{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:12:55Z","timestamp":1791403975271,"version":"4.3.3"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Sciences Foundation of China","award":["81630097, 81773718, 81773589"],"award-info":[{"award-number":["81630097, 81773718, 81773589"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["SQ2018YFA090025-04"],"award-info":[{"award-number":["SQ2018YFA090025-04"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"CAMS","doi-asserted-by":"publisher","award":["2016-I2M-3-011"],"award-info":[{"award-number":["2016-I2M-3-011"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Drug Innovation Major Project","award":["2018ZX09711001-003-020,2018ZX09711001-003-005, 2018ZX09711001-008-005"],"award-info":[{"award-number":["2018ZX09711001-003-020,2018ZX09711001-003-005, 2018ZX09711001-008-005"]}]},{"name":"The Fundamental Research Funds for the Central Universities","award":["2018RC350002"],"award-info":[{"award-number":["2018RC350002"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jep.2020.113491","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T13:20:49Z","timestamp":1603113649000},"page":"113491","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["GJ-4 ameliorates memory impairment in focal cerebral ischemia\/reperfusion of rats via inhibiting JAK2\/STAT1-mediated neuroinflammation"],"prefix":"10.1016","volume":"267","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5010-0243","authenticated-orcid":false,"given":"Hui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanjuan","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmei","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinsheng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqi","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.113491_bib1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1089\/rej.2009.1011","article-title":"NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat","volume":"13","author":"Acosta","year":"2010","journal-title":"Rejuvenat. Res."},{"key":"10.1016\/j.jep.2020.113491_bib2","first-page":"273","article-title":"Neflamapimod: clinical phase 2b-ready oral small molecule inhibitor of p38alpha to reverse synaptic dysfunction in early alzheimer's disease","volume":"4","author":"Alam","year":"2017","journal-title":"J. Prev. Alzheimers Dis."},{"key":"10.1016\/j.jep.2020.113491_bib3","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.neuroscience.2011.11.036","article-title":"FLZ protects dopaminergic neuron through activating protein kinase B\/mammalian target of rapamycin pathway and inhibiting RTP801 expression in Parkinson's disease models","volume":"202","author":"Bao","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.jep.2020.113491_bib4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.biopha.2018.12.082","article-title":"Tonguing, a traditional Chinese medication with neuroprotective ability: a review of the cellular, molecular and physiological mediators of TLJN's effectiveness","volume":"111","author":"Bibak","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2020.113491_bib5","doi-asserted-by":"crossref","first-page":"24626","DOI":"10.1038\/srep24626","article-title":"PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits","volume":"6","author":"Broadhead","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2020.113491_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.nlm.2017.03.017","article-title":"Lithium and memantine improve spatial memory impairment and neuroinflammation induced by beta-amyloid 1-42 oligomers in rats","volume":"141","author":"Budni","year":"2017","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.jep.2020.113491_bib7","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1007\/s12035-016-0130-x","article-title":"Bee venom ameliorates cognitive dysfunction caused by neuroinflammation in an animal model of vascular dementia","volume":"54","author":"Cai","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jep.2020.113491_bib8","first-page":"2651","article-title":"Activation of EphA4 induced by EphrinA1 exacerbates disruption of the blood-brain barrier following cerebral ischemia-reperfusion via the Rho\/ROCK signaling pathway","volume":"16","author":"Chen","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2020.113491_bib9","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1007\/s12035-016-9915-1","article-title":"Molecular mechanisms of vascular dementia: what can Be learned from animal models of chronic cerebral hypoperfusion?","volume":"54","author":"Du","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jep.2020.113491_bib10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3233\/JAD-180251","article-title":"Neuroprotective effects of Ginsenoside Rf on amyloid-beta-induced neurotoxicity in vitro and in vivo","volume":"64","author":"Du","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jep.2020.113491_bib11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ijdevneu.2013.12.003","article-title":"Investigation into the effects of prenatal alcohol exposure on postnatal spine development and expression of synaptophysin and PSD95 in rat hippocampus","volume":"33","author":"Elibol-Can","year":"2014","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.jep.2020.113491_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neuint.2014.12.002","article-title":"Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia","volume":"80","author":"Gallart-Palau","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jep.2020.113491_bib13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neuint.2019.02.010","article-title":"Propylammonium, a CCR2 inhibitor, attenuates cerebral ischemia\/reperfusion injury through inhibiting inflammatory response induced by microglia","volume":"125","author":"He","year":"2019","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jep.2020.113491_bib14","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neuroscience.2011.10.030","article-title":"Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride","volume":"200","author":"Hou","year":"2012","journal-title":"Neurosci."