{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:56:09Z","timestamp":1791453369412,"version":"4.3.3"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973573"],"award-info":[{"award-number":["81973573"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1703900"],"award-info":[{"award-number":["2017YFC1703900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jep.2020.113514","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T02:10:14Z","timestamp":1603505414000},"page":"113514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Ethyl acetate extract of Tibetan medicine Rhamnella gilgitica ameliorated type II collagen-induced arthritis in rats via regulating JAK-STAT signaling pathway"],"prefix":"10.1016","volume":"267","author":[{"given":"Jinsong","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhondrup","family":"W\u00fcntrang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2557-2622","authenticated-orcid":false,"family":"RuyuYao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianli","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.113514_bib1","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/ar2936","article-title":"Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors","volume":"12","author":"Adamopoulos","year":"2010","journal-title":"Arthritis Res."},{"key":"10.1016\/j.jep.2020.113514_bib2","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nri818","article-title":"Suppressors of cytokine signalling (SOCS) in the immune system","volume":"2","author":"Alexander","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2020.113514_bib3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrd.2016.253","article-title":"From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors","volume":"16","author":"Ashkenazi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jep.2020.113514_bib4","doi-asserted-by":"crossref","first-page":"153036","DOI":"10.1016\/j.phymed.2019.153036","article-title":"Genkwanin ameliorates adjuvant-induced arthritis in rats through inhibiting JAK\/STAT and NF-\u03baB signaling pathways","volume":"63","author":"Bao","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2020.113514_bib5","first-page":"3","article-title":"The pathogenesis of rheumatoid arthritis: pivotal cytokines involved in bone degradation and inflammation","volume":"65","author":"Bingham","year":"2002","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.jep.2020.113514_bib6","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1172\/JCI36389","article-title":"Evidence that cytokines play a role in rheumatoid arthritis","volume":"118","author":"Brennan","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2020.113514_bib7","first-page":"49","article-title":"Study on Chemical components of aqueous extract from raw nauclea officinalis by UPLC-Q-TOF-MS\/MS","volume":"24","author":"Chen","year":"2018","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"10.1016\/j.jep.2020.113514_bib8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jep.2017.03.005","article-title":"The therapeutic effects of periplocaforrestiischltr. stem extracts on collagen-induced arthritis by inhibiting the activation of src\/nf-\u03bab signaling pathway in rats","author":"Chen","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113514_bib9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jpba.2019.03.009","article-title":"Identification and analysis of components in Shen-Fu-Shu granule extract and in rat plasma after oral administration by UPLC-ESI\/Q-TOF-MS","volume":"169","author":"Chen","year":"2019","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2020.113514_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41584-018-0109-2","article-title":"Anti-inflammatory and immuneregulatory cytokines in rheumatoid arthritis","volume":"15","author":"Chen","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2020.113514_bib11","first-page":"34","article-title":"Simultaneous determination of five phenolic acids in salviaemiltiorrhizae and ligustrazine hydrochloride Injection by UPLC-Q-TOF-MS\/MS","volume":"41","author":"Cheng","year":"2019","journal-title":"Chinese Traditional Patent Medicine"},{"key":"10.1016\/j.jep.2020.113514_bib12","first-page":"42","article-title":"The study of the expression of interleukin-17 in serum and synovial fluid of rheumatoid arthritis patients","volume":"6","author":"Cheng","year":"2014","journal-title":"Chinese Journal of the Frontiers of Medical Science(Electronic Version)"},{"key":"10.1016\/j.jep.2020.113514_bib13","first-page":"2851","article-title":"Research progress of drugs commonly used to anti-rheumatoid arthritis","volume":"39","author":"Chi","year":"2014","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2020.113514_bib14","doi-asserted-by":"crossref","first-page":"R26","DOI":"10.1186\/ar4162","article-title":"Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6\/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes","volume":"15","author":"Choe","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2020.113514_bib15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bbrc.2005.01.110","article-title":"Anti-inflammatory