{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:33:10Z","timestamp":1781199190173,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Major Scientific and Technological Special Project","award":["2018ZX09731-001"],"award-info":[{"award-number":["2018ZX09731-001"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2018YFC1707100"],"award-info":[{"award-number":["2018YFC1707100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jep.2020.113589","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T12:52:19Z","timestamp":1605703939000},"page":"113589","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Effect of Hordei Fructus Germinatus on differential gene expression in the prolactin signaling pathway in the mammary gland of lactating rats"],"prefix":"10.1016","volume":"268","author":[{"given":"Zidong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9611-2653","authenticated-orcid":false,"given":"Yuanning","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhou","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanna","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.113589_bib1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-1-59745-372-1_3","article-title":"Expression profiling using affymetrix GeneChip microarrays","volume":"509","author":"Auer","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jep.2020.113589_bib2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3389\/fgene.2015.00342","article-title":"Targeted analysis reveals an important role of JAK-STAT-SOCS genes for milk production traits in Australian dairy cattle","volume":"6","author":"Arun","year":"2015","journal-title":"Front. Genet."},{"issue":"2","key":"10.1016\/j.jep.2020.113589_bib3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejogrb.2010.02.024","article-title":"Cabergoline versus bromocriptine for symptomatic treatment of premenstrual mastalgia: a randomised, open-label study","volume":"150","author":"Aydin","year":"2010","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"5","key":"10.1016\/j.jep.2020.113589_bib4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrendo.2015.36","article-title":"New insights in prolactin: pathological implications","volume":"11","author":"Bernard","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jep.2020.113589_bib5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.mce.2015.05.026","article-title":"Effect of hypothyroidism on the expression of nuclear receptors and their co-regulators in mammary gland during lactation in the rat","volume":"412","author":"Campo Verde Arbocc\u00f3","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"issue":"11","key":"10.1016\/j.jep.2020.113589_bib6","first-page":"59","article-title":"Effect of Semen vaccariae pressing ear points on lactation volume","volume":"12","author":"Chen","year":"2005","journal-title":"Chinese Journal of Information on Traditional Chinese Medicine"},{"issue":"2","key":"10.1016\/j.jep.2020.113589_bib7","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.gene.2013.06.091","article-title":"Peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms in nonalcoholic fatty liver disease: a study in Brazilian patients","volume":"529","author":"Domenici","year":"2013","journal-title":"Gene"},{"issue":"5","key":"10.1016\/j.jep.2020.113589_bib8","first-page":"191","article-title":"Suppression of pimozide-induced prolactin secretion by piridoxine (vitamin B6)","volume":"27","author":"Delitala","year":"1977","journal-title":"Biomedicine \/[publiee pour l'A.A.I.C.I.G.]"},{"issue":"1","key":"10.1016\/j.jep.2020.113589_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1748-7188-7-29","article-title":"Distributional fold change test - a statistical approach for detecting differential expression in microarray experiments","volume":"7","author":"Farztdinov","year":"2012","journal-title":"Algorithm Mol. Biol.: Assoc. M\u00e9d. Bras. (S\u00e3o Paulo) (AMB)"},{"issue":"4","key":"10.1016\/j.jep.2020.113589_bib10","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1152\/physrev.2000.80.4.1523","article-title":"Prolactin: structure, function, and regulation of secretion","volume":"80","author":"Freeman","year":"2000","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.jep.2020.113589_bib11","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00216-010-3681-0","article-title":"A comprehensive review of assay methods to determine drugs in breast milk and the safety of breastfeeding when taking drugs","volume":"397","author":"Fr\u00edguls","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"issue":"2","key":"10.1016\/j.jep.2020.113589_bib12","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1046\/j.1525-1373.2000.22517.x","article-title":"Anti-inflammatory effects of ergotamine in steers","volume":"225","author":"Filipov","year":"2010","journal-title":"Exp. Biol. Med."