{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:24:49Z","timestamp":1784031889701,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":279,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100009730","name":"Universidade Federal de Ouro Preto","doi-asserted-by":"publisher","award":["23109.004079\/2019\\u201353"],"award-info":[{"award-number":["23109.004079\/2019\\u201353"]}],"id":[{"id":"10.13039\/501100009730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009730","name":"Universidade Federal de Ouro Preto","doi-asserted-by":"publisher","award":["23109.004080\/2019-88"],"award-info":[{"award-number":["23109.004080\/2019-88"]}],"id":[{"id":"10.13039\/501100009730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-01160-15"],"award-info":[{"award-number":["APQ-01160-15"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00820-19"],"award-info":[{"award-number":["APQ-00820-19"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["23109.003517\/2018-85"],"award-info":[{"award-number":["23109.003517\/2018-85"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.jep.2020.113738","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T03:44:31Z","timestamp":1608867871000},"page":"113738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Sesquiterpene lactones from Lychnophora species: Antinociceptive, anti-inflammatory, and antioxidant pathways to treat acute gout"],"prefix":"10.1016","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4306-586X","authenticated-orcid":false,"given":"Ana Catharina Fernandes Pereira Ferreira","family":"Bernardes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Cunha","family":"Matosinhos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela Carolina","family":"de Paula Michel Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Helena","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Dian","family":"de Oliveira Aguiar Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Caldeira","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7533-1248","authenticated-orcid":false,"given":"D\u00eania Antunes","family":"Sa\u00fade-Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2020.113738_bib1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0895-4356(88)90127-8","article-title":"Gout and coronary heart disease: the Framingham Study","volume":"41","author":"Abbott","year":"1988","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.jep.2020.113738_bib2","first-page":"121","article-title":"Catalase in vitro","volume":"vol. 105","author":"Aebi","year":"1984"},{"key":"10.1016\/j.jep.2020.113738_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/ijmm.2015.2411","article-title":"Repositioning of drugs using open-access data portal DTome: a test case with probenecid","volume":"37","author":"Ahmed","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2020.113738_bib4","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/art.33355","article-title":"NLRP3 inflammasome\u2013mediated neutrophil recruitment and hypernociception depend on leukotriene B4 in a murine model of gout","volume":"64","author":"Amaral","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2020.113738_bib5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.iy.12.040194.001041","article-title":"Function and activation of NF-kB in the immune system","volume":"12","author":"Baeuerle","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jep.2020.113738_bib6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bjp.2018.12.008","article-title":"In vivo anti-hyperuricemic activity of sesquiterpene lactones from Lychnophora species","volume":"29","author":"Bernardes","year":"2019","journal-title":"Braz. J. Pharmacog."},{"key":"10.1016\/j.jep.2020.113738_bib7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3899\/jrheum.170137","article-title":"Corticosteroid or nonsteroidal anti-inflammatory drugs for the treatment of acute gout: a systematic review of randomized controlled trials","volume":"45","author":"Billy","year":"2018","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.jep.2020.113738_bib8","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/0031-9422(81)83051-8","article-title":"A guaianolide and other constituents from Lychnophora species","volume":"20","author":"Bohlmann","year":"1981","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2020.113738_bib9","first-page":"3","article-title":"Progress in the chemistry of the vernoniae (compositae)","volume":"4","author":"Bohlmann","year":"1990","journal-title":"PI. Syst. Evoi."},{"key":"10.1016\/j.jep.2020.113738_bib43","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1016\/S0031-9422(00)91032-X","article-title":"Caryophyllene derivatives and a Heliangolide from Lychnophora species","volume":"19","author":"Bohlmann","year":"1980","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2020.113738_bib10","series-title":"As bases farmacol\u00f3gicas da terap\u00eautica de Goodman & Gilman-10","first-page":"605","author":"Brunton","year":"2010"},{"key":"10.1016\/j.jep.2020.113738_bib11","first-page":"551","article-title":"A\u00e7\u00e3o analg\u00e9sica do extrato bruto aquoso liofilizado do caule e folhas da Lychnophora ericoides Mart. (Arnica)","volume":"39","author":"Cerqueira","year":"1987","journal-title":"Ciencia e Cult."},{"key":"10.1016\/j.jep.2020.113738_bib12","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bjp.2015.06.003","article-title":"Useful Brazilian plants under the view of the writer-naturalist jo\u00e3o guimar\u00e3es rosa","volume":"25","author":"Chaves","year":"2015","journal-title":"Revista Brasileira de Farmacognosia"},{"key":"10.1016\/j.jep.2020.113738_bib13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1590\/S0100-879X2004000300018","article-title":"An electronic pressure-meter nociception paw test for mice","volume":"37","author":"Cunha","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.jep.2020.113738_bib14","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jep.2012.06.012","article-title":"Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents","volume":"142","author":"De Souza","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113738_bib15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1161\/01.CIR.101.1.33","article-title":"Gene expression of antioxidative enzymes in the human heart: increased expression of catalase in the end-stage failing heart","volume":"101","author":"Dieterich","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2020.113738_bib16","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/ptr.4736","article-title":"Anti\u2010inflammatory sesquiterpene lactones from Lychnophora trichocarpha Spreng. (Brazilian Arnica)","volume":"27","author":"Ferrari","year":"2013","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2020.113738_bib17","first-page":"668","article-title":"What made sesquiterpene lactones reach cancer clinical trials? Drug Discov","volume":"15","author":"Ghantous","year":"2010","journal-title":"Today Off."