roles of retinoic acid in rat brain astrocytes: suppression of interferon-c-induced JAK\/STAT phosphorylation","volume":"329","author":"Choi","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2020.113514_bib16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/08923973.2018.1434793","article-title":"Experimental animal models for rheumatoid arthritis","volume":"40","author":"Choudhary","year":"2018","journal-title":"ImmunopharmImmunot"},{"key":"10.1016\/j.jep.2020.113514_bib17","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1093\/nar\/gky1113","article-title":"Ensembl 2019","volume":"47","author":"Cunningham","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2020.113514_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.autrev.2008.07.029","article-title":"Predictivity and sensitivity of animal models of arthritis","volume":"8","author":"Di","year":"2008","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jep.2020.113514_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.berh.2008.01.007","article-title":"Animal models for arthritis","volume":"22","author":"Dinser","year":"2008","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.jep.2020.113514_bib20","first-page":"341","article-title":"Chemical constituents from herpetospermumcaudigerum","volume":"41","author":"Dong","year":"2019","journal-title":"Chinese Traditional Patent Medicine"},{"key":"10.1016\/j.jep.2020.113514_bib21","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4049\/jimmunol.169.1.434","article-title":"Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1","volume":"169","author":"Federici","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2020.113514_bib22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev.immunol.19.1.163","article-title":"Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned","volume":"19","author":"Feldmann","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jep.2020.113514_bib23","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/BOR.0000000000000036","article-title":"T cell subsets and their role in the pathogenesis of rheumatic disease","volume":"26","author":"Gizinski","year":"2014","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jep.2020.113514_bib24","first-page":"192","article-title":"Study progress of IL-17 and NF-kappa B pathway in RA","volume":"31","author":"Guo","year":"2015","journal-title":"Journal of Changchun University of Chinese Medicine"},{"key":"10.1016\/j.jep.2020.113514_bib25","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1056\/NEJM199005033221805","article-title":"Rheumatoid arthritis. Pathophysiology and implications for therapy","volume":"322","author":"Harris","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2020.113514_bib26","first-page":"157","article-title":"Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis","volume":"31","author":"Hou","year":"2009","journal-title":"Chin. J. Cell Bio."},{"key":"10.1016\/j.jep.2020.113514_bib27","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1142\/S0192415X16500774","article-title":"Rhamnellagilgiticaattenuates inflammatory responses in LPS-induced murine macrophages and complete freund'sadjuvant-induced arthritis rats","volume":"44","author":"Huang","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2020.113514_bib28","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1007\/s00216-011-4998-z","article-title":"Identification of phenolic compounds in aqueous and ethanolic rooibos extracts (Aspalathus linearis) by HPLC-ESI-MS (TOF\/IT)","volume":"400","author":"Iswaldi","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jep.2020.113514_bib29","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jep.2014.04.052","article-title":"Hempseed oil induces reactive oxygen species- and C\/EBP homologous protein-mediated apoptosis in MH7A human rheumatoid arthritis fibroblast-like synovial cells","volume":"154","author":"Jeong","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113514_bib30","first-page":"1411","article-title":"Analgesia and anti-inflammatory effect of total flavonoids extracted from euphorbia prolifera","volume":"33","author":"Jin","year":"2014","journal-title":"Herald of Medicine"},{"key":"10.1016\/j.jep.2020.113514_bib31","doi-asserted-by":"crossref","first-page":"152825","DOI":"10.1016\/j.phymed.2019.152825","article-title":"Therapeutic e\ufb00ects of the total lignans from Vitex negundo seeds on collageninduced arthritis in rats","volume":"58","author":"Jing","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2020.113514_bib32","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1515\/bmc-2018-0007","article-title":"Interferon-gamma (IFN-\u03b3):exploring its implications in infectious