{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:42:51Z","timestamp":1791776571006,"version":"4.3.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.jep.2020.113073","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T21:57:56Z","timestamp":1594677476000},"page":"113073","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Lythrum salicaria L. herb and gut microbiota of healthy post-weaning piglets. Focus on prebiotic properties and formation of postbiotic metabolites in ex vivo cultures."],"prefix":"10.1016","volume":"261","author":[{"given":"Temesgen H.","family":"Dadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Vahjen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Zentek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias F.","family":"Melzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Granica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub P.","family":"Piwowarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jep.2020.113073_bib1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jep.2010.05.023","article-title":"Ethnoveterinary knowledge in navarra (iberian peninsula)","volume":"130","author":"Akerreta","year":"2010","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2020.113073_bib2","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1099\/ijsem.0.002735","article-title":"Ellagibacter isourolithinifaciens gen. nov., sp. nov., a new member of the family Eggerthellaceae, isolated from human gut","volume":"68","author":"Beltran","year":"2018","journal-title":"Int. J. Syst. Evol. Microbiol."},{"issue":"1","key":"10.1016\/j.jep.2020.113073_bib3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s40168-018-0470-z","article-title":"Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2's q2-feature-classifier plugin","volume":"6","author":"Bokulich","year":"2018","journal-title":"Microbiome"},{"issue":"8","key":"10.1016\/j.jep.2020.113073_bib4","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"issue":"4","key":"10.1016\/j.jep.2020.113073_bib5","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10142-014-0396-x","article-title":"Gut response induced by weaning in piglet features marked changes in immune and inflammatory response","volume":"14","author":"Bomba","year":"2014","journal-title":"Funct. Integr. Genom."},{"issue":"1","key":"10.1016\/j.jep.2020.113073_bib6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jep.2006.09.016","article-title":"Ethnobotany of Montseny biosphere reserve (Catalonia, Iberian Peninsula): plants used in veterinary medicine","volume":"110","author":"Bonet","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113073_bib7","series-title":"Plantes, remeis i cultura popular del Montseny. Etnobot\u00e0nica d\u2019una Reserva de la Biosfera","author":"Bonet","year":"2006"},{"issue":"10","key":"10.1016\/j.jep.2020.113073_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185056","article-title":"BBMerge - accurate paired shotgun read merging via overlap","volume":"12","author":"Bushnell","year":"2017","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.jep.2020.113073_bib9","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1038\/ismej.2017.119","article-title":"Exact sequence variants should replace operational taxonomic units in marker-gene data analysis","volume":"11","author":"Callahan","year":"2017","journal-title":"ISME J."},{"issue":"7","key":"10.1016\/j.jep.2020.113073_bib10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.jep.2020.113073_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2049-1891-4-19","article-title":"The biological stress of early weaned piglets","volume":"4","author":"Campbell","year":"2013","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.jep.2020.113073_bib12","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3389\/fmicb.2014.00551","article-title":"A new strategy to fight antimicrobial resistance: the revival of old antibiotics","volume":"5","author":"Cassir","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2020.113073_bib13","first-page":"162","article-title":"Traitement de l'enterite par l'extrait fluide de salicaire Recueil de M\u00e9decine V\u00e9t\u00e9rinaire","volume":"95","author":"Dufour","year":"1919"},{"issue":"25","key":"10.1016\/j.jep.2020.113073_bib14","doi-asserted-by":"crossref","first-page":"10476","DOI":"10.1021\/jf0723864","article-title":"Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans","volume":"55","author":"Espin","year":"2007","journal-title":"J. Agric. Food Chem."},{"issue":"29","key":"10.1016\/j.jep.2020.113073_bib15","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1021\/jf501808a","article-title":"Interplay between anthocyanins and gut microbiota","volume":"62","author":"Faria","year":"2014","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.jep.2020.113073_bib16","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1021\/jf103894m","article-title":"UV and MS identification of Urolithins and Nasutins, the bioavailable metabolites of ellagitannins and ellagic acid in different mammals","volume":"59","author":"Gonzalez-Barrio","year":"2011","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.jep.2020.113073_bib17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/pca.2492","article-title":"Determination of C-glucosidic ellagitannins in Lythri salicariaeherba by ultra-high performance liquid chromatography coupled with charged aerosol detector: method development and validation","volume":"25","author":"Granica","year":"2014","journal-title":"Phytochem. Anal."