI\/S studies in Zucker fatty rats","volume":"5","author":"Hockings","year":"2003","journal-title":"Diabetes Obes. Metabol."},{"key":"10.1016\/j.jep.2020.112999_bib20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2007.01.002","article-title":"Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance","volume":"5","author":"Holland","year":"2007","journal-title":"Cell Metabol."},{"issue":"1","key":"10.1016\/j.jep.2020.112999_bib21","first-page":"72","article-title":"Influence of medicinal herbal drug on the experimental model of thrombosis in animal","volume":"10","author":"Jeong","year":"1996","journal-title":"Kor. J. Orient. Pathol."},{"key":"10.1016\/j.jep.2020.112999_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jchromb.2017.08.003","article-title":"Chaihu-Shu-Gan-San regulates phospholipids and bile acid metabolism against hepatic injury induced by chronic unpredictable stress in rat","volume":"1064","author":"Jia","year":"2017","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jep.2020.112999_bib23","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1096\/fj.14-253187","article-title":"Plasma lipidomics discloses metabolic syndrome with a specific HDL phenotype","volume":"28","author":"Jov\u00e9","year":"2014","journal-title":"Faseb. J."},{"key":"10.1016\/j.jep.2020.112999_bib24","doi-asserted-by":"crossref","first-page":"G77","DOI":"10.1152\/ajpgi.00301.2011","article-title":"Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis","volume":"302","author":"Kakisaka","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jep.2020.112999_bib25","doi-asserted-by":"crossref","first-page":"9895","DOI":"10.1074\/jbc.271.17.9895","article-title":"Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1","volume":"271","author":"Kanety","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2020.112999_bib26","doi-asserted-by":"crossref","DOI":"10.1007\/s12013-007-0030-9","article-title":"Insulin signaling and glucose transport in insulin resistant human skeletal muscle","author":"Karlsson","year":"2007","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.jep.2020.112999_bib27","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.2337\/db12-0363","article-title":"A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults","volume":"62","author":"Kien","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.jep.2020.112999_bib28","doi-asserted-by":"crossref","first-page":"238","DOI":"10.9729\/AM.2017.47.4.238","article-title":"A histological study on the visual cell layer of the endemic Korean species Liobagrus mediadiposalis (Pisces: Amblycipitidae)","volume":"47","author":"Kim","year":"2017","journal-title":"Appl. Microsc."},{"key":"10.1016\/j.jep.2020.112999_bib29","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1142\/S0192415X0700493X","article-title":"Anti-inflammatory effect of dohongsamultang through inhibition of nuclear factor-kappaB activation in peripheral blood mononuclear cells of patients with cerebral infarction","volume":"35","author":"Kim","year":"2007","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2020.112999_bib30","article-title":"Lipidomic analysis reveals therapeutic effects of Yijin-Tang on high-fat\/high-cholesterol diet-induced obese mice","volume":"152936","author":"Lee","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2020.112999_bib31","first-page":"1868","article-title":"Progression of clinical application and experimental research of peach kernel and carthamus four substances decoction","volume":"28","author":"Lian","year":"2010","journal-title":"Chin. Arch. Tradit. Chin. Med"},{"key":"10.1016\/j.jep.2020.112999_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/nutd.2016.27","article-title":"Plasma phospholipids and fatty acid composition differ between liver biopsy-proven nonalcoholic fatty liver disease and healthy subjects","volume":"6","author":"Ma","year":"2016","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.jep.2020.112999_bib33","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1073\/pnas.1523356113","article-title":"Identification and quantitation of lipid C=C location isomers: a shotgun lipidomics approach enabled by photochemical reaction","volume":"113","author":"Ma","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jep.2020.112999_bib34","first-page":"1","article-title":"Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats","volume":"7","author":"Ma","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2020.112999_bib35","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nprot.2013.055","article-title":"Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease","volume":"8","author":"Mehlem","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jep.2020.112999_bib36","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4103\/0253-7613.125166","article-title":"Combination of vildagliptin and rosiglitazone ameliorates nonalcoholic fatty liver disease in C57BL\/6 mice","volume":"46","author":"Mookkan","year":"2014","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.jep.2020.112999_bib37","doi-asserted-by":"crossref","first-page":"386","DOI":"10.5582\/bst.2016.01152","article-title":"Ferulic acid prevents liver injury induced by diosbulbin B and its