{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:27:20Z","timestamp":1773678440165,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jep.2021.114042","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T18:48:48Z","timestamp":1616784528000},"page":"114042","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Network pharmacology integrated with molecular docking reveals the common experiment-validated antipyretic mechanism of bitter-cold herbs"],"prefix":"10.1016","volume":"274","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5588-9172","authenticated-orcid":false,"given":"Weiwei","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiujuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Sui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hairu","family":"Huo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114042_bib1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jpba.2007.07.001","article-title":"Quantitative analysis of iridoids, secoiridoids, xanthones and xanthone glycosides in Gentiana lutea L. roots by RP-HPLC and LC-MS","volume":"45","author":"Aberham","year":"2007","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2021.114042_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(06)62001-3","article-title":"The onset of fever: new insights into its mechanism","volume":"162","author":"Blatteis","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.jep.2021.114042_bib3","doi-asserted-by":"crossref","first-page":"525","DOI":"10.2165\/00003495-200363060-00001","article-title":"Nonsteroidal anti-inflammatory drugs and heart failure","volume":"63","author":"Bleumink","year":"2003","journal-title":"Drugs"},{"key":"10.1016\/j.jep.2021.114042_bib4","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1021\/jm0613166","article-title":"Structural and functional basis of cyclooxygenase inhibition","volume":"50","author":"Blobaum","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jep.2021.114042_bib5","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1186\/s12906-017-1945-3","article-title":"Radix Puerariae and Fructus Crataegi mixture inhibits renal injury in type 2 diabetes via decreasing of AKT\/PI3K","volume":"17","author":"Chen","year":"2017","journal-title":"Bmc. Complem. Altern. M."},{"key":"10.1016\/j.jep.2021.114042_bib6","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jep.2013.07.008","article-title":"Inhibitory effect of Coptis chinensis on inflammation in LPS-induced endotoxemia","volume":"149","author":"Choi","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114042_bib7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11101-014-9367-z","article-title":"The pharmaceutical industry and natural products: historical status and new trends","volume":"14","author":"David","year":"2014","journal-title":"Phytochemistry Rev."},{"key":"10.1016\/j.jep.2021.114042_bib8","first-page":"951","article-title":"Flavonoids rather than alkaloids as the diagnostic constituents to distinguish Sophorae Flavescentis Radix from Sophorae Tonkinensis Radix et Rhizoma: an HPLC fingerprint study","volume":"16","author":"Ding","year":"2018","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2021.114042_bib9","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/jssc.201400649","article-title":"Simultaneous determination of three alkaloids in Huangbo using an ionic liquid as a mobile phase additive in reversed\u2010phase liquid chromatography","volume":"38","author":"Ding","year":"2015","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.jep.2021.114042_bib10","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1056\/NEJM198411293112205","article-title":"Interleukin-1 and the pathogenesis of the acute-phase response","volume":"311","author":"Dinarello","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2021.114042_bib11","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s10753-015-0124-2","article-title":"Baicalin inhibits lipopolysaccharide-induced inflammation through signaling NF-\u03baB pathway in HBE16 airway epithelialcells","volume":"38","author":"Dong","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2021.114042_bib12","first-page":"821","article-title":"Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications","volume":"16","author":"Harirforoosh","year":"2013","journal-title":"J. Pharm. Pharmaceut. Sci."},{"key":"10.1016\/j.jep.2021.114042_bib13","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jep.2016.02.020","article-title":"Antipyretic, analgesic and anti-inflammatory effects of Kickxia ramosissima","volume":"182","author":"Jan","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114042_bib14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jep.2016.05.046","article-title":"Coptis chinensis Franch. extract up-regulate type I helper T-cell cytokine through MAPK activation in MOLT-4 T cell","volume":"189","author":"Kim","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114042_bib15","first-page":"1911","article-title":"Radix Sophorae Flavescentis inhibits proliferation and induces apoptosis of AGS human gastric cancer cells","volume":"19","author":"Kim","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2021.114042_bib16","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1021\/np100550t","article-title":"Modern natural products drug discovery and its relevance to biodiversity conservation","volume":"74","author":"Kingston","year":"2011","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2021.114042_bib17","doi-asserted-by":"crossref","first-page":"192","DOI":"10.17305\/bjbms.2010.2684","article-title":"Cyclooxygenase-2, p53 and glucose transporter-1 as predictors of malignancy in the development of gallbladder carcinomas","volume":"10","author":"Legan","year":"2010","journal-title":"Bosnian J. Basic Med."},{"key":"10.1016\/j.jep.2021.114042_bib18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","article-title":"Traditional Chinese medicine network pharmacology: theory, methodology and application","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2021.114042_bib19","first-page":"1630","article-title":"The nature and effectiveness of cold bitter medicinals","volume":"55","author":"Li","year":"2014","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2021.114042_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1749-6632.1998.tb08316.x","article-title":"Cytokines and fever: mechanisms and sites of action","volume":"856","author":"Luheshi","year":"1998","journal-title":"Ann. NY. Acad. Sci."},{"key":"10.1016\/j.jep.2021.114042_bib23","first-page":"1","article-title":"Network pharmacology integrated molecular docking reveals the antiosteosarcoma mechanism of biochanin A","volume":"6","author":"Luo","year":"2019","journal-title":"Evid-Based Compl. Ali."