{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:29:24Z","timestamp":1793881764663,"version":"4.7.0"},"reference-count":189,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jep.2021.113958","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T12:01:21Z","timestamp":1614168081000},"page":"113958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"special_numbering":"C","title":["Properties and molecular mechanisms underlying geniposide-mediated therapeutic effects in chronic inflammatory diseases"],"prefix":"10.1016","volume":"273","author":[{"given":"Deng","family":"Ran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Mengdie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.113958_bib1","first-page":"389","article-title":"Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities","volume":"16","author":"B\u00e4ck","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jep.2021.113958_bib2","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1007\/s10753-012-9433-x","article-title":"Rehmannia glutinosa suppresses inflammatory responses elicited by advanced glycation end products","volume":"35","author":"Baek","year":"2012","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2021.113958_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4542","article-title":"Comparative pharmacokinetic study of four major bioactive components after oral administration of Zhi-Zi-Hou-Po decoction in normal and corticosterone-induced depressive rats","volume":"33","author":"Bai","year":"2019","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jep.2021.113958_bib4","doi-asserted-by":"crossref","first-page":"111818","DOI":"10.1016\/j.yexcr.2020.111818","article-title":"Inhibition of TRIM8 restrains ischaemia-reperfusion-mediated cerebral injury by regulation of NF-\u03baB activation associated inflammation and apoptosis","volume":"388","author":"Bai","year":"2020","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jep.2021.113958_bib5","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1161\/CIRCULATIONAHA.119.039476","article-title":"Apolipoprotein AI promotes atherosclerosis regression in diabetic mice by suppressing Myelopoiesis and plaque inflammation","volume":"140","author":"Barrett","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2021.113958_bib6","first-page":"1","article-title":"Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus","volume":"9","author":"Burhans","year":"2018","journal-title":"Comp. Physiol."},{"key":"10.1016\/j.jep.2021.113958_bib7","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.euroneuro.2015.04.009","article-title":"Antidepressant-like effect of geniposide on chronic unpredictable mild stress-induced depressive rats by regulating the hypothalamus-pituitary-adrenal axis","volume":"25","author":"Cai","year":"2015","journal-title":"Eur. Neuropsychopharmacol"},{"key":"10.1016\/j.jep.2021.113958_bib8","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1007\/s10753-018-0861-0","article-title":"Therapeutic effect of penta-acetyl geniposide on adjuvant-induced arthritis in rats: involvement of inducing synovial apoptosis and inhibiting NF-\u03baB signal pathway","volume":"41","author":"Cai","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2021.113958_bib9","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.pharep.2019.05.014","article-title":"Penta-acetyl geniposide induces apoptosis of fibroblast-like synoviocytes from adjuvant-induced arthritis rats in vitro, associated with inhibition of NF-\u03baB activation","volume":"71","author":"Cai","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.jep.2021.113958_bib10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.kint.2019.07.019","article-title":"Regulatory innate lymphoid cells suppress innate immunity and reduce renal ischemia\/reperfusion injury","volume":"97","author":"Cao","year":"2020","journal-title":"Kidney Int."},{"key":"10.1016\/j.jep.2021.113958_bib11","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3390\/molecules21070923","article-title":"Evaluation of the antidepressant activity, hepatotoxicity and blood brain barrier permeability of methyl genipin","volume":"21","author":"Che","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2021.113958_bib12","first-page":"232","article-title":"Effects of geniposide on SNP-induced apoptosis of chondrocyte and cell cycle","volume":"26","author":"Chen","year":"2013","journal-title":"Zhong Guo Gu Shang"},{"key":"10.1016\/j.jep.2021.113958_bib13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.fitote.2014.05.023","article-title":"Identification and distribution of four metabolites of geniposide in rats with adjuvant arthritis","volume":"97","author":"Chen","year":"2014","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2021.113958_bib14","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jpba.2015.01.044","article-title":"Determination of geniposide in adjuvant arthritis rat plasma by ultra-high performance liquid chromatography tandem mass spectrometry method and its application to oral bioavailability and plasma protein binding ability studies","volume":"108","author":"Chen","year":"2015","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2021.113958_bib15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.intimp.2014.11.017","article-title":"Anti-inflammatory effects and pharmacokinetics study of geniposide on rats with adjuvant arthritis","volume":"24","author":"Chen","year":"2015","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2021.113958_bib16","article-title":"Anti-inflammatory effect of geniposide on osteoarthritis by suppressing the activation of p38 MAPK signaling pathway","author":"Chen","year":"2018","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2021.113958_bib17","first-page":"320","article-title":"Synergistic neuroprotective effects of Geniposide and ursodeoxycholic acid in hypoxia-reoxygenation injury in SH-SY5Y cells","volume":"15","author":"Cheng","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2021.113958_bib18","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.imbio.2018.12.005","article-title":"Geniposide regulates the miR-101\/MKP-1\/p38 pathway and alleviates atherosclerosis inflammatory injury in ApoE-\/- mice","volume":"224","author":"Cheng","year":"2019","journal-title":"Immunobiology"},{"key":"10.1016\/j.jep.2021.113958_bib19","series-title":"Editorial Committee of Chinese Pharmacopoeia. China","first-page":"746","author":"Chinese Pharmacopoeia","year":"2015"},{"key":"10.1016\/j.jep.2021.113958_bib20","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jep.2012.04.027","article-title":"The effects of notoginsenoside R\u2081 on the intestinal absorption of geniposide by the everted rat gut sac model","volume":"142","author":"Chula","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib21","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.3390\/ijms20225547","article-title":"MicroRNAs as potential biomarkers in atherosclerosis","volume":"20","author":"Churov","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2021.113958_bib22","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s11064-018-2469-z","article-title":"Geniposide increases unfolded protein response-mediating HRD1 expression to accelerate APP degradation in primary cortical neurons","volume":"43","author":"Cui","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2021.113958_bib23","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3389\/fphar.2019.00180","article-title":"Gardenia