{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T01:49:41Z","timestamp":1782352181266,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100013276","name":"Interreg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jep.2021.113865","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T22:23:20Z","timestamp":1611267800000},"page":"113865","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Trichilia catigua and Turnera diffusa extracts: In vitro inhibition of tyrosinase, antiglycation activity and effects on enzymes and pathways engaged in the neuroinflammatory process"],"prefix":"10.1016","volume":"271","author":[{"given":"Jo\u00e3o","family":"Bernardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Malheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romeu A.","family":"Videira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Valent\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cl\u00e1udia","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Veiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9764-3920","authenticated-orcid":false,"given":"Paula B.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.113865_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.algal.2017.09.009","article-title":"Phlorotannin extracts from Fucales: marine polyphenols as bioregulators engaged in inflammation-related mediators and enzymes","volume":"28","author":"Barbosa","year":"2017","journal-title":"Algal Res"},{"key":"10.1016\/j.jep.2021.113865_bib22","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/ptr.1579","article-title":"Inhibition of platelet phospholipase A2 activity by catuaba extract suggests antiinflammatory properties","volume":"18","author":"Barbosa","year":"2004","journal-title":"Phyther. Res."},{"key":"10.1016\/j.jep.2021.113865_bib23","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.fct.2017.06.014","article-title":"Medicinal species as MTDLs: Turnera diffusa Willd. Ex Schult inhibits CNS enzymes and delays glutamate excitotoxicity in SH-SY5Y cells via oxidative damage","volume":"106","author":"Bernardo","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2021.113865_bib24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jep.2017.09.039","article-title":"In vitro multimodal-effect of Trichilia catigua A. Juss. (Meliaceae) bark aqueous extract in CNS targets","volume":"211","author":"Bernardo","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113865_bib25","series-title":"Plantas de uso medicinal en Guatemala (No. 633.88097281 C118)","author":"C\u00e1ceres","year":"1996"},{"key":"10.1016\/j.jep.2021.113865_bib26","article-title":"Antinociceptive activity of Trichilia catigua hydroalcoholic extract: new evidence on its dopaminergic effects. Evidence-based Complement","author":"Calixto","year":"2011","journal-title":"Altern. Med."},{"key":"10.1016\/j.jep.2021.113865_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-08858-y","article-title":"Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis","volume":"10","author":"Carballo-Carbajal","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2021.113865_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jep.2017.09.040","article-title":"The Brazilian market of herbal medicinal products and the impacts of the new legislation on traditional medicines","volume":"15","author":"Carvalho","year":"2018","journal-title":"J. Ethnoparmacol."},{"key":"10.1016\/j.jep.2021.113865_bib29","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.3390\/ijms10062440","article-title":"An updated review of tyrosinase inhibitors","volume":"10","author":"Chang","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2021.113865_bib30","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11064-015-1776-x","article-title":"The lipoxygenases: their regulation and implication in Alzheimer's disease","volume":"41","author":"Czapski","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2021.113865_bib31","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.tem.2019.07.012","article-title":"A possible neurodegeneration mechanism triggered by diabetes","volume":"30","author":"Farhadi","year":"2019","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.jep.2021.113865_bib32","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.3390\/md10122766","article-title":"Phlorotannin extracts from Fucales characterized by HPLC-DAD-ESI-MSn: approaches to hyaluronidase inhibitory capacity and antioxidant properties","volume":"10","author":"Ferreres","year":"2012","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.jep.2021.113865_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/428010","article-title":"Mechanism of oxidative stress in neurodegeneration","author":"Gandhi","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2021.113865_bib34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jep.2018.04.018","article-title":"Ethyl-acetate fraction of Trichilia catigua protects against oxidative stress and neuroinflammation after cerebral ischemia\/reperfusion","volume":"221","author":"Godinho","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113865_bib35","article-title":"Meli\u00e1ceas. Flora ilustrada catarinense","volume":"18","author":"Klein","year":"1984","journal-title":"As plantas. Fascic.: Calyceraceas"},{"key":"10.1016\/j.jep.2021.113865_bib36","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3389\/fncel.2019.00514","article-title":"Pharmacological targeting of microglial activation: new therapeutic approach","volume":"13","author":"Liu","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jep.2021.113865_bib37","article-title":"Phlorotannins from brown algae (Fucus vesiculosus) inhibited the formation of advanced glycation endproducts by scavenging reactive carbonyls","volume":"60","author":"Liu","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2021.113865_bib38","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bjp.2016.10.005","article-title":"Trichilia catigua: therapeutic and cosmetic values","volume":"27","author":"Longhini","year":"2017","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.jep.2021.113865_bib39","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.foodchem.2009.04.010","article-title":"Antioxidant and tyrosinase inhibitory activity of mango seed kernel by product","volume":"117","author":"Maisuthisakul","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2021.113865_bib40","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jnutbio.2018.02.001","article-title":"Beneficial effects of white wine polyphenols-enriched diet on Alzheimer's disease-like pathology","volume":"55","author":"Mendes","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.jep.2021.113865_bib41","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1002\/ana.410440713","article-title":"Advanced glycation end products in neurodegeneration: more than early markers of oxidative stress?","volume":"44","author":"M\u00fcnch","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jep.2021.113865_bib42","doi-asserted-by":"crossref","first-page":"16R","DOI":"10.1093\/glycob\/cwi053","article-title":"Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation","volume":"15","author":"Ramasamy","year":"2005","journal-title":"Glycobiology"},{"key":"10.1016\/j.jep.2021.113865_bib43","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s12017-016-8430-x","article-title":"Role of dietary phenols in mitigating microglia-mediated neuroinflammation","volume":"18","author":"Rangarajan","year":"2016","journal-title":"NeuroMolecular Med."