{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:25:15Z","timestamp":1789503915836,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jep.2020.113444","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T09:47:13Z","timestamp":1601804833000},"page":"113444","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Protective effect of acorn (Quercus liaotungensis Koidz) on streptozotocin-damaged MIN6 cells and type 2 diabetic rats via p38 MAPK\/Nrf2\/HO-1 pathway"],"prefix":"10.1016","volume":"266","author":[{"given":"Jing","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xude","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.113444_bib1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jep.2015.10.034","article-title":"Antidiabetic properties of lyophilized extract of acorn (Quercus brantii Lindl.) on experimentally STZ-induced diabetic rats","volume":"176","author":"Abdulahad","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2020.113444_bib2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/jcb.24402","article-title":"Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus","volume":"114","author":"Akash","year":"2013","journal-title":"J. Cell. Biochem."},{"issue":"9","key":"10.1016\/j.jep.2020.113444_bib3","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.1038\/s41598-019-42633-9","article-title":"Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling","volume":"15","author":"Amani","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2020.113444_bib4","first-page":"947","article-title":"A new age for Quercus spp. fruits: review on nutritional and phytochemical composition and related biological activities of acorns","volume":"51","author":"Ana","year":"2016","journal-title":"Compr. Rev. Food Sci. F."},{"issue":"6","key":"10.1016\/j.jep.2020.113444_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0968-0004(00)01595-4","article-title":"p38 MAP kinases: beyond the stress response","volume":"25","author":"Angel","year":"2000","journal-title":"Trends Biochem. Sci."},{"issue":"21","key":"10.1016\/j.jep.2020.113444_bib6","doi-asserted-by":"crossref","first-page":"6248","DOI":"10.1021\/jf030216v","article-title":"Phenolic compounds and fatty acids from acorns (Quercus spp.): the main dietary constituent of free ranged iberian pigs","volume":"51","author":"Cantos","year":"2003","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.jep.2020.113444_bib7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1089\/ars.2010.3283","article-title":"Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway","volume":"14","author":"Cheng","year":"2011","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jep.2020.113444_bib8","doi-asserted-by":"crossref","first-page":"819065","DOI":"10.1155\/2014\/819065","article-title":"Streptozotocin-induced diabetes models: pathophysiological mechanisms and fetal outcomes","volume":"2014","author":"Damasceno","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"3","key":"10.1016\/j.jep.2020.113444_bib9","first-page":"183","article-title":"Polyphenolic constituents and biological activities of Quercus species","volume":"33","author":"Didem","year":"2004","journal-title":"Ank. Univ. Eczacilik Fak. Derg."},{"issue":"4","key":"10.1016\/j.jep.2020.113444_bib10","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s12291-015-0516-y","article-title":"Endothelial dysfunction in type 2 diabetes mellitus","volume":"31","author":"Dhananjayan","year":"2016","journal-title":"Indian J. Clin. Biochem."},{"issue":"1","key":"10.1016\/j.jep.2020.113444_bib11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Droge","year":"2002","journal-title":"Physiol. Rev."},{"issue":"19","key":"10.1016\/j.jep.2020.113444_bib12","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.2217\/nnm-2016-0204","article-title":"A newly developed silymarin nanoformulation as a potential antidiabetic agent in experimental diabetes","volume":"11","author":"Elfar","year":"2016","journal-title":"Nanomedicine"},{"issue":"2","key":"10.1016\/j.jep.2020.113444_bib13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2174\/1573399812666151020101222","article-title":"Pancreatic beta-cells and type 2 diabetes development","volume":"13","author":"Elizabeth","year":"2017","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.jep.2020.113444_bib14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/0471141755.ph0547s70","article-title":"Streptozotocin-induced diabetic models in mice and rats","volume":"70","author":"Furman","year":"2015","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.jep.2020.113444_bib15","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/181643","article-title":"Molecular events linking oxidative stress and inflammation to insulin resistance and \u03b2-cell dysfunction","author":"Keane","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2020.113444_bib16","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.biopha.2017.11.063","article-title":"Honokiol protects pancreatic \u03b2 cell against high glucose and intermittent hypoxia-induced injury by activating Nrf2\/ARE pathway in vitro and in vivo","volume":"97","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2020.113444_bib17","first-page":"18","article-title":"The analysis of distribution pattern of Fagaceace in China","volume":"23","author":"Liu","year":"1999","journal-title":"J. Nanjing For. Univ. (Nat. Sci. Ed.)"