decoction prevent intestinal mucosal injury by inhibiting pro-inflammatory cytokines and NF-\u03baB signaling","volume":"10","author":"Cui","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib24","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.intimp.2014.02.021","article-title":"Effects and mechanisms of Geniposide on rats with adjuvant arthritis","volume":"20","author":"Dai","year":"2014","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2021.113958_bib25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3389\/fphar.2018.00105","article-title":"Anti-inflammatory mechanism of geniposide: inhibiting the hyperpermeability of fibroblast-like synoviocytes via the RhoA\/p38MAPK\/NF-\u03baB\/F-actin signal pathway","volume":"9","author":"Deng","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib26","doi-asserted-by":"crossref","first-page":"987","DOI":"10.3390\/molecules23050987","article-title":"A microdialysis in adjuvant arthritic rats for pharmacokinetics-pharmacodynamics modeling study of geniposide with determination of drug concentration and efficacy levels in dialysate","volume":"23","author":"Deng","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2021.113958_bib27","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1080\/14786419.2012.673604","article-title":"Potential hepatotoxicity of geniposide, the major iridoid glycoside in dried ripe fruits of Gardenia jasminoides (Zhi-zi)","volume":"27","author":"Ding","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2021.113958_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3390\/nu10030265","article-title":"Eucommia ulmoides ameliorates glucotoxicity by suppressing advanced glycation end-products in diabetic mice kidney","volume":"10","author":"Do","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2021.113958_bib29","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/CIRCRESAHA.115.306300","article-title":"MicroRNA regulation of atherosclerosis","volume":"118","author":"Feinberg","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2021.113958_bib195","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature23002","article-title":"Cryo-EM structures of tau filaments from Alzheimer\u2019s disease","volume":"547","author":"Fitzpatrick","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jep.2021.113958_bib31","doi-asserted-by":"crossref","first-page":"106547","DOI":"10.1016\/j.intimp.2020.106547","article-title":"Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen-glucose deprivation\/reoxygenation","volume":"84","author":"Fu","year":"2020","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2021.113958_bib32","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1017\/jns.2012.12","article-title":"Asperuloside stimulates metabolic function in rats across several organs under high-fat diet conditions, acting like the major ingredient of Eucommia leaves with anti-obesity activity","volume":"1","author":"Fujikawa","year":"2012","journal-title":"J. Nutr. Sci."},{"key":"10.1016\/j.jep.2021.113958_bib33","doi-asserted-by":"crossref","DOI":"10.1021\/acschemneuro.0c00281","article-title":"Dual targeting of monomeric Tau and \u03b1-synuclein aggregation: a new multitarget therapeutic strategy for neurodegeneration","author":"Gabr","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.jep.2021.113958_bib34","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/bpa.12116","article-title":"Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3\u03b2 pathway in streptozotocin-induced alzheimer rat model","volume":"24","author":"Gao","year":"2014","journal-title":"Brain Pathol."},{"key":"10.1016\/j.jep.2021.113958_bib35","doi-asserted-by":"crossref","first-page":"E925","DOI":"10.1152\/ajpendo.00503.2015","article-title":"Formoterol decreases muscle wasting as well as inflammation in the rat model of rheumatoid arthritis","volume":"310","author":"G\u00f3mez-SanMiguel","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.jep.2021.113958_bib36","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/aps.2011.146","article-title":"Glucagon-like peptide 1 receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells","volume":"33","author":"Guo","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2021.113958_bib37","first-page":"1287","article-title":"Regulation of insulin secretion by geniposide: possible involvement of phosphatidylinositol 3-phosphate kinase","volume":"18","author":"Guo","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.jep.2021.113958_bib38","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1248\/bpb.b15-00591","article-title":"Geniposide suppresses hepatic glucose production via AMPK in HepG2 cells","volume":"39","author":"Guo","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2021.113958_bib39","doi-asserted-by":"crossref","first-page":"11659","DOI":"10.18632\/aging.102570","article-title":"Nickel induces inflammatory activation via NF-\u03baB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages","volume":"11","author":"Guo","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.jep.2021.113958_bib40","first-page":"1937","article-title":"Simultaneous determination of five index components in Rehmanniae Radix by HPCE-DAD","volume":"47","author":"Han","year":"2012","journal-title":"Chin. Pharmaceut. J."},{"key":"10.1016\/j.jep.2021.113958_bib41","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/cbf.3414","article-title":"Unfolded protein response is involved in geniposide-regulating glucose-stimulated insulin secretion in INS-1 cells","volume":"37","author":"Hao","year":"2019","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.jep.2021.113958_bib42","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jchromb.2016.08.030","article-title":"Comparative investigation on the pharmacokinetics of geniposide in type 2 diabetic and normal rats after oral administration of Fructus Gradeniae extract","volume":"1033\u20131034","author":"He","year":"2016","journal-title":"J. Chromatogr B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jep.2021.113958_bib43","first-page":"1499","article-title":"Geniposide attenuates cadmium-induced oxidative stress injury via Nrf2 signaling in osteoblasts","volume":"20","author":"He","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2021.113958_bib44","first-page":"3","article-title":"Effects of uncoupling proteins on nitric oxide synthesis and oxidative stress development in ishemia-reperfusion of old rat hearts","volume":"55","author":"Hoshovs'ka","year":"2009","journal-title":"Fiziol. Zh."