{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T20:41:19Z","timestamp":1784061679672,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074041"],"award-info":[{"award-number":["82074041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803508"],"award-info":[{"award-number":["81803508"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020M670674"],"award-info":[{"award-number":["2020M670674"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["82074041"],"award-info":[{"award-number":["82074041"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["81803508"],"award-info":[{"award-number":["81803508"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M670674"],"award-info":[{"award-number":["2020M670674"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.jep.2021.113792","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T18:39:12Z","timestamp":1610131152000},"page":"113792","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Network pharmacology reveals pharmacological effect and mechanism of Panax notoginseng (Burk.) F. H. Chen on reproductive and genetic toxicity in male mice"],"prefix":"10.1016","volume":"270","author":[{"given":"Kuo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0316-6076","authenticated-orcid":false,"given":"Chunfu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.113792_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.biopha.2017.10.095","article-title":"Taurine enhances spermatogenic function and antioxidant defense mechanisms in testes and epididymis of L-NAME-induced hypertensive rats","volume":"97","author":"Adedara","year":"2018","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"issue":"4","key":"10.1016\/j.jep.2021.113792_bib2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1056\/NEJMoa031644","article-title":"Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer","volume":"350","author":"Arriagada","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.jep.2021.113792_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.reprotox.2005.05.003","article-title":"Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats","volume":"21","author":"Atessahin","year":"2006","journal-title":"Reprod. Toxicol."},{"issue":"4","key":"10.1016\/j.jep.2021.113792_bib4","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/mutage\/gev011","article-title":"Prevention of myelosuppression and genotoxicity induced by cisplatin in murine bone marrow cells: effect of an organovanadium compound vanadium(III)-l-cysteine","volume":"30","author":"Basu","year":"2015","journal-title":"Mutagenesis"},{"key":"10.1016\/j.jep.2021.113792_bib5","doi-asserted-by":"crossref","first-page":"420","DOI":"10.2741\/s495","article-title":"Oxidative stress: major executioner in disease pathology, role in sperm DNA damage and preventive strategies","volume":"9","author":"Bisht","year":"2017","journal-title":"Front Biosci (Schol Ed)"},{"issue":"6","key":"10.1016\/j.jep.2021.113792_bib6","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/(SICI)1097-0215(19991210)83:6<848::AID-IJC29>3.0.CO;2-#","article-title":"Treatment of patients with cisplatin-refractory testicular germ-cell cancer. German Testicular Cancer Study Group (GTCSG)","volume":"83","author":"Bokemeyer","year":"1999","journal-title":"Int. J. Canc."},{"issue":"4","key":"10.1016\/j.jep.2021.113792_bib7","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jgr.2017.07.009","article-title":"Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments","volume":"43","author":"Chen","year":"2019","journal-title":"Journal of ginseng research"},{"key":"10.1016\/j.jep.2021.113792_bib8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1749-8546-5-38","article-title":"Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells","volume":"5","author":"Choi","year":"2010","journal-title":"Chin. Med."},{"issue":"5","key":"10.1016\/j.jep.2021.113792_bib9","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1634\/theoncologist.2016-0319","article-title":"A systematic review of strategies to prevent cisplatin-induced nephrotoxicity","volume":"22","author":"Crona","year":"2017","journal-title":"Oncol."},{"key":"10.1016\/j.jep.2021.113792_bib10","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3389\/fphar.2017.00702","article-title":"Panax notoginseng saponins for treating coronary artery disease: a functional and mechanistic overview","volume":"8","author":"Duan","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2021.113792_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijbiomac.2013.10.034","article-title":"Neuroprotective effect of Panax notoginseng plysaccharides against focal cerebral ischemia reperfusion injury in rats","volume":"63","author":"Jia","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.jep.2021.113792_bib12","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s12917-017-1156-7","article-title":"Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study","volume":"13","author":"Kenward","year":"2017","journal-title":"BMC Vet. Res."},{"issue":"5","key":"10.1016\/j.jep.2021.113792_bib13","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3109\/15376516.2015.1006492","article-title":"Possible mechanism of PNS protection against cisplatin-induced nephrotoxicity in rat models","volume":"25","author":"Liu","year":"2015","journal-title":"Toxicol. Mech. Methods"},{"issue":"1","key":"10.1016\/j.jep.2021.113792_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40620-017-0392-z","article-title":"Cisplatin nephrotoxicity: a review of the literature","volume":"31","author":"Manohar","year":"2018","journal-title":"J. Nephrol."},{"key":"10.1016\/j.jep.2021.113792_bib15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.chemosphere.2019.05.017","article-title":"Chronic dietary administration of lower levels of diethyl phthalate induces murine testicular germ cell inflammation and sperm pathologies: involvement of oxidative stress","volume":"229","author":"Mondal","year":"2019","journal-title":"Chemosphere"},{"issue":"8","key":"10.1016\/j.jep.2021.113792_bib16","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1211\/jpp.58.8.0001","article-title":"Pharmacological activity of sanchi ginseng (Panax notoginseng)","volume":"58","author":"Ng","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2021.113792_bib17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nprot.2006.5","article-title":"The comet assay: a method to measure DNA damage in individual cells","volume":"1","author":"Olive","year":"2006","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.jep.2021.113792_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0165-1161(75)90058-8","article-title":"The micronucleus test","volume":"31","author":"Schmid","year":"1975","journal-title":"Mutat. Res."