{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:39:31Z","timestamp":1787899171789,"version":"build-2784847793"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jep.2021.114031","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T11:30:40Z","timestamp":1616067040000},"page":"114031","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Isolation and characterization of bioactive xanthones from Hippocratea africana (Willd.)Loes.ex Engl. (Celastraceae)"],"prefix":"10.1016","volume":"280","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6852-0200","authenticated-orcid":false,"given":"Uwemedimo F.","family":"Umoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel E.","family":"Essien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jude E.","family":"Okokon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinella","family":"De Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kola\u2019 K.","family":"Ajibesin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2418-9349","authenticated-orcid":false,"given":"Guido","family":"Flamini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8232-7634","authenticated-orcid":false,"given":"Olorunfemi A.","family":"Eseyin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114031_bib1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jep.2007.10.021","article-title":"Ethnobotanical survey of Akwa Ibom state of Nigeria","volume":"115","author":"Ajibesin","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114031_bib2","first-page":"254","article-title":"Antioxidative activity of xanthones from Garcinia benthami Pierre leaves","volume":"7","author":"Amelia","year":"2014","journal-title":"Int. J. Pharm. Tech. Res."},{"key":"10.1016\/j.jep.2021.114031_bib3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0378-8741(97)00137-2","article-title":"Anti-nociceptive and anti-inflammatory effects of some Jordonian medicinal plant extracts","volume":"60","author":"Atta","year":"1998","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114031_bib4","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0031-9422(95)00255-6","article-title":"Hippocrateine III: a sesquiterpene alkaloid from Hippocrateaexcelsa","volume":"40","author":"Calzada","year":"1995","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2021.114031_bib5","series-title":"Useful Plants of West Tropical Africa","author":"Dalziel","year":"1956"},{"key":"10.1016\/j.jep.2021.114031_bib6","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1248\/bpb.28.596","article-title":"Analgesic and antioxidant activity of mangiferin and its derivatives: the structure activity relationship","volume":"28","author":"Dar","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2021.114031_bib7","first-page":"1335","article-title":"Antioxidative and antibacterial activity of the methanol extract of Artemisia anomalaS","volume":"7","author":"Guangrong","year":"2008","journal-title":"Moore. Afr. J. Biotech."},{"key":"10.1016\/j.jep.2021.114031_bib8","first-page":"2732","article-title":"Fatty acids of Hippocrateaafricana root: antioxidant and anti-microbial activity","volume":"5","author":"Ita","year":"2014","journal-title":"Int. J. Pharma Sci. Res."},{"key":"10.1016\/j.jep.2021.114031_bib9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jep.2010.04.032","article-title":"Evaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial properties","volume":"130","author":"Jansen","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114031_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jep.2021.114031_bib11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0014-2999(98)00385-9","article-title":"Decreased protein kinase C activation mediates inhibitory effect of norathyriol on serotonin-mediated endothelial permeability","volume":"353","author":"Lee","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2021.114031_bib12","first-page":"416","article-title":"The prescription pattern of outpatient polyclinic doctors","volume":"40","author":"Lim","year":"1999","journal-title":"Singap. Med. J."},{"key":"10.1016\/j.jep.2021.114031_bib13","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.2042-7158.1996.tb05969.x","article-title":"Synthesis and anti-inflammatory effects of xanthone derivatives","volume":"48","author":"Lin","year":"1996","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2021.114031_bib14","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1021\/np060559y","article-title":"Antigiardial activity of triterpenoids from the root bark of Hippocrateaexcelsa","volume":"70","author":"Mena-Rejon","year":"2007","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2021.114031_bib15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0031-9422(00)97103-6","article-title":"Antioxidant xanthones from garciniasubelliptica","volume":"36","author":"Minami","year":"1994","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2021.114031_bib16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0378-8741(01)00414-7","article-title":"Principles of root bark of Hippocrateaexcelsa(Hippocrataceae) with gastroprotective activity","volume":"79","author":"Navarrete","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114031_bib17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0378-8741(02)00213-1","article-title":"Anti-nociceptive and anti-inflammatory effects of methanolic extract of Asparagus pubescens roots in rodents","volume":"84","author":"Nwafor","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114031_bib18","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4314\/ajtcam.v4i3.31232","article-title":"Anti-inflammatory and anti-microbial activities of Hippocrateaindicaroot bark and Pogaoleosafruits","volume":"4","author":"Ogbole","year":"2007","journal-title":"Afr. J. Trad. Compl.Altern. Med."},{"key":"10.1016\/j.jep.2021.114031_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3923\/ijp.2008.51.55","article-title":"Analgesic and anti-inflammatory effects of ethanol root extract of Hippocrateaafricana","volume":"4","author":"Okokon","year":"2008","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.jep.2021.114031_bib20","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3109\/13880209.2013.768273","article-title":"Antioxidative burst and hepatoprotective effects of ethanol root extract of Hippocrateaafricana against paracetamol \u2013 induced liver injury","volume":"51","author":"Okokon","year":"2013","journal-title":"Pharmaceut. Biol."},{"key":"10.1016\/j.jep.2021.114031_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.5264\/eiyogakuzashi.44.307","article-title":"Studies on products of browning reaction: antioxidant activity of products of browning reaction prepared from glucosamin","volume":"44","author":"Oyaizu","year":"1986","journal-title":"Jap. J. Nutr. Sci."},{"key":"10.1016\/j.jep.2021.114031_bib22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0378-8741(95)01257-E","article-title":"Anti-inflammatory activity of the bark of Hippocrateaexcelsa","volume":"47","author":"Perez","year":"1995","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114031_bib23","first-page":"88","article-title":"Study on antiiflammatory and analgesic effect of Lonchocarpuscyanescensroot in mice","volume":"2","author":"Umoh","year":"2013","journal-title":"Afr. J. Pharmacol. Therapeut."},{"key":"10.1016\/j.jep.2021.114031_bib24","first-page":"304","article-title":"Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxy benzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice","volume":"278","author":"Vaz","year":"1996","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.jep.2021.114031_bib25","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jpba.2007.07.019","article-title":"Identification and determination of four metabolites of mangiferin in rat urine","volume":"45","author":"Wang","year":"2007","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2021.114031_bib26","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/(SICI)1099-1573(199709)11:6<446::AID-PTR128>3.0.CO;2-8","article-title":"Antioxidative activity of flavones and flavonols in vitro","volume":"11","author":"Yokozawa","year":"1997","journal-title":"Phytother Res."}],"updated-by":[{"DOI":"10.1016\/j.jep.2021.114703","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000}}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121002580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121002580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T17:10:28Z","timestamp":1676221828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121002580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":26,"alternative-id":["S0378874121002580"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114031","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.jep.2021.114703","asserted-by":"object"}]},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isolation and characterization of bioactive xanthones from Hippocratea africana (Willd.)Loes.ex Engl. (Celastraceae)","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114031"}}