{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:43:50Z","timestamp":1790887430437,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Taiwan Agricultural Research Institute","award":["105A3210"],"award-info":[{"award-number":["105A3210"]}]},{"name":"Taiwan Agricultural Research Institute","award":["106A3450"],"award-info":[{"award-number":["106A3450"]}]},{"name":"Taiwan Agricultural Research Institute","award":["107A3350"],"award-info":[{"award-number":["107A3350"]}]},{"name":"Taiwan Agricultural Research Institute","award":["108A3302-1"],"award-info":[{"award-number":["108A3302-1"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jep.2020.113395","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T22:56:53Z","timestamp":1600469813000},"page":"113395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Water extract of Armillaria mellea (Vahl) P. Kumm. Alleviates the depression-like behaviors in acute- and chronic mild stress-induced rodent models via anti-inflammatory action"],"prefix":"10.1016","volume":"265","author":[{"given":"Yu-En","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-Lan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Hung","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Ju","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraphan","family":"Panyod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Hsing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Shen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Yan","family":"Sheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2020.113395_bib1","article-title":"Selective serotonin Re-uptake inhibitors (SSRIs) induced weight changes: a dose and duration dependent study on albino rats","volume":"10","author":"Aggarwal","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"issue":"11","key":"10.1016\/j.jep.2020.113395_bib2","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/gps.2672","article-title":"The inflammation hypothesis in geriatric depression","volume":"26","author":"Alexopoulos","year":"2011","journal-title":"Int. J. Geriatr. Psychiatr."},{"key":"10.1016\/j.jep.2020.113395_bib3","doi-asserted-by":"crossref","first-page":"4184562","DOI":"10.1155\/2017\/4184562","article-title":"Pharmacological basis for use of Armillaria mellea polysaccharides in alzheimer's disease: antiapoptosis and antioxidation","volume":"2017","author":"An","year":"2017","journal-title":"Oxid. Med. Cell Longev"},{"issue":"2","key":"10.1016\/j.jep.2020.113395_bib4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/09168451.2015.1083396","article-title":"A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation","volume":"80","author":"Asahi","year":"2016","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.jep.2020.113395_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mbs.2016.10.007","article-title":"Patient specific modeling of the HPA axis related to clinical diagnosis of depression","volume":"287","author":"Bangsgaard","year":"2017","journal-title":"Math. Biosci."},{"key":"10.1016\/j.jep.2020.113395_bib6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.psyneuen.2014.09.025","article-title":"Is depression associated with increased oxidative stress? A systematic review and meta-analysis","volume":"51","author":"Black","year":"2015","journal-title":"Psychoneuroendocrinology"},{"issue":"6","key":"10.1016\/j.jep.2020.113395_bib7","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1179\/1476830512Y.0000000020","article-title":"Spirulina and C-phycocyanin reduce cytotoxicity and inflammation-related genes expression of microglial cells","volume":"15","author":"Chen","year":"2012","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.jep.2020.113395_bib8","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jep.2016.02.001","article-title":"Anti-depressant effects of Gastrodia elata Blume and its compounds gastrodin and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal cytoskeletal remodeling","volume":"182","author":"Chen","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2020.113395_bib9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0149-7634(01)00011-2","article-title":"A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field","volume":"25","author":"Choleris","year":"2001","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jep.2020.113395_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.physbeh.2012.11.001","article-title":"The effect of unpredictable chronic mild stress on depressive-like behavior and on hippocampal A1 and striatal A2A adenosine receptors","volume":"109","author":"Crema","year":"2013","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/j.jep.2020.113395_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/YCO.0b013e3280117733","article-title":"Animal models of mood disorders: recent developments","volume":"20","author":"Cryan","year":"2007","journal-title":"Curr. Opin. Psychiatr."