},{"key":"10.1016\/j.jep.2021.113958_bib45","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/hr.2016.189","article-title":"Preventive effect of Eucommia leaf extract on aortic media hypertrophy in Wistar-Kyoto rats fed a high-fat diet","volume":"40","author":"Hosoo","year":"2017","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.jep.2021.113958_bib46","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/fcp.12231","article-title":"Geniposide reduces development of streptozotocin-induced diabetic nephropathy via regulating nuclear factor-kappa B signaling pathways","volume":"31","author":"Hu","year":"2017","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib47","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.intimp.2018.03.035","article-title":"Geniposide improves hepatic inflammation in diabetic db\/db mice","volume":"59","author":"Hu","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jep.2021.113958_bib48","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.phymed.2018.07.005","article-title":"Comparative anti-arthritic investigation of iridoid glycosides and crocetin derivatives from Gardenia jasminoides Ellis in Freund's complete adjuvant-induced arthritis in rats","volume":"53","author":"Hu","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2021.113958_bib49","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cbi.2009.05.009","article-title":"Inhibitory effect of penta-acetyl geniposide on C6 glioma cells metastasis by inhibiting matrix metalloproteinase-2 expression involved in both the PI3K and ERK signaling pathways","volume":"181","author":"Huang","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2021.113958_bib50","doi-asserted-by":"crossref","first-page":"7557","DOI":"10.3390\/molecules19067557","article-title":"Effects of fructus psoraleae extract on the intestinal absorption kinetics of geniposide and geniposidic acid in rat","volume":"19","author":"Huo","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2021.113958_bib51","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/S0040-4039(01)88161-2","article-title":"New iridoid glucosides gardenoside and geniposide from gardenia jasminoides","volume":"28","author":"Inouye","year":"1969","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jep.2021.113958_bib52","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s40478-019-0791-6","article-title":"A\u03b243 in human Alzheimer's disease: effects of active A\u03b242 immunization","volume":"7","author":"J\u00e4kel","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.jep.2021.113958_bib53","doi-asserted-by":"crossref","first-page":"346783","DOI":"10.1155\/2015\/346783","article-title":"Ceramides in Alzheimer's disease: key mediators of neuronal apoptosis induced by oxidative stress and A\u03b2 accumulation","volume":"2015","author":"Jazvin\u0161\u0107ak Jembrek","year":"2015","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.jep.2021.113958_bib54","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.freeradbiomed.2017.05.009","article-title":"Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling","volume":"108","author":"Jeayeng","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2021.113958_bib55","article-title":"Genipin inhibits TNF-\u03b1-induced vascular smooth muscle cell proliferation and migration via induction of HO-1","volume":"8","author":"Jiang","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jep.2021.113958_bib56","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1159\/000445634","article-title":"Geniposide prevents hypoxia\/reoxygenation-induced apoptosis in H9c2 cells: improvement of mitochondrial dysfunction and activation of GLP-1R and the PI3K\/AKT signaling pathway","volume":"39","author":"Jiang","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2021.113958_bib57","doi-asserted-by":"crossref","first-page":"7237","DOI":"10.3892\/mmr.2017.7503","article-title":"Geniposide promotes autophagy to inhibit insulin resistance in HepG2 cells via P62\/NF-\u03baB\/GLUT-4","volume":"16","author":"Jiang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2021.113958_bib58","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jep.2010.02.019","article-title":"Ameliorative effect of Eucommia ulmoides Oliv. leaves extract (ELE) on insulin resistance and abnormal perivascular innervation in fructose-drinking rats","volume":"128","author":"Jin","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110015","article-title":"Geniposide alleviates atherosclerosis by regulating macrophage polarization via the FOS\/MAPK signaling pathway","volume":"125","author":"Jin","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2021.113958_bib60","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6392629","article-title":"(-)-Epicatechin modulates mitochondrial redox in vascular cell models of oxidative stress","volume":"2020","author":"Keller","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.jep.2021.113958_bib61","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4062\/biomolther.2013.005","article-title":"Protective effects of geniposide and genipin against hepatic ischemia\/reperfusion injury in mice","volume":"21","author":"Kim","year":"2013","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.jep.2021.113958_bib62","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1158\/1535-7163.MCT-18-0196","article-title":"Genipin enhances the therapeutic effects of oxaliplatin by upregulating BIM in colorectal cancer","volume":"18","author":"Kim","year":"2019","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.jep.2021.113958_bib63","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1248\/bpb.34.1613","article-title":"Preventive effect of geniposide on metabolic disease status in spontaneously obese type 2 diabetic mice and free fatty acid-treated HepG2 cells","volume":"34","author":"Kojima","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2021.113958_bib64","doi-asserted-by":"crossref","first-page":"214","DOI":"10.15585\/mmwr.mm6809e1","article-title":"Vital signs: epidemiology and recent trends in methicillin-resistant and in methicillin-susceptible Staphylococcus aureus bloodstream infections-United States","volume":"68","author":"Kourtis","year":"2019","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.jep.2021.113958_bib65","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.freeradbiomed.2011.11.002","article-title":"Role of reactive oxygen and nitrogen species in the vascular responses to inflammation","volume":"52","author":"Kvietys","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2021.113958_bib66","doi-asserted-by":"crossref","first-page":"462","DOI":"10.4062\/biomolther.2013.074","article-title":"Inhibitory effects of Eucommia ulmoides Oliv. Bark on scopolamine-induced learning and memory deficits in mice","volume":"21","author":"Kwon","year":"2013","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.jep.2021.113958_bib67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081349","article-title":"Eucommia ulmoides Oliver extract, aucubin, and geniposide enhance lysosomal activity to regulate ER stress and hepatic lipid accumulation","volume":"8","author":"Lee","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jep.2021.113958_bib68","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1007\/s12272-013-0293-1","article-title":"Simultaneous determination of bioactive marker compounds from Gardeniae fructus by high performance liquid chromatography","volume":"37","author":"Lee","year":"2014","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.jep.2021.113958_bib69","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12906-018-2189-6","article-title":"Synergistic effect of phytochemicals on cholesterol metabolism and lipid accumulation in HepG2 cells","volume":"18","author":"Leng","year":"2018","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2021.113958_bib70","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1002\/rcm.4728","article-title":"Characterization and identification of saponins in Achyranthes bidentata by rapid-resolution liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry","volume":"24","author":"Li","year":"2010","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jep.2021.113958_bib71","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/bcpt.12113","article-title":"Comparative pharmacokinetics study after oral administration of geniposide in normal rats and adjuvant-induced arthritis rats by UPLC-MS\/MS","volume":"113","author":"Li","year":"2013","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.jep.2021.113958_bib72","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.4103\/1673-5374.167760","article-title":"Geniposide prevents rotenone-induced apoptosis in primary cultured neurons","volume":"10","author":"Li","year":"2015","journal-title":"Neural. Regen. Res."