{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:45:37Z","timestamp":1769046337199,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373972"],"award-info":[{"award-number":["81373972"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673599"],"award-info":[{"award-number":["81673599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["BRA2020071"],"award-info":[{"award-number":["BRA2020071"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["SBK2020021421"],"award-info":[{"award-number":["SBK2020021421"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["2016-YY-026"],"award-info":[{"award-number":["2016-YY-026"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jep.2020.113489","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T13:20:30Z","timestamp":1603113630000},"page":"113489","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Diverse role of gut microbiota on reduction of ascites and intestinal injury in malignant ascites effusion rats treated with Euphorbia kansui stir-fried with vinegar"],"prefix":"10.1016","volume":"267","author":[{"given":"Sijia","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongjing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifeng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beihua","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.113489_bib1","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.3748\/wjg.v17.i10.1237","article-title":"Diagnosis and therapy of ascites in liver cirrhosis","volume":"17","author":"Biecker","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2020.113489_bib2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.transproceed.2015.08.048","article-title":"A grading score for colon preservation injury in the rat","volume":"48","author":"Bresler","year":"2016","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.jep.2020.113489_bib3","first-page":"3249","article-title":"Study on toxicity of vinegar-processed Kansui Radix on basis of symptom-based prescription theory","volume":"40","author":"Cao","year":"2015","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2020.113489_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10147-012-0396-6","article-title":"Malignant ascites: pathophysiology and treatment","volume":"18","author":"Cavazzoni","year":"2013","journal-title":"Int. J. Clin. Oncol."},{"key":"10.1016\/j.jep.2020.113489_bib5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00281-012-0352-6","article-title":"Inflammation and colorectal cancer: colitis-associated neoplasia","volume":"35","author":"Grivennikov","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.jep.2020.113489_bib6","series-title":"The Effect of FGC-3 to AQP8\u3001ET-1\u3001NO of Cirrhotic Ascites Rats","author":"Guan","year":"2016"},{"key":"10.1016\/j.jep.2020.113489_bib7","first-page":"128","article-title":"The research progress of Cancerous ascites treatment","volume":"32","author":"Hu","year":"2013","journal-title":"Nei Mongol J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2020.113489_bib8","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1007\/s00280-013-2158-1","article-title":"Treatment of malignant ascites with a combination of chemotherapy drugs and intraperitoneal perfusion of verapamil","volume":"71","author":"Jia","year":"2013","journal-title":"Canc. Chemother. Pharmacol."},{"key":"10.1016\/j.jep.2020.113489_bib10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jep.2018.07.029","article-title":"Euphorbia kansui fry-baked with vinegar modulates gut microbiota and reduces intestinal toxicity in rats","volume":"226","author":"Jiang","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113489_bib11","first-page":"744","article-title":"Dysbacteriosis of intestinal flora and functional diarrhea","volume":"36","author":"Li","year":"2016","journal-title":"Chin. J. Pract. Intern. Med."},{"key":"10.1016\/j.jep.2020.113489_bib12","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.biopha.2017.08.005","article-title":"The activity of Hou-Po-Da-Huang-Tang is improved through intestinal bacterial metabolism and Hou-Po-Da-Huang-Tang selectively stimulate the growth of intestinal bacteria associated with health","volume":"94","author":"Liu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2020.113489_bib13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jep.2018.03.010","article-title":"The toxicity and efficacy evaluation of different fractions of Kansui fry-baked with vinegar on Walker-256 tumor-bearing malignant ascites effusion rats and normal rats","volume":"219","author":"Lou","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113489_bib14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s42003-019-0424-4","article-title":"Lactobacillus maintains healthy gut mucosa by producing L-Ornithine","volume":"2","author":"Qi","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jep.2020.113489_bib15","first-page":"180","article-title":"Experimental study of tongbian granules on the regulation of AQP3 and AQP8 expression in colon of rats with slow transit constipation","volume":"20","author":"Qian","year":"2014","journal-title":"Chin. J. Exp. Tradit. Med. Formulae."