{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:49:18Z","timestamp":1783050558653,"version":"3.54.6"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.jep.2021.114140","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T07:39:16Z","timestamp":1619509156000},"page":"114140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Protection of Ficus pandurata Hance against acute alcohol-induced liver damage in mice via suppressing oxidative stress, inflammation, and apoptosis"],"prefix":"10.1016","volume":"275","author":[{"given":"Weibo","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiting","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangru","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"102","key":"10.1016\/j.jep.2021.114140_bib1","doi-asserted-by":"crossref","first-page":"84048","DOI":"10.1039\/C5RA16563F","article-title":"Metabolomics approach to identify therapeutically potential biomarkers of the Zhi-Zi-Da-Huang decoction effect on the hepatoprotective mechanism","volume":"5","author":"An","year":"2015","journal-title":"RSC Adv."},{"issue":"1","key":"10.1016\/j.jep.2021.114140_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.jep.2021.114140_bib3","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1136\/gut.41.6.845","article-title":"Drinking habits as cofactors of risk for alcohol induced liver damage","volume":"41","author":"Bellentani","year":"1997","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.jep.2021.114140_bib4","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"Bertola","year":"2013","journal-title":"Nat. Protoc."},{"issue":"6","key":"10.1016\/j.jep.2021.114140_bib5","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00204-009-0432-0","article-title":"Role of oxidative stress in alcohol-induced liver injury","volume":"83","author":"Cederbaum","year":"2009","journal-title":"Arch. Toxicol."},{"issue":"7","key":"10.1016\/j.jep.2021.114140_bib6","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1111\/acer.12437","article-title":"Protective effect of flos puerariae extract following acute alcohol intoxication in mice","volume":"38","author":"Chen","year":"2014","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.jep.2021.114140_bib7","first-page":"148","article-title":"Research advance of Ficus pandurata hance","volume":"22","author":"Chen","year":"2020","journal-title":"Food Drug"},{"key":"10.1016\/j.jep.2021.114140_bib8","author":"China Food and Drug Administration"},{"key":"10.1016\/j.jep.2021.114140_bib9","first-page":"845","volume":"vol. 1","year":"1996"},{"issue":"9","key":"10.1016\/j.jep.2021.114140_bib10","first-page":"1927","article-title":"Alcohol abuse, alcoholism, and damage to the immune system - a review","volume":"22","author":"Cook","year":"1998","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.jep.2021.114140_bib11","first-page":"497","volume":"vol. 2","author":"Editorial Board of National Administration of Traditional Chinese Medicine","year":"1999"},{"key":"10.1016\/j.jep.2021.114140_bib12","first-page":"7067619","article-title":"Methane alleviates acetaminophen-induced liver injury by inhibiting inflammation, oxidative stress, endoplasmic reticulum stress, and apoptosis through the Nrf2\/HO-1\/NQO1 signaling pathway","author":"Feng","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.jep.2021.114140_bib13","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2021.114140_bib14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/1471-2350-11-172","article-title":"Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease","volume":"11","author":"Hotta","year":"2010","journal-title":"BMC Med. Genet."},{"issue":"7","key":"10.1016\/j.jep.2021.114140_bib15","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s12272-016-0784-y","article-title":"New ursane triterpenoids from Ficus pandurata and their binding affinity for human cannabinoid and opioid receptors","volume":"39","author":"Khedr","year":"2016","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2021.114140_bib16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.phytol.2017.11.023","article-title":"Panduramides A-D, new ceramides from Ficus pandurata fruits","volume":"23","author":"Khedr","year":"2018","journal-title":"Phytochem. Lett."},{"issue":"4","key":"10.1016\/j.jep.2021.114140_bib17","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/gutjnl-2016-311861","article-title":"MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47phox-oxidative stress pathway in neutrophils","volume":"66","author":"Li","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jep.2021.114140_bib18","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.saa.2018.07.085","article-title":"Rapid and non-destructive discrimination of special-grade flat green tea using near-infrared spectroscopy","volume":"206","author":"Li","year":"2019","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"issue":"8","key":"10.1016\/j.jep.2021.114140_bib19","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1053\/j.gastro.2016.02.043","article-title":"Alcoholic liver disease in Asia, Europe, and North America","volume":"150","author":"Liangpunsakul","year":"2016","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jep.2021.114140_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.alcohol.2004.07.008","article-title":"Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis","volume":"34","author":"Lieber","year":"2004","journal-title":"Alcohol"},{"key":"10.1016\/j.jep.2021.114140_bib21","first-page":"84","article-title":"Research progress on the varietal identification and modern research of Ficus pandurata Hance","volume":"14","author":"Lu","year":"2018","journal-title":"Asia-Pacific Tradit. Med."},{"key":"10.1016\/j.jep.2021.114140_bib22","article-title":"Ursolic acid reduces hepatocellular apoptosis and alleviates alcohol-induced liver injury via irreversible inhibition of CASP3 in vivo","author":"Ma","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.jep.2021.114140_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-511X-12-11","article-title":"Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol mediated liver fibrosis in mice","volume":"12","author":"Nan","year":"2013","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.jep.2021.114140_bib24","series-title":"Chinese Herbal Dictionary","author":"Nanjing University of Traditional Chinese Medicine","year":"2006"},{"key":"10.1016\/j.jep.2021.114140_bib25","doi-asserted-by":"crossref","first-page":"S142","DOI":"10.1016\/S0261-5614(15)30472-6","article-title":"MON-PP040: a crude rhubarb extract protects from acute ethanol-induced liver damage in association with increased akkermansia muciniphila population in the gut microbiota of mice","volume":"34","author":"Neyrinck","year":"2015","journal-title":"Clin. Nutr."