{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:36:07Z","timestamp":1778776567793,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010250","name":"Sichuan Province Youth Science and Technology Innovation Team","doi-asserted-by":"publisher","award":["2017TD0001"],"award-info":[{"award-number":["2017TD0001"]}],"id":[{"id":"10.13039\/501100010250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373943"],"award-info":[{"award-number":["81373943"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573583"],"award-info":[{"award-number":["81573583"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.jep.2020.113275","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T02:35:05Z","timestamp":1597458905000},"page":"113275","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4\/MyD88\/NF-\u03baB and TGF-\u03b2\/smads signaling pathways"],"prefix":"10.1016","volume":"262","author":[{"given":"Naihua","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaocheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuyang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jep.2020.113275_bib1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1142\/S0192415X16500580","article-title":"Forsythiae Fructus inhibits B16 melanoma growth involving MAPKs\/nrf2\/HO-1 mediated anti-oxidation and anti-inflammation","volume":"44","author":"Bao","year":"2016","journal-title":"Am. J. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2020.113275_bib2","article-title":"Biochemical markers, extracellular components in liver fibrosis and cirrhosis","volume":"17","author":"Bolarin","year":"2007","journal-title":"Niger. Q. J. Hosp. Med."},{"issue":"1","key":"10.1016\/j.jep.2020.113275_bib3","first-page":"1","article-title":"Regression of liver fibrosis","volume":"37","author":"Campana","year":"2017","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.jep.2020.113275_bib4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0168-8278(99)80010-5","article-title":"The role of TGFfll in initiating hepatic stellate cell activation in vivo","volume":"30","author":"Claus Hellerbrand","year":"1999","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2020.113275_bib5","first-page":"170","article-title":"Pharmacopeia of the people's Republic of China (2015 version)","volume":"1","author":"Commission","year":"2015"},{"issue":"4","key":"10.1016\/j.jep.2020.113275_bib6","first-page":"5989","article-title":"Correlation of serum liver fibrosis markers with severity of liver dysfunction in liver cirrhosis: a retrospective cross-sectional study","volume":"8","author":"Cuihong Zhu","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"10","key":"10.1016\/j.jep.2020.113275_bib7","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/iub.1078","article-title":"TAK1, more than just innate immunity","volume":"64","author":"Dai","year":"2012","journal-title":"IUBMB Life"},{"issue":"4","key":"10.1016\/j.jep.2020.113275_bib8","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2131\/jts.41.561","article-title":"Mechanisms of CCl,-induced liver fibrosis with combined transcriptomic and proteomic analysis","volume":"41","author":"Dong","year":"2016","journal-title":"J. Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2020.113275_bib9","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1053\/j.gastro.2008.04.038","article-title":"Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage","volume":"135","author":"Dooley","year":"2008","journal-title":"Gastroenterology"},{"issue":"3\u20134","key":"10.1016\/j.jep.2020.113275_bib10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10555-012-9375-7","article-title":"TGF-beta signalling and its role in cancer progression and metastasis","volume":"31","author":"Drabsch","year":"2012","journal-title":"Canc. Metastasis Rev."},{"issue":"7007","key":"10.1016\/j.jep.2020.113275_bib11","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature02924","article-title":"NF-kB functions as a tumour promoter in inflammation-associated cancer","volume":"431","author":"Eli Pikarsky","year":"2004","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.jep.2020.113275_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/nu10070855","article-title":"Curcumin in liver diseases: a systematic review of the cellular mechanisms of oxidative stress and clinical perspective","volume":"10","author":"Farzaei","year":"2018","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jep.2020.113275_bib13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.jep.2020.113275_bib14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0163-7258(03)00035-4","article-title":"Genealogy, expression, and cellular function of transforming growth factor-\u03b2","volume":"98","author":"Govinden","year":"2003","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.jep.2020.113275_bib15","series-title":"Professor Zhang Chizhi's Academic Thoughts and Medication Rules of Treating Chronic Severe Hepatitis Using the Theory of Warm Disease","author":"Guo","year":"2018"},{"issue":"5","key":"10.1016\/j.jep.2020.113275_bib16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/CS20060242","article-title":"Liver fibrosis: cellular mechanisms of progression and resolution","volume":"112","author":"Henderson","year":"2007","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.jep.2020.113275_bib17","doi-asserted-by":"crossref","first-page":"112361","DOI":"10.1016\/j.jep.2019.112361","article-title":"Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"248","author":"Hu","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2020.113275_bib18","first-page":"147","article-title":"HPLC-tandem mass spectrometric analysis of the marker compounds in Forsythiae Fructus and multivariate analysis","volume":"17","author":"Hwang Eui Cho","year":"2011","journal-title":"Nat. Prod. Sci."},{"issue":"3","key":"10.1016\/j.jep.2020.113275_bib19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/MOG.0b013e3283279668","article-title":"Hepatic fibrosis","volume":"25","author":"Jingjing Jiao","year":"2009","journal-title":"Curr. Opin. Gastroenterol."