{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:39:40Z","timestamp":1792895980062,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010253","name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020170100437BA"],"award-info":[{"award-number":["20020170100437BA"]}],"id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.jep.2020.113712","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T03:43:59Z","timestamp":1608867839000},"page":"113712","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Pharmacologycal activity of peperina (Minthostachys verticillata) on gastrointestinal tract"],"prefix":"10.1016","volume":"269","author":[{"given":"A.","family":"Rodr\u00edguez Basso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Carranza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.M.","family":"Zainutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.B.","family":"Gorzalczany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.113712_bib1","series-title":"Plantas medicinales aut\u00f3ctonas de la Argentina. Bases cient\u00edficas para su aplicaci\u00f3n en atenci\u00f3n primaria de salud","author":"Alonso","year":"2015"},{"issue":"31","key":"10.1016\/j.jep.2020.113712_bib2","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.3748\/wjg.v25.i31.4414","article-title":"Gastrointestinal motility and absorptive disorders in patients with inflammatory bowel diseases: prevalence, diagnosis and treatment","volume":"25","author":"Barros","year":"2019","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jep.2020.113712_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3748\/wjg.v20.i1.37","article-title":"Gastrointestinal motility disorders in inflammatory bowel diseases","volume":"20","author":"Bassotti","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.jep.2020.113712_bib4","first-page":"113","article-title":"Estudios anat\u00f3micos de tres especies de Lamiaceae usadas en medicina popular","volume":"12","author":"Bonzani","year":"1993","journal-title":"Acta Farm. Bonaerense"},{"issue":"8","key":"10.1016\/j.jep.2020.113712_bib5","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.3390\/ijms20081912","article-title":"Curcumin and intestinal inflammatory diseases: molecular mechanisms of protection","volume":"20","author":"Burge","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"15","key":"10.1016\/j.jep.2020.113712_bib6","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1055\/s-0030-1271090","article-title":"Monoterpenes isolated from Minthostachys verticillata (Griseb.) Epling essential oil modulates immediate-type hypersensitivity responses in vitro and in vivo","volume":"77","author":"Cariddi","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2020.113712_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/bph.12759","article-title":"Ultramicronized palmitoylethanolamide normalizes intestinal motility in a murine model of post-inflammatory accelerated transit: involvement of CB1 receptors and TRPV1","volume":"171","author":"Capasso","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2020.113712_bib8","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1084\/jem.20111453","article-title":"IL-1\u03b2 mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells","volume":"209","author":"Coccia","year":"2012","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.jep.2020.113712_bib9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3390\/ph12020048","article-title":"Role of TRPV1 and TRPA1 ion channels in inflammatory bowel diseases: potential therapeutic targets?","volume":"12","author":"Csek\u0151","year":"2019","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.jep.2020.113712_bib10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/0192623313509729","article-title":"Murine models of inflammatory bowel disease (IBD): challenges of modeling human disease","volume":"42","author":"Devoss","year":"2014","journal-title":"Toxicol. Pathol."},{"issue":"1","key":"10.1016\/j.jep.2020.113712_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yrtph.2014.11.001","article-title":"Safety assessment of essential oil from Minthostachys verticillata (Grisel.) Epling (peperina): 90-days oral subchronic toxicity study in rats","volume":"71","author":"Escobar","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2020.113712_bib12","series-title":"Farmacopea Argentina VI","first-page":"736","year":"1978"},{"issue":"9","key":"10.1016\/j.jep.2020.113712_bib13","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1002\/ptr.6429","article-title":"Protective effects induced by alcoholic Phlomis fruticosa and Phlomis herba-venti extracts in isolated rat colon: focus on antioxidant, anti-inflammatory, and antimicrobial activities in vitro","volume":"33","author":"Ferrante","year":"2019","journal-title":"Phytother Res."},{"issue":"4","key":"10.1016\/j.jep.2020.113712_bib14","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.immuni.2019.03.017","article-title":"Cytokine networks in the pathophysiology of inflammatory bowel disease","volume":"50","author":"Friedrich","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jep.2020.113712_bib15","first-page":"42","article-title":"Phytotherapies in inflammatory bowel disease","volume":"24","author":"Ganji-Arjenaki","year":"2019","journal-title":"J. Res. Med. Sci."