},{"issue":"10","key":"10.1016\/j.jep.2020.113073_bib18","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.tim.2017.05.004","article-title":"Gut microbiota dysbiosis in postweaning piglets: understanding the keys to health","volume":"25","author":"Gresse","year":"2017","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jep.2020.113073_bib19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s40104-018-0269-6","article-title":"The dynamics of the piglet gut microbiome during the weaning transition in association with health and nutrition","volume":"9","author":"Guevarra","year":"2018","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.jep.2020.113073_bib20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12917-015-0419-4","article-title":"Characterization of the bacterial gut microbiota of piglets suffering from new neonatal porcine diarrhoea","volume":"11","author":"Hermann-Bank","year":"2015","journal-title":"BMC Vet. Res."},{"issue":"7","key":"10.1016\/j.jep.2020.113073_bib21","doi-asserted-by":"crossref","first-page":"R143","DOI":"10.1186\/gb-2007-8-7-r143","article-title":"Accuracy and quality of massively parallel DNA pyrosequencing","volume":"8","author":"Huse","year":"2007","journal-title":"Genome Biol."},{"issue":"7","key":"10.1016\/j.jep.2020.113073_bib22","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S2095-3119(15)61236-9","article-title":"Fermentation characteristics of Megasphaera elsdenii J6 derived from pig feces on different lactate isomers","volume":"15","author":"Jiang","year":"2016","journal-title":"J. Integr. Agric."},{"issue":"5","key":"10.1016\/j.jep.2020.113073_bib23","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri3430","article-title":"Role of the gut microbiota in immunity and inflammatory disease","volume":"13","author":"Kamada","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2020.113073_bib24","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1462-2920.2009.02051.x","article-title":"Wrinkles in the rare biosphere: pyrosequencing errors can lead to artificial inflation of diversity estimates","volume":"12","author":"Kunin","year":"2010","journal-title":"Environ. Microbiol."},{"issue":"6","key":"10.1016\/j.jep.2020.113073_bib25","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nchembio.1535","article-title":"Gut microbiota-generated metabolites in animal health and disease","volume":"10","author":"Lee","year":"2014","journal-title":"Nat. Chem. Biol."},{"issue":"13","key":"10.1016\/j.jep.2020.113073_bib26","doi-asserted-by":"crossref","first-page":"7641","DOI":"10.14233\/ajchem.2013.14697","article-title":"Two phenolic compounds from sarcopyramis bodinieri var. Delicate","volume":"25","author":"Liu","year":"2013","journal-title":"Asian J. Chem."},{"issue":"2","key":"10.1016\/j.jep.2020.113073_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.aninu.2018.01.007","article-title":"Non-antibiotic feed additives in diets for pigs: a review","volume":"4","author":"Liu","year":"2018","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.jep.2020.113073_bib28","series-title":"Gu\u00eda de las plantas medicinales de Cantabria. Salud y Tradici\u00f3n popular","author":"Pardo de Santayana","year":"2004"},{"issue":"1","key":"10.1016\/j.jep.2020.113073_bib29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tibtech.2011.06.011","article-title":"Advances and perspectives in in vitro human gut fermentation modeling","volume":"30","author":"Payne","year":"2012","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.jep.2020.113073_bib30","first-page":"2825","article-title":"Scikit-learn: machine learning in Python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J. Mach. Learn. Res."},{"key":"10.1016\/j.jep.2020.113073_bib31","first-page":"1","article-title":"Absorption, metabolism, and bioactivity of vitexin: recent advances in understanding the efficacy of an important nutraceutical","author":"Peng","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"3","key":"10.1016\/j.jep.2020.113073_bib32","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/jn\/134.3.641","article-title":"Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets","volume":"134","author":"Pie","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.jep.2020.113073_bib33","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jep.2015.05.017","article-title":"Lythrum salicaria L.-Underestimated medicinal plant from European traditional medicine. A review","volume":"170","author":"Piwowarski","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2020.113073_bib34","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1021\/acs.jnatprod.6b00602","article-title":"Differences in metabolism of ellagitannins by human gut microbiota ex vivo cultures","volume":"79","author":"Piwowarski","year":"2016","journal-title":"J. Nat. Prod."