},{"issue":"4","key":"10.1016\/j.jep.2020.113275_bib20","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s12072-010-9219-x","article-title":"The role of lipopolysaccharide\/toll-like receptor 4 signaling in chronic liver diseases","volume":"4","author":"Jo\u00e3o-Bruno Soares","year":"2010","journal-title":"Hepatol Int"},{"issue":"7","key":"10.1016\/j.jep.2020.113275_bib21","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1440-1746.1999.01928.x","article-title":"Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy","volume":"14","author":"Li","year":"1999","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2020.113275_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/949157","article-title":"Innate immune cells in liver inflammation","author":"Liaskou","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2020.113275_bib23","article-title":"Experimental study on the antioxidant activity of Malus hupehensis (Pamp.) Rehd extracts in vitro and in vivo","author":"Liu","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"7","key":"10.1016\/j.jep.2020.113275_bib24","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.cell.2005.04.014","article-title":"IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis","volume":"121","author":"Maeda","year":"2005","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.jep.2020.113275_bib25","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1053\/jhep.2003.50182","article-title":"Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells","volume":"37","author":"Paik","year":"2003","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jep.2020.113275_bib26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.intimp.2015.03.009","article-title":"Protective effect of forsythiaside A on lipopolysaccharide\/d-galactosamine-induced liver injury","volume":"26","author":"Pan","year":"2015","journal-title":"Int. Immunopharm."},{"issue":"3","key":"10.1016\/j.jep.2020.113275_bib27","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri3623","article-title":"Liver fibrosis and repair: immune regulation of wound healing in a solid organ","volume":"14","author":"Pellicoro","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.jep.2020.113275_bib28","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1055\/s-0030-1255353","article-title":"Toll-like receptor 4 and hepatic fibrogenesis","volume":"30","author":"Pradere","year":"2010","journal-title":"Semin. Liver Dis."},{"issue":"11","key":"10.1016\/j.jep.2020.113275_bib29","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.jep.2020.113275_bib30","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s12072-010-9219-x","article-title":"The role of lipopolysaccharide\/toll-like receptor 4 signaling in chronic liver diseases","volume":"4","author":"Soares","year":"2010","journal-title":"Hepatol Int"},{"issue":"1","key":"10.1016\/j.jep.2020.113275_bib31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ijc.31029","article-title":"The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice","volume":"142","author":"Song","year":"2018","journal-title":"Int. J. Canc."},{"issue":"4","key":"10.1016\/j.jep.2020.113275_bib32","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1111\/jcmm.13526","article-title":"Lipopolysaccharide enhances TGF-beta1 signalling pathway and rat pancreatic fibrosis","volume":"22","author":"Sun","year":"2018","journal-title":"J. Cell Mol. Med."},{"issue":"12","key":"10.1016\/j.jep.2020.113275_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167687","article-title":"Forsythia suspensa suppresses house dust mite extract-induced atopic dermatitis in NC\/nga mice","volume":"11","author":"Sung","year":"2016","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.jep.2020.113275_bib34","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/hep.21254","article-title":"Mechanisms of endotoxin-induced NO, IL-6, and TNF-alpha production in activated rat hepatic stellate cells: role of p38 MAPK","volume":"44","author":"Thirunavukkarasu","year":"2006","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jep.2020.113275_bib35","doi-asserted-by":"crossref","first-page":"9289","DOI":"10.1038\/s41598-017-09673-5","article-title":"Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-beta1\/Smads and PI3K\/Akt pathways","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2020.113275_bib36","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.biopha.2018.07.081","article-title":"Yu Gan Long reduces rat liver fibrosis by blocking TGF-beta1\/Smad pathway and modulating the immunity","volume":"106","author":"Xia","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.jep.2020.113275_bib37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1369\/0022155415627681","article-title":"TGF-beta\/SMAD pathway and its regulation in hepatic fibrosis","volume":"64","author":"Xu","year":"2016","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.jep.2020.113275_bib38","series-title":"The Empirical Research on the Cases of Professor Jin Shi Treating Chronic Liver Diseasebased on Data Mining","author":"Xu","year":"2014"},{"issue":"5","key":"10.1016\/j.jep.2020.113275_bib39","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1159\/000484192","article-title":"Protective effect of phillyrin on lethal LPS-induced neutrophil inflammation in zebrafish","volume":"43","author":"Yang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2020.113275_bib40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jep.2018.02.033","article-title":"Hepatoprotective effect of Forsythiae Fructus water extract against carbon tetrachloride-induced liver fibrosis in mice","volume":"218","author":"Zhang","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113275_bib41","article-title":"Phytochemistry, pharmacology, quality control and future research of Forsythia suspensa (Thunb.) Vahl: a review","author":"Zhaoyi Wang","year":"2017","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120331573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120331573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:53:13Z","timestamp":1778503993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874120331573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":41,"alternative-id":["S0378874120331573"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.113275","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4\/MyD88\/NF-\u03baB and TGF-\u03b2\/smads signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.113275","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113275"}}