{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T06:32:33Z","timestamp":1776666753759,"version":"3.51.2"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.jep.2021.113820","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T01:01:02Z","timestamp":1610931662000},"page":"113820","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Tibetan medicine Ershiwuwei Lvxue Pill attenuates collagen-induced arthritis via inhibition of JAK2\/STAT3 signaling pathway"],"prefix":"10.1016","volume":"270","author":[{"given":"Chuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsong","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W\u00fcntrang","family":"Dhondrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianli","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.113820_bib1","doi-asserted-by":"crossref","first-page":"10018","DOI":"10.1002\/jcp.27860","article-title":"Strategies toward rheumatoid arthritis therapy; the old and the new","volume":"234","author":"Abbasi","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jep.2021.113820_bib101","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.biopha.2017.05.055","article-title":"Rheumatoid arthritis: Recent advances on its etiology, role of cytokines and pharmacotherapy","volume":"92","author":"Alam","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2021.113820_bib2","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1097\/SCS.0000000000004691","article-title":"Acetyl-11-Keto-\u03b2-Boswellic acid promotes osteoblast differentiation by inhibiting tumor necrosis factor-\u03b1 and nuclear factor-\u03baB activity","volume":"29","author":"Bai","year":"2018","journal-title":"J. Craniofac. Surg."},{"key":"10.1016\/j.jep.2021.113820_bib3","doi-asserted-by":"crossref","first-page":"110985","DOI":"10.1016\/j.biopha.2020.110985","article-title":"Gallic acid: pharmacological activities and molecular mechanisms involved in inflammation-related diseases","volume":"133","author":"Bai","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2021.113820_bib4","first-page":"26","article-title":"The understanding and treatment of huangshui disease in Tibetan medicine","volume":"15","author":"Bianba","year":"2019","journal-title":"Asia-Pac. Trad. Med."},{"key":"10.1016\/j.jep.2021.113820_bib5","doi-asserted-by":"crossref","first-page":"116956","DOI":"10.1016\/j.lfs.2019.116956","article-title":"Rheumatoid arthritis induces enteric neurodegeneration and jejunal inflammation, and quercetin promotes neuroprotective and anti-inflammatory actions","volume":"238","author":"Bossolani","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2021.113820_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00281-003-0127-1","article-title":"Immunopathogenesis of collagen arthritis","volume":"25","author":"Brand","year":"2003","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.jep.2021.113820_bib7","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1016\/S0140-6736(17)31491-5","article-title":"Novel treatment strategies in rheumatoid arthritis","volume":"389","author":"Burmester","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2021.113820_bib8","first-page":"386","article-title":"Vasicine: research advances in resources, pharmacological activities, pharmacokinetics, toxicity and analysis methods","volume":"40","author":"Chen","year":"2013","journal-title":"J.Int. Pharmaceut. Res"},{"key":"10.1016\/j.jep.2021.113820_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41584-018-0109-2","article-title":"Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis","volume":"15","author":"Chen","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2021.113820_bib10","series-title":"Pharmacopoeia of the People's Republic of China","author":"China Pharmacopoeia Committee","year":"2015"},{"key":"10.1016\/j.jep.2021.113820_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar4162","article-title":"Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6\/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes","volume":"15","author":"Choe","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2021.113820_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2015.11.005","article-title":"Oleanolic acid acetate inhibits rheumatoid arthritis by modulating T cell immune responses and matrix-degrading enzymes","volume":"290","author":"Choi","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2021.113820_bib13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/08923973.2018.1434793","article-title":"Experimental animal models for rheumatoid arthritis","volume":"40","author":"Choudhary","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.jep.2021.113820_bib14","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM200103223441207","article-title":"Cytokine pathways and joint inflammation in rheumatoid arthritis","volume":"344","author":"Choy","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2021.113820_bib15","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.intimp.2018.04.001","article-title":"Dihydromyricetin relieves rheumatoid arthritis symptoms and suppresses expression of pro-inflammatory cytokines via the activation of Nrf2 pathway in rheumatoid arthritis model","volume":"59","author":"Chu","year":"2018","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2021.113820_bib16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s40744-018-0097-3","article-title":"Worldwide, 3-year, post-marketing surveillance experience with tofacitinib in rheumatoid arthritis","volume":"5","author":"Cohen","year":"2018","journal-title":"Rheumatol. Ther."