},{"key":"10.1016\/j.jep.2020.113444_bib18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.indcrop.2012.12.011","article-title":"Extracts from Quercus sp. acorns exhibit in vitro neuroprotective features through inhibition of cholinesterase and protection of the human dopaminergic cell line SHSY5Y from hydrogen peroxide-induced cytotoxicity","volume":"45","author":"Lu\u00edsa","year":"2013","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jep.2020.113444_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.indcrop.2014.11.001","article-title":"Phenolic composition, antioxidant potential and in vitro inhibitory activity of leaves and acorns of Quercus suber on key enzymes relevant for hyperglycemia and Alzheimer's disease","volume":"64","author":"Lu\u00edsa","year":"2015","journal-title":"Ind. Crop. Prod."},{"issue":"3","key":"10.1016\/j.jep.2020.113444_bib20","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3177\/jnsv.63.200","article-title":"Coffee ingestion suppresses hyperglycemia in streptozotocin-induced diabetic mice","volume":"63","author":"Misato","year":"2017","journal-title":"J. Nutr. Sci. Vitaminol."},{"issue":"1","key":"10.1016\/j.jep.2020.113444_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1530\/JOE-12-0072","article-title":"Reactive oxygen and nitrogen species generation, antioxidant defenses, and \u03b2-cell function: a critical role for amino acids","volume":"214","author":"Newsholme","year":"2012","journal-title":"J. Endocrinol."},{"issue":"12","key":"10.1016\/j.jep.2020.113444_bib22","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1021\/acsbiomaterials.8b00992","article-title":"Supercritical fluid-assisted decoration of nanoparticles on porous microcontainers for codelivery of therapeutics and inhalation therapy of diabetes","volume":"4","author":"Ranjith","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.jep.2020.113444_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jchemneu.2018.03.005","article-title":"The effects of maternal diabetes and insulin treatment on neurogenesis in the developing hippocampus of male rats","volume":"91","author":"Sadeghi","year":"2018","journal-title":"J. Chem. Neuroanat."},{"issue":"9","key":"10.1016\/j.jep.2020.113444_bib24","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrd1177","article-title":"p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases","volume":"2","author":"Sanjay","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jep.2020.113444_bib25","doi-asserted-by":"crossref","first-page":"E621","DOI":"10.1152\/ajpendo.00054.2015","article-title":"ACE2 defificiency reduces \u03b2-cell mass and impairs \u03b2-cell proliferation in obese C57BL\/6 mice","volume":"309","author":"Shoemaker","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.jep.2020.113444_bib26","first-page":"1770","article-title":"Microporous polymer scaffolds for the transplantation of embryonic stem cell derived pancreatic progenitors to a clinically translatable site for the treatment of type I diabetes","volume":"4","author":"Tadas","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.jep.2020.113444_bib27","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.foodchem.2010.07.058","article-title":"Acorns (Quercus rotundifolia Lam.) and grass as natural sources of antioxidants and fatty acids in the \u201cmontanera\u201d feeding of Iberian pig: intra- and inter-annual variations","volume":"124","author":"Tejerina","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2020.113444_bib28","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jff.2017.12.054","article-title":"New triterpenoids from acorns of Quercus liaotungensis and their inhibitory activity against \u03b1-glucosidase, \u03b1-amylase and protein-tyrosine phosphatase 1B","volume":"41","author":"Xu","year":"2018","journal-title":"J. Funct. Foods."},{"key":"10.1016\/j.jep.2020.113444_bib29","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jff.2018.05.031","article-title":"The antioxidant and anti-hepatic fibrosis activities of acorns (Quercus liaotungensis) and their natural galloyl triterpenes","volume":"46","author":"Xu","year":"2018","journal-title":"J. Funct. Foods."},{"key":"10.1016\/j.jep.2020.113444_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9073037","article-title":"Advanced glycation end products impair glucose-stimulated insulin secretion of a pancreatic beta-cell line INS-1-3 by disturbance of microtubule cytoskeleton via p38\/MAPK activation","volume":"2016","author":"You","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.jep.2020.113444_bib31","first-page":"85","article-title":"Development and utilization of acorn resources in our country","volume":"4","author":"Zhang","year":"2014","journal-title":"Forest by-Product and Speciality in China"},{"issue":"4","key":"10.1016\/j.jep.2020.113444_bib32","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s00125-008-1255-x","article-title":"Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis","volume":"52","author":"Zraika","year":"2009","journal-title":"Diabetologia"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120333298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120333298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:44:11Z","timestamp":1759941851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874120333298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":32,"alternative-id":["S0378874120333298"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.113444","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of acorn (Quercus liaotungensis Koidz) on streptozotocin-damaged MIN6 cells and type 2 diabetic rats via p38 MAPK\/Nrf2\/HO-1 pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.113444","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113444"}}