{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T02:10:20Z","timestamp":1769220620340,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"FUNCAP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["308433\/2017\u20133"],"award-info":[{"award-number":["308433\/2017\u20133"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jep.2020.113501","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T20:53:52Z","timestamp":1603745632000},"page":"113501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Polysaccaride-rich extract of Caesalpina ferrea stem barks attenuates mice acute inflammation induced by zymosan: Oxidative stress modulation"],"prefix":"10.1016","volume":"267","author":[{"given":"Bianca Feitosa","family":"Holanda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Freitas de Araujo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Nilo R.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Gon\u00e7alves","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana","family":"de Freitas Pires","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2323-5385","authenticated-orcid":false,"given":"Ana Maria","family":"Assreuy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.113501_bib1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jep.2014.07.031","article-title":"Quantification of polyphenols and evaluation of antimicrobial, analgesic and anti-inflammatory activities of aqueous and acetone\u2013water extracts of Libidibia ferrea, Parapiptadenia rigida and Psidium guajava","volume":"156","author":"Ara\u00fajo","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113501_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jfbc.13145","article-title":"Understanding oxidants and antioxidants: classical team with new players","volume":"44","author":"Ali","year":"2020","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.jep.2020.113501_bib3","series-title":"Plantas Do Nordeste, Especialmente Do Cear\u00e1","first-page":"p540","author":"Braga","year":"1976"},{"key":"10.1016\/j.jep.2020.113501_bib4","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1055\/s-2006-958056","article-title":"Antiulcer action and toxicity of Styrax camporum and Caesalpinia ferrea","volume":"61","author":"Bacchi","year":"1996","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2020.113501_bib5","first-page":"71","article-title":"Antioxidant and hepatoprotective activities of Libidibia ferrea bark and fruit extracts","volume":"6","author":"Barros","year":"2014","journal-title":"Int. J. Pharm. Pharmaceut. Sci."},{"key":"10.1016\/j.jep.2020.113501_bib6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2020.113501_bib7","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1182\/blood.V60.3.618.618","article-title":"Cellular and extracellular myeloperoxidase in pyogenic inflammation","volume":"60","author":"Bradley","year":"1982","journal-title":"Blood"},{"key":"10.1016\/j.jep.2020.113501_bib8","series-title":"Minist\u00e9rio da Sa\u00fade. Programa nacional de plantas medicinais e fitoter\u00e1picos. Secretaria de Ci\u00eancia, Tecnologia e Insumos Estrat\u00e9gicos","first-page":"7","year":"2009"},{"key":"10.1016\/j.jep.2020.113501_bib9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0378-8741(96)01441-9","article-title":"Preliminary studies of the analgesic and anti-inflammatory properties of Caesalpinia ferrea crude extract","volume":"53","author":"Carvalho","year":"1996","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113501_bib10","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/abio.1998.2952","article-title":"Free and total malondialdehyde assessment in biological matrices by gas chromatography-mass spectrometry: what is needed for an accurate detection","volume":"266","author":"Cighetti","year":"1999","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2020.113501_bib11","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/med.21599","article-title":"Inducible nitric oxide synthase: regulation, structure, and inhibition","volume":"40","author":"Cinelli","year":"2019","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jep.2020.113501_bib12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.niox.2011.06.004","article-title":"Pain and analgesia: the dual effect of nitric oxide in the nociceptive system","volume":"25","author":"Cury","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.jep.2020.113501_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/3859856","article-title":"Cynanchum wilfordii polysaccharides suppress dextran sulfate sodium-induced acute colitis in mice and the production of inflammatory mediators from macrophages","author":"Cho","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2020.113501_bib14","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ijbiomac.2019.09.039","article-title":"Tetrastigma hemsleyanum tubers polysaccharide ameliorates LPS-induced inflammation in macrophages and Caenorhabditis elegans","volume":"141","author":"Chu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2020.113501_bib15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0021-9258(17)35155-4","article-title":"A new specific color reaction of hexuronic acids","volume":"167","author":"Dische","year":"1947","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2020.113501_bib16","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/0090-6980(85)90006-1","article-title":"Intraperitoneal injection of zymosan in mice induces pain, inflammation and the synthesis of Peptidoleukotrienes and prostaglandin E2","volume":"30","author":"Doherty","year":"1985","journal-title":"Prostaglandins"},{"key":"10.1016\/j.jep.2020.113501_bib17","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/ac60111a017","article-title":"Colorimetric method for determination of sugars and related substances","volume":"28","author":"Dubois","year":"1956","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jep.2020.113501_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1871523014666150514102027","article-title":"An update on anti-inflammatory compounds: a review","volume":"14","author":"Dhingra","year":"2015","journal-title":"Antiinflamm Antiallergy Agents Med Chem"},{"key":"10.1016\/j.jep.2020.113501_bib19","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0076-6879(84)05015-1","article-title":"Assays of glutathione peroxidase","volume":"105","author":"Floh\u00e9","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jep.2020.113501_bib20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbrc.2016.10.086","article-title":"Lipid peroxidation in cell death","volume":"482","author":"Stockwell","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2020.113501_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cbdv.201800343","article-title":"Anti-inflammatory activities and related mechanism of the polysaccharides isolated from Sargentodoxa cuneate","volume":"15","author":"Guo","year":"2018","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jep.2020.113501_bib22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2020.113501_bib23","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.redox.2017.01.023","article-title":"Redox regulation in metabolic programming and inflammation","volume":"12","author":"Griffiths","year":"2017","journal-title":"Redox Biol"},{"key":"10.1016\/j.jep.2020.113501_bib24","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0021-9258(19)68075-0","article-title":"Evidence