{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T16:52:32Z","timestamp":1794243152682,"version":"4.9.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jep.2021.114070","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T12:13:40Z","timestamp":1616847220000},"page":"114070","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Egg yolk oils exert anti-inflammatory effect via regulating Nrf2\/NF-\u03baB pathway"],"prefix":"10.1016","volume":"274","author":[{"given":"Nanhai","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingsheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaying","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3603-1565","authenticated-orcid":false,"given":"Yonggang","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114070_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2020.101066","article-title":"Modulatory role of dietary polyunsaturated fatty acids in Nrf2-mediated redox homeostasis","volume":"80","author":"Abrescia","year":"2020","journal-title":"Prog. Lipid Res."},{"issue":"6","key":"10.1016\/j.jep.2021.114070_bib2","first-page":"158662","article-title":"Comparative anti-inflammatory effects of plant-and marine-derived omega-3 fatty acids explored in an endothelial cell line","volume":"1865","author":"Baker","year":"2020","journal-title":"BBA-Mol. Cell Biol. L"},{"key":"10.1016\/j.jep.2021.114070_bib3","first-page":"1","article-title":"Evidence on n-3 fatty acids and oleic acid role in retinal inflammation and microvascular integrity: insight from a hyperlipidemic rat model","author":"Bettadahalli","year":"2020","journal-title":"Inflammation"},{"issue":"7","key":"10.1016\/j.jep.2021.114070_bib4","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.jep.2021.114070_bib5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1039\/C8FO01404C","article-title":"DHA-phospholipids (DHA-PL) and EPA-phospholipids (EPA-PL) prevent intestinal dysfunction induced by chronic stress","volume":"10","author":"Cao","year":"2019","journal-title":"Food Funct."},{"issue":"6","key":"10.1016\/j.jep.2021.114070_bib6","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.jep.2021.114070_bib7","doi-asserted-by":"crossref","first-page":"H1862","DOI":"10.1152\/ajpheart.00651.2005","article-title":"Activation of Nrf2\/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression","volume":"290","author":"Chen","year":"2006","journal-title":"Am. J. Physiol.-Heart C"},{"key":"10.1016\/j.jep.2021.114070_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/501792","article-title":"Endogenous generation and signaling actions of omega-3 fatty acid electrophilic derivatives","author":"Cipollina","year":"2015","journal-title":"BioMed Res. Int."},{"issue":"9","key":"10.1016\/j.jep.2021.114070_bib9","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.3390\/nu12092699","article-title":"In vivo anti-inflammatory effects and related mechanisms of processed egg yolk, a potential anti-inflammaging dietary supplement","volume":"12","author":"Cunill","year":"2020","journal-title":"Nutrients"},{"issue":"42","key":"10.1016\/j.jep.2021.114070_bib10","doi-asserted-by":"crossref","first-page":"11702","DOI":"10.1021\/acs.jafc.0c02476","article-title":"Peptides from extruded lupin (lupinus albus L.) regulate inflammatory activity via the p38 MAPK signal transduction pathway in RAW 264.7 cells","volume":"68","author":"Gao","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2021.114070_bib11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.tifs.2017.07.010","article-title":"Non-extractable polyphenols produce gut microbiota metabolites that persist in circulation and show anti-inflammatory and free radical-scavenging effects","volume":"69","author":"Gonz\u00e1lez-Sarr\u00edas","year":"2017","journal-title":"Trends Food Sci. Technol."},{"issue":"8","key":"10.1016\/j.jep.2021.114070_bib12","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/ps\/80.8.1171","article-title":"Influence of source and percentage of fat added to diet on performance and fatty acid composition of egg yolks of two strains of laying hens","volume":"80","author":"Grobas","year":"2001","journal-title":"Poultry Sci."},{"issue":"12","key":"10.1016\/j.jep.2021.114070_bib13","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1194\/jlr.M010371","article-title":"Oleic acid inhibits stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells","volume":"51","author":"Harvey","year":"2010","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.jep.2021.114070_bib14","first-page":"582","article-title":"Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-\u03baB and JNK signalling pathways","volume":"44","author":"Huang","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"5","key":"10.1016\/j.jep.2021.114070_bib15","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(00)80153-1","article-title":"Tyrosine phosphorylation of I\u03baB-\u03b1 activates NF-\u03baB without proteolytic degradation of I\u03baB-\u03b1","volume":"86","author":"Imbert","year":"1996","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jep.2021.114070_bib16","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1101\/gad.13.1.76","article-title":"Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain","volume":"13","author":"Itoh","year":"1999","journal-title":"Gene Dev."