},{"key":"10.1016\/j.jep.2021.114042_bib24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1517\/17425255.2012.722995","article-title":"Pharmacokinetic properties, potential herb-drug interactions and acute toxicity of oral Rhizoma Coptidis alkaloids","volume":"9","author":"Ma","year":"2013","journal-title":"Expet Opin. Drug Metabol. Toxicol."},{"key":"10.1016\/j.jep.2021.114042_bib25","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1158\/1078-0432.CCR-09-0788","article-title":"Cyclooxygenase-2 and cancer treatment: understanding the risk should Be worth the reward","volume":"16","author":"Menter","year":"2010","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.jep.2021.114042_bib26","doi-asserted-by":"crossref","first-page":"R800","DOI":"10.1152\/ajpregu.00258.2002","article-title":"Suppression of fever at near term is associated with, reduced COX-2 protein expression in rat hypothalamus","volume":"283","author":"Mouihate","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.jep.2021.114042_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1615\/CritRevNeurobiol.v13.i1.30","article-title":"Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology","volume":"13","author":"O'Banion","year":"1999","journal-title":"Crit. Rev. Neurobiol."},{"key":"10.1016\/j.jep.2021.114042_bib28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.socnet.2010.03.006","article-title":"Node centrality in weighted networks: generalizing degree and shortest paths","volume":"32","author":"Opsahl","year":"2010","journal-title":"Soc. Network."},{"key":"10.1016\/j.jep.2021.114042_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00011-009-0085-8","article-title":"Diacere in decreases TNF-alpha and IL-1 beta level sinperitoneal fluid and prevents Baker's yeast-induced fever in young rats","volume":"59","author":"Pasin","year":"2010","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jep.2021.114042_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/3709874","article-title":"Elucidation of the anti-inflammatory mechanisms of bupleuri and Scutellariae Radix using system pharmacological analyses","author":"Shen","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2021.114042_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07391102.2020.1762741","article-title":"An in-silico evaluation of different Saikosaponins for their potency against SARS-CoV-2 using NSP15 and fusion spike glycoprotein as targets","volume":"10","author":"Sinha","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.jep.2021.114042_bib32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12906-019-2560-2","article-title":"Inhibitory effects of oxymatrine on hepatic stellate cells activation through TGF-beta\/miR-195\/Smad signaling pathway","volume":"19","author":"Song","year":"2019","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2021.114042_bib33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1113\/jphysiol.1991.sp018378","article-title":"Differential sensitivity in the sites of fever production by prostaglandin E1 within the hypothalamus of the rat","volume":"432","author":"Stitt","year":"1991","journal-title":"J. Physiol."},{"key":"10.1016\/j.jep.2021.114042_bib34","first-page":"573","article-title":"The fight against rheumatism: from willow bark to COX-1 sparing drugs","volume":"12","author":"Vane","year":"2000","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.jep.2021.114042_bib35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/13880209.2019.1577466","article-title":"Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology","volume":"57","author":"Wang","year":"2019","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2021.114042_bib36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jep.2015.10.028","article-title":"Berberine and Coptidis rhizoma as potential anticancer agents: recent updates and future perspectives","volume":"176","author":"Wang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114042_bib38","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jep.2015.12.061","article-title":"UHPLC\/QTOFMS-based metabolomics for the characterization of cold and hot properties of Chinese materia medica","volume":"179","author":"Wang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114042_bib39","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.3390\/ijms13066964","article-title":"A novel chemometric method for the prediction of human oral bioavailability","volume":"13","author":"Xu","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2021.114042_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113834","article-title":"Gentiolactone, a secoiridoid dilactone from Gentiana triflora, inhibits TNF-\u03b1, iNOS and cox-2 mRNA expression and blocks NF-\u03baB promoter activity in murine macrophages","volume":"9","author":"Yamada","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jep.2021.114042_bib41","doi-asserted-by":"crossref","first-page":"i246","DOI":"10.1093\/bioinformatics\/btq176","article-title":"Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework","volume":"26","author":"Yamanishi","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2021.114042_bib42","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1186\/1472-6882-14-430","article-title":"A novel systems pharmacology model for herbal medicine injection: a case using reduning injection","volume":"14","author":"Yang","year":"2014","journal-title":"Bmc. Complem. Altern. M."},{"key":"10.1016\/j.jep.2021.114042_bib43","article-title":"A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data","volume":"7","author":"Yu","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.jep.2021.114042_bib44","first-page":"196","article-title":"Clinical application and pharmacological study of treating chronic osteomyelitis with Phellodendron","volume":"37","author":"Zhang","year":"2018","journal-title":"China &Foreign Medical Treatment"},{"key":"10.1016\/j.jep.2021.114042_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4296","article-title":"Compatibility effects of herb pair Phellodendri chinensis cortex and Anemarrhenae rhizoma on benign prostatic hyperplasia using targeted metabolomics","volume":"32","author":"Zhao","year":"2018","journal-title":"Biomed. Chromatogr."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121002695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121002695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:05:27Z","timestamp":1759943127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121002695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":42,"alternative-id":["S0378874121002695"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114042","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Network pharmacology integrated with molecular docking reveals the common experiment-validated antipyretic mechanism of bitter-cold herbs","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114042"}}