{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:34:00Z","timestamp":1783528440350,"version":"3.55.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.jep.2020.113686","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T17:03:15Z","timestamp":1607619795000},"page":"113686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Tiliacora racemosa leaves induce oxidative stress mediated DNA damage leading to G2\/M phase arrest and apoptosis in cervical cancer cells SiHa"],"prefix":"10.1016","volume":"269","author":[{"given":"Asmita","family":"Pal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumee","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0504-454X","authenticated-orcid":false,"given":"Rita","family":"Kundu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.113686_bib1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.4103\/0257-7941.107361","article-title":"Estimation of total alkaloid in Chitrakadivati by UV-Spectrophotometer","volume":"31","author":"Ajanal","year":"2012","journal-title":"Ancient Sci. Life"},{"key":"10.1016\/j.jep.2020.113686_bib2","series-title":"Alkaloids-Secrets of Life, Alkaloid Chemistry, Biological Significance, Applications and Ecological Role","first-page":"141","author":"Aniszewski","year":"2007"},{"key":"10.1016\/j.jep.2020.113686_bib3","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1016\/S0040-4020(01)82842-8","article-title":"Alkaloids of Tiliacora racemosa Colebr","volume":"25","author":"Anjaneyulu","year":"1969","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jep.2020.113686_bib4","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1002\/ijc.24748","article-title":"Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt","volume":"125","author":"Bai","year":"2009","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.jep.2020.113686_bib5","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nrc2523","article-title":"GammaH2AX and cancer","volume":"8","author":"Bonner","year":"2008","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.jep.2020.113686_bib6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Canc. J. Clin."},{"key":"10.1016\/j.jep.2020.113686_bib7","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/jsfa.2740290908","article-title":"Analysis of condensed tannins using acidified vanillin","volume":"29","author":"Broadhurst","year":"1978","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.jep.2020.113686_bib8","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/sj.cdd.4401261","article-title":"Nitric oxide: NO apoptosis or turning it ON?","volume":"10","author":"Br\u00fcne","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2020.113686_bib9","series-title":"Human Papillomavirus and Related Diseases in the World. Summary Report 17 June 2019","article-title":"ICO\/IARC information Centre on HPV and cancer (HPV information Centre)","author":"Bruni","year":"2019"},{"key":"10.1016\/j.jep.2020.113686_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41571-020-0341-y","article-title":"Targeting apoptosis in cancer therapy","author":"Carneiro","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jep.2020.113686_bib11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/ptr.1501","article-title":"Cytotoxic effect of root extract of Tiliacora racemosa and oil of Semecarpus anacardium nut in human tumour cells","volume":"18","author":"Chakraborty","year":"2004","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2020.113686_bib12","doi-asserted-by":"crossref","first-page":"31289","DOI":"10.1074\/jbc.M702777200","article-title":"Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3","volume":"282","author":"Chandra","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2020.113686_bib13","first-page":"398","article-title":"Antibacterial, antioxidant and antiproliferative activities of solvent extracts of Tiliacora acuminata","volume":"6","author":"Chandrakanthan","year":"2014","journal-title":"Int. J. Pharm. Pharmaceut. Sci."},{"key":"10.1016\/j.jep.2020.113686_bib14","series-title":"Glossary of Indian Medicinal Plants","author":"Chopra","year":"1956"},{"key":"10.1016\/j.jep.2020.113686_bib15","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/ardp.19602931202","article-title":"Zur serienmaessigen Bestimmung des Gehaltes an Flavonol-Derivaten in Drogen","volume":"293","author":"Christ","year":"1960","journal-title":"Arch. Pharmazie"},{"key":"10.1016\/j.jep.2020.113686_bib16","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12906-017-1583-9","article-title":"Sinularin induces DNA damage, G2\/M phase arrest, and apoptosis in human hepatocellular carcinoma cells","volume":"17","author":"Chung","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2020.113686_bib17","doi-asserted-by":"crossref","first-page":"e2215","DOI":"10.1038\/cddis.2016.113","article-title":"Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell induced auto-immune responses","volume":"7","author":"Cunin","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2020.113686_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0092-8674(00)00008-8","article-title":"Smac, a mitochondrial protein that promotes cytochrome c\u2013dependent caspase activation by eliminating IAP inhibition","volume":"102","author":"Du","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jep.2020.113686_bib19","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1023\/A:1020035124855","article-title":"The roles of Bid","volume":"7","author":"Esposti","year":"2002","journal-title":"Apoptosis"},{"key":"10.1016\/j.jep.2020.113686_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/protex.2012.055","article-title":"Estimation of total terpenoids concentration in plant tissues using a monoterpene, linalool as standard reagent","author":"Ghorai","year":"2012","journal-title":"Protoc. Exch."