},{"key":"10.1016\/j.jep.2021.113820_bib17","series-title":"Jingzhu Bencao","author":"DiMaEr","year":"2012"},{"key":"10.1016\/j.jep.2021.113820_bib18","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10787-019-00629-x","article-title":"Hydrolysable tannin-rich fraction from Terminalia chebula Retz. fruits ameliorate collagen-induced arthritis in BALB\/c mice","volume":"28","author":"Ekambaram","year":"2020","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2021.113820_bib102","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.biopha.2018.03.142","article-title":"Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K\/AKT\/mTOR signaling pathway in rat models with rheumatoid arthritis","volume":"102","author":"Feng","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2021.113820_bib19","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jep.2021.113820_bib20","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s13075-017-1361-6","article-title":"Animal models of rheumatoid pain: experimental systems and insights","volume":"19","author":"Fischer","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2021.113820_bib21","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/art.41032","article-title":"Padacitinib versus placebo or adalimumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase III, double-lind, randomized controlled trial","volume":"71","author":"Fleischmann","year":"2019","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2021.113820_bib22","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/art.39953","article-title":"Baricitinib, methotrexate, or combination in patients with rheumatoid arthritis and no or limited prior disease-modifying antirheumatic drug treatment","volume":"69","author":"Fleischmann","year":"2017","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2021.113820_bib23","first-page":"1","article-title":"Chlorogenic acid inhibits BAFF expression in collagen-induced arthritis and human synoviocyte MH7A cells by modulating the activation of the NF-\u03baB signaling pathway","volume":"2019","author":"Fu","year":"2019","journal-title":"J Immunol. Res."},{"key":"10.1016\/j.jep.2021.113820_bib24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11926-009-0052-y","article-title":"The role of interleukin-17 in the pathogenesis of rheumatoid arthritis","volume":"11","author":"Gaffen","year":"2009","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.jep.2021.113820_bib25","first-page":"1053","article-title":"Discussion of treating effects and its mechanism of Tibetan medicine twenty- five flavor Lvxue pills to Bi syndrome (rheumatoid arthritis)","volume":"22","author":"Gang","year":"2016","journal-title":"J.Basic .Chin. Med."},{"key":"10.1016\/j.jep.2021.113820_bib26","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1016\/S0140-6736(18)31116-4","article-title":"Safety and efficacy of upadacitinib in patients with active rheumatoid arthritis refractory to biologic disease-modifying anti-rheumatic drugs (SELECT-BEYOND): a double-blind, randomised controlled phase 3 trial","volume":"391","author":"Genovese","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2021.113820_bib27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.imlet.2018.11.009","article-title":"Anti-rheumatoid arthritis effects in adjuvant-induced arthritis in rats and molecular docking studies of Polygonum orientale L. extracts","volume":"201","author":"Gou","year":"2018","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jep.2021.113820_bib28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.biopha.2017.03.026","article-title":"Therapeutic effect of quercetin in collagen-induced arthritis","volume":"90","author":"Haleagrahara","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2021.113820_bib29","first-page":"900","article-title":"Pharmacological and toxicological studies on the volatile oil of Myristica fragrans Houtt","volume":"5","author":"Han","year":"2007","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2021.113820_bib30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.imlet.2009.10.006","article-title":"IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients","volume":"127","author":"Heo","year":"2010","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jep.2021.113820_bib31","doi-asserted-by":"crossref","first-page":"112426","DOI":"10.1016\/j.jep.2019.112426","article-title":"Longzhibu disease and its therapeutic effects by traditional Tibetan medicine: ershi-wei Chenxiang pills","volume":"249","author":"Hou","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113820_bib32","first-page":"1053","article-title":"Discussion of treating effects and its mechanism of Tibetan medicine twenty-five flavor Lvxue pills to Bi syndrome (rheumatoid arthritis)","volume":"22","author":"Hu","year":"2016","journal-title":"J.Basic .Chin. Med."