},{"issue":"1\u20132","key":"10.1016\/j.jep.2020.113395_bib12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.psychres.2008.12.014","article-title":"Mechanisms of change in negative thinking and urinary monoamines in depressed patients during acute treatment with group cognitive behavior therapy and antidepressant medication","volume":"175","author":"Dingle","year":"2010","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.jep.2020.113395_bib13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bbi.2019.06.015","article-title":"Markers of central inflammation in major depressive disorder: a systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue","volume":"81","author":"Enache","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jep.2020.113395_bib14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neuroscience.2018.09.028","article-title":"Curcumin protects against chronic stress-induced dysregulation of neuroplasticity and depression-like behaviors via suppressing IL-1beta pathway in rats","volume":"392","author":"Fan","year":"2018","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.jep.2020.113395_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001547","article-title":"Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010","volume":"10","author":"Ferrari","year":"2013","journal-title":"PLoS Med."},{"issue":"3","key":"10.1016\/j.jep.2020.113395_bib16","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1006\/hbeh.2002.1763","article-title":"Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats","volume":"41","author":"Frye","year":"2002","journal-title":"Horm. Behav."},{"key":"10.1016\/j.jep.2020.113395_bib17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.phymed.2017.01.005","article-title":"Bioassay-guided fractionation of ethyl acetate extract from Armillaria mellea attenuates inflammatory response in lipopolysaccharide (LPS) stimulated BV-2 microglia","volume":"26","author":"Geng","year":"2017","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jep.2020.113395_bib18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1615\/IntJMedMushrooms.v16.i4.20","article-title":"Anti-inflammatory activity of mycelial extracts from medicinal mushrooms","volume":"16","author":"Geng","year":"2014","journal-title":"Int. J. Med. Mushrooms"},{"issue":"10","key":"10.1016\/j.jep.2020.113395_bib19","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1007\/s10620-006-9729-5","article-title":"Preventing relapse of major depression during interferon-alpha therapy for hepatitis C--A pilot study","volume":"52","author":"Gleason","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jep.2020.113395_bib20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fimmu.2013.00085","article-title":"Regulation of inflammation by adenosine","volume":"4","author":"Hasko","year":"2013","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.jep.2020.113395_bib21","article-title":"Salvianolic acid B abolished chronic mild stress-induced depression through suppressing oxidative stress and neuro-inflammation via regulating NLRP3 inflammasome activation","volume":"43","author":"Huang","year":"2019","journal-title":"J. Food Biochem."},{"issue":"12","key":"10.1016\/j.jep.2020.113395_bib22","doi-asserted-by":"crossref","first-page":"8094","DOI":"10.1039\/C9FO00601J","article-title":"Garlic essential oil mediates acute and chronic mild stress-induced depression in rats via modulation of monoaminergic neurotransmission and brain-derived neurotrophic factor levels","volume":"10","author":"Huang","year":"2019","journal-title":"Food Funct."},{"issue":"1\u20132","key":"10.1016\/j.jep.2020.113395_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neulet.2003.10.040","article-title":"Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors","volume":"355","author":"Kaster","year":"2004","journal-title":"Neurosci. Lett."},{"issue":"1\u20132","key":"10.1016\/j.jep.2020.113395_bib24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainresbull.2005.05.025","article-title":"Involvement of 5-HT1A receptors in the antidepressant-like effect of adenosine in the mouse forced swimming test","volume":"67","author":"Kaster","year":"2005","journal-title":"Brain Res. Bull."},{"issue":"4","key":"10.1016\/j.jep.2020.113395_bib25","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3949\/ccjm.73.4.351","article-title":"Side effects of antidepressants: an overview","volume":"73","author":"Khawam","year":"2006","journal-title":"Cleve. Clin. J. Med."},{"issue":"7","key":"10.1016\/j.jep.2020.113395_bib26","doi-asserted-by":"crossref","first-page":"732","DOI":"10.2174\/1570159X14666151208113700","article-title":"Inflammation in depression and the potential for anti-inflammatory treatment","volume":"14","author":"Kohler","year":"2016","journal-title":"Curr. Neuropharmacol."},{"issue":"25","key":"10.1016\/j.jep.2020.113395_bib27","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.1021\/jf500803c","article-title":"Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress","volume":"62","author":"Lai","year":"2014","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.jep.2020.113395_bib28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrd1634","article-title":"Depression, antidepressants and suicidality: a critical appraisal","volume":"4","author":"Licinio","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"issue":"43","key":"10.1016\/j.jep.2020.113395_bib29","doi-asserted-by":"crossref","first-page":"10493","DOI":"10.1021\/jf503132c","article-title":"Down-regulation of Slit-Robo pathway mediating neuronal cytoskeletal remodeling processes facilitates the antidepressive-like activity of Gastrodia elata Blume","volume":"62","author":"Lin","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2020.113395_bib30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jep.2016.04.032","article-title":"Antidepressant-like effects of water extract of Gastrodia elata