diseases","volume":"9","author":"Kak","year":"2018","journal-title":"Biomol. Concepts"},{"key":"10.1016\/j.jep.2020.113514_bib33","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/rheumatology\/keh366","article-title":"The e\ufb00ect of individualized diet challenges consisting of allergenic foods on TNF-alpha and IL-1beta levels in patients with rheumatoid arthritis","volume":"43","author":"Karatay","year":"2004","journal-title":"Rheumatology"},{"key":"10.1016\/j.jep.2020.113514_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2008.07.008","article-title":"Regulation of autoimmune inflammation by pro-inflammatory cytokines","volume":"120","author":"Kim","year":"2008","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jep.2020.113514_bib35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cyto.2017.04.012","article-title":"Immunomodulation of autoimmune arthritis by pro-inflammatory cytokines","volume":"98","author":"Kim","year":"2017","journal-title":"Cytokine"},{"key":"10.1016\/j.jep.2020.113514_bib36","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/cmi.2016.65","article-title":"Defciency of the G protein G\u03b1q ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 di\ufb00erentiation","volume":"14","author":"Lai","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jep.2020.113514_bib37","series-title":"Study on the Total Phenol of Sargentodoxaecaulisthe and its Function of Bone Destruction of Anti-rheumatic Arthritis","author":"Lei","year":"2019"},{"key":"10.1016\/j.jep.2020.113514_bib38","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bbrc.2013.04.084","article-title":"AG490 inhibits NFATc1 expression and STAT3 activation during RANKL induced osteoclastogenesis","volume":"435","author":"Li","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2020.113514_bib39","first-page":"1375","article-title":"Pathologic finding of increased expression of interleukin-17 in the synovial tissue of rheumatoid arthritis patients","volume":"6","author":"Li","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.jep.2020.113514_bib40","first-page":"453","article-title":"Clinical manifestations and the main evaluation method on adjuvant-induced arthritis model in rats","volume":"28","author":"Li","year":"2012","journal-title":"Chinese Journal of Immunology"},{"key":"10.1016\/j.jep.2020.113514_bib41","first-page":"1348","article-title":"Clinic treating discussion of rheumatoid arthritis","volume":"25","author":"Li","year":"2007","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2020.113514_bib42","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.intimp.2019.05.024","article-title":"The roles of synovial hyperplasia, angiogenesis and osteoclastogenesis in the protective effect of apigenin on collagen-induced arthritis","volume":"73","author":"Li","year":"2019","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2020.113514_bib43","series-title":"Jing Zhu Materia Medica [M]","author":"Luo","year":"2018"},{"key":"10.1016\/j.jep.2020.113514_bib44","doi-asserted-by":"crossref","first-page":"5741","DOI":"10.1007\/s11033-013-2677-1","article-title":"Effects of ischemic preconditioning on myocardium Caspase-3, SOCS-1, SOCS-3, TNF-\u03b1 and IL-6 mRNA expression levels in myocardium IR rats","volume":"40","author":"Ma","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jep.2020.113514_bib45","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2094","article-title":"Cytokines in the pathogenesis of rheumatoid arthritis","volume":"7","author":"Mcinnes","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2020.113514_bib46","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"Mcinnes","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2020.113514_bib47","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/S0140-6736(17)31472-1","article-title":"Pathogenetic insights from the treatment of rheumatoid arthritis","volume":"389","author":"Mcinnes","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2020.113514_bib48","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1002\/eji.200838415","article-title":"LILRA5 is expressed by synovial tissue macrophages in rheumatoid arthritis, selectively induces pro-in\ufb02ammatory cytokines and IL-10 and is regulated by TNF-alpha, IL-10 and IFN-gamma","volume":"38","author":"Mitchell","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jep.2020.113514_bib49","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.intimp.2017.12.011","article-title":"Kaempferol inhibits the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes by blocking activation of the MAPK pathway","volume":"55","author":"Pan","year":"2018","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2020.113514_bib50","first-page":"76","article-title":"Studies on the chemical constituents of traditional tibetsnmedieinal herb Shengdeng (Rhamnellagilgitiea) (I)","volume":"2","author":"Pan","year":"1998","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.jep.2020.113514_bib51","first-page":"114","article-title":"Study on the bio-active components from hardwoods of