},{"key":"10.1016\/j.jep.2021.113958_bib73","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s10753-015-0219-9","article-title":"Apoptotic effect of geniposide on fibroblast-like synoviocytes in rats with adjuvant-induced arthritis via inhibiting ERK signal pathway in vitro","volume":"39","author":"Li","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2021.113958_bib74","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3390\/molecules23010091","article-title":"Immunosuppressive effect of geniposide on mitogen-activated protein kinase signalling pathway and their cross-talk in fibroblast-like synoviocytes of adjuvant arthritis rats","volume":"23","author":"Li","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2021.113958_bib75","article-title":"GLP-1 receptor regulates cell growth through regulating IDE expression level in A\u03b21-42-treated PC12 cells","volume":"38","author":"Li","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jep.2021.113958_bib76","first-page":"4163","article-title":"Role of catalpol in ameliorating the pathogenesis of experimental autoimmune encephalomyelitis by increasing the level of noradrenaline in the locus coeruleus","volume":"17","author":"Li","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2021.113958_bib77","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ejphar.2019.04.021","article-title":"Geniposide protects against hypoxia\/reperfusion-induced blood-brain barrier impairment by increasing tight junction protein expression and decreasing inflammation, oxidative stress, and apoptosis in an in vitro system","volume":"854","author":"Li","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib78","doi-asserted-by":"crossref","first-page":"114624","DOI":"10.1016\/j.taap.2019.114624","article-title":"Role of intestinal microbiota-mediated genipin dialdehyde intermediate formation in geniposide-induced hepatotoxicity in rats","volume":"377","author":"Li","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib79","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1021\/acs.jafc.9b00402","article-title":"Geniposide improves glucose homeostasis via regulating FoxO1\/PDK4 in skeletal muscle","volume":"67","author":"Li","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2021.113958_bib80","first-page":"601","article-title":"Geniposide protects against ox-LDL-induced foam cell formation through inhibition of MAPKs and NF-kB signaling pathways","volume":"74","author":"Li","year":"2019","journal-title":"Pharmazie"},{"key":"10.1016\/j.jep.2021.113958_bib81","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.ejphar.2014.06.039","article-title":"Baicalin and geniposide attenuate atherosclerosis involving lipids regulation and immunoregulation in ApoE-\/- mice","volume":"740","author":"Liao","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib82","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jacc.2017.10.081","article-title":"Taming immune and inflammatory responses to treat atherosclerosis","volume":"71","author":"Libby","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jep.2021.113958_bib83","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.neuint.2007.04.021","article-title":"Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway","volume":"51","author":"Liu","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jep.2021.113958_bib84","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/aps.2008.25","article-title":"Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway","volume":"30","author":"Liu","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2021.113958_bib85","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.tiv.2012.07.004","article-title":"Glucagon-like peptide 1 receptor plays an essential role in geniposide attenuating lipotoxicity-induced \u03b2-cell apoptosis","volume":"26","author":"Liu","year":"2012","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.jep.2021.113958_bib86","first-page":"1625","article-title":"Hepatoprotective iridoid glycosides from the roots of Rehmannia glutinosa","volume":"75","author":"Liu","year":"2012","journal-title":"J. Anal. Methods Chem."},{"key":"10.1016\/j.jep.2021.113958_bib87","first-page":"787","article-title":"Geniposide decreases the level of A\u03b21-42 in the hippocampus of streptozotocin-induced diabetic rats","volume":"45","author":"Liu","year":"2013","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.jep.2021.113958_bib88","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1093\/abbs\/gmv106","article-title":"Leptin signaling plays a critical role in the geniposide-induced decrease of tau phosphorylation","volume":"47","author":"Liu","year":"2015","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.jep.2021.113958_bib89","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s40618-016-0591-9","article-title":"Geniposide accelerates proteasome degradation of TXNIP to inhibit insulin secretion in pancreatic \u03b2-cells","volume":"40","author":"Liu","year":"2017","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.jep.2021.113958_bib90","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s12272-016-0875-9","article-title":"Geniposide attenuates the level of A\u03b21-42 via enhancing leptin signaling in cellular and APP\/PS1 transgenic mice","volume":"40","author":"Liu","year":"2017","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.jep.2021.113958_bib91","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2147\/DMSO.S240794","article-title":"Geniposide balances the redox signaling to mediate glucose-stimulated insulin secretion in pancreatic \u03b2-cells","volume":"13","author":"Liu","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes"},{"key":"10.1016\/j.jep.2021.113958_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113302","article-title":"Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK\/GSK-3\u03b2","volume":"329","author":"Liu","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jep.2021.113958_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104631","article-title":"Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids","volume":"152","author":"Liu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2021.113958_bib94","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00213-019-05379-w","article-title":"The protective effect of Geniposide on diabetic cognitive impairment through BTK\/TLR4\/NF-\u03baB pathway","volume":"237","author":"Liu","year":"2020","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jep.2021.113958_bib96","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.3109\/14756360902829741","article-title":"Studies on the antioxidant activity and phenolic compounds of enzyme-assisted water extracts from Du-zhong (Eucommia ulmoides Oliv.) leaves","volume":"24","author":"Luo","year":"2009","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.jep.2021.113958_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106609","article-title":"Inhibition