{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:27:12Z","timestamp":1783164432066,"version":"3.54.6"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974519"],"award-info":[{"award-number":["81974519"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012176","name":"Program of Introducing Talents of Discipline to Universities","doi-asserted-by":"publisher","award":["B13038"],"award-info":[{"award-number":["B13038"]}],"id":[{"id":"10.13039\/501100012176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jep.2020.113615","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T22:30:26Z","timestamp":1606170626000},"page":"113615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Chemical profile of Cimicifuga heracleifolia Kom. And immunomodulatory effect of its representative bioavailable component, cimigenoside on Poly(I:C)-induced airway inflammation"],"prefix":"10.1016","volume":"267","author":[{"given":"Liufang","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kiyohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinsheng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0739-9590","authenticated-orcid":false,"given":"Zhihong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.113615_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.abb.2018.01.004","article-title":"Myeloperoxidase: its role for host defense, inflammation, and neutrophil function","volume":"640","author":"Aratani","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jep.2020.113615_bib2","series-title":"Chinese Pharmacopeia","first-page":"73","author":"Commission","year":"2015"},{"key":"10.1016\/j.jep.2020.113615_bib3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.apsb.2016.11.002","article-title":"Identification and differentiation of major components in three different \"sheng-ma\" crude drug species by uplc\/q-tof-ms","volume":"7","author":"Fan","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jep.2020.113615_bib4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jep.2012.06.031","article-title":"Pharmacokinetics and bioavailability of cimicifugosides after oral administration of cimicifuga foetida l. Extract to rats","volume":"143","author":"Gai","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113615_bib5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1183\/09031936.00186109","article-title":"Neutrophils in chronic inflammatory airway diseases: can we target them and how?","volume":"35","author":"Gernez","year":"2010","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jep.2020.113615_bib6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jep.2017.07.040","article-title":"Traditional uses, phytochemistry, pharmacology and toxicology of the genus cimicifuga: a review","volume":"209","author":"Guo","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113615_bib7","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/mi.2012.86","article-title":"Double-stranded rna induces molecular and inflammatory signatures that are directly relevant to copd","volume":"6","author":"Harris","year":"2013","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jep.2020.113615_bib8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.chroma.2006.01.004","article-title":"Cimicifuga species identification by high performance liquid chromatography-photodiode array\/mass spectrometric\/evaporative light scattering detection for quality control of black cohosh products","volume":"1112","author":"He","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jep.2020.113615_bib9","doi-asserted-by":"crossref","first-page":"9010","DOI":"10.1021\/acs.jafc.8b03600","article-title":"Metabolic profiles of ginger, a functional food, and its representative pungent compounds in rats by ultraperformance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry","volume":"66","author":"He","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2020.113615_bib10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/s-2006-958060","article-title":"Inhibitory effect of ferulic acid and isoferulic acid on murine interleukin-8 production in response to influenza-virus infections in-vitro and in-vivo","volume":"61","author":"Hirabayashi","year":"1995","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2020.113615_bib11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jpba.2019.04.001","article-title":"In vivo metabolic profiles of bu-zhong-yi-qi-tang, a famous traditional Chinese medicine prescription, in rats by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry","volume":"171","author":"Hu","year":"2019","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2020.113615_bib12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/1534735410383170","article-title":"Bojungikki-tang for cancer-related fatigue: a pilot randomized clinical trial","volume":"9","author":"Jeong","year":"2010","journal-title":"Integr. Canc. Ther."},{"key":"10.1016\/j.jep.2020.113615_bib13","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/tkm2.1231","article-title":"Modulating effects of a decoction of a traditional Japanese herbal formula, hochuekkito (with hedysari radix and atractylodis rhizoma), on the local mucosal immune system of aged mice","volume":"6","author":"Kajita","year":"2019","journal-title":"Trad. Kampo Med."},{"key":"10.1016\/j.jep.2020.113615_bib14","series-title":"Janeway's Immunobiology","first-page":"10","author":"Kenneth","year":"2017"},{"key":"10.1016\/j.jep.2020.113615_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1248\/jhs.57.289","article-title":"Protective effect of cimicifuga heracleifolia ethanol extract and its constituents against gastric injury","volume":"57","author":"Kim","year":"2011","journal-title":"J. Health Sci."},{"key":"10.1016\/j.jep.2020.113615_bib16","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1248\/yakushi.121.497","article-title":"Studies on the constituents of cimicifuga species","volume":"121","author":"Kusano","year":"2001","journal-title":"Yakugaku Zasshi-Journal of the Pharmaceutical Society of Japan"},{"key":"10.1016\/j.jep.2020.113615_bib17","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.2174\/092986706778521869","article-title":"Cimicifugae rhizoma: from origins, bioactive constituents to clinical outcomes","volume":"13","author":"Li","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jep.2020.113615_bib18","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jep.2018.08.003","article-title":"Mucosal immunomodulatory evaluation and chemical profile elucidation of a classical traditional Chinese formula, bu-zhong-yi-qi-tang","volume":"228","author":"Liu","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113615_bib19","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00970-2017","article-title":"Neutrophil extracellular trap formation is regulated by cxcr2 in copd neutrophils","volume":"51","author":"Pedersen","year":"2018","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jep.2020.113615_bib20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/09629359990513","article-title":"Inhibitory effect of ferulic acid and isoferulic acid on the production of macrophage inflammatory protein-2 in response to respiratory syncytial virus infection in raw264.7 cells","volume":"8","author":"Sakai","year":"1999","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2020.113615_bib21","doi-asserted-by":"crossref","DOI":"10.1186\/1465-9921-10-43","article-title":"Long-term activation of tlr3 by poly(i:C) induces inflammation and impairs lung function in mice","volume":"10","author":"Stowell","year":"2009","journal-title":"Respir. Res."},{"key":"10.1016\/j.jep.2020.113615_bib22","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.1016\/j.bmcl.2014.10.066","article-title":"New 9,19-cycloartenol glycosides isolated from the roots of cimicifuga simplex and their anti-inflammatory effects","volume":"24","author":"Su","year":"2014","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.jep.2020.113615_bib23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12931-016-0474-9","article-title":"Respiratory viral infections and host responses; insights from genomics","volume":"17","author":"Troy","year":"2016","journal-title":"Respir. Res."},{"key":"10.1016\/j.jep.2020.113615_bib24","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1021\/jf048300d","article-title":"Lc\/tis-ms fingerprint profiling of cimicifuga species and analysis of 23-epi-26-deoxyactein in cimicifuga racemosa commercial products","volume":"53","author":"Wang","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2020.113615_bib25","first-page":"1","article-title":"Studies on serum pharmacochemistry of traditional Chinese medicine","volume":"2","author":"Wang","year":"2002","journal-title":"World Science Technology-Modernization of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2020.113615_bib26","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cclet.2016.11.021","article-title":"Bioactivity-based uplc\/q-tof\/ms strategy for screening of anti-inflammatory components from cimicifugae rhizoma","volume":"28","author":"Wang","year":"2017","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jep.2020.113615_bib27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.yrtph.2015.07.006","article-title":"Pre-clinical in vitro and in vivo safety evaluation of cimicifuga heracleifolia","volume":"73","author":"Yun","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120335030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120335030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:40:59Z","timestamp":1759941659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874120335030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":27,"alternative-id":["S0378874120335030"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.113615","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemical profile of Cimicifuga heracleifolia Kom. And immunomodulatory effect of its representative bioavailable component, cimigenoside on Poly(I:C)-induced airway inflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.113615","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113615"}}