{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T20:55:08Z","timestamp":1782248108112,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.jep.2021.114118","type":"journal-article","created":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T18:39:23Z","timestamp":1618771163000},"page":"114118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Proteomics analysis in the kidney of mice following oral feeding Realgar"],"prefix":"10.1016","volume":"275","author":[{"given":"Sheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhong","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2329-0157","authenticated-orcid":false,"given":"Shen","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2021.114118_bib1","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1038\/s41598-018-24591-w","article-title":"A new family of periplasmic-binding proteins that sense arsenic oxyanions","volume":"8","author":"Badilla","year":"2018","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.jep.2021.114118_bib2","first-page":"290","article-title":"Urinary proteomics in biomarker discovery of kidney-related disorders: diabetic nephropathy and drug-induced nephrotoxicity in chronic headache","volume":"29","author":"Bellei","year":"2018","journal-title":"EJIFCC"},{"issue":"3","key":"10.1016\/j.jep.2021.114118_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/14789450.2018.1443007","article-title":"The future role of proteomics in the understanding of acute kidney injury","volume":"15","author":"Bennett","year":"2018","journal-title":"Expert Rev. Proteomics"},{"issue":"1","key":"10.1016\/j.jep.2021.114118_bib4","doi-asserted-by":"crossref","first-page":"17496","DOI":"10.1038\/s41598-019-53695-0","article-title":"Expression of the BAD pathway is a marker of triple-negative status and poor outcome","volume":"9","author":"Boac","year":"2019","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.jep.2021.114118_bib5","first-page":"1136","article-title":"Comparative study on crude and processed Realgar by X-ray diffraction","volume":"34","author":"Cao","year":"2012","journal-title":"Chin. Tradit. Patent Med."},{"issue":"6","key":"10.1016\/j.jep.2021.114118_bib6","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1681\/ASN.2004121145","article-title":"Molecular identification of canine podocalyxin-like protein 1 as a renal tubulogenic regulator","volume":"16","author":"Cheng","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"issue":"5","key":"10.1016\/j.jep.2021.114118_bib7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s11655-011-0697-z","article-title":"Realgar-induced apoptosis of cervical cancer cell line Siha via cytochrome c release and caspase-3 and caspase-9 activation","volume":"18","author":"Cheng","year":"2012","journal-title":"Chin. J. Integr. Med."},{"issue":"2","key":"10.1016\/j.jep.2021.114118_bib8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: critical control points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.jep.2021.114118_bib9","doi-asserted-by":"crossref","first-page":"110699","DOI":"10.1016\/j.jinorgbio.2019.110699","article-title":"The role of catalases in the prevention\/promotion of oxidative stress","volume":"197","author":"Gebicka","year":"2019","journal-title":"J. Inorg. Biochem."},{"issue":"3","key":"10.1016\/j.jep.2021.114118_bib10","doi-asserted-by":"crossref","first-page":"582","DOI":"10.4103\/1319-2442.132194","article-title":"Plasma neutrophil gelatinase-associated lipocalin (NGAL) and plasma cystatin C (CysC) as biomarker of acute kidney injury after cardiac surgery","volume":"25","author":"Ghonemy","year":"2014","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"10.1016\/j.jep.2021.114118_bib11","doi-asserted-by":"crossref","first-page":"19667","DOI":"10.1038\/srep19667","article-title":"Urinary Kininogen-1 and Retinol binding protein-4 respond to Acute Kidney Injury: predictors of patient prognosis","volume":"6","author":"Gonzalez-Calero","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2021.114118_bib12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.envpol.2016.08.035","article-title":"Proteomic profiling reveals candidate markers for arsenic-induced skin keratosis","volume":"218","author":"Guo","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jep.2021.114118_bib13","doi-asserted-by":"crossref","first-page":"32518","DOI":"10.1038\/srep32518","article-title":"Integrated proteomics and metabolomics analysis of rat testis: mechanism of arsenic-induced male reproductive toxicity","volume":"6","author":"Huang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2021.114118_bib14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.envpol.2017.05.077","article-title":"Comparative proteomic analysis reveals heart toxicity induced by chronic arsenic exposure in rats","volume":"229","author":"Huang","year":"2017","journal-title":"Environ. Pollut."