{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:38:03Z","timestamp":1793281083758,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001846","name":"Natural Resources Data Management System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.jep.2021.114076","type":"journal-article","created":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T11:17:29Z","timestamp":1616930249000},"page":"114076","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Evaluation of ethnopharmacologically selected Vitex negundo L. for In vitro antimalarial activity and secondary metabolite profiling"],"prefix":"10.1016","volume":"275","author":[{"given":"Manish Kumar","family":"Dwivedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen Kumar","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashan","family":"Manhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumkum","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niti","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114076_bib1","doi-asserted-by":"crossref","first-page":"S289","DOI":"10.1016\/S1995-7645(14)60248-0","article-title":"Comparative assessment of extraction methods and quantitative estimation of luteolin in the leaves of Vitex negundo Linn by HPLC","volume":"7","author":"Abidin","year":"2014","journal-title":"Asian Pac J Trop Med"},{"key":"10.1016\/j.jep.2021.114076_bib2","first-page":"25","article-title":"Nishinda (Vitex negundo Linn) \u2013 a valuable medicinal plant used in herbal medicine","volume":"2","author":"Abu Bin Nyeem","year":"2017","journal-title":"Int. J. Adv. Educ. Res."},{"key":"10.1016\/j.jep.2021.114076_bib3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.20510\/ukjpb\/5\/i5\/166558","article-title":"Preliminary phytochemical analysis and characterization of flavonoid moiety from vitex negundo leaves origin in Madhya Pradesh state by HPLC study","volume":"5","author":"Ahmad Dar","year":"2017","journal-title":"UK J. Pharm. Biosci."},{"key":"10.1016\/j.jep.2021.114076_bib4","first-page":"158","article-title":"The wealth of India, raw materials","volume":"10","author":"Anonymous","year":"2003","journal-title":"CSIR Council Sci. Ind. Res."},{"issue":"2","key":"10.1016\/j.jep.2021.114076_bib5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/acm.2000.6.195","article-title":"The first international meeting of the research initiative on traditional antimalarial methods (RITAM)","volume":"6","author":"Bodeker","year":"2000","journal-title":"J. Alternative Compl. Med."},{"key":"10.1016\/j.jep.2021.114076_bib6","first-page":"418\u2010425","article-title":"Flavonoid compounds identified in Alchemilla L. species collected in the north-eastern black sea region of Turkey","volume":"9","author":"Bulent","year":"2012","journal-title":"Afr. J. Tradit., Complementary Altern. Med."},{"key":"10.1016\/j.jep.2021.114076_bib7","first-page":"261","article-title":"Geospatial mapping of antimalarial plants used by the ethnic groups of Anuppur district (Madhya Pradesh), India","volume":"18","author":"Dwivedi","year":"2019","journal-title":"Indian J. Tradit. Knowl."},{"key":"10.1016\/j.jep.2021.114076_bib8","first-page":"1","article-title":"GIS mapping of antimalarial plants based on traditional knowledge in pushparajgarh division, district Anuppur, Madhya Pradesh, India","author":"Dwivedi","year":"2020","journal-title":"J. Herbs, Spices, Med. Plants"},{"key":"10.1016\/j.jep.2021.114076_bib9","first-page":"204","article-title":"Approaches, challenges and prospects of antimalarial drug discovery from plant sources","volume":"187","author":"Ezenyi","year":"2016","journal-title":"Current Topics in Malaria"},{"key":"10.1016\/j.jep.2021.114076_bib10","doi-asserted-by":"crossref","first-page":"29584","DOI":"10.1074\/jbc.272.47.29584","article-title":"Identification and characterization of the functional amino acids at the active site of the large Thioredoxin reductase from Plasmodium falciparum","volume":"272","author":"Gilberger","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.jep.2021.114076_bib11","first-page":"147","article-title":"An Ethnobotanical Survey of Anti-malarial Plants in some highly malarial effected districts of Assam","volume":"7","author":"Gohain","year":"2015","journal-title":"Int. J. Pharm. Pharmaceut. Sci."},{"key":"10.1016\/j.jep.2021.114076_bib12","article-title":"Antioxidant and antiradical properties of selected flavonoids and phenolic compounds","volume":"10","author":"Huyut","year":"2017","journal-title":"Biochem. Res. Int."},{"key":"10.1016\/j.jep.2021.114076_bib13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1473-3099(17)30048-8","article-title":"The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study","volume":"17","author":"Imwong","year":"2017","journal-title":"Lancet Infect. Dis."