mechanism","volume":"10","author":"Niu","year":"2016","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.jep.2020.112999_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-10299-w","article-title":"Lipidomic signatures of nonhuman primates with radiation-induced hematopoietic syndrome","volume":"7","author":"Pannkuk","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2020.112999_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4829180","article-title":"Ethanolamine and phosphatidylethanolamine: partners in health and disease","author":"Patel","year":"2017","journal-title":"Oxid. Med. Cell. Longev"},{"key":"10.1016\/j.jep.2020.112999_bib41","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S1388-1981(02)00331-1","article-title":"Ceramide in apoptosis: an overview and current perspectives","volume":"1585","author":"Pettus","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2020.112999_bib42","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/hep.21763","article-title":"A lipidomic analysis of nonalcoholic fatty liver disease","volume":"46","author":"Puri","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2020.112999_bib43","doi-asserted-by":"crossref","first-page":"34496","DOI":"10.1074\/jbc.273.51.34496","article-title":"Attenuation of mammalian target of rapamycin activity by increased cAMP in 3T3-L1 adipocytes","volume":"273","author":"Scott","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2020.112999_bib45","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1186\/s12906-017-2038-z","article-title":"Anti-adipogenic effects of the traditional herbal formula Dohongsamul-tang in 3T3-L1 adipocytes","volume":"17","author":"Shim","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2020.112999_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11766-0","article-title":"Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice","volume":"7","author":"Sugasini","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2020.112999_bib47","article-title":"Sphingolipids in apoptosis","author":"Tirodkar","year":"2012","journal-title":"Exp. Oncol."},{"key":"10.1016\/j.jep.2020.112999_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/nu10050649","article-title":"Circulating phospholipid patterns in NAFLD patients associated with a combination of metabolic risk factors","volume":"10","author":"Tiwari-Heckler","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2020.112999_bib49","doi-asserted-by":"crossref","DOI":"10.1152\/ajpendo.1991.261.5.E620","article-title":"1,2-Diacylglycerol and ceramide levels in rat liver and skeletal muscle in vivo","volume":"261","author":"Turinsky","year":"1991","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.jep.2020.112999_bib50","doi-asserted-by":"crossref","DOI":"10.1210\/jc.2006-0587","article-title":"Review: the role of insulin resistance in nonalcoholic fatty liver disease","author":"Utzschneider","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jep.2020.112999_bib51","series-title":"Biochemistry of Lipids, Lipoproteins and Membranes","first-page":"205","article-title":"Phospholipid biosynthesis in eukaryotes","author":"Vance","year":"2002"},{"key":"10.1016\/j.jep.2020.112999_bib52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/bse0590043","article-title":"Biological membranes","volume":"59","author":"Watson","year":"2015","journal-title":"Essays Biochem."},{"key":"10.1016\/j.jep.2020.112999_bib53","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1016\/j.celrep.2017.03.011","article-title":"Liver-specific activation of AMPK prevents steatosis on a high-fructose diet","volume":"18","author":"Woods","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2020.112999_bib54","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jep.2016.01.030","article-title":"The effects of Tao-Hong-Si-Wu on hepatic necroinflammatory activity and fibrosis in a murine model of chronic liver disease","volume":"180","author":"Xi","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.112999_bib55","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1002\/ptr.6161","article-title":"Paeoniflorin protects against liver ischemia\/reperfusion injury in mice via inhibiting HMGB1-TLR4 signaling pathway","volume":"32","author":"Xie","year":"2018","journal-title":"Phyther. Res."},{"key":"10.1016\/j.jep.2020.112999_bib56","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.biopha.2017.02.084","article-title":"Paeoniflorin attenuates ANIT-induced cholestasis by inhibiting apoptosis in vivo via mitochondria-dependent pathway","volume":"89","author":"Zhou","year":"2017","journal-title":"Biomed. Pharmacother."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120308242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120308242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:37:03Z","timestamp":1759941423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874120308242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":54,"alternative-id":["S0378874120308242"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.112999","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An unbiased lipidomics approach identifies key lipid molecules as potential therapeutic targets of Dohongsamul-tang against non-alcoholic fatty liver diseases in a mouse model of obesity","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.112999","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112999"}}