},{"key":"10.1016\/j.jep.2020.113738_bib18","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1021\/jo00135a028","article-title":"Structure of goyazensolide and its congeners","volume":"47","author":"Herz","year":"1982","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.jep.2020.113738_bib19","first-page":"243","article-title":"Sesquiterpene lactones: structural diversity and perspectives as anti-inflammatory molecules","volume":"vol. 49","author":"Hohmann","year":"2016"},{"key":"10.1016\/j.jep.2020.113738_bib20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/PL00000710","article-title":"Inhibition of xanthine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis","volume":"57","author":"Kong","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jep.2020.113738_bib21","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nrrheum.2015.91","article-title":"Global epidemiology of gout: prevalence, incidence and risk factors","volume":"11","author":"Kuo","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2020.113738_bib22","first-page":"1","article-title":"Uricosuric medications for chronic gout","volume":"11","author":"Kydd","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jep.2020.113738_bib23","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1039\/p19780001572","article-title":"Novel modified germacranolides and other constituents of Eremanthus elaegnus schultz-bip. (Compositae)","volume":"12","author":"Le Quesne","year":"1978","journal-title":"J. Chem. Soc. Perkin Trans. I"},{"key":"10.1016\/j.jep.2020.113738_bib24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2020.113738_bib25","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jep.2020.113738_bib26","first-page":"41","article-title":"Assessing mechanical allodynia in the rat paw with a new electronic algometer","volume":"84","author":"M\u00f6ller","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jep.2020.113738_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/696215","article-title":"Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stress","author":"Naudi","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.jep.2020.113738_bib28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/BOR.0b013e3282f4b1ed","article-title":"Hyperuricemia, gout and the metabolic syndrome","volume":"20","author":"Puig","year":"2008","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jep.2020.113738_bib29","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.berh.2015.04.025","article-title":"Molecular mechanisms of pain in crystal-induced arthritis","volume":"29","author":"Ramonda","year":"2015","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.jep.2020.113738_bib30","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/S0031-9422(00)97430-2","article-title":"Biological activities of sesquiterpene lactones","volume":"15","author":"Rodriguez","year":"1976","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2020.113738_bib31","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1016\/S0968-0896(99)00195-9","article-title":"Inhibition of transcription factor NF-\u03baB by sesquiterpene lactones: a proposed molecular mechanism of action","volume":"7","author":"R\u00fcngeler","year":"1999","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.jep.2020.113738_bib32","first-page":"90","article-title":"Constituents from the aerial parts of Lychnophora trichocarpha","volume":"69","author":"Sa\u00fade","year":"1998","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2020.113738_bib33","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1002\/mrc.2093","article-title":"Complete assignments of 1H and 13C NMR data for trypanocidal eremantholide C oxide derivatives","volume":"45","author":"Sa\u00fade-Guimar\u00e3es","year":"2007","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.jep.2020.113738_bib34","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1590\/S1516-05722014000200017","article-title":"In vitro antitumor activity of sesquiterpene lactones from Lychnophora trichocarpha","volume":"16","author":"Sa\u00fade-Guimar\u00e3es","year":"2014","journal-title":"Rev. Bras. Plantas Med."},{"key":"10.1016\/j.jep.2020.113738_bib35","series-title":"Revis\u00e3o taxonomica de Lychnophora Mart. (Vernoniaeae: compositae)","author":"Semir","year":"1991"},{"key":"10.1016\/j.jep.2020.113738_bib36","first-page":"1","article-title":"The global burden of gout: estimates from the Global Burden of Disease 2010 study","author":"Smith","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2020.113738_bib37","first-page":"63","article-title":"Biosynthesis and biological functions of terpenoids in plants","volume":"148","author":"Tholl","year":"2015","journal-title":"Adv. Biochem. Engin.\/Biotechnol."},{"key":"10.1016\/j.jep.2020.113738_bib38","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jep.2017.01.017","article-title":"The influence of seasonality on the content of goyazensolide and on anti-inflammatory and anti-hyperuricemic effects of the ethanolic extract of Lychnophora passerina (Brazilian arnica)","volume":"198","author":"Ugoline","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2020.113738_bib39","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jep.2020.113738_bib40","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0031-9422(00)89082-2","article-title":"Goyazensolide, a schistosomicidal heliangolide from Eremanthus goyazensis","volume":"15","author":"Vichnewsky","year":"1976","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2020.113738_bib41","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/S0031-9422(00)97763-X","article-title":"Sesquiterpene lactones and other constituents from Eremanthus seidelii, E. goyazensis and Vanillosmopsis erythropappa","volume":"28","author":"Vichnewiski","year":"1989","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2020.113738_bib42","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1186\/ar3806","article-title":"Risk of end-stage renal disease associated with gout: a nationwide population study","volume":"14","author":"Yu","year":"2012","journal-title":"Arthritis Res. Ther."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120336266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874120336266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:53:09Z","timestamp":1778503989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874120336266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":43,"alternative-id":["S0378874120336266"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2020.113738","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sesquiterpene lactones from Lychnophora species: Antinociceptive, anti-inflammatory, and antioxidant pathways to treat acute gout","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2020.113738","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113738"}}