of autophagy by geniposide protects against myocardial ischemia\/reperfusion injury","volume":"85","author":"Luo","year":"2020","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2021.113958_bib98","doi-asserted-by":"crossref","first-page":"580","DOI":"10.2174\/1567205011666140618095925","article-title":"Geniposide attenuates mitochondrial dysfunction and memory deficits in APP\/PS1 transgenic mice","volume":"11","author":"Lv","year":"2014","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.jep.2021.113958_bib99","doi-asserted-by":"crossref","first-page":"430","DOI":"10.2174\/1567205011666140514111204","article-title":"Geniposide attenuates oligomeric A\u03b2(1-42)-induced inflammatory response by targeting RAGE-dependent signaling in BV2 cells","volume":"11","author":"Lv","year":"2014","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.jep.2021.113958_bib100","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neuropharm.2014.09.019","article-title":"Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model","volume":"89","author":"Lv","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2021.113958_bib101","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.2042-7158.2011.01256.x","article-title":"Hepatoprotective effects of geniposide in a rat model of nonalcoholic steatohepatitis","volume":"63","author":"Ma","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib102","first-page":"899","article-title":"Effects of Gardenia jasminoides extracts on cognition and innate immune response in an adult Drosophila model of Alzheimer's disease","volume":"15","author":"Ma","year":"2017","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2021.113958_bib103","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/875961","article-title":"New insights for oxidative stress and diabetes mellitus","volume":"2015","author":"Maiese","year":"2015","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.jep.2021.113958_bib104","doi-asserted-by":"crossref","first-page":"C23","DOI":"10.1530\/EJE-19-0555","article-title":"Three percent annually on systemic glucocorticoids: facts, worries and perspectives","volume":"181","author":"Meijer","year":"2019","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.jep.2021.113958_bib105","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1136\/annrheumdis-2018-213036","article-title":"Short-term and low-dose IL-2 therapy restores the Th17\/Treg balance in the peripheral blood of patients with primary Sj\u00f6gren's syndrome","volume":"77","author":"Miao","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2021.113958_bib106","doi-asserted-by":"crossref","first-page":"575","DOI":"10.18632\/aging.100921","article-title":"Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation","volume":"8","author":"Miklossy","year":"2016","journal-title":"Aging"},{"key":"10.1016\/j.jep.2021.113958_bib107","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0254-6272(13)60129-6","article-title":"Ameliorating effect of zhizi (Fructus gardeniae) extract and its glycosides on scopolamine-induced memory impairment","volume":"33","author":"Nam","year":"2013","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2021.113958_bib108","doi-asserted-by":"crossref","DOI":"10.2337\/db19-1174","article-title":"3-Hydroxyisobutyrate, a strong marker of insulin resistance in type 2 diabetes and obesity that modulates white and Brown adipocyte metabolism","author":"Nilsen","year":"2020","journal-title":"Diabetes db191174"},{"key":"10.1016\/j.jep.2021.113958_bib109","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/glia.23741","article-title":"NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes","volume":"68","author":"Oksanen","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.jep.2021.113958_bib110","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s10753-017-0694-2","article-title":"Geniposide suppresses interleukin-1\u03b2-induced inflammation and apoptosis in rat chondrocytes via the PI3K\/Akt\/NF-\u03baB signaling pathway","volume":"41","author":"Pan","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2021.113958_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112015","article-title":"Gardenia jasminoides extract without crocin improved atopic dermatitis-like skin lesions via suppression of Th2-related cytokines in Dfe-induced NC\/Nga mice","volume":"241","author":"Park","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib112","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.1523\/JNEUROSCI.2574-18.2019","article-title":"Neuroinflammation and functional connectivity in Alzheimer's disease: interactive influences on cognitive performance","volume":"39","author":"Passamonti","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jep.2021.113958_bib113","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/MED.0000000000000170","article-title":"Obesity, insulin resistance, and type 1 diabetes mellitus","volume":"22","author":"Polsky","year":"2015","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.jep.2021.113958_bib114","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1055\/s-0028-1088330","article-title":"Genetic relationships among Rehmannia glutinosa cultivars and varieties","volume":"74","author":"Qi","year":"2008","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2021.113958_bib115","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2337\/db08-0968","article-title":"Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women","volume":"58","author":"Qi","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.jep.2021.113958_bib116","doi-asserted-by":"crossref","first-page":"108760","DOI":"10.18632\/oncotarget.21897","article-title":"Dissect new mechanistic insights for geniposide efficacy on the hepatoprotection using multiomics approach","volume":"8","author":"Qiu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2021.113958_bib117","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.3389\/fimmu.2019.03087","article-title":"miR-221-3p drives the shift of M2-macrophages to a pro-inflammatory function by suppressing JAK3\/STAT3 activation","volume":"10","author":"Quero","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2021.113958_bib118","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1523\/JNEUROSCI.1136-17.2017","article-title":"Microglia-mediated synapse loss in Alzheimer's disease","volume":"38","author":"Rajendran","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jep.2021.113958_bib119","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1016\/j.celrep.2018.05.010","article-title":"Obesity and insulin resistance promote atherosclerosis through an IFN\u03b3-regulated macrophage protein network","volume":"23","author":"Reardon","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2021.113958_bib120","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.neurobiolaging.2019.09.020","article-title":"Linking APOE-\u03b54, blood-brain barrier dysfunction, and inflammation to Alzheimer's pathology","volume":"85","author":"Riphagen","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jep.2021.113958_bib121","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1136\/annrheumdis-2019-215355","article-title":"Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis","volume":"78","author":"Rodr\u00edguez-Ubreva","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2021.113958_bib122","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.transproceed.2017.02.063","article-title":"Protective