},{"issue":"6","key":"10.1016\/j.jep.2021.114140_bib26","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0168-8278(00)80120-8","article-title":"Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases","volume":"33","author":"Niemel\u00e4","year":"2000","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2021.114140_bib27","volume":"vol. 2","author":"Pan","year":"2007"},{"issue":"11","key":"10.1016\/j.jep.2021.114140_bib28","first-page":"CD001511","article-title":"Glucocorticosteroids for people with alcoholic hepatitis","volume":"11","author":"Pavlov","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jep.2021.114140_bib29","first-page":"123","article-title":"Qualitative identification and content determination of Bergamolactone in Ficus pandurata Hance","volume":"18","author":"Peng","year":"2020","journal-title":"Chin. Med. Mod. Distance Educ. China"},{"issue":"6","key":"10.1016\/j.jep.2021.114140_bib30","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.neo.2018.02.012","article-title":"Targeting liver cancer and associated pathologies in mice with a mitochondrial VDAC1-based peptide","volume":"20","author":"Pittala","year":"2018","journal-title":"Neoplasia"},{"issue":"13","key":"10.1016\/j.jep.2021.114140_bib31","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1080\/14786410902757899","article-title":"Chemical composition of the stem bark and leaves of Ficus pandurata Hance","volume":"23","author":"Ramadan","year":"2009","journal-title":"Nat. Prod. Res."},{"issue":"7","key":"10.1016\/j.jep.2021.114140_bib32","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrgastro.2015.94","article-title":"Inflammasome activation and function in liver disease","volume":"12","author":"Szabo","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.jep.2021.114140_bib33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3390\/biomedicines6040106","article-title":"Alcoholic liver disease: alcohol metabolism, cascade of molecular mechanisms, cellular targets, and clinical aspects","volume":"6","author":"Teschke","year":"2018","journal-title":"Biomedicines"},{"key":"10.1016\/j.jep.2021.114140_bib34","first-page":"63","article-title":"Chrysanthemum extract attenuates hepatotoxicity via inhibiting oxidative stress in vivo and in vitro","volume":"15","author":"Tian","year":"2019","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.jep.2021.114140_bib35","author":"Unite State Food and Drug Administration"},{"issue":"12","key":"10.1016\/j.jep.2021.114140_bib36","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.3748\/wjg.v25.i12.1445","article-title":"Growing burden of alcoholic liver disease in China: a review","volume":"25","author":"Wang","year":"2019","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jep.2021.114140_bib37","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10120-020-01111-2","article-title":"Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop","volume":"24","author":"Wang","year":"2020","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.jep.2021.114140_bib38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jep.2017.11.011","article-title":"Acute and sub-acute oral toxicity studies of the aqueous extract from radix, radix with cortex and cortex of Psammosilene tunicoides in mice and rats","volume":"213","author":"Wu","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2021.114140_bib39","doi-asserted-by":"crossref","first-page":"805","DOI":"10.3390\/nu10070805","article-title":"Shanxi aged vinegar protects against alcohol-induced liver injury via activating NRF2-mediated antioxidant and inhibiting TLR4-induced inflammatory response","volume":"10","author":"Xia","year":"2018","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jep.2021.114140_bib40","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jhep.2019.03.004","article-title":"Global liver disease burdens and research trends: analysis from a Chinese perspective","volume":"71","author":"Xiao","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2021.114140_bib41","doi-asserted-by":"crossref","first-page":"111853","DOI":"10.1016\/j.jep.2019.111853","article-title":"A comparative assessment of acute oral toxicity and traditional pharmacological activities between extracts of Fritillaria cirrhosae Bulbus and Fritillaria pallidiflora Bulbus","volume":"238","author":"Xu","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"14","key":"10.1016\/j.jep.2021.114140_bib42","first-page":"90","article-title":"Analysis of the nutritional components and content determination of total flavonoids in Ficus pandurata Hance var.angustifolia Cheng","volume":"33","author":"Ying","year":"2012","journal-title":"Sci. Technol. Food Ind."},{"issue":"2","key":"10.1016\/j.jep.2021.114140_bib43","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.dld.2019.10.012","article-title":"Contribution of high body mass index and alcohol use to liver cancer-related mortality: a study based on 195 countries or territories","volume":"52","author":"Zhang","year":"2020","journal-title":"Dig. Liver Dis."},{"issue":"8","key":"10.1016\/j.jep.2021.114140_bib44","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41419-020-02890-3","article-title":"Computational repositioning of dimethyl fumarate for treating alcoholic liver disease","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2021.114140_bib45","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.redox.2018.07.002","article-title":"Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1\/Nrf2 pathway","volume":"18","author":"Zhao","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2021.114140_bib46","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.biopha.2016.06.036","article-title":"Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K\/AKT and NF-\u03baB related signaling","volume":"83","author":"Zhong","year":"2016","journal-title":"Biomed. Pharmacother."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121003676?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121003676?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:10:08Z","timestamp":1759943408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121003676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":46,"alternative-id":["S0378874121003676"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114140","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protection of Ficus pandurata Hance against acute alcohol-induced liver damage in mice via suppressing oxidative stress, inflammation, and apoptosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114140"}}