},{"key":"10.1016\/j.jep.2020.113489_bib16","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/nrc3610","article-title":"The microbiome and cancer","volume":"13","author":"Schwabe","year":"2013","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.jep.2020.113489_bib17","first-page":"1713","article-title":"Dosage-toxicity-efficacy relationship of Kansni Radix in malignant pleural effusion models based on Walker 256 analysis","volume":"41","author":"Shen","year":"2016","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2020.113489_bib18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jep.2016.04.012","article-title":"The dosage-toxicity-efficacy relationship of kansui and licorice in malignant pleural effusion rats based on factor analysis","volume":"186","author":"Shen","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113489_bib19","series-title":"Study on the Processing Technology, Quality Standard and Detoxifcation Mechanism of Euphorbia Kansui Root","author":"Shu","year":"2008"},{"key":"10.1016\/j.jep.2020.113489_bib20","first-page":"139","article-title":"Application status of external treatment in cirrhosis of liver in refractory ascites","volume":"19","author":"Sun","year":"2019","journal-title":"World Latest Med. Inf."},{"key":"10.1016\/j.jep.2020.113489_bib21","first-page":"1389","article-title":"Clinical observation on 40 cases of ascites with spleen and kidney yang deficiency syndrome treated by external application of xiaozhang lishui powder and moxibustion","volume":"60","author":"Wang","year":"2019","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2020.113489_bib22","first-page":"1966","article-title":"Study on reducing mechanism of hepatotoxicity induced by ethyl acetate fractions of kansui radix stir-baked with vinegar in mice","volume":"38","author":"Yang","year":"2013","journal-title":"Chin. Mater. Medica"},{"key":"10.1016\/j.jep.2020.113489_bib23","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1139\/y06-052","article-title":"Protective effects of polysaccharide from Euphorbia kansui (Euphorbiaceae) on the swimming exercise-induced oxidative stress in mice","volume":"84","author":"Yu","year":"2006","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.jep.2020.113489_bib24","first-page":"43","article-title":"Cultivation conditions on biological characteristic of Lactobacillus acidophilus","volume":"31","author":"Zhang","year":"2005","journal-title":"Food Ferment. Ind."},{"key":"10.1016\/j.jep.2020.113489_bib25","first-page":"681","article-title":"Study on preparation processing technique of Radix Kansui stir-baked with vinegar","volume":"34","author":"Zhang","year":"2009","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2020.113489_bib26","first-page":"2492","article-title":"Comparative study on expelling water retention with drastic purgative of crude and vinegar stir-baked Kansui Radix in cancerous ascites rats","volume":"47","author":"Zhang","year":"2016","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.jep.2020.113489_bib27","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.7150\/ijbs.28890","article-title":"Revealing the effects of the herbal pair of Euphorbia kansui and Glycyrrhiza on hepatocellular carcinoma ascites with integrating network target analysis and experimental validation","volume":"14","author":"Zhang","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2020.113489_bib28","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jpba.2018.03.035","article-title":"Simultaneous quantification of twelve compounds in ethyl acetate extracts of, Euphorbia kansui, before and after fry-baked with vinegar by UPLC\u2013MS\/MS and its toxic effect on zebrafish","volume":"155","author":"Zhang","year":"2018","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2020.113489_bib29","first-page":"112423","article-title":"Kansuiphorin C and Kansuinin A ameliorate malignant ascites by modulating gut microbiota and related metabolic functions","author":"Zhang","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113489_bib30","series-title":"The Expression of Aquaporin 3 and 8 in Digestive System and Their Alterations in the Animal Model of Inflammatory Bowel Disease","author":"Zhao","year":"2014"},{"key":"10.1016\/j.jep.2020.113489_bib31","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1186\/s40064-016-2821-1","article-title":"Intestinal microbiota and chronic constipation","volume":"5","author":"Zhao","year":"2016","journal-title":"SpringerPlus"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120333754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120333754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:00:09Z","timestamp":1759942809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874120333754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":30,"alternative-id":["S0378874120333754"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.113489","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diverse role of gut microbiota on reduction of ascites and intestinal injury in malignant ascites effusion rats treated with Euphorbia kansui stir-fried with vinegar","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.113489","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113489"}}