},{"key":"10.1016\/j.jep.2021.113820_bib33","article-title":"Comparative study on acute toxicity of different extraction methods of Cassia semen on normal mice","volume":"13","author":"Huang","year":"2016","journal-title":"Chin. J. Pharm."},{"key":"10.1016\/j.jep.2021.113820_bib34","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1093\/rheumatology\/kem198","article-title":"Silvennoinen OThe expression of SOCS is altered in rheumatoid arthritis","volume":"46","author":"Isom\u00e4ki","year":"2007","journal-title":"Rheumatology"},{"key":"10.1016\/j.jep.2021.113820_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2016.05.027","article-title":"Iridoid glycosides from the flowers of Gentiana macrophylla Pall. ameliorate collagen-induced arthritis in rats","volume":"189","author":"Jia","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113820_bib36","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.3389\/fphar.2019.01435","article-title":"Network pharmacology-based prediction of active ingredients and mechanisms of (Benth.) kudo against rheumatoid arthritis","volume":"10","author":"Jiang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2021.113820_bib37","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3109\/1547691X.2015.1136010","article-title":"Triphala herbal extract suppresses inflammatory responses in LPS-stimulated RAW 264.7 macrophages and adjuvant-induced arthritic rats via inhibition of NF-\u03baB pathway","volume":"13","author":"Kalaiselvan","year":"2016","journal-title":"J. Immunot."},{"key":"10.1016\/j.jep.2021.113820_bib38","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/03009742.2019.1602164","article-title":"Interleukin-6 and tumour necrosis factor-\u03b1 cooperatively promote cell cycle regulators and proliferate rheumatoid arthritis fibroblast-like synovial cells","volume":"48","author":"Kaneshiro","year":"2019","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.jep.2021.113820_bib39","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1136\/annrheumdis-2017-212762","article-title":"Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis","volume":"77","author":"Koenen","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2021.113820_bib40","doi-asserted-by":"crossref","first-page":"104497","DOI":"10.1016\/j.phrs.2019.104497","article-title":"Role of biological agents in treatment of rheumatoid arthritis","volume":"150","author":"Law","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2021.113820_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2017.05.011","article-title":"Ursodeoxycholic acid attenuates experimental autoimmune arthritis by targeting Th17 and inducing pAMPK and transcriptional corepressor SMILE","volume":"188","author":"Lee","year":"2017","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jep.2021.113820_bib42","first-page":"534","article-title":"A robust approximate confidence-interval for components of variance","volume":"31","author":"Levene","year":"1960","journal-title":"Ann. Math. Stat."},{"key":"10.1016\/j.jep.2021.113820_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201900294","article-title":"Chemical composition of Bawei longzuan granule and its anti-arthritic activity on collagen-induced arthritis in rats by inhibiting inflammatory responses","volume":"16","author":"Li","year":"2019","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jep.2021.113820_bib44","first-page":"852","article-title":"Study on acute toxicology and pharmacodynamics of Phyllanthus emblica L","volume":"6","author":"Li","year":"2002","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2021.113820_bib45","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/08923973.2012.723010","article-title":"7,3\u2032-dimethoxy hesperetin inhibits inflammation by inducing synovial apoptosis in rats with adjuvant-induced arthritis","volume":"35","author":"Li","year":"2013","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.jep.2021.113820_bib46","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/eji.201344369","article-title":"SOCS signaling in autoimmune diseases: molecular mechanisms and therapeutic implications","volume":"44","author":"Liang","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jep.2021.113820_bib47","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/s41467-018-04013-1","article-title":"The molecular basis of JAK\/STAT inhibition by SOCS1","volume":"9","author":"Liau","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2021.113820_bib48","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/13880209.2018.1448874","article-title":"Crocin exerts anti-inflammatory and anti-arthritic effects on type II collagen-induced arthritis in rats","volume":"56","author":"Liu","year":"2018","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2021.113820_bib49","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1196\/annals.1393.008","article-title":"Tibetan medicine","volume":"1172","author":"Loizzo","year":"2009","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.jep.2021.113820_bib50","first-page":"145","article-title":"Observation on the curative effect of Tibetan medicine twenty-five taste donkey blood pills in treating gout","volume":"19","author":"Ma","year":"2019","journal-title":"World Latest Medicine Information"},{"key":"10.1016\/j.jep.2021.113820_bib51","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/1759720X18776224","article-title":"The role of the JAK\/STAT signal pathway in rheumatoid arthritis","volume":"10","author":"Malemud","year":"2018","journal-title":"Ther. Adv. Musculoskel."