},{"issue":"12","key":"10.1016\/j.jep.2021.114118_bib15","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1210\/endo.138.12.5588","article-title":"Expression and function of a proapoptotic Bcl-2 family member Bcl-XL\/Bcl-2-associated death promoter (BAD) in rat ovary","volume":"138","author":"Kaipia","year":"1997","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.jep.2021.114118_bib16","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.bbrc.2019.04.172","article-title":"Quantitative proteomic study of arsenic treated mouse liver sinusoidal endothelial cells using a reverse super-SILAC method","volume":"514","author":"Li","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2021.114118_bib17","article-title":"Use status and metabolism of realgar in Chinese patent medicine","author":"Li","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2021.114118_bib18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jep.2010.11.052","article-title":"Realgar and realgar-containing Liu-Shen-Wan are less acutely toxic than arsenite and arsenate","volume":"134","author":"Liu","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"1\u20132","key":"10.1016\/j.jep.2021.114118_bib19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cbpa.2012.01.015","article-title":"Arsenic compounds: revived ancient remedies in the fight against human malignancies","volume":"16","author":"Liu","year":"2012","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.jep.2021.114118_bib20","first-page":"250387","article-title":"Toxicology evaluation of realgar-containing niu-huang-jie-du pian as compared to arsenicals in cell cultures and in mice","volume":"2011","author":"Miao","year":"2011","journal-title":"ISRN Toxicol"},{"key":"10.1016\/j.jep.2021.114118_bib21","series-title":"Pharmacopoeia of People's Republic of China, Part 1, Beijing","first-page":"350","author":"National pharmacopoeia committee","year":"2020"},{"issue":"6788","key":"10.1016\/j.jep.2021.114118_bib22","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/35015709","article-title":"Proteomics to study genes and genomes","volume":"405","author":"Pandey","year":"2000","journal-title":"Nature"},{"issue":"1\u20133","key":"10.1016\/j.jep.2021.114118_bib23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0014-5793(02)02607-8","article-title":"Nuclear Apaf-1 and cytochrome c redistribution following stress-induced apoptosis","volume":"517","author":"Ruiz-Vela","year":"2002","journal-title":"FEBS Lett."},{"issue":"15","key":"10.1016\/j.jep.2021.114118_bib24","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.1158\/0008-5472.CAN-04-0240","article-title":"Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression","volume":"64","author":"Somasiri","year":"2004","journal-title":"Canc. Res."},{"issue":"2","key":"10.1016\/j.jep.2021.114118_bib25","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3390\/jcm9020417","article-title":"Circulating arsenic is associated with long-term risk of graft failure in kidney transplant recipients: a prospective cohort study","volume":"9","author":"Sotomayor","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jep.2021.114118_bib26","first-page":"73","article-title":"Effects of Realgar and prescription containing Realgar on stress response proteins, inflammatory mediators and complements in fever rat models","volume":"32","author":"Tang","year":"2009","journal-title":"Zhong Yao Cai"},{"issue":"18","key":"10.1016\/j.jep.2021.114118_bib27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.csbj.2014.08.004","article-title":"Proteomics for systems toxicology","volume":"11","author":"Titz","year":"2014","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"10","key":"10.1016\/j.jep.2021.114118_bib28","first-page":"1342","article-title":"Retrospective study of adverse reactions of Niuhuang Jiedu tablet (pill) and risk control based on literature analysis","volume":"35","author":"Tong","year":"2010","journal-title":"Zhongguo Zhongyao Zazhi"},{"issue":"3","key":"10.1016\/j.jep.2021.114118_bib29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.14715\/cmb\/2017.63.3.2","article-title":"A proteomics research of apoptosis of leukemia cells induced by arsenic trioxide","volume":"63","author":"Wang","year":"2017","journal-title":"Cell. Mol. Biol."