effects of geniposide on hepatic ischemia\/reperfusion injury","volume":"49","author":"Rong","year":"2017","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.jep.2021.113958_bib123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI92035","article-title":"Inflammatory mechanisms linking obesity and metabolic disease","volume":"127","author":"Saltiel","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2021.113958_bib124","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7518510","article-title":"Nrf2 activation protects mouse beta cells from glucolipotoxicity by restoring mitochondrial function and physiological redox balance","author":"Schultheis","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.jep.2021.113958_bib125","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature19323","article-title":"The antibody aducanumab reduces A\u03b2 plaques in Alzheimer's disease","volume":"537","author":"Sevigny","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jep.2021.113958_bib126","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.3390\/molecules22101689","article-title":"A review on the phytochemistry, pharmacology, pharmacokinetics and toxicology of geniposide, a natural product","volume":"22","author":"Shan","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2021.113958_bib127","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jep.2019.01.004","article-title":"Comparative analysis of sixteen active compounds and antioxidant and anti-influenza properties of Gardenia jasminoides fruits at different times and application to the determination of the appropriate harvest period with hierarchical cluster analysis","volume":"233","author":"Shan","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172728","article-title":"Geniposide against atherosclerosis by inhibiting the formation of foam cell and lowering reverse lipid transport via p38\/MAPK signaling pathways","volume":"864","author":"Shen","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuropharm.2019.04.018","article-title":"Topical ocular administration of the GLP-1 receptor agonist liraglutide arrests hyperphosphorylated tau-triggered diabetic retinal neurodegeneration via activation of GLP-1R\/Akt\/GSK3\u03b2 signaling","volume":"153","author":"Shu","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2021.113958_bib130","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3390\/cancers11060813","article-title":"Hexokinase 2 regulates ovarian cancer cell migration, invasion and stemness via FAK\/ERK1\/2\/MMP9\/NANOG\/SOX9 signaling cascades","volume":"11","author":"Siu","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.jep.2021.113958_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107843","article-title":"Alzheimer's patient microglia exhibit enhanced aging and unique transcriptional activation","volume":"31","author":"Srinivasan","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2021.113958_bib132","first-page":"874","article-title":"Simultaneous determination of six components in Eucommia ulmoides by UPLC","volume":"28","author":"Sun","year":"2016","journal-title":"Nat. Prod. Res. Dev."},{"key":"10.1016\/j.jep.2021.113958_bib133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2018.04.015","article-title":"Low-level shear stress promotes migration of liver cancer stem cells via the FAK-ERK1\/2 signalling pathway","volume":"427","author":"Sun","year":"2018","journal-title":"Canc. Lett."},{"key":"10.1016\/j.jep.2021.113958_bib134","article-title":"CREB-mediated generation and neuronal growth regulates the behavioral improvement of geniposide in diabetes-associated depression mouse model","author":"Sun","year":"2020","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.jep.2021.113958_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117988","article-title":"Sphingosine kinase 1\/sphingosine 1-phosphate\/sphingosine 1-phosphate receptor 1 pathway: a novel target of geniposide to inhibit angiogenesis","volume":"256","author":"Sun","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2021.113958_bib136","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.3390\/nu10111625","article-title":"Crocin ameliorates atopic dermatitis symptoms by down regulation of Th2 response via blocking of NF-\u03baB\/STAT6 signaling pathways in mice","volume":"10","author":"Sung","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2021.113958_bib137","doi-asserted-by":"crossref","first-page":"8938","DOI":"10.1038\/s41598-017-09131-2","article-title":"Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation","volume":"7","author":"Tian","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2021.113958_bib138","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jep.2017.11.008","article-title":"Oral chronic toxicity study of geniposide in rats","volume":"213","author":"Tian","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib139","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55821-4","article-title":"Schisandrin A protects intestinal epithelial cells from deoxynivalenol-induced cytotoxicity, oxidative damage and inflammation","volume":"9","author":"Wan","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2021.113958_bib141","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/aps.2010.83","article-title":"Geniposide inhibits high glucose-induced cell adhesion through the NF-kappaB signaling pathway in human umbilical vein endothelial cells","volume":"31","author":"Wang","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2021.113958_bib194","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cytogfr.2018.10.002","article-title":"Pro-inflammatory cytokines: the link between obesity and osteoarthritis","volume":"44","author":"Wang","year":"2018","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jep.2021.113958_bib142","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s11064-012-0852-8","article-title":"Geniposide reduces inflammatory responses of oxygen-glucose deprived rat microglial cells via inhibition of the TLR4 signaling pathway","volume":"37","author":"Wang","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2021.113958_bib143","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.4103\/1673-5374.121649","article-title":"Radix Achyranthis Bidentatae improves learning and memory capabilities in ovariectomized rats","volume":"8","author":"Wang","year":"2013","journal-title":"Neural. Regen. Res."},{"key":"10.1016\/j.jep.2021.113958_bib144","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/bdd.1869","article-title":"Pharmacokinetics, bioavailability and tissue distribution of geniposide following intravenous and peroral administration to rats","volume":"35","author":"Wang","year":"2014","journal-title":"Biopharm Drug Dispos."},{"key":"10.1016\/j.jep.2021.113958_bib145","first-page":"846","article-title":"Baicalin and geniposide inhibit the development of atherosclerosis by increasing Wnt1 and inhibiting dickkopf-related protein-1 expression","volume":"13","author":"Wang","year":"2016","journal-title":"J. Geriatr. Cardiol."