},{"key":"10.1016\/j.jep.2021.113820_bib52","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2094","article-title":"Cytokines in the pathogenesis of rheumatoid arthritis","volume":"7","author":"McInnes","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2021.113820_bib53","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/S0140-6736(17)31472-1","article-title":"Pathogenetic insights from the treatment of rheumatoid arthritis","volume":"389","author":"McInnes","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2021.113820_bib54","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3389\/fimmu.2018.00961","article-title":"IL-10 producing B cells ability to induce regulatory T cells is maintained in rheumatoid arthritis","volume":"9","author":"Mielle","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2021.113820_bib55","series-title":"Drug Standards of the Ministry of Health of the People's Republic of China","author":"Ministry of Health of the People's Republic of China","year":"1995"},{"key":"10.1016\/j.jep.2021.113820_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2017.04.020","article-title":"Anti-rheumatoid arthritis effects of traditional Chinese herb couple in adjuvant-induced arthritis in rats","volume":"205","author":"Pan","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113820_bib58","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1038\/s41598-018-21856-2","article-title":"Interleukin-10 produced by myeloid-derived suppressor cells is critical for the induction of Tregs and attenuation of rheumatoid inflammation in mice","volume":"8","author":"Park","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2021.113820_bib59","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nri846","article-title":"Apoptosis as a therapeutic tool in rheumatoid arthritis","volume":"2","author":"Pope","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2021.113820_bib60","first-page":"36","article-title":"Experimental study of the acute toxicity on common-used bitter and cold medicines","volume":"2","author":"Qiu","year":"2004","journal-title":"Central South Pharmacy"},{"key":"10.1016\/j.jep.2021.113820_bib61","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jaut.2017.01.002","article-title":"MicroRNA-155 contributes to enhanced resistance to apoptosis in monocytes from patients with rheumatoid arthritis","volume":"79","author":"Rajasekhar","year":"2017","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jep.2021.113820_bib62","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1242\/jcs.00963","article-title":"The JAK\/STAT signaling pathway","volume":"117","author":"Rawlings","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jep.2021.113820_bib63","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"Faseb. J."},{"key":"10.1016\/j.jep.2021.113820_bib64","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1142\/S0192415X13500420","article-title":"5,7,3\u2019-Triacetyl hesperetin suppresses adjuvant-induced arthritis in rats through modulating JAK2\/STAT3 pathway","volume":"41","author":"Ren","year":"2013","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2021.113820_bib65","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1039\/C6FO00485G","article-title":"An update on dietary phenolic compounds in the prevention and management of rheumatoid arthritis","volume":"7","author":"Rosillo","year":"2016","journal-title":"Food Funct"},{"key":"10.1016\/j.jep.2021.113820_bib66","doi-asserted-by":"crossref","first-page":"161","DOI":"10.5114\/reum.2016.62469","article-title":"Esculetin reduces leukotriene B4 level in plasma of rats with adjuvant-induced arthritis","volume":"54","author":"Rzodkiewicz","year":"2016","journal-title":"Reumatologia"},{"key":"10.1016\/j.jep.2021.113820_bib67","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/biomet\/52.3-4.591","article-title":"An analysis of variance test for normality (complete samples)","volume":"52","author":"Shapiro","year":"1965","journal-title":"Biometrika"},{"key":"10.1016\/j.jep.2021.113820_bib68","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.3389\/fimmu.2018.01714","article-title":"Glycogen metabolism and rheumatoid arthritis: the role of glycogen synthase 1 in regulation of synovial inflammation via blocking AMP-activated protein kinase activation","volume":"9","author":"Shi","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2021.113820_bib69","first-page":"336","article-title":"Studies on the effect of corilagin isolated from Euphorbia helioscopia on collagen-induced arthritis (II); cytokines analysis of collagen II induced arthritis mice model","volume":"21","author":"Shin","year":"2008","journal-title":"Korean J. Polar Res."