Blume in rats exposed to unpredictable chronic mild stress via modulation of monoamine regulatory pathways","volume":"187","author":"Lin","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113395_bib31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.psyneuen.2016.11.031","article-title":"Oxidative stress, inflammation and treatment response in major depression","volume":"76","author":"Lindqvist","year":"2017","journal-title":"Psychoneuroendocrinology"},{"issue":"10","key":"10.1016\/j.jep.2020.113395_bib32","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.3390\/ijms12106367","article-title":"Antioxidant properties of the edible Basidiomycete Armillaria mellea in submerged cultures","volume":"12","author":"Lung","year":"2011","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jep.2020.113395_bib33","first-page":"287","article-title":"The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression","volume":"29","author":"Maes","year":"2008","journal-title":"Neuroendocrinol. Lett."},{"issue":"3","key":"10.1016\/j.jep.2020.113395_bib34","first-page":"e242","article-title":"The complex interplay of Depression, Inflammation and Omega-3: state of the art and progresses in research","volume":"166","author":"Mazza","year":"2015","journal-title":"Clin. Ter."},{"issue":"1","key":"10.1016\/j.jep.2020.113395_bib35","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2020.113395_bib36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.foodchem.2017.09.149","article-title":"Anti-inflammatory properties of edible mushrooms: a review","volume":"243","author":"Muszynska","year":"2018","journal-title":"Food Chem."},{"issue":"2","key":"10.1016\/j.jep.2020.113395_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"issue":"4","key":"10.1016\/j.jep.2020.113395_bib38","first-page":"495","article-title":"Antioxidant activities of cultured Armillariella mellea","volume":"43","author":"Ng","year":"2007","journal-title":"Prikl. Biokhim. Mikrobiol."},{"issue":"4","key":"10.1016\/j.jep.2020.113395_bib39","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/mp.2009.91","article-title":"Stress and IL-1beta contribute to the development of depressive-like behavior following peripheral nerve injury","volume":"15","author":"Norman","year":"2010","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.jep.2020.113395_bib40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cyto.2016.10.001","article-title":"Sex differences in the effect of acute peripheral IL-1beta administration on the brain and serum BDNF and VEGF expression in rats","volume":"90","author":"Obuchowicz","year":"2017","journal-title":"Cytokine"},{"issue":"12","key":"10.1016\/j.jep.2020.113395_bib41","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1021\/acs.jafc.9b00485","article-title":"Effects of ergothioneine-rich mushroom extract on the oxidative stability of astaxanthin in liposomes","volume":"67","author":"Pahila","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.jep.2020.113395_bib42","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s11095-006-9905-5","article-title":"Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin","volume":"23","author":"Parepally","year":"2006","journal-title":"Pharm. Res. (N. Y.)"},{"issue":"2","key":"10.1016\/j.jep.2020.113395_bib43","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"issue":"3","key":"10.1016\/j.jep.2020.113395_bib44","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-2999(78)90414-4","article-title":"Behavioural despair\" in rats and mice: strain differences and the effects of imipramine","volume":"51","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2020.113395_bib45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.it.2005.11.006","article-title":"Cytokines sing the blues: inflammation and the pathogenesis of depression","volume":"27","author":"Raison","year":"2006","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.jep.2020.113395_bib46","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1089\/jmf.2017.4006","article-title":"Hericium erinaceus extract reduces anxiety and depressive behaviors by promoting hippocampal neurogenesis in the adult mouse brain","volume":"21","author":"Ryu","year":"2018","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2020.113395_bib47","article-title":"BDNF prevents central oxidative damage in a chronic unpredictable mild stress model: the possible role of PRDX-1 in anhedonic behavior","volume":"378","author":"Scotton","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jep.2020.113395_bib48","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1038\/tp.2012.120","article-title":"Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes","volume":"2","author":"Sukoff Rizzo","year":"2012","journal-title":"Transl. Psychiatry"},{"issue":"5","key":"10.1016\/j.jep.2020.113395_bib49","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.biortech.2008.09.036","article-title":"Structural elucidation and immunological activity of a polysaccharide from the fruiting body of Armillaria mellea","volume":"100","author":"Sun","year":"2009","journal-title":"Bioresour. Technol."},{"issue":"30","key":"10.1016\/j.jep.2020.113395_bib50","doi-asserted-by":"crossref","first-page":"21362","DOI":"10.1074\/jbc.M600504200","article-title":"Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner","volume":"281","author":"Takeuchi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2020.113395_bib51","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.tifs.2016.02.005","article-title":"Anti-inflammatory potential of mushroom extracts and isolated metabolites","volume":"50","author":"Taofiq","year":"2016","journal-title":"Trends Food Sci. Technol."