},{"issue":"1","key":"10.1016\/j.jep.2021.114070_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms11624","article-title":"Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription","volume":"7","author":"Kobayashi","year":"2016","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.jep.2021.114070_bib18","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.3390\/ijms19092714","article-title":"Peptides as therapeutic agents for inflammatory-related diseases","volume":"19","author":"La Manna","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2021.114070_bib19","doi-asserted-by":"crossref","first-page":"112530","DOI":"10.1016\/j.jep.2019.112530","article-title":"Comprehensive comparison on the anti-inflammatory effects of three species of Sigesbeckia plants based on NF-\u03baB and MAPKs signal pathways in vitro","volume":"250","author":"Linghu","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2021.114070_bib20","first-page":"1","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Tar."},{"issue":"15","key":"10.1016\/j.jep.2021.114070_bib21","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1080\/10408398.2017.1329704","article-title":"Bioactive peptides derived from egg proteins: a review","volume":"58","author":"Liu","year":"2018","journal-title":"Crit. Rev. Food Sci."},{"issue":"4","key":"10.1016\/j.jep.2021.114070_bib22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"4","key":"10.1016\/j.jep.2021.114070_bib23","first-page":"472","article-title":"Anti-inflammatory and analgesic effects of egg yolk: a comparison between organic and machine made","volume":"17","author":"Mahmoudi","year":"2013","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"48","key":"10.1016\/j.jep.2021.114070_bib24","doi-asserted-by":"crossref","first-page":"12666","DOI":"10.1021\/acs.jafc.8b04138","article-title":"Resveratrol ameliorates intestinal barrier defects and inflammation in colitic mice and intestinal cells","volume":"66","author":"Mayangsari","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.jep.2021.114070_bib25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1476-511X-12-101","article-title":"Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells","volume":"12","author":"Mobraten","year":"2013","journal-title":"Lipids Health Dis."},{"issue":"2","key":"10.1016\/j.jep.2021.114070_bib26","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1021\/acs.jafc.8b05480","article-title":"Thymol improves barrier function and attenuates inflammatory responses in porcine intestinal epithelial cells during lipopolysaccharide (LPS)-induced inflammation","volume":"67","author":"Omonijo","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"10","key":"10.1016\/j.jep.2021.114070_bib27","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.3390\/nu11102283","article-title":"Role of oleic acid in the gut-liver axis: from diet to the regulation of its synthesis via Stearoyl-CoA Desaturase 1 (SCD1)","volume":"11","author":"Piccinin","year":"2019","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.jep.2021.114070_bib28","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1365-2036.2004.02262.x","article-title":"A distinct subset of chemokines dominates the mucosal chemokine response in inflammatory bowel disease","volume":"21","author":"Puleston","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"10","key":"10.1016\/j.jep.2021.114070_bib29","first-page":"739","article-title":"The effect of egg yolk oil in the healing of third degree burn wound in rats","volume":"13","author":"Rastegar","year":"2011","journal-title":"Iran. Red Crescent Med. J."},{"issue":"3","key":"10.1016\/j.jep.2021.114070_bib30","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2141\/jpsa.41.161","article-title":"Factors affecting egg internal quality and egg shell quality in laying hens","volume":"41","author":"Roberts","year":"2004","journal-title":"J. Poultry Sci."},{"key":"10.1016\/j.jep.2021.114070_bib31","doi-asserted-by":"crossref","first-page":"108984","DOI":"10.1016\/j.foodres.2020.108984","article-title":"Oleic acid and hydroxytyrosol present in olive oil promote ROS and inflammatory response in normal cultures of murine dermal fibroblasts through the NF-\u03baB and NRF2 pathways","volume":"131","author":"Romana-Souza","year":"2020","journal-title":"Food Res. Int."},{"issue":"11","key":"10.1016\/j.jep.2021.114070_bib32","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1039\/C7FO01172E","article-title":"The anti-inflammatory effect of Agaricus brasiliensis is partly due to its linoleic acid content","volume":"8","author":"Saiki","year":"2017","journal-title":"Food Funct."