},{"key":"10.1016\/j.jep.2021.113820_bib70","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00204-014-1448-7","article-title":"The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update","volume":"89","author":"Siddiqui","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jep.2021.113820_bib71","doi-asserted-by":"crossref","first-page":"241","DOI":"10.7326\/0003-4819-123-4-199508150-00001","article-title":"Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs: a randomized, double-blind, placebo-controlled trial","volume":"123","author":"Silverstein","year":"1995","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.jep.2021.113820_bib72","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/art.20382","article-title":"Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis","volume":"50","author":"Sims","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2021.113820_bib73","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2021.113820_bib74","article-title":"Ethyl acetate extract of Tibetan medicine Rhamnella gilgitica ameliorated type II collagen-induced arthritis in rats via regulating JAK-STAT signaling pathway","volume":"113514","author":"Su","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113820_bib75","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12079-018-0475-1","article-title":"Baicalin attenuates collagen-induced arthritis via inhibition of JAK2-STAT3 signaling and regulation of Th17 cells in mice","volume":"13","author":"Sun","year":"2019","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/j.jep.2021.113820_bib76","doi-asserted-by":"crossref","first-page":"106384","DOI":"10.1016\/j.intimp.2020.106384","article-title":"Anti-rheumatoid arthritis effects of flavonoids from Daphne genkwa","volume":"83","author":"Sun","year":"2020","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2021.113820_bib77","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/pds.4555","article-title":"Concomitant use of low-dose methotrexate and NSAIDs and the risk of serious adverse events among patients with rheumatoid arthritis","volume":"27","author":"Svanstr\u00f6m","year":"2018","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.jep.2021.113820_bib78","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1084\/jem.20160792","article-title":"Historical observations contributing insights on etiopathogenesis of rheumatoid arthritis and role of rheumatoid factor","volume":"213","author":"Tan","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jep.2021.113820_bib79","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.4314\/tjpr.v17i6.17","article-title":"Network pharmacology and UPLC-Q-TOF\/MS studies on the anti-arthritic mechanism of Pterocephalus hookeri","volume":"17","author":"Tang","year":"2018","journal-title":"Trop. J. Pharmaceut. Res."},{"key":"10.1016\/j.jep.2021.113820_bib80","first-page":"27","article-title":"Protective effects of fraxini cortex extract and aesculin on rats with rheumatoid arthritis","volume":"25","author":"Tang","year":"2016","journal-title":"Chin. Pharm."},{"key":"10.1016\/j.jep.2021.113820_bib81","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1056\/NEJMoa1608345","article-title":"Baricitinib versus placebo or adalimumab in rheumatoid arthritis","volume":"376","author":"Taylor","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2021.113820_bib82","doi-asserted-by":"crossref","first-page":"112841","DOI":"10.1016\/j.jep.2020.112841","article-title":"Oral treatments with a flavonoid-enriched fraction from Cecropia hololeuca and with rutin reduce articular pain and inflammation in murine zymosan-induced arthritis","volume":"260","author":"Teixeira","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113820_bib83","series-title":"Guidance Suggestions for the Care and Use of Laboratory Animals","author":"The Ministry of Science and Technology of the People's Republic of China","year":"2006"},{"key":"10.1016\/j.jep.2021.113820_bib84","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/jcsm.12189","article-title":"Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis","volume":"8","author":"Tournadre","year":"2017","journal-title":"J. Caxhexia Sarcopenia Muscle."