},{"key":"10.1016\/j.jep.2020.113686_bib21","first-page":"223","article-title":"Ethnobotanical use of plants as living fence in and around radhanagar village of jhargram block, paschim medinipur district, West Bengal","volume":"29","author":"Ghosh","year":"2014","journal-title":"Indian J. Appl. Pure Biol."},{"key":"10.1016\/j.jep.2020.113686_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4161\/cc.8.2.7550","article-title":"p21Cip1\/WAF1 mediates cyclin B1 degradation in response to DNA damage","volume":"8","author":"Gillis","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jep.2020.113686_bib23","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/sj.onc.1205181","article-title":"Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis","volume":"21","author":"Gottlieb","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.jep.2020.113686_bib24","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1126\/science.287.5459.1824","article-title":"DNA damage-induced activation of p53 by the checkpoint kinase Chk2","volume":"287","author":"Hirao","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jep.2020.113686_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/cells9010023","article-title":"Functional characterization of HSP60-survivin interaction between mitochondria and cytosol in cancer cells","volume":"9","author":"Huang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jep.2020.113686_bib26","first-page":"188","article-title":"DNA and its associated processes as targets for cancer therapy","volume":"2","author":"Hurley","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jep.2020.113686_bib27","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.7314\/APJCP.2014.15.17.7473","article-title":"In vitro and in vivo antitumor activity of tiliacorinine in human cholangiocarcinoma","volume":"15","author":"Janeklang","year":"2014","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.jep.2020.113686_bib28","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1354\/vp.41-6-599","article-title":"Survivin: a bifunctional inhibitor of apoptosis protein","volume":"41","author":"Johnson","year":"2004","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.jep.2020.113686_bib29","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1074\/jbc.M003670200","article-title":"Livin, a novel inhibitor of apoptosis protein family member","volume":"276","author":"Kasof","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2020.113686_bib30","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1038\/sj.onc.1210008","article-title":"Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance","volume":"26","author":"Kilic","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.jep.2020.113686_bib31","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.biopha.2016.12.030","article-title":"Evaluation of antibacterial, antioxidant and nootropic activities of Tiliacora racemosa Colebr. leaves: in vitro and in vivo approach","volume":"86","author":"Kumar","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2020.113686_bib32","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0092-8674(00)80197-X","article-title":"DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis","volume":"89","author":"Liu","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.jep.2020.113686_bib33","series-title":"Method of Enzymatic Analysis","first-page":"885","article-title":"Catalase","author":"Luck","year":"1965"},{"key":"10.1016\/j.jep.2020.113686_bib34","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1200\/GO.20.00122","article-title":"Cancer statistics, 2020: report from national cancer registry programme, India","volume":"6","author":"Mathur","year":"2020","journal-title":"JCO Global Oncol."},{"key":"10.1016\/j.jep.2020.113686_bib35","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1016\/S0021-9258(18)63504-5","article-title":"Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)","volume":"244","author":"McCord","year":"1969","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2020.113686_bib36","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2307\/3577587","article-title":"Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the \"comet\" assay","volume":"122","author":"Olive","year":"1990","journal-title":"Radiat. Res."},{"key":"10.1016\/j.jep.2020.113686_bib37","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3389\/fonc.2019.00853","article-title":"Cinobufagin induces cell cycle arrest at the G2\/M phase and promotes apoptosis in malignant melanoma cells","volume":"9","author":"Pan","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.jep.2020.113686_bib38","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1128\/MCB.01536-07","article-title":"p27kip1 deficiency impairs G2\/M arrest in response to DNA damage, leading to an increase in genetic instability","volume":"28","author":"Payne","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jep.2020.113686_bib39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.drup.2004.01.004","article-title":"ROS stress in cancer cells and therapeutic implications","volume":"7","author":"Pelicano","year":"2004","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.jep.2020.113686_bib40","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.275.15.10761","article-title":"Akt\/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein","volume":"275","author":"Pugazhenthi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2020.113686_bib41","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.fct.2012.10.007","article-title":"Taurine ameliorate alloxan induced oxidative stress and intrinsic apoptotic pathway in the hepatic tissue of diabetic rats","volume":"51","author":"Rashid","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.jep.2020.113686_bib42","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00411-019-00778-1","article-title":"Improved identification of DNA double strand breaks: \u03b3-H2AX-epitope