},{"key":"10.1016\/j.jep.2021.113958_bib146","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s11011-016-9856-4","article-title":"Geniposide alleviates depression-like behavior via enhancing BDNF expression in hippocampus of streptozotocin-evoked mice","volume":"31","author":"Wang","year":"2016","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jep.2021.113958_bib147","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jep.2016.10.038","article-title":"Extract from Eucommia ulmoides Oliv. ameliorates arthritis via regulation of inflammation, synoviocyte proliferation and osteoclastogenesis in vitro and in vivo","volume":"194","author":"Wang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib148","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4956589","article-title":"Simultaneous determination of catalpol, aucubin, and geniposidic acid in different developmental stages of Rehmannia glutinosa leaves by high performance liquid chromatography","volume":"2016","author":"Wang","year":"2016","journal-title":"J. Anal. Methods Chem."},{"key":"10.1016\/j.jep.2021.113958_bib149","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jep.2016.12.022","article-title":"Geniposide attenuates ANIT-induced cholestasis through regulation of transporters and enzymes involved in bile acids homeostasis in rats","volume":"196","author":"Wang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib150","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/ptr.5775","article-title":"Antiinflammation effects and mechanisms study of geniposide on rats with collagen-induced arthritis","volume":"31","author":"Wang","year":"2017","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2021.113958_bib151","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.intimp.2018.09.049","article-title":"Novel anti-inflammatory target of geniposide: inhibiting Itg\u03b21\/Ras-Erk1\/2 signal pathway via the miRNA-124a in rheumatoid arthritis synovial fibroblasts","volume":"65","author":"Wang","year":"2018","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2021.113958_bib152","article-title":"Development and application of an UHPLC-MS\/MS method for comparative pharmacokinetic study of eight major bioactive components from Yin Chen Hao Tang in normal and acute liver injured rats","author":"Wang","year":"2018","journal-title":"Evid. Based Complement Alternat Med."},{"key":"10.1016\/j.jep.2021.113958_bib153","first-page":"35","article-title":"Attenuation of Myocardial ischemia reperfusion injury by Geniposide preconditioning in diabetic rats","volume":"67","author":"Wang","year":"2019","journal-title":"Curr. Res. Transl. Med."},{"key":"10.1016\/j.jep.2021.113958_bib154","article-title":"A protective role of paeoniflorin in fluctuant hyperglycemia-induced vascular endothelial injuries through antioxidative and anti-inflammatory effects and reduction of PKC\u03b21","author":"Wang","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.jep.2021.113958_bib155","doi-asserted-by":"crossref","first-page":"5724","DOI":"10.1021\/pr5007119","article-title":"Proteomic investigation of signatures for geniposide-induced hepatotoxicity","volume":"13","author":"Wei","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jep.2021.113958_bib156","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1021\/acs.jproteome.9b00140","article-title":"Proteomic investigations of transcription factors critical in geniposide-mediated suppression of alcoholic steatosis and in overdose-induced hepatotoxicity on liver in rats","volume":"18","author":"Wei","year":"2019","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jep.2021.113958_bib158","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1161\/CIRCRESAHA.118.313591","article-title":"Immunity and inflammation in atherosclerosis","volume":"124","author":"Wolf","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2021.113958_bib159","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/aps.2008.17","article-title":"Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin","volume":"30","author":"Wu","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2021.113958_bib160","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3260278","article-title":"Inhibition of rheumatoid arthritis using bark, leaf, and male flower extracts of Eucommia ulmoides","volume":"2020","author":"Xing","year":"2020","journal-title":"Evid. Based complement. Alternat. Med."},{"key":"10.1016\/j.jep.2021.113958_bib161","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jep.2013.12.046","article-title":"The effect of stroke and other components in Xing-Nao-Jing on the pharmacokinetics of geniposide","volume":"152","author":"Xu","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.113958_bib162","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/aps.2016.168","article-title":"Geniposide ameliorates TNBS-induced experimental colitis in rats via reducing inflammatory cytokine release and restoring impaired intestinal barrier function","volume":"38","author":"Xu","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2021.113958_bib163","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4526","article-title":"UHPLC-MS\/MS analysis of sphingosine 1-phosphate in joint cavity dialysate and hemodialysis solution of adjuvant arthritis rats: application to geniposide pharmacodynamic study","volume":"33","author":"Xuejing","year":"2019","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jep.2021.113958_bib164","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.arcmed.2018.10.005","article-title":"Geniposide and gentiopicroside suppress hepatic gluconeogenesis via regulation of AKT-FOXO1 pathway","volume":"49","author":"Yang","year":"2018","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.jep.2021.113958_bib165","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.107","article-title":"Geniposide promotes beta-cell regeneration and survival through regulating \u03b2-catenin\/TCF7L2 pathway","volume":"6","author":"Yao","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2021.113958_bib166","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1080\/15592294.2018.1450033","article-title":"Genipin normalizes depression-like behavior induced by prenatal stress through inhibiting DNMT1","volume":"13","author":"Ye","year":"2018","journal-title":"Epigenetics"},{"key":"10.1016\/j.jep.2021.113958_bib167","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3233\/JAD-190682","article-title":"Maresin1 decreased microglial chemotaxis and ameliorated inflammation induced by amyloid-\u03b242 in neuron-microglia Co-culture models","volume":"73","author":"Yin","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jep.2021.113958_bib169","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jpba.2013.01.017","article-title":"Effects of borneol on the pharmacokinetics of geniposide in cortex, hippocampus, hypothalamus and striatum of conscious rat by simultaneous brain microdialysis coupled with UPLC-MS","volume":"77","author":"Yu","year":"2013","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2021.113958_bib171","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/s13287-019-1474-8","article-title":"Treatment with adipose tissue-derived mesenchymal stem cells exerts anti-diabetic effects, improves long-term complications, and attenuates inflammation in type 2 diabetic rats","volume":"10","author":"Yu","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jep.2021.113958_bib172","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13075-019-1861-7","article-title":"Hypoxia-induced miR-191-C\/EBP\u03b2 signaling regulates cell proliferation and apoptosis of fibroblast-like synoviocytes