},{"key":"10.1016\/j.jep.2021.113820_bib85","series-title":"Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers","author":"Us Food and Drug Administration","year":"2005"},{"key":"10.1016\/j.jep.2021.113820_bib86","first-page":"1673","article-title":"Analysis on composition and medication regularities of Tibetan medicine treating Zhenbu disease based on association rule and entropy method","volume":"35","author":"Wang","year":"2017","journal-title":"Chin. Archives Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2021.113820_bib87","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3390\/toxins11030142","article-title":"Evaluation of the liver toxicity of Pterocephalus hookeri extract via triggering necrosis","volume":"11","author":"Wang","year":"2019","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.jep.2021.113820_bib88","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ejmech.2018.09.027","article-title":"Side effects of methotrexate therapy for rheumatoid arthritis: a systematic review","volume":"158","author":"Wang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jep.2021.113820_bib89","doi-asserted-by":"crossref","first-page":"111801","DOI":"10.1016\/j.jep.2019.03.028","article-title":"Rhodiola crenulata attenuates apoptosis and mitochondrial energy metabolism disorder in rats with hypobaric hypoxia-induced brain injury by regulating the HIF-1\u03b1\/microRNA 210\/ISCU1\/2(COX10) signaling pathway","volume":"241","author":"Wang","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113820_bib90","first-page":"164","article-title":"Study on the mechanism of Tibetan medicine wuwei shexiang pills in the treatment of \u201cGrum bu\u201d disease based on \u201cro nus ZhurJes-network target-molecular docking\u201d","volume":"31","author":"Wencheng","year":"2020","journal-title":"China Pharmacy"},{"key":"10.1016\/j.jep.2021.113820_bib91","first-page":"53","article-title":"Identification of Ershiwuwei Luxue pellets and determination of gallic acid","volume":"18","author":"Xia","year":"2003","journal-title":"West China J. Pharm. Sci."},{"key":"10.1016\/j.jep.2021.113820_bib92","doi-asserted-by":"crossref","first-page":"106210","DOI":"10.1016\/j.intimp.2020.106210","article-title":"The role of JAK\/STAT signaling pathway and its inhibitors in diseases","volume":"80","author":"Xin","year":"2020","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2021.113820_bib93","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.phymed.2018.12.023","article-title":"Tibetan medicine Kuan-Jin-Teng exerts anti-arthritic effects on collagen-induced arthritis rats via inhibition the production of pro-inflammatory cytokines and down-regulation of MAPK signaling pathway","volume":"57","author":"Xiong","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2021.113820_bib94","first-page":"2685","article-title":"Protective effect of lignum dalbergiae odoriferae volatile oil on acute myocardial ischemia induced by pituitrin in rats and acute toxicity experiment","volume":"22","author":"Yang","year":"2011","journal-title":"Lishizhen.Med. Mater. Med.Res."},{"key":"10.1016\/j.jep.2021.113820_bib95","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3892\/ijmm.2016.2843","article-title":"Matrine induces the apoptosis of fibroblast-like synoviocytes derived from rats with collagen-induced arthritis by suppressing the activation of the JAK\/STAT signaling pathway","volume":"39","author":"Yang","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2021.113820_bib96","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jbspin.2012.08.010","article-title":"Gallic acid, a natural polyphenolic acid, induces apoptosis and inhibits proinflammatory gene expressions in rheumatoid arthritis fibroblast-like synoviocytes","volume":"80","author":"Yoon","year":"2013","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.jep.2021.113820_bib97","series-title":"The Four Medical Tantras, Tibet People","author":"Yutuo","year":"1982"},{"key":"10.1016\/j.jep.2021.113820_bib98","doi-asserted-by":"crossref","first-page":"109367","DOI":"10.1016\/j.biopha.2019.109367","article-title":"Guizhi-Shaoyao-Zhimu decoction possesses anti-arthritic effects on type II collagen-induced arthritis in rats via suppression of inflammatory reactions, inhibition of invasion & migration and induction of apoptosis in synovial fibroblasts","volume":"118","author":"Zhang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2021.113820_bib99","first-page":"130","article-title":"Research process of chemical constituents and pharmacological effects of Tibetan medicine triphala","volume":"20","author":"Zhou","year":"2018","journal-title":"World Sci. Technol.Mod.Tradit.Chin. Med.Mater. Med"},{"key":"10.1016\/j.jep.2021.113820_bib100","first-page":"128","article-title":"On the origin and protection of Tibetan medical Books \"Si bu yi dian","volume":"17","author":"Zhu","year":"2013","journal-title":"Lan Tai Shi Jie"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121000465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121000465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:02:52Z","timestamp":1759942972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121000465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":101,"alternative-id":["S0378874121000465"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.113820","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tibetan medicine Ershiwuwei Lvxue Pill attenuates collagen-induced arthritis via inhibition of JAK2\/STAT3 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.113820","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113820"}}