visualization by confocal microscopy and 3D reconstructed images","volume":"58","author":"Ruprecht","year":"2019","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.jep.2020.113686_bib43","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1093\/emboj\/16.23.6914","article-title":"The c\u2010IAP\u20101 and c\u2010IAP\u20102 proteins are direct inhibitors of specific caspases","volume":"16","author":"Roy","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.jep.2020.113686_bib44","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/ptr.993","article-title":"(+)-Tiliarine, a selective in vitro inhibitor of human melanoma cells","volume":"16","author":"Seal","year":"2002","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2020.113686_bib45","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/sj.emboj.7600544","article-title":"XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs","volume":"24","author":"Scott","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.jep.2020.113686_bib46","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3892\/or.2013.2815","article-title":"Induction of G2\/M phase cell cycle arrest and apoptosis by ginsenoside Rf in human osteosarcoma MG-63 cells through the mitochondrial pathway","volume":"31","author":"Shangguan","year":"2014","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jep.2020.113686_bib47","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrm3546","article-title":"The ATM protein kinase: regulating the cellular response to genotoxic stress, and more","volume":"14","author":"Shiloh","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jep.2020.113686_bib48","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1097-2765(03)00054-6","article-title":"Mechanism of XIAP-mediated inhibition of caspase-9","volume":"11","author":"Shiozaki","year":"2003","journal-title":"Mol. Cell."},{"key":"10.1016\/j.jep.2020.113686_bib49","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1093\/nar\/24.9.1669","article-title":"Cloning and characterization of RAD17, a gene controlling cell cycle responses to DNA damage in Saccharomyces cerevisiae","volume":"24","author":"Siede","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2020.113686_bib50","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5344\/ajev.1965.16.3.144","article-title":"Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents","volume":"16","author":"Singleton","year":"1965","journal-title":"Am. J. Enol. Vitic."},{"key":"10.1016\/j.jep.2020.113686_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007059","article-title":"Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members","volume":"4","author":"Snyder","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.jep.2020.113686_bib52","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1006\/bbrc.1998.8185","article-title":"Cytokine induced expression of porcine inhibitor of apoptosis protein (iap) family member is regulated by NF-\u03baB","volume":"243","author":"Stehlik","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.jep.2020.113686_bib53","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.canlet.2005.07.016","article-title":"Does \u03b3H2AX foci formation depend on the presence of DNA double strand breaks?","volume":"229","author":"Takahashi","year":"2005","journal-title":"Canc. Lett."},{"key":"10.1016\/j.jep.2020.113686_bib54","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0092-8674(95)90412-3","article-title":"Tumor suppressor p53 is a direct transcriptional activator of the human bax gene","volume":"80","author":"Toshiyuki","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.jep.2020.113686_bib55","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1046\/j.1365-2443.1998.00223.x","article-title":"Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?","volume":"3","author":"Tsujimoto","year":"1998","journal-title":"Gene Cell."},{"key":"10.1016\/j.jep.2020.113686_bib56","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3892\/ijo.2014.2399","article-title":"HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy (review)","volume":"45","author":"Wang","year":"2014","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.jep.2020.113686_bib57","first-page":"141","article-title":"Drug resistance and combating drug resistance in cancer","volume":"2","author":"Wang","year":"2019","journal-title":"Canc. Drug Resist"},{"key":"10.1016\/j.jep.2020.113686_bib58","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s13046-018-0909-x","article-title":"The role of cellular reactive oxygen species in cancer chemotherapy","volume":"37","author":"Yang","year":"2018","journal-title":"J. Exp. Clin. Canc. Res."},{"key":"10.1016\/j.jep.2020.113686_bib59","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.274.17.11549","article-title":"An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9","volume":"274","author":"Zou","year":"1999","journal-title":"J. Biol. Chem."}],"updated-by":[{"DOI":"10.1016\/j.jep.2024.117916","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000}}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120335741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120335741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T23:03:26Z","timestamp":1697324606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874120335741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":59,"alternative-id":["S0378874120335741"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.113686","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.jep.2024.117916","asserted-by":"object"}]},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tiliacora racemosa leaves induce oxidative stress mediated DNA damage leading to G2\/M phase arrest and apoptosis in cervical cancer cells SiHa","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.113686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113686"}}