},{"key":"10.1016\/j.jep.2021.113865_bib44","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.aag2590","article-title":"How neuroinflammation contributes to neurodegeneration","volume":"353","author":"Ransohoff","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jep.2021.113865_bib45","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.freeradbiomed.2011.06.027","article-title":"Lipid peroxidation and neurodegenerative disease","volume":"51","author":"Reed","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2021.113865_bib100","doi-asserted-by":"crossref","DOI":"10.4172\/2472-0992.1000e109","article-title":"Flavonoids and the structure-antioxidant activity relationship","volume":"4","author":"Russo","year":"2018","journal-title":"J. Pharmacogn. Nat. Prod"},{"key":"10.1016\/j.jep.2021.113865_bib46","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.neuint.2005.03.007","article-title":"Distinct signaling pathways for induction of type II NOS by IFN\u03b3 and LPS in BV-2 microglial cells","volume":"47","author":"Shen","year":"2005","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jep.2021.113865_bib47","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.bjp.2019.04.007","article-title":"Anxiolytic-like and proneurogenic effects of Trichilia catigua ethyl-acetate fraction in mice with cerebral ischemia","volume":"29","author":"Soares","year":"2019","journal-title":"Brazilian J. Pharmacogn."},{"key":"10.1016\/j.jep.2021.113865_bib48","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3945\/an.114.007500","article-title":"Flavonoid-based therapies in the early management of neurodegenerative diseases","volume":"6","author":"Solanki","year":"2015","journal-title":"Adv. Nutr. An Int. Rev. J."},{"key":"10.1016\/j.jep.2021.113865_bib49","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1021\/jf072740y","article-title":"Tronchuda cabbage (Brassica oleracea L. var. costata DC): scavenger of reactive nitrogen species","volume":"56","author":"Sousa","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2021.113865_bib50","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12263-009-0136-3","article-title":"Flavonoids and brain health: multiple effects underpinned by common mechanisms","volume":"4","author":"Spencer","year":"2009","journal-title":"Genes Nutr"},{"key":"10.1016\/j.jep.2021.113865_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162497","article-title":"Mechanisms underlying interferon-\u03b3-induced priming of microglial reactive oxygen species production","volume":"11","author":"Spencer","year":"2016","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.jep.2021.113865_bib13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jep.2014.01.019","article-title":"Ethnobotany, phytochemistry, and bioactivity of the genus Turnera (Passifloraceae) with a focus on damiana\u2014Turnera diffusa","volume":"152","author":"Szewczyk","year":"2014","journal-title":"J. Ethnopharmacol"},{"key":"10.1016\/j.jep.2021.113865_bib53","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2174\/092986707780597961","article-title":"Microglial activation and its implications in the brain diseases","volume":"14","author":"Thameem","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jep.2021.113865_bib54","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3389\/fncel.2018.00242","article-title":"An overview of in vitro methods to study microglia","volume":"12","author":"Timmerman","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jep.2021.113865_bib55","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1021\/jm3015926","article-title":"Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers","volume":"56","author":"Trippier","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jep.2021.113865_bib56","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3390\/medicines5030093","article-title":"Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: an overview","volume":"5","author":"Tungmunnithum","year":"2018","journal-title":"Medicines"},{"key":"10.1016\/j.jep.2021.113865_bib57","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1021\/jf048550u","article-title":"Inhibitory effect of naturally occurring flavonoids on the formation of advanced glycation endproducts","volume":"53","author":"Wu","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2021.113865_bib58","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3389\/fncel.2015.00322","article-title":"Implications of glial nitric oxide in neurodegenerative diseases","volume":"9","author":"Yuste","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jep.2021.113865_bib59","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/14756366.2018.1545767","article-title":"A comprehensive review on tyrosinase inhibitors","volume":"34","author":"Zolghadri","year":"2019","journal-title":"J. Enzym. Inhib. Med. Chem."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412100091X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412100091X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:48:03Z","timestamp":1759942083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412100091X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":40,"alternative-id":["S037887412100091X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.113865","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trichilia catigua and Turnera diffusa extracts: In vitro inhibition of tyrosinase, antiglycation activity and effects on enzymes and pathways engaged in the neuroinflammatory process","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.113865","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113865"}}