},{"issue":"10","key":"10.1016\/j.jep.2021.114070_bib33","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.19082\/3035","article-title":"Efficacy of egg yolk and nitroglycerin ointment as treatments for acute anal fissures: a randomized clinical trial study","volume":"8","author":"Salari","year":"2016","journal-title":"Electron. Physician"},{"key":"10.1016\/j.jep.2021.114070_bib34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.foodchem.2014.06.100","article-title":"Anti-inflammatory effect of chlorogenic acid on the IL-8 production in Caco-2 cells and the dextran sulphate sodium-induced colitis symptoms in C57BL\/6 mice","volume":"168","author":"Shin","year":"2015","journal-title":"Food Chem."},{"issue":"46","key":"10.1016\/j.jep.2021.114070_bib35","doi-asserted-by":"crossref","first-page":"28931","DOI":"10.1039\/C7RA02562A","article-title":"Comparative suppression of NLRP3 inflammasome activation with LPS-induced inflammation by blueberry extracts (Vaccinium spp.)","volume":"7","author":"Wang","year":"2017","journal-title":"RSC Adv."},{"issue":"2","key":"10.1016\/j.jep.2021.114070_bib36","doi-asserted-by":"crossref","first-page":"1500523","DOI":"10.1002\/ejlt.201500523","article-title":"Simultaneous texturization and extraction of phospholipids from liquid egg yolk using renewable solvents","volume":"119","author":"Wang","year":"2017","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"10.1016\/j.jep.2021.114070_bib37","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jff.2017.07.064","article-title":"Anti-inflammatory activity of di-peptides derived from ovotransferrin by simulated peptide-cut in TNF-\u03b1-induced Caco-2 cells","volume":"37","author":"Wang","year":"2017","journal-title":"J. Funct. Foods"},{"issue":"1","key":"10.1016\/j.jep.2021.114070_bib38","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3390\/molecules21010106","article-title":"Assessment of egg yolk oil extraction methods of for ShiZhenKang oil by pharmacodynamic index evaluation","volume":"21","author":"Wu","year":"2016","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.jep.2021.114070_bib39","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1021\/acs.jafc.9b06616","article-title":"Biological activities of egg yolk lipids: a review","volume":"68","author":"Xiao","year":"2020","journal-title":"J. Agric. Food Chem."},{"issue":"17","key":"10.1016\/j.jep.2021.114070_bib40","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1021\/acs.jafc.9b00312","article-title":"Comparative transcriptomics reveals the role of the toll-like receptor signaling pathway in fluoride-induced cardiotoxicity","volume":"67","author":"Yan","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2021.114070_bib41","article-title":"High-throughput transcriptome profiling in drug and biomarker discovery","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Genet."},{"issue":"6","key":"10.1016\/j.jep.2021.114070_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.221","article-title":"NF-\u03ba B and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis","volume":"5","author":"Yao","year":"2014","journal-title":"Cell Death Dis."},{"issue":"13","key":"10.1016\/j.jep.2021.114070_bib43","doi-asserted-by":"crossref","first-page":"7624","DOI":"10.1021\/jf1011598","article-title":"Egg yolk peptides up-regulate glutathione synthesis and antioxidant enzyme activities in a porcine model of intestinal oxidative stress","volume":"58","author":"Young","year":"2010","journal-title":"J. Agric. Food Chem."},{"issue":"12","key":"10.1016\/j.jep.2021.114070_bib44","doi-asserted-by":"crossref","first-page":"6444","DOI":"10.1039\/C8FO01939H","article-title":"The anti-inflammatory activity of peptides from simulated gastrointestinal digestion of preserved egg white in DSS-induced mouse colitis","volume":"9","author":"Zhang","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2021.114070_bib45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jnutbio.2018.09.019","article-title":"Isolation and identification of peptides from simulated gastrointestinal digestion of preserved egg white and their anti-inflammatory activity in TNF-\u03b1-induced Caco-2 cells","volume":"63","author":"Zhang","year":"2019","journal-title":"J. Nutr. Biochem."},{"issue":"4","key":"10.1016\/j.jep.2021.114070_bib46","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1021\/acs.jafc.8b06263","article-title":"Anti-inflammatory mechanism involved in 4-ethylguaiacol-mediated inhibition of LPS-induced inflammation in THP-1 cells","volume":"67","author":"Zhao","year":"2019","journal-title":"J. Agric. Food Chem."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412100297X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412100297X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:08:52Z","timestamp":1759943332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412100297X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":46,"alternative-id":["S037887412100297X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114070","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Egg yolk oils exert anti-inflammatory effect via regulating Nrf2\/NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114070"}}