},{"issue":"8","key":"10.1016\/j.jep.2021.114076_bib14","first-page":"289","article-title":"Evaluation of phytochemical compounds in leaf extract of vitex negundo L. Using TLC, UV-VIS and FTIR analysis","volume":"5","author":"Janakiraman","year":"2015","journal-title":"Int. J. Health Sci. Res."},{"key":"10.1016\/j.jep.2021.114076_bib15","series-title":"International Book Distributors","first-page":"1937","article-title":"Indian medicinal plants","author":"Kirtikar","year":"2008"},{"key":"10.1016\/j.jep.2021.114076_bib16","author":"Kumar"},{"key":"10.1016\/j.jep.2021.114076_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051714","article-title":"Bioactivity guided fractionation of leaves extract of nyctanthes arbor tristis (harshringar) against P falciparum","volume":"7","author":"Kumari","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.jep.2021.114076_bib18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.phymed.2004.09.001","article-title":"Tyrosinase inhibitory lignans from the methanol extract of the roots of Vitex negundo Linn. and their structure\u2013activity relationship","volume":"13","author":"Malik Haq","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2021.114076_bib19","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jep.2010.01.033","article-title":"Antimalarial herbal remedies of Msambweni, Kenya","volume":"128","author":"Nguta","year":"2010","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2021.114076_bib20","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1365-3156.2011.02922.x","article-title":"In vitro antiplasmodial activity and cytotoxicity of extracts and fractions of Vitex madiensis, medicinal plant of Gabon","volume":"17","author":"Ondo","year":"2012","journal-title":"Trop. Med. Int. Health"},{"issue":"6","key":"10.1016\/j.jep.2021.114076_bib21","first-page":"226","article-title":"Phytochemical screening, elemental and functional groups analysis of Vitex negundo L. leaves","volume":"9","author":"Pawar","year":"2017","journal-title":"Int. J. Pharm. Pharmaceut. Sci."},{"issue":"6","key":"10.1016\/j.jep.2021.114076_bib22","doi-asserted-by":"crossref","first-page":"102","DOI":"10.7897\/2230-8407.04622","article-title":"Ethnobotanical utilization of some medicinal plants by Bodo people of manas biosphere reserve in the treatment of malaria","volume":"4","author":"Paul","year":"2013","journal-title":"Int. Res. J. Pharm."},{"key":"10.1016\/j.jep.2021.114076_bib23","first-page":"23","article-title":"A Review on ethanomedicinal uses and Phytopharmacology of anti-inflammatory herb Vitex negundo","volume":"1","author":"Rastogi","year":"2010","journal-title":"Int. J. Pharma Sci. Res."},{"issue":"10 Suppl. 1","key":"10.1016\/j.jep.2021.114076_bib24","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1475-2875-10-S1-S4","article-title":"Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions","volume":"15","author":"Rasoanaivo","year":"2011","journal-title":"Malar. J."},{"key":"10.1016\/j.jep.2021.114076_bib25","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jep.2014.05.047","article-title":"Traditional uses of medicinal plants against malarial disease by the tribal communities of Lesser Himalayas-Pakistan","volume":"155","author":"Shah","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114076_bib26","first-page":"128","article-title":"Anti-microfilarial activity of methanolic extract of Vitex negundo and Aegle marmelos and their phytochemical analysis","volume":"46","author":"Sahare","year":"2008","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.jep.2021.114076_bib27","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.jff.2015.06.018","article-title":"Phenolics and polyphenolics in foods, beverages and spices: antioxidant activity and health effects - a review","volume":"18","author":"Shahidi","year":"2015","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.jep.2021.114076_bib28","series-title":"Database on Medicinal Plants Used in Ayurveda","first-page":"450","volume":"vol. 3","author":"Sharma","year":"2005"},{"key":"10.1016\/j.jep.2021.114076_bib29","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1128\/AAC.48.5.1803-1806.2004","article-title":"Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening","volume":"48","author":"Smilkstein","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jep.2021.114076_bib30","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.jep.2011.01.044","article-title":"Deciphering molecular mechanism underlying antileishmanial activity of Nyctanthes arbortristis, an Indian medicinal plant","volume":"134","author":"Shukla","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114076_bib31","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/01496395.2015.1105822","article-title":"Parametric optimization and modeling of batch extraction process for extraction of betulinic acid from leaves of Vitex Negundo Linn","volume":"51","author":"Taralkara","year":"2016","journal-title":"Separ. Sci. Technol."