},{"issue":"23","key":"10.1016\/j.jep.2021.114118_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201900245","article-title":"motifeR: an integrated web software for identification and visualization of protein posttranslational modification motifs","volume":"19","author":"Wang","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.jep.2021.114118_bib31","doi-asserted-by":"crossref","first-page":"112370","DOI":"10.1016\/j.jep.2019.112370","article-title":"Comparative health risk assessment of realgar and Niu Huang Jie Du tablets based on tissue arsenic levels after multiple oral administration to rats","volume":"249","author":"Wu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114118_bib32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.taap.2016.07.006","article-title":"Effects of realgar on GSH synthesis in the mouse hippocampus: involvement of system XAG(-), system XC(-), MRP-1 and Nrf2","volume":"308","author":"Wang","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2021.114118_bib33","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jep.2011.03.071","article-title":"The medicinal use of realgar (As\u2084S\u2084) and its recent development as an anticancer agent","volume":"135","author":"Wu","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114118_bib34","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3389\/fphar.2018.00618","article-title":"UPLC\/Q-TOFMS-Based metabolomics approach to reveal the protective role of other herbs in an-Gong-niu-huang wan against the hepatorenal toxicity of cinnabar and realgar","volume":"9","author":"Xia","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2021.114118_bib35","doi-asserted-by":"crossref","first-page":"103572","DOI":"10.1016\/j.dib.2018.12.011","article-title":"Data on the sub-chronic toxicity in rats after 30 days of oral realgar administration and the accumulation and distribution of arsenic species","volume":"23","author":"Yi","year":"2018","journal-title":"Data Brief"},{"key":"10.1016\/j.jep.2021.114118_bib36","doi-asserted-by":"crossref","first-page":"111576","DOI":"10.1016\/j.jep.2018.10.037","article-title":"Study of the accumulation and distribution of arsenic species and association with arsenic toxicity in rats after 30 days of oral realgar administration","volume":"247","author":"Yi","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114118_bib37","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1016\/j.forsciint.2019.03.012","article-title":"Fatal acute arsenic poisoning by external use of realgar: case report and 30 years literature retrospective study in China","volume":"300","author":"Zheng","year":"2019","journal-title":"Forensic Sci. Int."},{"issue":"11","key":"10.1016\/j.jep.2021.114118_bib38","doi-asserted-by":"crossref","first-page":"26871","DOI":"10.3390\/ijms161125994","article-title":"Identification of arsenic direct-binding proteins in acute promyelocytic Leukaemia cells","volume":"16","author":"Zhang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2021.114118_bib39","doi-asserted-by":"crossref","first-page":"103532","DOI":"10.1016\/j.jprot.2019.103532","article-title":"Evaluation of sample preparation methods for label-free quantitative profiling of salivary proteome","volume":"210","author":"Zhang","year":"2020","journal-title":"J Proteomics"},{"issue":"53","key":"10.1016\/j.jep.2021.114118_bib40","doi-asserted-by":"crossref","first-page":"90879","DOI":"10.18632\/oncotarget.18741","article-title":"Integration of microRNAome, proteomics and metabolomics to analyze arsenic-induced malignant cell transformation","volume":"8","author":"Zhou","year":"2017","journal-title":"Oncotarget"},{"issue":"7","key":"10.1016\/j.jep.2021.114118_bib41","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1182\/blood.2019000760","article-title":"The simpler, the better: oral arsenic for acute promyelocytic leukemia","volume":"134","author":"Zhu","year":"2019","journal-title":"Blood"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121003457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121003457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:04:27Z","timestamp":1759943067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121003457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":41,"alternative-id":["S0378874121003457"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114118","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomics analysis in the kidney of mice following oral feeding Realgar","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114118","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114118"}}