},{"issue":"1","key":"10.1016\/j.jep.2020.113073_bib35","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.jep.2014.06.032","article-title":"Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials","volume":"155","author":"Piwowarski","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2020.113073_bib36","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/pca.2415","article-title":"C-glucosidic ellagitannins from lythri herba (European pharmacopoeia): chromatographic profile and structure determination","volume":"24","author":"Piwowarski","year":"2013","journal-title":"Phytochem. Anal."},{"issue":"6","key":"10.1016\/j.jep.2020.113073_bib37","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1124\/dmd.117.075200","article-title":"Phase II conjugates of urolithins isolated from human urine and potential role of beta-glucuronidases in their disposition","volume":"45","author":"Piwowarski","year":"2017","journal-title":"Drug Metab. Dispos."},{"issue":"12","key":"10.1016\/j.jep.2020.113073_bib38","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1002\/mnfr.201300280","article-title":"Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome","volume":"57","author":"Puupponen-Pimia","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jep.2020.113073_bib39","first-page":"744","article-title":"De l'emploi therapeutique du glucoside de la Salicaire en medecine veterinaire","volume":"106","author":"Roy","year":"1930","journal-title":"Recl. Med. Vet."},{"issue":"6","key":"10.1016\/j.jep.2020.113073_bib40","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2217\/fmb.15.17","article-title":"Role of virulence factors on host inflammatory response induced by diarrheagenic Escherichia coli pathotypes","volume":"10","author":"Sanchez-Villamil","year":"2015","journal-title":"Future Microbiol."},{"issue":"8","key":"10.1016\/j.jep.2020.113073_bib41","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1039\/C4FO00092G","article-title":"Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species","volume":"5","author":"Selma","year":"2014","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.jep.2020.113073_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55328-y","article-title":"Identification of the core bacteria in rectums of diarrheic and non-diarrheic piglets","volume":"9","author":"Sun","year":"2019","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.jep.2020.113073_bib43","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/ner.12761","article-title":"Short-term interferential transabdominal electrical stimulation did not change oral-rectal transit time in piglets","volume":"21","author":"Tan","year":"2018","journal-title":"Neuromodulation"},{"issue":"1","key":"10.1016\/j.jep.2020.113073_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201500901","article-title":"Urolithins, the rescue of \"old\" metabolites to understand a \"new\" concept: metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status","volume":"61","author":"Tomas-Barberan","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"issue":"1","key":"10.1016\/j.jep.2020.113073_bib45","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40168-017-0237-y","article-title":"Normalization and microbial differential abundance strategies depend upon data characteristics","volume":"5","author":"Weiss","year":"2017","journal-title":"Microbiome"},{"issue":"1","key":"10.1016\/j.jep.2020.113073_bib46","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.aninu.2017.10.006","article-title":"Fecal scores and microbial metabolites in weaned piglets fed different protein sources and levels","volume":"4","author":"Wen","year":"2018","journal-title":"Anim. Nutr."},{"issue":"8","key":"10.1016\/j.jep.2020.113073_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23081901","article-title":"Structural revisions in natural ellagitannins","volume":"23","author":"Yamada","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2020.113073_bib48","doi-asserted-by":"crossref","first-page":"D643","DOI":"10.1093\/nar\/gkt1209","article-title":"The SILVA and \"All-species living tree project (LTP)\" taxonomic frameworks","volume":"42","author":"Yilmaz","year":"2014","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412031610X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412031610X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:42:14Z","timestamp":1759941734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412031610X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":48,"alternative-id":["S037887412031610X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.113073","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lythrum salicaria L. herb and gut microbiota of healthy post-weaning piglets. Focus on prebiotic properties and formation of postbiotic metabolites in ex vivo cultures.","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.113073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113073"}}