},{"key":"10.1016\/j.jep.2020.113491_bib15","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.jep.2020.113491_bib16","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0197-4580(00)00125-1","article-title":"The role of cerebral ischemia in Alzheimer's disease","volume":"21","author":"Kalaria","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jep.2020.113491_bib17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10787-016-0271-6","article-title":"Neurokinin-1 receptor inhibition reverses ischaemic brain injury and dementia in bilateral common carotid artery occluded rats: possible mechanisms","volume":"24","author":"Kaur","year":"2016","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2020.113491_bib18","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1749-6632.1999.tb08022.x","article-title":"Neuroprotective actions of novel and potent ligands of group I and group II metabotropic glutamate receptors","volume":"890","author":"Kingston","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jep.2020.113491_bib19","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/WAD.0b013e31816c92e6","article-title":"Panax ginseng enhances cognitive performance in Alzheimer disease","volume":"22","author":"Lee","year":"2008","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.jep.2020.113491_bib20","doi-asserted-by":"crossref","first-page":"172789","DOI":"10.1016\/j.ejphar.2019.172789","article-title":"Integration of transcriptomics and network analysis deciphers the mechanisms of baicalein in improving learning and memory impairment in senescence-accelerated mouse prone 8 (SAMP8)","volume":"865","author":"Li","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2020.113491_bib21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.nbd.2013.06.014","article-title":"Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model","volume":"59","author":"Li","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jep.2020.113491_bib22","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0254-6272(15)30088-1","article-title":"Effect of tongluojiunao injection made from sanqi (Radix Notoginseng) and zhizi (Fructus Gardeniae) on brain microvascular endothelial cells and astrocytes in an in vitro ischemic model","volume":"34","author":"Li","year":"2014","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2020.113491_bib23","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/jnc.13904","article-title":"Etidronate rescues cognitive deficits through improving synaptic transmission and suppressing apoptosis in 2-vessel occlusion model rats","volume":"140","author":"Li","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jep.2020.113491_bib24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.lfs.2016.01.045","article-title":"Electroacupuncture improves motor impairment via inhibition of microglia-mediated neuroinflammation in the sensorimotor cortex after ischemic stroke","volume":"151","author":"Liu","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2020.113491_bib25","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jep.2007.03.019","article-title":"Clinical systematic observation of Kangxin capsule curing vascular dementia of senile kidney deficiency and blood stagnation type","volume":"112","author":"Liu","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113491_bib26","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.jep.2011.07.031","article-title":"Effect of tong Luo jiu nao on a\u03b2-degrading enzymes in AD rat brains","volume":"137","author":"Liu","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113491_bib27","first-page":"899","article-title":"Effects of Gardenia jasminoides extracts on cognition and innate immune response in an adult Drosophila model of Alzheimer's disease","volume":"15","author":"Ma","year":"2017","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2020.113491_bib28","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1021\/acs.jafc.6b03866","article-title":"Discovery and LC-MS characterization of new crocins in gardeniae fructus and their neuroprotective potential","volume":"65","author":"Ni","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2020.113491_bib29","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/S0140-6736(15)00463-8","article-title":"Vascular dementia","volume":"386","author":"O'Brien","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2020.113491_bib30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0014-2999(91)90151-F","article-title":"Effect of the kappa-receptor agonist, U-50,488H, on cerebral ischemia-induced impairment of working memory assessed in rats by a three-panel runway task","volume":"193","author":"Ohno","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2020.113491_bib31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn3504","article-title":"NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease","volume":"14","author":"Paoletti","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jep.2020.113491_bib32","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1042\/BST0341267","article-title":"Signalling pathways mediating inflammatory responses in brain ischaemia","volume":"34","author":"Planas","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.jep.2020.113491_bib33","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1161\/STROKEAHA.113.004534","article-title":"Multimodal markers of inflammation in the subcortical ischemic vascular disease type of vascular cognitive impairment","volume":"45","author":"Rosenberg","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2020.113491_bib34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neubiorev.2015.12.004","article-title":"Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: can exercise compensate?","volume":"61","author":"Ryan","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jep.2020.113491_bib35","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3389\/fimmu.2012.00132","article-title":"Post-ischemic inflammation in the brain","volume":"3","author":"Shichita","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2020.113491_bib36","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/nan.12215","article-title":"Synaptic protein levels altered in vascular dementia","volume":"41","author":"Sinclair","year":"2015","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.jep.2020.113491_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24020343","article-title":"Hwangryunhaedok-tang exerts neuropreventive effect on memory impairment by reducing cholinergic system dysfunction and inflammatory response in a vascular dementia rat model","volume":"24","author":"Sohn","year":"2019","journal-title":"Mole."