},{"issue":"1","key":"10.1016\/j.jep.2020.113712_bib16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","article-title":"The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"5","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.jep.2020.113712_bib17","first-page":"105","article-title":"Immunomodulating properties of Minthostachys verticillata on human lymphocytes and basophils","volume":"52","author":"Gonz\u00e1lez Pereyra","year":"2005","journal-title":"Rev. Alerg. Mex."},{"key":"10.1016\/j.jep.2020.113712_bib18","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1080\/14786419.2012.688049","article-title":"Spasmolytic activity of Artemisia copa aqueous extract and isolated compounds","volume":"27","author":"Gorzalczany","year":"2013","journal-title":"Nat. Prod. Res."},{"issue":"3","key":"10.1016\/j.jep.2020.113712_bib19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0304-3959(01)00275-5","article-title":"A new model of visceral pain and referred hyperalgesia in the mouse","volume":"92","author":"Laird","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.jep.2020.113712_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2020.113712_bib21","first-page":"83","article-title":"La Medicina tradicional de los Criollos campesinos de Paravachasca y Calamuchita, C\u00f3rdoba (Argentina)","volume":"25","author":"Mart\u00ednez","year":"2003","journal-title":"Scr. Ethnol."},{"issue":"3","key":"10.1016\/j.jep.2020.113712_bib22","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.jep.2013.10.006","article-title":"Antidiarrheal and intestinal anti-inflammatory activities of a methanolic extract of Qualea parviflora Mart in experimental models","volume":"150","author":"Mazzolin","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113712_bib23","first-page":"210","article-title":"Evaluation of the antimicrobial efficacy of Minthostachys verticillata essential oil and limonene against Streptococcus uberis strains isolated from bovine mastitis","volume":"48","author":"Montironi","year":"2016","journal-title":"Rev. Argent. Microbiol."},{"issue":"23","key":"10.1016\/j.jep.2020.113712_bib24","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.3390\/ijms20236085","article-title":"Azathioprine has a deleterious effect on the bone Health of mice with DSS-induced inflammatory bowel disease","volume":"20","author":"Morgan","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2020.113712_bib25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.redox.2015.10.006","article-title":"Antioxidant therapy for treatment of inflammatory bowel disease: does it work?","volume":"6","author":"Moura","year":"2015","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.jep.2020.113712_bib26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s11894-010-0129-9","article-title":"Enteric nervous system in the small intestine: pathophysiology and clinical implications","volume":"12","author":"Nezami","year":"2010","journal-title":"Curr. Gastroenterol. Rep."},{"issue":"4","key":"10.1016\/j.jep.2020.113712_bib27","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/ptr.6296","article-title":"The effects of Nigella sativa on quality of life, disease activity index, and some of inflammatory and oxidative stress factors in patients with ulcerative colitis","volume":"33","author":"Nikkhah-Bodaghi","year":"2019","journal-title":"Phytother Res."},{"issue":"1","key":"10.1016\/j.jep.2020.113712_bib28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00535-015-1098-4","article-title":"Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease","volume":"51","author":"Okamoto","year":"2016","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.jep.2020.113712_bib29","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3389\/fphar.2016.00341","article-title":"An orally active cannabis extract with high content in cannabidiol attenuates chemically-induced intestinal inflammation and hypermotility in the mouse","volume":"7","author":"Pagano","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2020.113712_bib30","doi-asserted-by":"crossref","first-page":"104464","DOI":"10.1016\/j.phrs.2019.104464","article-title":"The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients","volume":"149","author":"Pagano","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"6","key":"10.1016\/j.jep.2020.113712_bib31","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1537-1891(03)00028-4","article-title":"Anti-inflammatory effect of kaurenoic acid, a diterpene from Copaifera langsdorffi on acetic acid-induced colitis in rats","volume":"39","author":"Paiva","year":"2002","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.jep.2020.113712_bib32","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1734-1140(11)70575-8","article-title":"Treatment of inflammatory bowel disease (IBD)","volume":"63","author":"Pithadia","year":"2011","journal-title":"Pharmacol. Rep."