},{"issue":"2","key":"10.1016\/j.jep.2020.113589_bib13","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.3390\/ijms16024265","article-title":"\u03b2-Hydroxybutyric sodium salt inhibition of growth hormone and prolactin secretion via the cAMP\/PKA\/CREB and AMPK signaling pathways in dairy cow anterior pituitary cells","volume":"16","author":"Fu","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2020.113589_bib14","article-title":"Underlying mechanism of insulin resistance: a bioinformatics analysis based on validated related-genes from public disease databases","volume":"26","author":"Gao","year":"2020","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res.: international medical journal of experimental and clinical research"},{"issue":"2","key":"10.1016\/j.jep.2020.113589_bib15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/ajo.12731","article-title":"Phone calls to an Australian pregnancy and lactation counselling service regarding use of galactagogues during lactation - the MotherSafe experience","volume":"58","author":"Grzeskowiak","year":"2018","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"issue":"5","key":"10.1016\/j.jep.2020.113589_bib16","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3390\/nu11050974","article-title":"What evidence do we have for pharmaceutical galactagogues in the treatment of lactation insufficiency? A narrative review","volume":"11","author":"Grzeskowiak","year":"2019","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.jep.2020.113589_bib17","doi-asserted-by":"crossref","first-page":"T101","DOI":"10.1530\/JOE-15-0213","article-title":"60 years OF neuroendocrinology: the hypothalamo-prolactin axis","volume":"226","author":"Grattan","year":"2015","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.jep.2020.113589_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05607","article-title":"The genetic architecture of NAFLD among inbred strains of rats","volume":"4","author":"Hui","year":"2015","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.jep.2020.113589_bib19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1891\/2158-0782.9.1.10","article-title":"Domperidone versus metoclopramide: self-reported side effects in a large sample of breastfeeding mothers who used these medications to increase milk production","volume":"9","author":"Hale","year":"2018","journal-title":"Clin. Lactation"},{"issue":"1","key":"10.1016\/j.jep.2020.113589_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1530\/ror.0.0020014","article-title":"Prolactin receptor subtypes: a possible mode of tissue specific regulation of prolactin function","volume":"2","author":"Jabbour","year":"1997","journal-title":"Rev. Reprod."},{"issue":"4","key":"10.1016\/j.jep.2020.113589_bib21","first-page":"554","article-title":"Clinical observation on the treatment of traditional Chinese medicine with vitamin b6 in treating hyperprolactinemia","volume":"29","author":"Juan","year":"2017","journal-title":"Clin. J. Tradit. Chin. Med."},{"issue":"3","key":"10.1016\/j.jep.2020.113589_bib22","first-page":"134","article-title":"Chinese journal of modern developments in traditional medicine","volume":"4","author":"Kuang","year":"1984","journal-title":"Chin. J. Integr. Med."},{"issue":"3","key":"10.1016\/j.jep.2020.113589_bib23","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.repbio.2012.09.005","article-title":"Effects of quinestrol and levonorgestrel on prolactin serum concentration in lactating Mongolian gerbils (Meriones unguiculatus) and reproductive parameters of their offspring","volume":"12","author":"Lv","year":"2012","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.jep.2020.113589_bib24","doi-asserted-by":"crossref","first-page":"14356","DOI":"10.1038\/ncomms14356","article-title":"The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies","volume":"8","author":"Li","year":"2017","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.jep.2020.113589_bib26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods (San Diego, Calif.)"},{"issue":"3","key":"10.1016\/j.jep.2020.113589_bib27","first-page":"169","article-title":"The effect of malt on the mammary glands of lactating female mice","volume":"25","author":"Liu","year":"1991","journal-title":"J. Shandong Univ. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2020.113589_bib25","article-title":"The pharmacological effects and application of malt","volume":"1","author":"Liao","year":"2020","journal-title":"Medical ind."},{"issue":"4","key":"10.1016\/j.jep.2020.113589_bib28","first-page":"105","article-title":"Effect of ethanol extract of Rhododendron L. On lactation signal pathway of dairy cow mammary epithelial cells","volume":"592","author":"Liu","year":"2020","journal-title":"Heilongjiang Animal Husbandry and Veterinary"},{"issue":"5","key":"10.1016\/j.jep.2020.113589_bib29","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1071\/RD11160","article-title":"The inhibitory effect of progesterone on lactogenesis during pregnancy is already evident by mid- to late gestation in rodents","volume":"24","author":"L\u00f3pez-Fontana","year":"2012","journal-title":"Reprod. Fertil. Dev."},{"issue":"1","key":"10.1016\/j.jep.2020.113589_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1152\/physiolgenomics.90341.2008","article-title":"Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome","volume":"37","author":"Maningat","year":"2009","journal-title":"Physiol. Genom."},{"issue":"1","key":"10.1016\/j.jep.2020.113589_bib31","first-page":"60","article-title":"The risk of abuse of vitamin supplements","volume":"60","author":"Marosz","year":"2014","journal-title":"Ann. Acad. Med. Stetin"},{"key":"10.1016\/j.jep.2020.113589_bib32","series-title":"The Pharmacopoeia of the People's Republic of China[S]. One","first-page":"163","year":"2020"},{"key":"10.1016\/j.jep.2020.113589_bib33","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.3389\/fimmu.2018.02392","article-title":"Protein inhibitor of activated STAT (PIAS) negatively regulates the JAK\/STAT pathway by inhibiting STAT phosphorylation and translocation","volume":"9","author":"Niu","year":"2018","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.jep.2020.113589_bib34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.radonc.2011.02.005","article-title":"Tamoxifen added to radiotherapy and surgery for the treatment of ductal carcinoma in situ of the breast: a meta-analysis of 2 randomized trials","volume":"100","author":"Petrelli","year":"2011","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.jep.2020.113589_bib35","doi-asserted-by":"crossref","first-page":"101844","DOI":"10.1016\/j.jchemneu.2020.101844","article-title":"Metoclopramide use to induce lactation can alter bdnf and drd2 in the prefrontal cortex of offspring","volume":"109","author":"Seren","year":"2020","journal-title":"J. Chem. Neuroanat."},{"issue":"1\u20132","key":"10.1016\/j.jep.2020.113589_bib36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tox.2010.01.016","article-title":"Evangelista de Duffard, A.M.,. Effect of 2,4-dichlorophenoxyacetic acid on milk transfer to the litter and prolactin release in lactating rats","volume":"271","author":"St\u00fcrtz","year":"2010","journal-title":"Toxicology"},{"issue":"4","key":"10.1016\/j.jep.2020.113589_bib40","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-2036.2004.01867.x","article-title":"Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics","volume":"19","author":"Tonini","year":"2004","journal-title":"Aliment Pharmacol. Therapeut."},{"issue":"7","key":"10.1016\/j.jep.2020.113589_bib37","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.fct.2012.04.040","article-title":"Flaxseed bioactive compounds change milk, hormonal and biochemical parameters of dams and offspring during lactation","volume":"50","author":"Troina","year":"2012","journal-title":"Food Chem. Toxicol.: an international journal published for the British Industrial Biological Research Association"},{"issue":"5","key":"10.1016\/j.jep.2020.113589_bib38","first-page":"37","article-title":"Talking about the relationship between malt dosage of Tujia medicine and lactation reversion","volume":"14","author":"Tian","year":"2008","journal-title":"Chinese Journal of Minority Medicine"},{"issue":"4","key":"10.1016\/j.jep.2020.113589_bib39","doi-asserted-by":"crossref","first-page":"274","DOI":"10.4161\/jkst.22313","article-title":"Alternative ways of modulating JAK-STAT pathway: looking beyond phosphorylation","volume":"1","author":"Timofeeva","year":"2012","journal-title":"JAK-STAT"},{"issue":"4","key":"10.1016\/j.jep.2020.113589_bib42","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1530\/REP-06-0032","article-title":"Hormonal profile and reproductive performance in lactation deficient (OFA hr\/hr) and normal (Sprague\u2013Dawley) female rats","volume":"133","author":"Valdez","year":"2007","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.jep.2020.113589_bib43","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ando.2016.04.025","article-title":"Endocrinology of human parturition","volume":"77","author":"Vannuccini","year":"2016","journal-title":"Ann. Endocrinol."