},{"key":"10.1016\/j.jep.2020.113491_bib38","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1527-3458.2002.tb00232.x","article-title":"YM872: a selective, potent and highly water-soluble alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist","volume":"8","author":"Takahashi","year":"2002","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.jep.2020.113491_bib39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neubiorev.2014.06.012","article-title":"Synapses, spines and kinases in mammalian learning and memory, and the impact of aging","volume":"50","author":"van der Zee","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jep.2020.113491_bib40","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3389\/fnagi.2018.00376","article-title":"Dysfunction of cerebrovascular endothelial cells: prelude to vascular dementia","volume":"10","author":"Wang","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.jep.2020.113491_bib41","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/jnr.22237","article-title":"Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion","volume":"88","author":"Wang","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jep.2020.113491_bib42","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.freeradbiomed.2015.10.426","article-title":"Acupuncture ameliorates cognitive impairment and hippocampus neuronal loss in experimental vascular dementia through Nrf2-mediated antioxidant response","volume":"89","author":"Wang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2020.113491_bib43","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0002-8703(03)00398-3","article-title":"Selective COX-2 inhibition and cardiovascular effects: a review of the rofecoxib development program","volume":"146","author":"Weir","year":"2003","journal-title":"Am. Heart J."},{"key":"10.1016\/j.jep.2020.113491_bib44","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.nbd.2017.11.009","article-title":"Axl activation attenuates neuroinflammation by inhibiting the TLR\/TRAF\/NF-\u03baB pathway after MCAO in rats","volume":"110","author":"Wu","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jep.2020.113491_bib45","doi-asserted-by":"crossref","first-page":"2530105","DOI":"10.1155\/2016\/2530105","article-title":"Rannasangpei is a therapeutic agent in the treatment of vascular dementia","volume":"2016","author":"Wu","year":"2016","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2020.113491_bib46","doi-asserted-by":"crossref","first-page":"7677","DOI":"10.1007\/s12035-018-0943-x","article-title":"Acupuncture prevents the impairment of hippocampal LTP through beta 1-AR in vascular dementia rats","volume":"55","author":"Xiao","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jep.2020.113491_bib47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jfda.2016.11.005","article-title":"Chemistry and bioactivity of Gardenia jasminoides","volume":"25","author":"Xiao","year":"2017","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.jep.2020.113491_bib48","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0378-8741(00)00303-2","article-title":"Protective effect of Oren-sudoku-to (Huang-Lian-Jie-Du-Tang) against impairment of learning and memory induced by transient cerebral ischemia in mice","volume":"73","author":"Xu","year":"2000","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113491_bib49","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.brainresbull.2017.04.019","article-title":"The protective effect of astaxanthin on learning and memory deficits and oxidative stress in a mouse model of repeated cerebral ischemia\/reperfusion","volume":"131","author":"Xue","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jep.2020.113491_bib50","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1142\/S0192415X18500192","article-title":"The protective effects of gardenia jasminoides (fructus gardenia) on amyloid-beta-induced mouse cognitive impairment and neurotoxicity","volume":"46","author":"Zang","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2020.113491_bib51","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/ptr.5481","article-title":"Can Chinese herbal medicine adjunctive therapy improve outcomes of senile vascular dementia? Systematic review with meta-analysis of clinical trials","volume":"29","author":"Zeng","year":"2015","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2020.113491_bib52","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jep.2016.11.042","article-title":"Learning and memory improvement and neuroprotection of Gardenia jasminoides (Fructus gardenia) extract on ischemic brain injury rats","volume":"196","author":"Zhang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113491_bib53","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/s11655-015-2124-3","article-title":"Paeoniflorin improves regional cerebral blood flow and suppresses inflammatory factors in the hippocampus of rats with vascular dementia","volume":"23","author":"Zhang","year":"2017","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2020.113491_bib54","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.neuroscience.2015.10.038","article-title":"Repetitive transcranial magnetic stimulation enhances spatial learning and synaptic plasticity via the VEGF and BDNF-NMDAR pathways in a rat model of vascular dementia","volume":"311","author":"Zhang","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.jep.2020.113491_bib55","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neulet.2011.05.001","article-title":"Activation of JAK2\/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats","volume":"498","author":"Zhao","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jep.2020.113491_bib56","first-page":"4925682","article-title":"Diverse pharmacological activities and potential medicinal benefits of geniposide. Evid.Based complement","volume":"2019","author":"Zhou","year":"2019","journal-title":"Alternat. Med."},{"key":"10.1016\/j.jep.2020.113491_bib57","doi-asserted-by":"crossref","first-page":"28908","DOI":"10.1038\/srep28908","article-title":"(-)-SCR1693 protects against memory impairment and hippocampal damage in a chronic cerebral hypoperfusion rat model","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2020.113491_bib58","doi-asserted-by":"crossref","first-page":"42660","DOI":"10.1038\/srep42660","article-title":"Protective effect of 17 beta-estradiol upon hippocampal spine density and cognitive function in an animal model of vascular dementia","volume":"7","author":"Zhu","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120333778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120333778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:43:55Z","timestamp":1759941835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874120333778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":58,"alternative-id":["S0378874120333778"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.113491","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GJ-4 ameliorates memory impairment in focal cerebral ischemia\/reperfusion of rats via inhibiting JAK2\/STAT1-mediated neuroinflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.113491","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113491"}}