},{"issue":"3","key":"10.1016\/j.jep.2021.113792_bib19","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/19396368.2018.1541114","article-title":"Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: effects on ERK1\/2, JNK, and Akt pathways","volume":"65","author":"Shati","year":"2019","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.jep.2021.113792_bib20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.fct.2015.04.018","article-title":"Vetiver oil (Java) attenuates cisplatin-induced oxidative stress, nephrotoxicity and myelosuppression in Swiss albino mice","volume":"81","author":"Sinha","year":"2015","journal-title":"Food Chem. Toxicol. : Int. J.Publ.Br. Ind.Biol. Res. Assoc."},{"issue":"5","key":"10.1016\/j.jep.2021.113792_bib21","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.jpba.2006.01.058","article-title":"Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD","volume":"41","author":"Wan","year":"2006","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2021.113792_bib22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jep.2016.05.005","article-title":"Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: a review","volume":"188","author":"Wang","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2021.113792_bib23","doi-asserted-by":"crossref","first-page":"220","DOI":"10.5582\/bst.2018.01144","article-title":"An update on Chinese herbal medicines as adjuvant treatment of anticancer therapeutics","volume":"12","author":"Wang","year":"2018","journal-title":"Bioscience trends"},{"issue":"11","key":"10.1016\/j.jep.2021.113792_bib24","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.ejca.2004.02.029","article-title":"Supplementation with antioxidant micronutrients and chemotherapy-induced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised, double-blind, placebo-controlled study","volume":"40","author":"Weijl","year":"2004","journal-title":"Eur. J. Canc."},{"issue":"5","key":"10.1016\/j.jep.2021.113792_bib25","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1142\/S0192415X18500519","article-title":"Panax notoginseng for inflammation-related chronic diseases: a review on the modulations of multiple pathways","volume":"46","author":"Xu","year":"2018","journal-title":"Am. J. Chin. Med."},{"issue":"8","key":"10.1016\/j.jep.2021.113792_bib26","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1248\/bpb.b110535","article-title":"Panax notoginseng saponins enhances the cytotoxicity of cisplatin via increasing gap junction intercellular communication","volume":"35","author":"Yu","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2021.113792_bib27","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ecoenv.2016.01.016","article-title":"Application of the micronucleus test and comet assay in Trachemys callirostris erythrocytes as a model for in situ genotoxic monitoring","volume":"127","author":"Zapata","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jep.2021.113792_bib28","doi-asserted-by":"crossref","first-page":"112269","DOI":"10.1016\/j.jep.2019.112269","article-title":"Protective effect of Liuwei Dihuang Pill on cisplatin-induced reproductive toxicity and genotoxicity in male mice","volume":"247","author":"Zhang","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2021.113792_bib29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00204-007-0224-3","article-title":"Protective effects of ginsenoside Rg(3) against cyclophosphamide-induced DNA damage and cell apoptosis in mice","volume":"82","author":"Zhang","year":"2008","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.jep.2021.113792_bib30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.fct.2007.08.025","article-title":"Protective effects of total saponins from stem and leaf of Panax ginseng against cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells","volume":"46","author":"Zhang","year":"2008","journal-title":"Food Chem. Toxicol. : Int. J.Publ.Br. Ind.Biol. Res. Assoc."},{"issue":"11","key":"10.1016\/j.jep.2021.113792_bib31","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1002\/ptr.6167","article-title":"Phytochemistry, pharmacology, and clinical use of Panax notoginseng flowers buds","volume":"32","author":"Zhang","year":"2018","journal-title":"Phytother Res. : PTR"},{"issue":"11","key":"10.1016\/j.jep.2021.113792_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4670","article-title":"Dose-dependent exposure profile and metabolic characterization of notoginsenoside R1 in rat plasma by ultra-fast liquid chromatography-electrospray ionization-tandem mass spectrometry","volume":"33","author":"Zhang","year":"2019","journal-title":"Biomed. Chromatogr. : BMC (Biomed. Chromatogr.)"},{"key":"10.1016\/j.jep.2021.113792_bib33","doi-asserted-by":"crossref","first-page":"9463","DOI":"10.1038\/srep09463","article-title":"Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: drug-target prediction, network analysis and experimental validation","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"issue":"17","key":"10.1016\/j.jep.2021.113792_bib34","doi-asserted-by":"crossref","first-page":"7389","DOI":"10.7314\/APJCP.2014.15.17.7389","article-title":"Pu-erh tea powder preventive effects on cisplatin-induced liver oxidative damage in Wistar rats","volume":"15","author":"Zheng","year":"2014","journal-title":"Asian Pac. J. Cancer Prev. APJCP : Asian Pac. J. Cancer Prev. APJCP"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121000180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121000180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:44:34Z","timestamp":1759941874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121000180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":34,"alternative-id":["S0378874121000180"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.113792","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Network pharmacology reveals pharmacological effect and mechanism of Panax notoginseng (Burk.) F. H. Chen on reproductive and genetic toxicity in male mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.113792","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113792"}}