rhamnelagilgitica","volume":"2","author":"Peng","year":"1996","journal-title":"Chinese journal of medicinel chemistry"},{"key":"10.1016\/j.jep.2020.113514_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2016.06.028","article-title":"Therapeutic effects of caragana pruinosakom. roots extract on type II collagen-induced arthritis in rats","volume":"191","author":"Peng","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113514_bib53","first-page":"74","article-title":"Research progress of animal model of rheumatoid arthritis","volume":"32","author":"Qiang","year":"2015","journal-title":"Journal of Gansu College of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2020.113514_bib54","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd726","article-title":"Apoptosis-based therapies","volume":"1","author":"Reed","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jep.2020.113514_bib55","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1136\/ard.2011.150284","article-title":"The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon","volume":"71","author":"Rosengren","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2020.113514_bib56","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1039\/C6FO00485G","article-title":"An update on dietary phenolic compounds in the prevention and management of rheumatoid arthritis","volume":"7","author":"Rosillo","year":"2016","journal-title":"Food Funct"},{"key":"10.1016\/j.jep.2020.113514_bib57","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1136\/ard.2007.074278","article-title":"The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis","volume":"67","author":"Schett","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2020.113514_bib58","first-page":"20","article-title":"Joint damage and disability in rheumatoid arthritis: an updated systematic review","volume":"21","author":"Scott","year":"2003","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.jep.2020.113514_bib59","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/1529-0131(199906)42:6<1071::AID-ANR1>3.0.CO;2-8","article-title":"The genetics revolution and the assault on rheumatoid arthritis","volume":"42","author":"Seldin","year":"1999","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2020.113514_bib60","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/cdd.2014.216","article-title":"Old, new and emerging functions of caspases","volume":"22","author":"Shalini","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2020.113514_bib61","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/dta.2155","article-title":"Profiling and identification of (-)-epicatechin metabolites in rats using ultra-high performance liquid chromatography coupled with linear trap-Orbitrap mass spectrometer","volume":"9","author":"Shang","year":"2017","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jep.2020.113514_bib62","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00204-014-1448-7","article-title":"The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update","volume":"89","author":"Siddiqui","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jep.2020.113514_bib63","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/art.20382","article-title":"Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen\u2010induced arthritis","volume":"50","author":"Sims","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2020.113514_bib64","first-page":"53","article-title":"Preparation and early performance evaluation of collagen induced rheumatoid arthritis rat model","volume":"42","author":"Su","year":"2020","journal-title":"Journal of Inner Mongolia Medical University"},{"key":"10.1016\/j.jep.2020.113514_bib65","doi-asserted-by":"crossref","first-page":"6162","DOI":"10.3892\/mmr.2017.7389","article-title":"Beneficial effect of 20-hydroxyecdysone exerted by modulating antioxidants and inflammatory cytokine levels in collagen-induced arthritis: a model for rheumatoid arthritis","volume":"16","author":"Sun","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2020.113514_bib66","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jep.2019.03.035","article-title":"Glycine tabacina ethanol extract ameliorates collagen-induced arthritis in rats via inhibiting pro-inflammatory cytokines and oxidation","volume":"237","author":"Tu","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113514_bib67","first-page":"1272","article-title":"HPLC-HRMS analysis of propolis total flavonoids dripping pills","volume":"35","author":"Wang","year":"2015","journal-title":"Jilin Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2020.113514_bib68","first-page":"1","article-title":"K nearest neighbor algorithm coupled withmetabonomics to study the therapeutic mechanism of Sendeng-4 in adjuvant-induced rheumatoid arthritis rat","author":"Wang","year":"2018","journal-title":"Evid-BasedCompl Alt."