for two sources of arachidonic acid for oxidative metabolism by mouse peritoneal macrophages","volume":"257","author":"Humes","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2020.113501_bib25","first-page":"1","article-title":"Oxidative stress and inflammation: what polyphenols can do for us?","author":"Hussain","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jep.2020.113501_bib26","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1476-5381.1995.tb17178.x","article-title":"Inhibition of carrageenin-induced rat paw o edema by crotapotin, a polypeptide complexed with phospholipase A2","volume":"114","author":"Landucci","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2020.113501_bib27","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s12576-016-0494-8","article-title":"Prostaglandins mediate zymosan-induced sickness behavior in mice","volume":"67","author":"Lima","year":"2016","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.jep.2020.113501_bib28","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1590\/S0102-695X2012005000031","article-title":"Anti-inflamatory polysaccharides of Azadirachta indica seed tegument","volume":"22","author":"Pereira","year":"2012","journal-title":"Rev Bras Farmacog"},{"key":"10.1016\/j.jep.2020.113501_bib29","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jep.2011.12.012","article-title":"Polysaccharide fractions of Caesalpinia ferrea pods: potential antiinflamatory usage","volume":"139","author":"Pereira","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113501_bib30","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1590\/2179-8087.024212","article-title":"Esp\u00e9cies da caatinga como alternativa para o desenvolvimento de novos fitof\u00e1rmacos","volume":"21","author":"Pereira J\u00fanior","year":"2014","journal-title":"J Floram"},{"key":"10.1016\/j.jep.2020.113501_bib31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jep.2016.04.043","article-title":"Modulator effect of a polysaccharide-rich extract from Caesalpinia ferrea stem barks in rat cutaneous wound healing: Role of TNF-\u03b1, IL-1\u03b2, NO, TGF-\u03b2","volume":"187","author":"Pereira","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113501_bib32","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.chemosphere.2017.04.130","article-title":"Protective effect of vitamin C in female Swiss mice dermally-exposed to the tannery effluent","volume":"181","author":"Rabelo","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.jep.2020.113501_bib33","first-page":"360","article-title":"Spectrophotometric determination of the total phenolic content, spectral and fluorescence study of the herbal Unani drug Gul-eZoofa","volume":"12","author":"Siddiqui","year":"2017","journal-title":"J Taibah Univ Sci"},{"key":"10.1016\/j.jep.2020.113501_bib34","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.biopha.2018.07.067","article-title":"Ximenia americana heteropolysaccharides ameliorate inflammation and visceral hypernociception in murine caerulein-induced acute pancreatitis: involvement of CB2 receptors","volume":"106","author":"Silva-Leite","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2020.113501_bib35","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","article-title":"Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent","volume":"25","author":"Sedlak","year":"1968","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2020.113501_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-57486-w","article-title":"Anti-diabetic activity of crude polysaccharide and rhamnose enriched polysaccharide from G. lithophila on Streptozotocin (STZ)-induced in Wistar rats","volume":"10","author":"Seedevi","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2020.113501_bib37","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF01966691","article-title":"Blockade by antimacrophage serum of the migration of PMN neutrophils into the inflamed peritoneal cavity","volume":"17","author":"Souza","year":"1985","journal-title":"Agents Actions"},{"key":"10.1016\/j.jep.2020.113501_bib38","first-page":"1","article-title":"The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment","volume":"12","author":"Takahashi","year":"2019","journal-title":"Sci. Sin."},{"key":"10.1016\/j.jep.2020.113501_bib40","doi-asserted-by":"crossref","first-page":"1.199","DOI":"10.1097\/j.pain.0000000000000499","article-title":"Gain control mechanisms in the nociceptive system","volume":"157","author":"Treede","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.jep.2020.113501_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2018.03.037","article-title":"The other myeloperoxidase: emerging functions","volume":"649","author":"Vanhamme","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jep.2020.113501_bib42","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijbiomac.2016.01.010","article-title":"A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression","volume":"86","author":"Wang","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2020.113501_bib43","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.imbio.2008.09.002","article-title":"Zymosan treatment of mouse mast cells enhances dectin-1 expression and induces dectin-1-dependent reactive oxygen species (ROS) generation","volume":"214","author":"Yang","year":"2009","journal-title":"Immunobiology"},{"key":"10.1016\/j.jep.2020.113501_bib44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3748\/wjg.v26.i1.55","article-title":"Synergistic protection of polysaccharides and astragalus matrices against ulcerative colitis and associated lung injury in rats","volume":"26","author":"Yan","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2020.113501_bib45","doi-asserted-by":"crossref","first-page":"7887","DOI":"10.3390\/molecules17077887","article-title":"The Genus Caesalpinia L. (Caesalpiniaceae): phytochemical and pharmacological characteristics","volume":"17","author":"Zanin","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2020.113501_bib46","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.carbpol.2014.01.059","article-title":"Isolation, characterization and antioxidante activity of polysaccharide from Schisandra sphenanthera","volume":"105","author":"Zhao","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2020.113501_bib47","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ijbiomac.2018.04.083","article-title":"Oxidative stress in osteoarthritis and antioxidant effect of polysaccharide from Angelica sinensis","volume":"115","author":"Zhuang","year":"2018","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120333870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120333870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:00:49Z","timestamp":1759942849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874120333870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":46,"alternative-id":["S0378874120333870"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.113501","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polysaccaride-rich extract of Caesalpina ferrea stem barks attenuates mice acute inflammation induced by zymosan: Oxidative stress modulation","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.113501","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113501"}}