},{"issue":"7","key":"10.1016\/j.jep.2020.113395_bib52","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.bbi.2010.02.001","article-title":"Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions","volume":"24","author":"Tynan","year":"2010","journal-title":"Brain Behav. Immun."},{"issue":"6","key":"10.1016\/j.jep.2020.113395_bib53","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2165\/00023210-200216060-00006","article-title":"Spotlight on paroxetine in psychiatric disorders in adults","volume":"16","author":"Wagstaff","year":"2002","journal-title":"CNS Drugs"},{"issue":"4","key":"10.1016\/j.jep.2020.113395_bib54","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1001\/jamapsychiatry.2014.2502","article-title":"Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis","volume":"72","author":"Walker","year":"2015","journal-title":"JAMA Psychiatr."},{"issue":"4","key":"10.1016\/j.jep.2020.113395_bib55","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.jep.2020.113395_bib56","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ynstr.2016.08.002","article-title":"The chronic mild stress (CMS) model of depression: history, evaluation and usage","volume":"6","author":"Willner","year":"2017","journal-title":"Neurobiol Stress"},{"issue":"4","key":"10.1016\/j.jep.2020.113395_bib57","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ijbiomac.2012.06.040","article-title":"A polysaccharide from Armillaria mellea exhibits strong in vitro anticancer activity via apoptosis-involved mechanisms","volume":"51","author":"Wu","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.jep.2020.113395_bib58","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12013-014-0413-7","article-title":"The effects of armillarisin A on serum IL-1beta and IL-4 and in treating ulcerative colitis","volume":"72","author":"Wu","year":"2015","journal-title":"Cell Biochem. Biophys."},{"issue":"3","key":"10.1016\/j.jep.2020.113395_bib59","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1142\/S0192415X07005028","article-title":"Armillariella mellea shows anti-inflammatory activity by inhibiting the expression of NO, iNOS, COX-2 and cytokines in THP-1 cells","volume":"35","author":"Wu","year":"2007","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2020.113395_bib60","doi-asserted-by":"crossref","first-page":"40530","DOI":"10.1038\/srep40530","article-title":"Circulating T lymphocyte subsets, cytokines, and immune checkpoint inhibitors in patients with bipolar II or major depression: a preliminary study","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.jep.2020.113395_bib61","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1055\/s-2007-969711","article-title":"Chemical constituents of Armillaria mellea mycelium. I. Isolation and characterization of armillarin and armillaridin","volume":"50","author":"Yang","year":"1984","journal-title":"Planta Med."},{"issue":"1","key":"10.1016\/j.jep.2020.113395_bib62","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/s41467-018-03423-5","article-title":"The Gastrodia elata genome provides insights into plant adaptation to heterotrophy","volume":"9","author":"Yuan","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jep.2020.113395_bib63","first-page":"273","article-title":"Armillaria mellea: phenolic content, in vitro antioxidant and antihyperglycemic effects","volume":"119","author":"Zavastin","year":"2015","journal-title":"Rev. Med.-Chir. Soc. Med. Nat. Iasi"},{"key":"10.1016\/j.jep.2020.113395_bib64","first-page":"1","article-title":"Study on antidepressant-like effect of protoilludane sesquiterpenoid aromatic esters from Armillaria Mellea","author":"Zhang","year":"2019","journal-title":"Nat. Prod. Res."},{"issue":"7","key":"10.1016\/j.jep.2020.113395_bib65","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x20198434","article-title":"Baicalin ameliorates chronic mild stress-induced depression-like behaviors in mice and attenuates inflammatory cytokines and oxidative stress","volume":"52","author":"Zhong","year":"2019","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"10","key":"10.1016\/j.jep.2020.113395_bib66","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1038\/sj.npp.1301029","article-title":"The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters","volume":"31","author":"Zhu","year":"2006","journal-title":"Neuropsychopharmacology"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120332803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120332803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:53:13Z","timestamp":1759942393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874120332803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":66,"alternative-id":["S0378874120332803"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.113395","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Water extract of Armillaria mellea (Vahl) P. Kumm. Alleviates the depression-like behaviors in acute- and chronic mild stress-induced rodent models via anti-inflammatory action","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.113395","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113395"}}