},{"key":"10.1016\/j.jep.2020.113514_bib69","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bcp.2017.05.006","article-title":"Therapeutic effect of cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation","volume":"138","author":"Wang","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2020.113514_bib70","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9348075","article-title":"Comparative pharmacokinetic study of taxifolin after oral administration of fructus polygoniorientalisextract in normal and fibrotic rats by UPLC-MS\/MS","author":"Wei","year":"2019","journal-title":"Evid-BasedCompl Alt"},{"key":"10.1016\/j.jep.2020.113514_bib71","first-page":"2524","article-title":"Salvianolic acid B suppresses inflammatory mediator levels by downregulating NF-\u03baB in a rat model of rheumatoid arthritis","volume":"24","author":"Xia","year":"2018","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.jep.2020.113514_bib72","first-page":"1","article-title":"Study on the mechanism of Xue'sWuyeLugen Decoction tea drink on the prevention and control of COVID-19 based on network pharmacology and molecular docking","author":"Xiang","year":"2020","journal-title":"Journal of Hubei University of Chinese Medicine"},{"key":"10.1016\/j.jep.2020.113514_bib73","article-title":"Naltrexone (NTX) relieves inflammation in the collagen-induced-arthritis (CIA) rat models through regulating TLR4\/NF\u03baB signaling pathway","volume":"79","author":"Xu","year":"2020","journal-title":"IntImmunopharmacol"},{"key":"10.1016\/j.jep.2020.113514_bib74","doi-asserted-by":"crossref","first-page":"112428","DOI":"10.1016\/j.jep.2019.112428","article-title":"ZishenTongluo formula ameliorates collagen-induced arthritis in mice by modulation of Th17\/Treg balance","volume":"250","author":"Yang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113514_bib75","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.biopha.2018.12.040","article-title":"CP-25 combined with MTX\/LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation","volume":"110","author":"Yang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2020.113514_bib76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2015.10.003","article-title":"Treatment of rheumatoid arthritis: unraveling the conundrum","volume":"65","author":"Zampeli","year":"2015","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jep.2020.113514_bib77","first-page":"228","article-title":"Tfh comes from IL-2\/IL-2R integrating the signal of CD4+T cell in humoral immunity","volume":"51","author":"Zhang","year":"2015","journal-title":"J. Lanzhou Univ."},{"key":"10.1016\/j.jep.2020.113514_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109367","article-title":"Guizhi-Shaoyao-Zhimu decoction possesses anti-arthritic effects on type II collagen-induced arthritis in rats via suppression of inflammatory reactions, inhibition of invasion & migration and induction of apoptosis in synovial fibroblasts","volume":"118","author":"Zhang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2020.113514_bib79","first-page":"1","article-title":"Identification of major bioactive components and metabolites of Gandou decoction in rat urine by an integrative approach based on UPLC-Q-TOF-MSE coupled with xenometabolomics analytical platform","author":"Zhang","year":"2020","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.jep.2020.113514_bib80","first-page":"210","article-title":"Antioxidant effect of each part of ethanol extract of rhmnellagilgitica in vitro","volume":"19","author":"Zhao","year":"2013","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"10.1016\/j.jep.2020.113514_bib81","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41584-018-0109-2","article-title":"Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis","volume":"15","author":"Zhu","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2020.113514_bib82","first-page":"20","article-title":"Correlation between TCM constitution types and rheumatoid arthritis","volume":"9","author":"Zhu","year":"2020","journal-title":"Rheumatism and Arthritis"},{"key":"10.1016\/j.jep.2020.113514_bib83","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10753-014-0027-7","article-title":"Effects of Naringenin on inflammation in complete freund's adjuvant-induced arthritis by regulating Bax\/Bcl-2 balance","volume":"38","author":"Zhu","year":"2015","journal-title":"Inflammation"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120334000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120334000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:45:56Z","timestamp":1759941956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874120334000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":83,"alternative-id":["S0378874120334000"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.113514","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ethyl acetate extract of Tibetan medicine Rhamnella gilgitica ameliorated type II collagen-induced arthritis in rats via regulating JAK-STAT signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.113514","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113514"}}