from patients with rheumatoid arthritis","volume":"21","author":"Yu","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2021.113958_bib173","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/jpi.12419","article-title":"Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis","volume":"63","author":"Zhai","year":"2017","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.jep.2021.113958_bib174","first-page":"364","article-title":"Pharmacokinetics of Achyranthes bidentata on adjuvant arthritis rats by microdialysis and UHPLC-MS\/MS","volume":"44","author":"Zhan","year":"2019","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.jep.2021.113958_bib175","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/13880209.2012.717088","article-title":"Antithrombotic activities of aqueous extract from Gardenia jasminoides and its main constituent","volume":"51","author":"Zhang","year":"2013","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2021.113958_bib176","article-title":"Ameliorative effects of a combination of baicalin, jasminoidin and cholic acid on ibotenic acid-induced dementia model in rats","volume":"8","author":"Zhang","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jep.2021.113958_bib177","doi-asserted-by":"crossref","first-page":"370","DOI":"10.2174\/1871527314666141229110156","article-title":"Cell signaling mechanisms by which geniposide regulates insulin- degrading enzyme expression in primary cortical neurons","volume":"14","author":"Zhang","year":"2015","journal-title":"CNS Neurol. Disord. - Drug Targets"},{"key":"10.1016\/j.jep.2021.113958_bib178","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuint.2015.04.002","article-title":"Geniposide attenuates insulin-deficiency-induced acceleration of \u03b2-amyloidosis in an APP\/PS1 transgenic model of Alzheimer's disease","volume":"89","author":"Zhang","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jep.2021.113958_bib179","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/cbin.10394","article-title":"Geniposide protects pancreatic INS-1E \u03b2 cells from hIAPP-induced cell damage: potential involvement of insulin degrading-enzyme","volume":"39","author":"Zhang","year":"2015","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.jep.2021.113958_bib180","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/cbdd.12673","article-title":"Geniposide attenuates the phosphorylation of Tau protein in cellular and insulin-deficient APP\/PS1 transgenic mouse model of Alzheimer's disease","volume":"87","author":"Zhang","year":"2016","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.jep.2021.113958_bib181","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3389\/fncel.2016.00309","article-title":"Geniposide alleviates amyloid-induced synaptic injury by protecting axonal mitochondrial trafficking","volume":"10","author":"Zhang","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jep.2021.113958_bib182","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jpba.2017.03.040","article-title":"Online microdialysis-ultra performance liquid chromatography-mass spectrometry method for comparative pharmacokinetic investigation on iridoids from Gardenia jasminoides Ellis in rats with different progressions of type 2 diabetic complications","volume":"140","author":"Zhang","year":"2017","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2021.113958_bib183","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.intimp.2017.05.033","article-title":"Administration of geniposide ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of inflammation and mucosal damage","volume":"49","author":"Zhang","year":"2017","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2021.113958_bib184","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/ptr.5847","article-title":"Immune tolerance effect in mesenteric lymph node lymphocytes of geniposide on adjuvant arthritis rats","volume":"31","author":"Zhang","year":"2017","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2021.113958_bib185","doi-asserted-by":"crossref","first-page":"536","DOI":"10.18632\/aging.101759","article-title":"Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease","volume":"11","author":"Zhang","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.jep.2021.113958_bib186","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.134749","article-title":"Geniposide effectively reverses cognitive impairment and inhibits pathological cerebral damage by regulating the mTOR Signal pathway in APP\/PS1 mice","volume":"720","author":"Zhang","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jep.2021.113958_bib187","article-title":"Geniposide protects primary cortical neurons against oligomeric A\u03b21-42-induced neurotoxicity through a mitochondrial pathway","volume":"11","author":"Zhao","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.jep.2021.113958_bib188","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuropharm.2016.12.002","article-title":"Geniposide ameliorates cognitive deficits by attenuating the cholinergic defect and amyloidosis in middle-aged Alzheimer model mice","volume":"116","author":"Zhao","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2021.113958_bib189","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13024-017-0188-6","article-title":"Microglia limit the expansion of \u03b2-amyloid plaques in a mouse model of Alzheimer's disease","volume":"12","author":"Zhao","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.jep.2021.113958_bib190","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neulet.2018.04.010","article-title":"Geniposide improves repeated restraint stress-induced depression-like behavior in mice by ameliorating neuronal apoptosis via regulating GLP-1R\/AKT signaling pathway","volume":"676","author":"Zhao","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jep.2021.113958_bib191","first-page":"670","article-title":"Simultaneous determination of eight components in Radix Scrophulariae by HPLC-MS\/MS","volume":"19","author":"Zhou","year":"2017","journal-title":"Mod. Chin. Med."},{"key":"10.1016\/j.jep.2021.113958_bib192","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jafc.7b06082","article-title":"Fecal metabolomics of type 2 diabetic rats and treatment with gardenia jasminoides Ellis based on mass spectrometry technique","volume":"66","author":"Zhou","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2021.113958_bib193","first-page":"1305","article-title":"miR-21\/PTEN pathway mediates the cardioprotection of geniposide against oxidized low-density lipoprotein-induced endothelial injury via suppressing oxidative stress and inflammatory response","volume":"45","author":"Zhou","year":"2020","journal-title":"Int. J. Mol. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121001847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121001847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:57:04Z","timestamp":1759942624000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121001847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":189,"alternative-id":["S0378874121001847"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.113958","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Properties and molecular mechanisms underlying geniposide-mediated therapeutic effects in chronic inflammatory diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.113958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113958"}}