},{"issue":"1","key":"10.1016\/j.jep.2020.113712_bib33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.30972\/bon.2914106","article-title":"Lamiaceae medicinales y arom\u00e1ticas comercializadas en el \u00c1rea Metropolitana de Buenos Aires, Argentina","volume":"29","author":"Puentes","year":"2020","journal-title":"Bonplandia (Corrientes)"},{"issue":"4","key":"10.1016\/j.jep.2020.113712_bib34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4196\/kjpp.2014.18.4.279","article-title":"A review on chemical-induced inflammatory bowel disease models in rodents","volume":"18","author":"Randhawa","year":"2014","journal-title":"KOREAN J. PHYSIOL. PHARMACOL."},{"issue":"2","key":"10.1016\/j.jep.2020.113712_bib35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0378-4347(94)00111-1","article-title":"Rapid determination of glutathione status in fish liver using high-performance liquid chromatography and electrochemical detection","volume":"656","author":"Rodriguez-Ariza","year":"1994","journal-title":"J. Chromatogr. B Biomed. Appl."},{"issue":"5","key":"10.1016\/j.jep.2020.113712_bib36","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/ptr.6581","article-title":"The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis","volume":"34","author":"Sadeghi","year":"2019","journal-title":"Phytother Res."},{"issue":"3","key":"10.1016\/j.jep.2020.113712_bib37","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jep.2008.05.030","article-title":"a). Ethnobotany, biochemistry and pharmacology of Minthostachys (Lamiaceae)","volume":"118","author":"Schmidt-Lebuhn","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113712_bib38","first-page":"1","article-title":"A revision of the genus Minthostachys (labiatae)","volume":"98","author":"Schmidt-Lebuhn","year":"2008","journal-title":"Memoir. N. Y. Bot. Gard."},{"issue":"4","key":"10.1016\/j.jep.2020.113712_bib39","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.gtc.2017.08.009","article-title":"Herbs and inflammatory bowel disease","volume":"46","author":"Sebepos-Rogers","year":"2017","journal-title":"Gastroenterol. Clin. N. Am."},{"issue":"1","key":"10.1016\/j.jep.2020.113712_bib40","first-page":"65","article-title":"Role of nitric oxide-synthase and cyclooxygenase\/lipooxygenase systems in development of experimental ulcerative colitis","volume":"62","author":"Sklyarov","year":"2011","journal-title":"J. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2020.113712_bib41","first-page":"44","article-title":"Therapeutic potential to modify the mucus barrier in","volume":"8","author":"Sun","year":"2016","journal-title":"Inflam. Bowel Dis. Nutrients"},{"issue":"8","key":"10.1016\/j.jep.2020.113712_bib42","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.3390\/molecules24081546","article-title":"The anti-inflammatory role of mannich curcuminoids; special focus on colitis","volume":"24","author":"Szebeni","year":"2019","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jep.2020.113712_bib43","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1586\/egh.11.64","article-title":"New molecular insights into inflammatory bowel disease-induced diarrhea","volume":"5","author":"Tang","year":"2011","journal-title":"Expet Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2020.113712_bib44","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4535194","article-title":"Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies","author":"Tian","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"issue":"3","key":"10.1016\/j.jep.2020.113712_bib45","first-page":"268","article-title":"Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies","volume":"29","author":"Triantafillidis","year":"2016","journal-title":"Ann. Gastroenterol."},{"issue":"1\u20133","key":"10.1016\/j.jep.2020.113712_bib46","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jep.2005.04.006","article-title":"Antidiarrhoeal activity of the methanol extract of the barks of Xylocarpus moluccensis in castor oil- and magnesium sulphate-induced diarrhoea models in mice","volume":"101","author":"Uddin","year":"2005","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2020.113712_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105102","article-title":"Redox-sensitive induction of Src\/PI3-kinase\/Akt and MAPKs pathways activate eNOS in response to EPA:DHA 6:1","volume":"9","author":"Zgheel","year":"2014","journal-title":"PloS One"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412033600X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412033600X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:00:02Z","timestamp":1759942802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412033600X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":47,"alternative-id":["S037887412033600X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.113712","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacologycal activity of peperina (Minthostachys verticillata) on gastrointestinal tract","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.113712","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113712"}}