},{"key":"10.1016\/j.jep.2021.114076_bib32","first-page":"162","article-title":"Medicinal uses and biological activities of Vitex negundo","volume":"4","author":"Tandon","year":"2005","journal-title":"Nat. Product. Radiance"},{"key":"10.1016\/j.jep.2021.114076_bib33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.phytochem.2004.11.013","article-title":"Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots","volume":"66","author":"Tasdemir","year":"2005","journal-title":"Phytochemistry"},{"issue":"1\u20132","key":"10.1016\/j.jep.2021.114076_bib44","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.exppara.2004.07.008","article-title":"Plasmodium falciparum: modified medium composition supports continuous cultivation with foetal bovine serum","volume":"108","author":"Srivastava","year":"2004","journal-title":"Exp. Parasitol"},{"key":"10.1016\/j.jep.2021.114076_bib34","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.bmcl.2010.01.095","article-title":"New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides","volume":"20","author":"Tamura","year":"2010","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"4254","key":"10.1016\/j.jep.2021.114076_bib35","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.jep.2021.114076_bib36","first-page":"126","article-title":"Vitex negundo: medicinal values, biological Activities,Toxicity studies and phytopharmacological actions","volume":"2","author":"Venkateswarlu","year":"2012","journal-title":"Int. J. Pharm. Phytopharmacol. Res."},{"key":"10.1016\/j.jep.2021.114076_bib37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.foodchem.2017.03.131","article-title":"Identification of the bioactive compounds and antioxidant, antimutagenic and antimicrobial activities of thermally processed agro-industrial waste","volume":"231","author":"Vodnar","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2021.114076_bib38","article-title":"Targeting asexual and sexual blood stages of human malaria parasite P. falciparum with 7-Chloroquinoline Based [1,2,3]- Triazoles","author":"Wadi","year":"2018","journal-title":"ChemMedChem"},{"issue":"1","key":"10.1016\/j.jep.2021.114076_bib39","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.fitote.2010.11.016","article-title":"Synergy research: approaching a new generation of phytopharmaceuticals","volume":"82","author":"Wagner","year":"2011","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2021.114076_bib40","first-page":"156","article-title":"Traditional herbal medicines for malaria","volume":"13","author":"Willcox","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.jep.2021.114076_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2875-9-235","article-title":"Poverty and fever vulnerability in Nigeria: a multilevel analysis","volume":"9","author":"Yusuf","year":"2010","journal-title":"Malar. J."},{"key":"10.1016\/j.jep.2021.114076_bib42","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00436-011-2363-y","article-title":"In vitro antiplasmodial activity and cytotoxicity of crude extracts and compounds from the stem bark of Kigelia africana (lam.) benth (bignoniaceae)","volume":"108","author":"Zofou","year":"2011","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.jep.2021.114076_bib43","doi-asserted-by":"crossref","first-page":"539\u2010544","DOI":"10.1007\/s00436-011-2519-9","article-title":"Antimalarial drug interactions of compounds isolated from Kigelia africana (Bignoniaceae) and their synergism with artemether, against the multidrug-resistant W2mef Plasmodium falciparum strain","volume":"110","author":"Zofou","year":"2012","journal-title":"Parasitol. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121003032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121003032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:01:11Z","timestamp":1759942871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121003032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":44,"alternative-id":["S0378874121003032"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114076","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of ethnopharmacologically selected Vitex negundo L. for In vitro antimalarial activity and secondary metabolite profiling","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114076"}}