},{"key":"10.1016\/j.jep.2020.113589_bib44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s11658-017-0042-4","article-title":"Cells of human breast milk","volume":"22","author":"Witkowska","year":"2017","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"1\u20132","key":"10.1016\/j.jep.2020.113589_bib45","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/pr.2014.160","article-title":"Breast milk, microbiota, and intestinal immune homeostasis","volume":"77","author":"Walker","year":"2015","journal-title":"Pediatr. Res."},{"issue":"11","key":"10.1016\/j.jep.2020.113589_bib47","first-page":"1677","article-title":"Pharmacological research and clinical application of malt","volume":"29","author":"Wang","year":"2007","journal-title":"Chinese Patent Medicine"},{"issue":"3","key":"10.1016\/j.jep.2020.113589_bib48","first-page":"131","article-title":"Study on the lactation effect of 4 chemical parts of malt on postpartum hypogalactia model rats via dopamine d2 receptors","volume":"51","author":"Xia","year":"2020","journal-title":"Chinese herbal medicine"},{"issue":"3","key":"10.1016\/j.jep.2020.113589_bib49","first-page":"169","article-title":"Discussion on the two-way nature of malt \"prolactin\" and \"returning lactation","volume":"25","author":"Xiang","year":"1990","journal-title":"Chin. Pharmaceut. J."},{"issue":"6","key":"10.1016\/j.jep.2020.113589_bib50","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1007\/s11033-008-9352-y","article-title":"Induced apoptotic action of recombinant trichosanthin in human stomach adenocarcinoma MCG803 cells","volume":"36","author":"Xu","year":"2009","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.jep.2020.113589_bib51","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.gene.2016.09.047","article-title":"Integrative transcriptomic analysis of NAFLD animal model reveals dysregulated genes and pathways in metabolism","volume":"595","author":"Yang","year":"2016","journal-title":"Gene"},{"issue":"8","key":"10.1016\/j.jep.2020.113589_bib52","first-page":"2319","article-title":"Serum fibronectin 1 and ApoE levels increase with risk of lymphedema in Korean breast cancer survivors","volume":"23","author":"Yim","year":"2015","journal-title":"Support. Care Canc."},{"issue":"3","key":"10.1016\/j.jep.2020.113589_bib53","first-page":"162","article-title":"Discussion on the relationship between stir-frying malt with raw malt and prolactin","volume":"13","author":"Yin","year":"2002","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"key":"10.1016\/j.jep.2020.113589_bib54","doi-asserted-by":"crossref","first-page":"173190","DOI":"10.1016\/j.ejphar.2020.173190","article-title":"Vaccarin promotes proliferation of and milk synthesis in bovine mammary epithelial cells through the prl receptor-pi3k signaling pathway","volume":"880","author":"Yu","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.jep.2020.113589_bib55","article-title":"Study on the effect of high-dose vitamin E on lactation","volume":"22","author":"Yuan","year":"2012","journal-title":"China Health & Nutrition"},{"issue":"3","key":"10.1016\/j.jep.2020.113589_bib56","first-page":"12","article-title":"The identification of specific methylation patterns across different cancers","volume":"10","author":"Zhang","year":"2015","journal-title":"PloS One"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120334772?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120334772?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:03:05Z","timestamp":1759942985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874120334772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":54,"alternative-id":["S0378874120334772"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.113589","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Hordei Fructus Germinatus on differential gene expression in the prolactin signaling pathway in the mammary gland of lactating rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.113589","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113589"}}